$VAR1 = undef;

Summary for peptidase A02.007: feline immunodeficiency virus retropepsin

Names
MEROPS Name	feline immunodeficiency virus retropepsin
Other names	retropepsin (feline immunodeficiency virus)

Domain architecture

MEROPS Classification
Classification	Clan AA >> Subclan (none) >> Family A2 >> Subfamily A >> A02.007
Holotype	feline immunodeficiency virus retropepsin, Uniprot accession P31822 (peptidase unit: 46-153), MERNUM MER0000965
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Aspartic
Peplist	Included in the Peplist with identifier PL00029
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (8 cleavages)
Physiology	Processing of viral polyprotein.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	apt/qr/Vatq/ylmpy/ie/qai/tsv (based on 28 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	2	2	0	0	0	0	0	2
Pro	6	0	0	0	7	0	0	0
Ala	7	0	6	0	2	3	5	2
Val	0	0	14	0	2	3	1	4
Leu	0	2	0	4	2	0	0	1
Ile	0	0	0	0	0	11	4	0
Met	0	3	0	4	2	0	0	0
Phe	0	2	0	3	0	0	0	0
Tyr	0	0	0	8	4	0	0	0
Trp	0	0	0	2	0	0	2	0
Ser	1	0	0	0	2	2	0	5
Thr	5	0	4	0	0	0	0	6
Cys	2	0	0	0	0	0	0	0
Asn	0	0	1	2	0	2	0	0
Gln	0	9	3	3	0	2	9	1
Asp	0	0	0	0	0	0	2	0
Glu	0	2	0	0	0	5	3	2
Lys	3	3	0	0	1	0	2	0
Arg	2	5	0	0	0	0	0	0
His	0	0	0	0	0	0	0	0