Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P01857

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
105	plasmin	1-330	P			Ryan et al., 2008
106	papain	1-330	P	normal turnover		Gearing et al., 2002
106	elastase-2	1-330	P			Ryan et al., 2008
107	papain	1-330	P			Ryan et al., 2008
107	cathepsin L1 (Fasciola sp.)	1-330	N	normal turnover		Berasain et al., 2000
115	matrix metallopeptidase-3	1-330	P	normal turnover		Gearing et al., 2002
115	matrix metallopeptidase-12	1-330	P			Ryan et al., 2008
116	cathepsin G	1-330	P			Ryan et al., 2008
116	glutamyl endopeptidase I	1-330	P			Ryan et al., 2008
117	pepsin A4	1-330	P			Ryan et al., 2008
117	matrix metallopeptidase-7	1-330	P	normal turnover		Gearing et al., 2002
119	IdeS peptidase	1-330	P			von Pawel-Rammingen et al., 2002
121	pepsin A	1-330	N			Gearing et al., 2002
169	legumain, animal-type	98-330	P		NT	Stickler et al., 2011
208	legumain, animal-type	98-330	P		NT	Stickler et al., 2011
244	legumain, animal-type	98-330	P		NT	Stickler et al., 2011
304	legumain, animal-type	98-330	P		NT	Stickler et al., 2011