| Activity |
|---|
| Catalytic type | Serine |
| Peplist | Included in the Peplist with identifier PL00334 |
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.108
|
| Enzymology | BRENDA database |
| Proteolytic events | CutDB database (6 cleavages) |
| Activity status | human: active (Dingwall & Holbrook, 2004)
mouse: active (Jones et al., 2003)
|
| Physiology | Contributes to apoptosis in some systems (Cilenti et al., 2004). |
| Knockout | The mouse mutant mnd2 (motor neuron degeneration 2) carries a missense mutation Ser276Cys in the protease domain of the HtrA2 protease (Jones et al., 2003). Mice lacking expression of HtrA2 as a result of deletion of the gene showed loss of a population of neurons in the striatum, resulting in a neurodegenerative disorder with a parkinsonian phenotype that led to death of the mice around 30 days after birth (Martins etal, 2004). The nature of links between the HTRA2 peptidase and Parkinson"s disease was further investigated by Strauss et al. (2005). |
| Pathways |
KEGG | Parkinson's disease |
|
Other databases
| TREEFAM | http://www.treefam.org/family/TF323480 |
| Cleavage site specificity |
Explanations of how to interpret the
following cleavage site sequence logo and specificity matrix can be found here. |
|---|
| Cleavage pattern | g/-/l/lvt -/-/g/- (based on 235 cleavages) |
