Substrates for peptidase A01.070: pepsin A4

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
IgG1 heavy chain (hinge region)	P01857	1-330	peptide-Leu16+Leu-peptide	P		Ala	Pro	Glu	Leu	Leu	Gly	Gly	Pro	Ryan et al., 2008	20258
Pepsin A-4	P0DJD7	16-388	Peptide-Leu38+Lys-Peptide	P	NT	Arg	Gly	Leu	Leu	Lys	Asp	Phe	Leu	Athauda et al., 1989
Pepsin A-4	P0DJD7	16-388	Peptide-Asp40+Phe-Peptide	P	NT	Leu	Leu	Lys	Asp	Phe	Leu	Lys	Lys	Athauda et al., 1989
Pepsin A-4	P0DJD7	16-388	Peptide-Leu62+Val-Peptide	P	NT	Ala	Pro	Thr	Leu	Val	Asp	Glu	Gln	Athauda et al., 1989