Substrates for peptidase A01.011: penicillopepsin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ac-(Ala)2-Lys-Nph-(Ala)2-NH2 Ac-(Ala)2-Lys+Nph-(Ala)2-NH2 S Ac Ala Ala Lys Nph Ala Ala NH2 Hofmann, 2004
Ac-Ala-Ala-Ala-Lys-Nph-Ala-Ala-NH2 Ac-Ala-Ala-Ala-Lys+Nph-Ala-Ala-NH2 S Ala Ala Ala Lys Nph Ala Ala NH2 Cao et al., 2000
Ac-Ala-Ala-Ala-Lys-Nph-Ala-Ala-NH2 Ac-Ala-Ala-Ala-Lys+Nph-Ala-Ala-NH2 S Ala Ala Ala Lys Nph Ala Ala NH2 Cao et al., 2000
Ac-Ala-Ala-Lys-Ala-Ala-NH2 Ac-Ala-Ala-Lys+Ala-Ala-NH2 S Ac Ala Ala Lys Ala Ala NH2 - Hofmann, 2004
Ac-Ala-Ala-Lys-Nph-Ala-NH2 Ac-Ala-Ala-Lys+Nph-Ala-NH2 S Ac Ala Ala Lys Nph Ala NH2 - Cao et al., 2000
Ac-Ala-Ala-Lys-Nph-NH2 Ac-Ala-Ala-Lys+Nph-NH2 S Ac Ala Ala Lys Nph NH2 - - Cao et al., 2000
Ac-Ala-Lys-Nph-Ala-Ala-NH2 Ac-Ala-Lys+Nph-Ala-Ala-NH2 S - Ac Ala Lys Nph Ala Ala NH2 Cao et al., 2000
Ac-Ala-Lys-Nph-Ala-Ala-NH2 Ac-Ala-Lys-Nph+Ala-Ala-NH2 S Ac Ala Lys Nph Ala Ala NH2 - Cao et al., 2000
Ac-Ala-Lys-Nph-Ala-NH2 Ac-Ala-Lys+Nph-Ala-NH2 S - Ac Ala Lys Nph Ala NH2 - Cao et al., 2000
Ac-Ala-Lys-Nph-NH2 Ac-Ala-Lys+Nph-NH2 S - Ac Ala Lys Nph NH2 - - Cao et al., 2000
Ac-Lys-Nph-Ala-Ala-NH2 Ac-Lys+Nph-Ala-Ala-NH2 S - - Ac Lys Nph Ala Ala NH2 Cao et al., 2000
Ac-Lys-Nph-Ala-NH2 Ac-Lys+Nph-Ala-NH2 S - - Ac Lys Nph Ala NH2 - Cao et al., 2000
Ac-Lys-Nph-NH2 Ac-Lys+Nph-NH2 S - - Ac Lys Nph NH2 - - Hofmann, 2004
cationic trypsin P07477 16-247 Val-Asp-Asp-Asp-Asp-Lys+Ile-peptide N Asp Asp Asp Lys Ile Val Gly Gly Hofmann, 2004 15816
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly+Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Leu Val Cya Gly Glu Arg Gly Phe Hofmann, 2004
Nph-Ala-Ala-NH2 Nph+Ala-Ala-NH2 S - - - Nph Ala Ala NH2 - Hofmann, 2004
trypsin inhibitor I P01074 1-29 peptide-Leu7+Met-peptide N Pro Arg Ile Leu Met Glu Cys Lys Hofmann, 2004 15815