Substrates for peptidase C11.001: clostripain

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
alpha-1-antichymotrypsin	P01011	24-423	peptide-Arg18+Gly-peptide	N	Asn	Gln	Asp	Arg	Gly	Thr	His	Val		16214
Bz-Arg-OEt [BAEE]			Bz-Arg+OEt	S	-	-	Bz	Arg	OEt	-	-	-	Ullmann & Bordusa, 2004
hemagglutinin components HA-22/23/53	P46085	7-623	peptide-Lys192+Asn-peptide	P	Lys	Glu	Ser	Lys	Asn	Ser	Asn	Asn	Suzuki et al., 2009
interleukin-20 receptor alpha chain precursor	Q9UHF4	30-553	peptide-Arg92+Thr-peptide	N	Asn	Ile	Asn	Arg	Thr	Tyr	Cys	Asp	Pham et al., 2005
interleukin-20 receptor alpha chain precursor	Q9UHF4	30-553	peptide-Arg128+Phe-peptide	N	Glu	Ser	Gly	Arg	Phe	Tyr	Pro	Phe	Pham et al., 2005
memapsin-2	P56817	13-501	peptide-Arg57+Gly-peptide	N	Pro	Gly	Arg	Arg	Gly	Ser	Phe	Val	Ermolieff et al., 2000
memapsin-2 precursor	P56817	13-501	peptide-Arg42+Leu-peptide	N	Leu	Gly	Leu	Arg	Leu	Pro	Arg	Glu	Ermolieff et al., 2000
tubulin beta-2B chain	Q6B856	1-445	peptide-Arg282+Ala-peptide	N	Gln	Gln	Tyr	Arg	Ala	Leu	Thr	Val	de Pereda & Andreu, 1996
Z-Phe-Arg-NHMec			Z-Phe-Arg+NHMec	S	-	Z	Phe	Arg	AMC	-	-	-	Ullmann & Bordusa, 2004