Substrates for peptidase M12.167: najalysin

Summary Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
coagulation factor V	P12259	29-2224	peptide-Asp725+Tyr-peptide	N	Ala	Asp	Tyr	Asp	Tyr	Gln	Asn	Arg	Camire et al., 1998
P-selectin glycoprotein ligand 1	Q14242	42-412	peptide-Tyr10+Asp11-peptide	N	Tyr	Leu	Asp	Tyr	Asp	Phe	Leu	Pro	Evans, 2004	16884
platelet glycoprotein Ib alpha chain	P07359	17-626	peptide-Glu282+Asp283-peptide	N	Tyr	Pro	Glu	Glu	Asp	Thr	Glu	Gly	Evans, 2004	16883