Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 1 |
unknown peptidase |
1-463 |
P |
release of an initiating methionine |
MS |
Bantscheff et al., 2007 |
| 9 |
HIV-1 retropepsin |
5-20 |
N |
|
MS |
Schilling & Overall, 2008 |
| 11 |
elastase-2 |
5-20 |
N |
|
MS |
Schilling & Overall, 2008 |
| 12 |
cathepsin S |
6-20 |
N |
|
MS |
Biniossek et al., 2011 |
| 19 |
peptidyl-Lys metallopeptidase |
1-463 |
N |
|
MS |
|
| 20 |
trypsin 1 |
1-463 |
N |
|
MS |
Schilling & Overall, 2008 |
| 23 |
cathepsin K |
20-30 |
N |
|
MS |
Schilling & Overall, 2008 |
| 29 |
peptidyl-Lys metallopeptidase |
1-463 |
N |
|
MS |
|
| 30 |
trypsin 1 |
1-463 |
N |
|
MS |
Schilling & Overall, 2008 |
| 110 |
matrix metallopeptidase-2 |
108-129 |
N |
|
MS |
Schilling & Overall, 2008 |
| 113 |
matrix metallopeptidase-2 |
108-129 |
N |
|
MS |
Schilling & Overall, 2008 |
| 129 |
trypsin 1 |
1-463 |
N |
|
MS |
Schilling & Overall, 2008 |
| 134 |
trypsin 1 |
1-463 |
N |
|
MS |
Schilling & Overall, 2008 |
| 137 |
matrix metallopeptidase-2 |
134-146 |
N |
|
MS |
Schilling & Overall, 2008 |
| 145 |
peptidyl-Lys metallopeptidase |
1-463 |
N |
|
MS |
|
| 146 |
trypsin 1 |
1-463 |
N |
|
MS |
Schilling & Overall, 2008 |
| 153 |
peptidyl-Lys metallopeptidase |
1-463 |
N |
|
MS |
|
| 243 |
peptidyl-Lys metallopeptidase |
1-463 |
N |
|
MS |
|
| 246 |
elastase-2 |
219-255 |
N |
|
MS |
Schilling & Overall, 2008 |
| 247 |
trypsin 1 |
1-463 |
N |
|
MS |
Schilling & Overall, 2008 |
| 254 |
matrix metallopeptidase-2 |
252-268 |
N |
|
MS |
Schilling & Overall, 2008 |
| 255 |
matrix metallopeptidase-2 |
252-268 |
N |
|
MS |
Schilling & Overall, 2008 |
| 255 |
trypsin 1 |
1-463 |
N |
|
MS |
Schilling & Overall, 2008 |
| 266 |
trypsin 1 |
1-463 |
N |
|
MS |
Schilling & Overall, 2008 |
| 268 |
glutamyl endopeptidase I |
1-463 |
N |
|
MS |
Schilling & Overall, 2008 |
| 280 |
astacin |
277-290 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 280 |
meprin beta subunit |
277-290 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 280 |
LAST peptidase (Limulus-type) |
277-290 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 280 |
LAST_MAM peptidase (Limulus-type) |
277-290 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 300 |
cathepsin L |
291-313 |
N |
|
MS |
Biniossek et al., 2011 |
| 301 |
astacin |
298-313 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 301 |
meprin beta subunit |
298-313 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 301 |
LAST_MAM peptidase (Limulus-type) |
298-313 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 361 |
cathepsin L |
331-371 |
N |
|
MS |
Biniossek et al., 2011 |
| 361 |
cathepsin S |
331-371 |
N |
|
MS |
Biniossek et al., 2011 |
| 362 |
matrix metallopeptidase-2 |
361-372 |
N |
|
MS |
Schilling & Overall, 2008 |
| 372 |
chymotrypsin A (cattle-type) |
1-463 |
N |
|
MS |
Schilling & Overall, 2008 |
| 393 |
matrix metallopeptidase-2 |
389-403 |
N |
|
MS |
Schilling & Overall, 2008 |
| 403 |
glutamyl endopeptidase I |
1-463 |
N |
|
MS |
Schilling & Overall, 2008 |
| 430 |
trypsin 1 |
1-463 |
N |
|
MS |
Schilling & Overall, 2008 |
| 439 |
trypsin 1 |
1-463 |
N |
|
MS |
Schilling & Overall, 2008 |
