Structure for peptidase S01.278: HtrA2 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

PDB	Organism	Resolution	Comment
1LCY_A	Homo sapiens	2.00 Å	mature
Catalytic residues are shown in ball-and-stick representation: His198 in purple, Asp228 in pink and Ser306 (engineered to be Ala) in orange.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
mature peptidase	2.00 Å	1LCY	1LCY	1LCY	1LCY	1LCY	1LCY	Li et al., 2002
mature peptidase	2.75 Å	2PZD	2PZD	2PZD	2PZD	2PZD	2PZD	Zhang et al., 2007
htra2 protease mutant v226k	1.95 Å	5FHT	5FHT	5FHT	5FHT	5FHT	5FHT
htra2 wild-type structure	1.65 Å	5M3N	5M3N	5M3N	5M3N	5M3N	5M3N
htra2 a141s mutant structure	1.70 Å	5M3O	5M3O	5M3O	5M3O	5M3O	5M3O
htra2 g399s mutant	1.70 Å	5TNY	5TNY	5TNY	5TNY	5TNY	5TNY
htra2 s142d mutant	1.75 Å	5TNZ	5TNZ	5TNZ	5TNZ	5TNZ	5TNZ
htra2 s276c mutant	1.90 Å	5TO0	5TO0	5TO0	5TO0	5TO0	5TO0
htra2 exposed (l266r, f303a) mutant	1.69 Å	5TO1	5TO1	5TO1	5TO1	5TO1	5TO1
htra2 pathogenic mutant	2.05 Å	5WYN	5WYN	5WYN	5WYN	5WYN	5WYN