Substrates for peptidase A02.007: feline immunodeficiency virus retropepsin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ac-Arg-Pro-Gln-Ala-Tyr-Pro-Ile-Gln-Thr-Arg-NH2 Ac-Arg-Pro-Gln-Ala-Tyr+Pro-Ile-Gln-Thr-Arg-NH2 S Pro Gln Ala Tyr Pro Ile Gln Thr Dunn, 2004
Arg-Ala-Leu-Thr-Lys(epsilon-ABZ)-Val-Gln-Nph-Val-Gln-Ser-Lys-Gly-Arg Arg-Ala-Leu-Thr-Lys(epsilon-Abz)-Val-Gln+Nph-Val-Gln-Ser-Lys-Gly-Arg S Thr Lys Val Gln Nph Val Gln Ser Dunn, 2004
Arg-Lys-Glu-Glu-Gly-Pro-Pro-Gln-Ala-Tyr-Pro-Ile-Gln-Thr-Val-Asn-Gly-Pro-Gln-Tyr-Arg Arg-Lys-Glu-Glu-Gly-Pro-Pro-Gln-Ala-Tyr+Pro-Ile-Gln-Thr-Val-Asn-Gly-Pro-Gln-Tyr-Arg N Pro Gln Ala Tyr Pro Ile Gln Thr Dunn, 2004
feline immunodeficiency virus gag polyprotein P19027 1-450 peptide-Tyr135+Pro-peptide P Pro Gln Ala Tyr Pro Ile Gln Thr Dunn, 2004
feline immunodeficiency virus gag polyprotein P16087 1-450 peptide-Tyr135+Pro-peptide P Pro Gln Ala Tyr Pro Ile Gln Thr Dunn, 2004 15965
feline immunodeficiency virus gag polyprotein P16087 1-450 peptide-Leu357+Lys-peptide P Lys Met Gln Leu Leu Ala Glu Ala Dunn, 2004 15964
feline immunodeficiency virus gag polyprotein P16087 1-450 peptide-Gln366+Val-peptide P Thr Lys Val Gln Val Val Gln Ser Dunn, 2004 15963
feline immunodeficiency virus gag polyprotein-derived peptide 1 P19027 132-139 Pro-Gln-Ala-Tyr+Pro-Ile-Gln-Thr P Pro Gln Ala Tyr Pro Ile Gln Thr Dunn, 2004
feline immunodeficiency virus gag polyprotein-derived peptide 10 Ac-Arg-Ser-Gln-Asn-Tyr+Pro-Ile-Val-Gln-Arg-NH2 P Ser Gln Asn Tyr Pro Ile Val Gln Dunn, 2004
feline immunodeficiency virus gag polyprotein-derived peptide 11 Ac-Tyr-Lys-Met-Gln-Leu+Leu-Ala-Glu-Leu-Thr-Lys-NH2 P Lys Met Gln Leu Leu Ala Glu Leu Dunn, 2004
feline immunodeficiency virus gag polyprotein-derived peptide 2 P19027 354-361 Lys-Met-Gln-Leu+Lys-Ala-Glu-Ala P Lys Met Gln Leu Lys Ala Glu Ala Dunn, 2004
feline immunodeficiency virus gag polyprotein-derived peptide 3 P19027 362-370 Thr-Lys-Val-Gln+Val-Val-Gln-Ser P Thr Lys Val Gln Val Val Gln Ser Dunn, 2004
feline immunodeficiency virus gag polyprotein-derived peptide 4 P16088 35-42 Gly-Phe-Val-Asn+Tyr-Asn-Lys-Val P Gly Phe Val Asn Tyr Asn Lys Val Dunn, 2004
feline immunodeficiency virus gag polyprotein-derived peptide 5 P16088 Arg-Leu-Val-Met+Ala-Gln-Ile-Ser P Arg Leu Val Met Ala Gln Ile Ser Dunn, 2004
feline immunodeficiency virus gag polyprotein-derived peptide 6 P16088 595-602 Ala-Glu-Thr-Trp+Tyr-Ile-Asp-Gly P Ala Glu Thr Trp Tyr Ile Asp Gly Dunn, 2004
feline immunodeficiency virus gag polyprotein-derived peptide 7 P16088 707-714 Cys-Gln-Thr-Met+Met-Ile-Ile-Glu P Cys Gln Thr Met Met Ile Ile Glu Dunn, 2004
feline immunodeficiency virus gag polyprotein-derived peptide 8 P16088 840-847 Thr-Gly-Val-Phe+Ser-Ser-Trp-Val P Thr Gly Val Phe Ser Ser Trp Val Dunn, 2004
feline immunodeficiency virus gag polyprotein-derived peptide 9 Ac-Arg-Pro-Gln-Ala-Tyr+Pro-Ile-Gln-Thr-Arg-NH2 P Pro Gln Ala Tyr Pro Ile Gln Thr Dunn, 2004
feline immunodeficiency virus pol polyprotein P16088 1-1124 peptide-Asn38+Tyr-peptide P Gly Phe Val Asn Tyr Asn Lys Val Dunn, 2004 15978
feline immunodeficiency virus pol polyprotein P16088 1-1124 peptide-Met154+Ala-peptide P Arg Leu Val Met Ala Gln Ile Ser Dunn, 2004 15979
feline immunodeficiency virus pol polyprotein P16088 1-1124 peptide-Trp598+Tyr-peptide P Ala Glu Thr Trp Tyr Ile Asp Gly Dunn, 2004 15982
feline immunodeficiency virus pol polyprotein P16088 1-1124 peptide-Met710+Met-peptide P Cys Gln Thr Met Met Ile Ile Glu Dunn, 2004 15980
feline immunodeficiency virus pol polyprotein P16088 1-1124 peptide-Phe843+Ser-peptide P Thr Gly Val Phe Ser Ser Trp Val Dunn, 2004 15981
H-1048 Lys-Ala-Arg-Val-Tyr+Nph-Glu-Ala-Nle-Gly-NH2 N Ala Arg Val Tyr Nph Glu Ala Nle Dunn, 2004
Lys-Ala-Arg-Val-Leu-Nph-Glu-Ala-Nle-Gly-NH2 Lys-Ala-Arg-Val-Leu+Nph-Glu-Ala-Nle-Gly-NH2 S Ala Arg Val Leu Nph Glu Ala Nle Dunn, 2004
Lys-Ala-Arg-Val-NAl-Nph-Glu-Ala-Nle-Gly-NH2 Lys-Ala-Arg-Val-NAl+Nph-Glu-Ala-Nle-Gly-NH2 S Ala Arg Val NAl Nph Glu Ala Nle Dunn, 2004
Lys-Ala-Arg-Val-Nle-Nph-Glu-Ala-Nle-Gly-NH2 Lys-Ala-Arg-Val-Nle+Nph-Glu-Ala-Nle-Gly-NH2 S Ala Arg Val Nle Nph Glu Ala Nle Dunn, 2004
Lys-Ala-Arg-Val-Phe-Nph-Glu-Ala-Nle-Gly-NH2 Lys-Ala-Arg-Val-Phe+Nph-Glu-Ala-Nle-Gly-NH2 S Ala Arg Val Phe Nph Glu Ala Nle Dunn, 2004