Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence Q13263

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-835	P		NT	<%Agarwal et al., 2012[]%>
6	cathepsin L	2-32	N		MS	Biniossek et al., 2011
15	cathepsin B	2-32	N		MS	Biniossek et al., 2011
17	meprin alpha subunit	2-835	N		MS	Becker-Pauly et al., 2011
17	meprin beta subunit	2-835	N		MS	Becker-Pauly et al., 2011
17	LAST peptidase (Limulus-type)	14-32	N		MS	Becker-Pauly et al., 2011
18	cathepsin L	2-32	N		MS	Biniossek et al., 2011
18	cathepsin S	2-32	N		MS	Biniossek et al., 2011
18	cathepsin B	2-32	N		MS	Biniossek et al., 2011
18	meprin alpha subunit	15-32	N		MS	Becker-Pauly et al., 2011
49	meprin alpha subunit	2-835	N		MS	Becker-Pauly et al., 2011
49	meprin beta subunit	2-835	N		MS	Becker-Pauly et al., 2011
49	LAST_MAM peptidase (Limulus-type)	46-69	N		MS	Becker-Pauly et al., 2011
56	LAST_MAM peptidase (Limulus-type)	53-69	N		MS	Becker-Pauly et al., 2011
57	meprin alpha subunit	54-69	N		MS	Becker-Pauly et al., 2011
58	meprin beta subunit	55-69	N		MS	Becker-Pauly et al., 2011
127	trypsin 1	2-835	N		MS	Schilling & Overall, 2008
136	trypsin 1	2-835	N		MS	Schilling & Overall, 2008
141	lysyl endopeptidase (bacteria)	1-835	N		MS
184	HtrA2 peptidase	2-835	P			Vande Walle et al., 2007
238	trypsin 1	2-835	N		MS	Schilling & Overall, 2008
250	trypsin 1	2-835	N		MS	Schilling & Overall, 2008
296	trypsin 1	2-835	N		MS	Schilling & Overall, 2008
304	trypsin 1	2-835	N		MS	Schilling & Overall, 2008
316	granzyme B (Homo sapiens-type)	2-835	N		MS	Van Damme et al., 2010
347	trypsin 1	2-835	N		MS	Schilling & Overall, 2008
365	trypsin 1	2-835	N		MS	Schilling & Overall, 2008
377	trypsin 1	2-835	N		MS	Schilling & Overall, 2008
390	trypsin 1	2-835	N		MS	Schilling & Overall, 2008
400	trypsin 1	2-835	N		MS	Schilling & Overall, 2008
407	trypsin 1	2-835	N		MS	Schilling & Overall, 2008
410	cathepsin L	408-427	N		MS	Biniossek et al., 2011
427	trypsin 1	2-835	N		MS	Schilling & Overall, 2008
459	cathepsin L	435-469	N		MS	Biniossek et al., 2011
459	cathepsin S	435-469	N		MS	Biniossek et al., 2011
492	trypsin 1	2-835	N		MS	Schilling & Overall, 2008
507	trypsin 1	2-835	N		MS	Schilling & Overall, 2008
524	trypsin 1	2-835	N		MS	Schilling & Overall, 2008
538	LAST_MAM peptidase (Limulus-type)	535-553	N		MS	Becker-Pauly et al., 2011
579	granzyme B (Homo sapiens-type)	2-835	N		MS	Van Damme et al., 2010
674	granzyme B (Homo sapiens-type)	2-835	N		MS	Van Damme et al., 2010
685	unknown peptidase		P		MS	Mahrus et al., 2008
688	caspase-3	2-835	P		MS	Impens et al., 2010
726	granzyme B (Homo sapiens-type)	2-835	N		MS	Van Damme et al., 2010
735	granzyme B (Homo sapiens-type)	2-835	N		MS	Van Damme et al., 2010
750	trypsin 1	2-835	N		MS	Schilling & Overall, 2008
756	cathepsin L	751-767	N		MS	Biniossek et al., 2011
756	cathepsin S	751-767	N		MS	Biniossek et al., 2011
767	trypsin 1	2-835	N		MS	Schilling & Overall, 2008
774	LAST_MAM peptidase (Limulus-type)	774-790	N		MS	Becker-Pauly et al., 2011
774	trypsin 1	2-835	N		MS	Schilling & Overall, 2008
777	meprin beta subunit	774-790	N		MS	Becker-Pauly et al., 2011
779	trypsin 1	2-835	N		MS	Schilling & Overall, 2008
790	trypsin 1	2-835	N		MS	Schilling & Overall, 2008