Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P00441

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-154	P		NT	<%Agarwal et al., 2012[]%>
8	matrix metallopeptidase-2	4-24	N		MS	Schilling & Overall, 2008
10	cathepsin L	2-22	N		MS	Biniossek et al., 2011
12	LAST peptidase (Limulus-type)	9-24	N		MS	Becker-Pauly et al., 2011
12	LAST_MAM peptidase (Limulus-type)	9-24	N		MS	Becker-Pauly et al., 2011
16	cathepsin L	11-24	N		MS	Biniossek et al., 2011
16	cathepsin S	11-24	N		MS	Biniossek et al., 2011
16	cathepsin B	11-24	N		MS	Biniossek et al., 2011
17	matrix metallopeptidase-2	10-31	N		MS	Schilling & Overall, 2008
22	glutamyl endopeptidase I	2-154	N		MS	Schilling & Overall, 2008
23	peptidyl-Lys metallopeptidase	2-154	N		MS
24	trypsin 1	2-154	N		MS	Schilling & Overall, 2008
31	matrix metallopeptidase-2	30-41	N		MS	Schilling & Overall, 2008
31	trypsin 1	2-154	N		MS	Schilling & Overall, 2008
33	chymotrypsin A (cattle-type)	2-154	N		MS	Schilling & Overall, 2008
40	cathepsin L	38-47	N		MS	Biniossek et al., 2011
40	cathepsin S	38-47	N		MS	Biniossek et al., 2011
41	glutamyl endopeptidase I	2-154	N		MS	Schilling & Overall, 2008
44	cathepsin L	38-59	N		MS	Biniossek et al., 2011
44	cathepsin S	38-59	N		MS	Biniossek et al., 2011
45	cathepsin B	38-52	N		MS	Biniossek et al., 2011
50	glutamyl endopeptidase I	37-70	N		MS	Schilling & Overall, 2008
51	cathepsin G	37-70	N		MS	Schilling & Overall, 2008
57	cathepsin L	38-70	N		MS	Biniossek et al., 2011
57	cathepsin B	38-68	N		MS	Biniossek et al., 2011
57	matrix metallopeptidase-2	37-70	N		MS	Schilling & Overall, 2008
59	cathepsin L	38-70	N		MS	Biniossek et al., 2011
59	cathepsin S	38-70	N		MS	Biniossek et al., 2011
59	elastase-2	37-70	N		MS	Schilling & Overall, 2008
60	cathepsin L	38-70	N		MS	Biniossek et al., 2011
60	cathepsin S	38-70	N		MS	Biniossek et al., 2011
61	LAST peptidase (Limulus-type)	58-70	N		MS	Becker-Pauly et al., 2011
61	LAST_MAM peptidase (Limulus-type)	58-70	N		MS	Becker-Pauly et al., 2011
70	trypsin 1	2-154	N		MS	Schilling & Overall, 2008
87	matrix metallopeptidase-2	80-116	N		MS	Schilling & Overall, 2008
91	peptidyl-Lys metallopeptidase	2-154	N		MS
101	LAST_MAM peptidase (Limulus-type)	98-116	N		MS	Becker-Pauly et al., 2011
101	glutamyl endopeptidase I	92-116	N		MS	Schilling & Overall, 2008
102	HIV-1 retropepsin	92-116	N		MS	Schilling & Overall, 2008
102	caspase-1	2-154	N		MS	Agard et al., 2010
105	elastase-2	92-116	N		MS	Schilling & Overall, 2008
106	cathepsin L	93-116	N		MS	Biniossek et al., 2011
106	cathepsin S	93-116	N		MS	Biniossek et al., 2011
106	cathepsin B	93-116	N		MS	Biniossek et al., 2011
106	matrix metallopeptidase-2	92-116	N		MS	Schilling & Overall, 2008
106	meprin alpha subunit	103-116	N		MS	Becker-Pauly et al., 2011
107	cathepsin S	93-116	N		MS	Biniossek et al., 2011
107	cathepsin G	92-116	N		MS	Schilling & Overall, 2008
108	cathepsin L	93-116	N		MS	Biniossek et al., 2011
108	cathepsin S	93-116	N		MS	Biniossek et al., 2011
111	matrix metallopeptidase-2	110-122	N		MS	Schilling & Overall, 2008
112	matrix metallopeptidase-2	110-122	N		MS	Schilling & Overall, 2008
116	trypsin 1	2-154	N		MS	Schilling & Overall, 2008
122	glutamyl endopeptidase I	2-154	N		MS	Schilling & Overall, 2008
125	meprin alpha subunit	122-137	N		MS	Becker-Pauly et al., 2011