Literature for peptidase S01.278: HtrA2 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Zheng,N., Li,K., Cao,J., Wang,Z., Zhang,L., Zhao,Z., He,J., Wang,Y., Zhu,X., Chen,Y., Meng,J., Zhao,D., Niu,M., Luo,H., Zhang,X., Sun,H. and Zhang,Y.W. Electrophysiology-based screening identifies neuronal HtrA serine peptidase 2 (HTRA2) as a synaptic plasticity regulator participating in tauopathy Transl Psychiatry (2025) 15, 5-5. PubMed Europe PubMed DOI PMC EPMC

2024

Aspholm,E.E., Lidman,J. and Burmann,B.M. Structural basis of substrate recognition and allosteric activation of the proapoptotic mitochondrial HtrA2 protease Nat Commun (2024) 15, 4592-4592. PubMed Europe PubMed DOI
Baker,M.J., Blau,K.U., Anderson,A.J., Palmer,C.S., Fielden,L.F., Crameri,J.J., Milenkovic,D., Thorburn,D.R., Frazier,A.E., Langer,T. and Stojanovski,D. CLPB disaggregase dysfunction impacts the functional integrity of the proteolytic SPY complex J Cell Biol (2024) 223 PubMed Europe PubMed DOI PMC EPMC
Bi,P.Y., Killackey,S.A., Schweizer,L., Arnoult,D., Philpott,D.J. and Girardin,S.E. Cytosolic retention of HtrA2 during mitochondrial protein import stress triggers the DELE1-HRI pathway Commun Biol (2024) 7, 391-391. PubMed Europe PubMed DOI PMC EPMC
Liu,Q., Yan,X., Yuan,Y., Li,R., Zhao,Y., Fu,J., Wang,J. and Su,J. HTRA2/OMI-Mediated Mitochondrial Quality Control Alters Macrophage Polarization Affecting Systemic Chronic Inflammation Int J Mol Sci (2024) 25 PubMed Europe PubMed DOI PMC EPMC V
Mudrale,S.P., Dutta,S., Natu,K., Chaudhari,P. and Bose,K. Comparative Analysis of Canine and Human HtrA2 to Delineate Its Role in Apoptosis and Cancer Biochem J (2024) 481, 1603-1620. PubMed Europe PubMed DOI
Rosochowicz,M.A., Kulcenty,K. and Suchorska,W.M. Exploring the Role of HtrA Family Genes in Cancer: A Systematic Review Mol Diagn Ther (2024) 28, 347-377. PubMed Europe PubMed DOI V

2023

Nam,M.K., Shin,H.A., Yun,H., Yoo,S.A. and Rhim,H. Delayed hair cycle in mnd2 mutant mice lacking HtrA2 serine protease activity Biochem Biophys Res Commun (2023) 641, 102-109. PubMed Europe PubMed DOI
Nam,M.K., Seong,Y., Jeong,G.H., Yoo,S.A. and Rhim,H. HtrA2 regulates alpha-Synuclein-mediated mitochondrial reactive oxygen species production in the mitochondria of microglia Biochem Biophys Res Commun (2023) 638, 84-93. PubMed Europe PubMed DOI K
Weiss,J., Heib,M., Korn,T., Hoyer,J., Fuchslocher Chico,J., Voigt,S., Koudelka,T., Tholey,A. and Adam,D. Protease-independent control of parthanatos by HtrA2/Omi Cell Mol Life Sci (2023) 80, 258-258. PubMed Europe PubMed DOI PMC EPMC

2022

Chakraborty,A., Bose,R. and Bose,K. Unraveling the Dichotomy of Enigmatic Serine Protease HtrA2 Front Mol Biosci (2022) 9, 824846-824846. PubMed Europe PubMed DOI PMC EPMC
Nam,M.K., Moon,J.M., Kim,G.Y., Kim,S.M. and Rhim,H. The novel human HtrA2 ortholog in zebrafish: New molecular insight and challenges into the imbalance of homeostasis Gene (2022) 819, 146263-146263. PubMed Europe PubMed DOI
Parui,A.L., Singh,N., Dutta,S. and Bose,K. Corrigendum to "Role of conserved regulatory loop residues in allosteric propagation of serine protease HtrA2" Biochem Biophys Res Commun (2022) 598, 138-138. PubMed Europe PubMed DOI
Parui,A.L., Singh,N., Dutta,S. and Bose,K. Role of conserved regulatory loop residues in allosteric propagation of serine protease HtrA2 Biochem Biophys Res Commun (2022) 594, 63-68. PubMed Europe PubMed DOI
Parui,A.L., Mishra,V., Dutta,S., Bhaumik,P. and Bose,K. Inter-subunit crosstalk via PDZ synergistically governs allosteric activation of proapoptotic HtrA2 Structure (2022) 30, 1307-1320. PubMed Europe PubMed DOI
Toyama,Y., Harkness,R.W. and Kay,L.E. Structural basis of protein substrate processing by human mitochondrial high-temperature requirement A2 protease Proc Natl Acad Sci U S A (2022) 119, e2203172119-e2203172119. PubMed Europe PubMed DOI PMC EPMC
Wachoski-Dark,E., Zhao,T., Khan,A., Shutt,T.E. and Greenway,S.C. Mitochondrial Protein Homeostasis and Cardiomyopathy Int J Mol Sci (2022) 23 PubMed Europe PubMed DOI PMC EPMC V

2021

Fantone,S., Giannubilo,S.R., Marzioni,D. and Tossetta,G. HTRA family proteins in pregnancy outcome Tissue Cell (2021) 72, 101549-101549. PubMed Europe PubMed DOI
Kummari,R., Dutta,S., Patil,S., Mudrale,S.P. and Bose,K. Elucidating the role of GRIM-19 as a substrate and allosteric activator of pro-apoptotic serine protease HtrA2 Biochem J (2021) 478, 1241-1259. PubMed Europe PubMed DOI
Toyama,Y., Harkness,R.W., Lee,T.Y.T., Maynes,J.T. and Kay,L.E. Oligomeric assembly regulating mitochondrial HtrA2 function as examined by methyl-TROSY NMR Proc Natl Acad Sci U S A (2021) 118 PubMed Europe PubMed DOI PMC EPMC
Toyama,Y., Harkness,R.W. and Kay,L.E. Dissecting the role of interprotomer cooperativity in the activation of oligomeric high-temperature requirement A2 protein Proc Natl Acad Sci U S A (2021) 118 PubMed Europe PubMed DOI

2020

Chung,H.J., Jamal,M.A.H.M. and Hong,S.T. The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi Sci Rep (2020) 10, 5284-5284. PubMed Europe PubMed DOI PMC EPMC
Nam,H.Y., Song,D., Eo,J., Choi,N.E., Hong,J.A., Hong,K.T., Lee,J.S., Seo,J. and Lee,J. Activity-Based Probes for the High Temperature Requirement A Serine Proteases ACS Chem Biol (2020) PubMed Europe PubMed DOI

2019

Chaganti,L.K., Dutta,S., Kuppili,R.R., Mandal,M. and Bose,K. Structural modeling and role of HAX-1 as a positive allosteric modulator of human serine protease HtrA2 Biochem J (2019) 476, 2965-2980. PubMed Europe PubMed DOI
Darreh-Shori,T., Rezaeianyazdi,S., Lana,E., Mitra,S., Gellerbring,A., Karami,A., Bogdanovic,N., Lithner,C.U., Winblad,B. and Behbahani,H. Increased active OMI/HTRA2 serine protease displays a positive correlation with cholinergic alterations in the Alzheimer's disease brain Mol Neurobiol (2019) 56, 4601-4619. PubMed Europe PubMed DOI
Hu,Y., Bi,Y., Yao,D., Wang,P. and Li,Y. Omi/HtrA2 Protease associated cell apoptosis participates in blood-brain barrier dysfunction Front Mol Neurosci (2019) 12, 48-48. PubMed Europe PubMed DOI PMC EPMC I
Hur,W., Kang,B.Y., Kim,S.M., Lee,G.W., Kim,J.H., Nam,M.K., Rhim,H. and Yoon,A.S.K. Serine protease HtrA2/Omi deficiency impairs mitochondrial homeostasis and promotes hepatic fibrogenesis via activation of hepatic stellate cells Cells (2019) 8 PubMed Europe PubMed DOI M
Su,X.J., Huang,L., Qu,Y. and Mu,D. Progress in research on the role of Omi/HtrA2 in neurological diseases Rev Neurosci (2019) 30, 279-287. PubMed Europe PubMed DOI

2018

Gambardella,S., Ferese,R., Scala,S., Carboni,S., Biagioni,F., Emiliano,G., Zampatti,S., Modugno,N., Fabbiano,F., Fornai,F., Centonze,D. and Ruggieri,S. Mitochondrial serine protease HTRA2 p.G399S in a female with Di George syndrome and Parkinson's disease Parkinsons Dis (2018) 2018, 5651435-5651435. PubMed Europe PubMed DOI PMC EPMC M
Kovacs-Nagy,R., Morin,G., Nouri,M.A., Brandau,O., Saadi,N.W., Nouri,M.A., van den Broek,F., Prokisch,H., Mayr,J.A. and Wortmann,S.B. HTRA2 Defect: a recognizable inborn error of metabolism with 3-methylglutaconic aciduria as discriminating feature characterized by neonatal movement disorder and epilepsy-report of 11 patients Neuropediatrics (2018) 49, 373-378. PubMed Europe PubMed DOI M
Rodrigue-Gervais,I.G., Doiron,K., Champagne,C., Mayes,L., Leiva-Torres,G.A., Vanie P Jr, Douglas,T., Vidal,S.M., Alnemri,E.S. and Saleh,M. The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes Sci Rep (2018) 8, 8446-8446. PubMed Europe PubMed DOI PMC EPMC
Sun,M.L., Sun,L.M. and Wang,Y.Q. Peptide selectivity between the PDZ domains of human pregnancy-related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen probes J Mol Recognit (2018) 31, e2698-e2698. PubMed Europe PubMed DOI I
Wagh,A.R. and Bose,K. Structural basis of inactivation of human counterpart of mouse motor neuron degeneration 2 mutant in serine protease HtrA2 Biosci Rep (2018) 38 PubMed Europe PubMed DOI PMC EPMC
Xu,J., Jiao,K., Liu,X., Sun,Q., Wang,K., Xu,H., Zhang,S., Wu,Y., Wu,L., Liu,D., Wang,W. and Liu,H. Omi/HtrA2 participates in age-related autophagic deficiency in rat liver Aging Dis (2018) 9, 1031-1042. PubMed Europe PubMed DOI PMC EPMC K

2017

Fu,K., Wang,Y., Guo,D., Wang,G. and Ren,H. Familial Parkinson's Disease-Associated L166P Mutant DJ-1 is Cleaved by Mitochondrial Serine Protease Omi/HtrA2 Neurosci Bull (2017) 33, 685-694. PubMed Europe PubMed DOI M
Goo,H.G., Rhim,H. and Kang,S. Pathogenic role of serine protease HtrA2/Omi in neurodegenerative diseases Curr Protein Pept Sci (2017) 18, 1-12. PubMed Europe PubMed DOI
Liu,X., Lei,J., Wang,K., Ma,L., Liu,D., Du,Y., Wu,Y., Zhang,S., Wang,W., Ma,X. and Liu,H. Mitochondrial Omi/HtrA2 promotes caspase activation through cleavage of HAX-1 in aging heart Rejuvenation Res (2017) 20, 183-192. PubMed Europe PubMed DOI I
M'Angale,P.G. and Staveley,B.E. The HtrA2 Drosophila model of Parkinson's disease is suppressed by the pro-survival Bcl-2 Buffy Genome (2017) 60, 1-7. PubMed Europe PubMed DOI M
Merski,M., Moreira,C., Abreu,R.M., Ramos,M.J., Fernandes,P.A., Martins,L.M., Pereira,P.J.B. and Macedo-Ribeiro,S. Molecular motion regulates the activity of the mitochondrial serine protease HtrA2 Cell Death Dis (2017) 8, e3119-e3119. PubMed Europe PubMed DOI S
Olahova,M., Thompson,K., Hardy,S.A., Barbosa,I.A., Besse,A., Anagnostou,M.E., White,K., Davey,T., Simpson,M.A., Champion,M., Enns,G., Schelley,S., Lightowlers,R.N., Chrzanowska-Lightowlers,Z.M., McFarland,R., Deshpande,C., Bonnen,P.E. and Taylor,R.W. Pathogenic variants in HTRA2 cause an early-onset mitochondrial syndrome associated with 3-methylglutaconic aciduria J Inherit Metab Dis (2017) 40, 121-130. PubMed Europe PubMed DOI M
Zurawa-Janicka,D., Wenta,T., Jarzab,M., Skorko-Glonek,J., Glaza,P., Gieldon,A., Ciarkowski,J. and Lipinska,B. Structural insights into the activation mechanisms of human HtrA serine proteases Arch Biochem Biophys (2017) 621, 6-23. PubMed Europe PubMed DOI V

2016

Casadei,N., Sood,P., Ulrich,T., Fallier-Becker,P., Kieper,N., Helling,S., May,C., Glaab,E., Chen,J., Nuber,S., Wolburg,H., Marcus,K., Rapaport,D., Ott,T., Riess,O., Kruger,R. and Fitzgerald,J.C. Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2 Hum Mol Genet (2016) 25, 459-471. PubMed Europe PubMed DOI M
Csizmadia,V., Hales,P., Tsu,C., Ma,J., Chen,J., Shah,P., Fleming,P., Senn,J.J., Kadambi,V.J., Dick,L. and Wolenski,F.S. Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi Toxicol Res (2016) 5, 1619-1628. DOI I
Gibellini,L., DeBiasi,S., Nasi,M., Iannone,A., Cossarizza,A. and Pinti,M. Mitochondrial proteases as emerging pharmacological targets Curr Pharm Des (2016) 22, 2679-2688. PubMed Europe PubMed T
Gieldon,A., Zurawa-Janicka,D., Jarzab,M., Wenta,T., Golik,P., Dubin,G., Lipinska,B. and Ciarkowski,J. Distinct 3D architecture and dynamics of the human HtrA2(Omi) protease and its mutated variants PLoS ONE (2016) 11, e0161526-e0161526. PubMed Europe PubMed DOI M S
Jarzab,M., Wenta,T., Zurawa-Janicka,D., Polit,A., Gieldon,A.J., Wysocka,M., Glaza,P., Skorko-Glonek,J., Ciarkowski,J., Lesner,A. and Lipinska,B. Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer Biochim Biophys Acta (2016) 1864, 283-296. PubMed Europe PubMed DOI
Lee,S.H., Moon,Y.M., Seo,H.B., Kim,S.Y., Kim,E.K., Yi,J., Nam,M.K., Min,J.K., Park,S.H., Rhim,H. and Cho,M.L. HtrA2 suppresses autoimmune arthritis and regulates activation of STAT3 Sci Rep (2016) 6, 39393-39393. PubMed Europe PubMed DOI

2015

Chao,Y.X., Ng,E.Y., Foo,J.N., Liu,J., Zhao,Y. and Tan,E.K. Mitochondrial serine protease HTRA2 gene mutation in Asians with coexistent essential tremor and Parkinson disease Neurogenetics (2015) 16, 241-242. PubMed Europe PubMed DOI M
Lucotte,B., Tajhizi,M., Alkhatib,D., Samuelsson,E.-B., Wiehager,B., Schedin-Weiss,S., Sundstrom,E., Winblad,B., Tjernberg,L.O. and Behbahani,H. Stress conditions increase vimentin cleavage by Omi/HtrA2 protease in human primary neurons and differentiated neuroblastoma cells Mol Neurobiol (2015) 52, 1077-1092. PubMed Europe PubMed DOI I
Ma,Q., Hu,Q.S., Xu,R.J., Zhen,X.C. and Wang,G.H. Protease Omi facilitates neurite outgrowth in mouse neuroblastoma N2a cells by cleaving transcription factor E2F1 Acta Pharmacol Sin (2015) 36, 966-975. PubMed Europe PubMed DOI
Wu,J.Y., Li,M., Cao,L.J., Sun,M.L., Chen,D., Ren,H.G., Xia,Q., Tao,Z.T., Qin,Z.H., Hu,Q.S. and Wang,G.H. Protease Omi cleaving Hax-1 protein contributes to OGD/R-induced mitochondrial damage in neuroblastoma N2a cells and cerebral injury in MCAO mice Acta Pharmacol Sin (2015) 36, 1043-1052. PubMed Europe PubMed DOI
Wysocka,M., Wojtysiak,A., Okonska,M., Gruba,N., Jarzab,M., Wenta,T., Lipinska,B., Grzywa,R., Sienczyk,M., Rolka,K. and Lesner,A. Design and synthesis of new substrates of HtrA2 protease Anal Biochem (2015) 475, 44-52. PubMed Europe PubMed DOI A P

2014

Chen,Y.Y., Chuang,P.Y., Chen,C.P., Chiu,Y.H., Lo,H.F., Cheong,M.L., Huang,J.Y., Kuo,P.L. and Chen,H. Functional antagonism between high temperature requirement protein A (HtrA) family members regulates trophoblast invasion J Biol Chem (2014) 289, 22958-22968. PubMed Europe PubMed DOI
Cilenti,L., Ambivero,C.T., Ward,N., Alnemri,E.S., Germain,D. and Zervos,A.S. Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy Biochim Biophys Acta (2014) 1843, 1295-1307. PubMed Europe PubMed DOI
Patterson,V.L., Zullo,A.J., Koenig,C., Stoessel,S., Jo,H., Liu,X., Han,J., Choi,M., DeWan,A.T., Thomas,J.L., Kuan,C.Y. and Hoh,J. Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1 PLoS ONE (2014) 9, e115789-e115789. PubMed Europe PubMed DOI K
Singh,N., D'Souza,A., Cholleti,A., Sastry,G.M. and Bose,K. Dual regulatory switch confers tighter control on HtrA2 proteolytic activity FEBS J (2014) 281, 2456-2470. PubMed Europe PubMed DOI
Unal Gulsuner,H., Gulsuner,S., Mercan,F.N., Onat,O.E., Walsh,T., Shahin,H., Lee,M.K., Dogu,O., Kansu,T., Topaloglu,H., Elibol,B., Akbostanci,C., King,M.C., Ozcelik,T. and Tekinay,A.B. Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease Proc Natl Acad Sci U S A (2014) 111, 18285-18290. PubMed Europe PubMed DOI M
Xu,R., Hu,Q., Ma,Q., Liu,C. and Wang,G. The protease Omi regulates mitochondrial biogenesis through the GSK3beta/PGC-1alpha pathway Cell Death Dis (2014) 5, e1373-e1373. PubMed Europe PubMed DOI

2013

Bejugam,P.R., Kuppili,R.R., Singh,N., Gadewal,N., Chaganti,L.K., Sastry,G.M. and Bose,K. Allosteric regulation of serine protease HtrA2 through novel non-canonical substrate binding pocket PLoS ONE (2013) 8, e55416-e55416. PubMed Europe PubMed DOI PMC EPMC
Goo,H.G., Jung,M.K., Han,S.S., Rhim,H. and Kang,S. HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA Biochim Biophys Acta (2013) 1833, 1866-1875. PubMed Europe PubMed DOI K
Kang,S., Louboutin,J.P., Datta,P., Landel,C.P., Martinez,D., Zervos,A.S., Strayer,D.S., Fernandes-Alnemri,T. and Alnemri,E.S. Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging Cell Death Differ (2013) 20, 259-269. PubMed Europe PubMed DOI K
Kang,S., Fernandes-Alnemri,T. and Alnemri,E.S. A novel role for the mitochondrial HTRA2/OMI protease in aging Autophagy (2013) 9, 420-421. PubMed Europe PubMed DOI
Skorko-Glonek,J., Zurawa-Janicka,D., Koper,T., Jarzab,M., Figaj,D., Glaza,P. and Lipinska,B. HtrA protease family as therapeutic targets Curr Pharm Des (2013) 19, 977-1009. PubMed Europe PubMed V
Sun,H., Li,L., Zhou,F., Zhu,L., Ke,K., Tan,X., Xu,W., Rui,Y., Zheng,H., Zhou,Z. and Yang,H. The member of high temperature requirement family HtrA2 participates in neuronal apoptosis after intracerebral hemorrhage in adult rats J Mol Histol (2013) 44, 369-379. PubMed Europe PubMed DOI
Suwannaboon,R., Phiwsaiya,K., Senapin,S., Khunrae,P. and Rattanarojpong,T. The identification and expression of the full-length HtrA2 gene from Penaeus monodon (black tiger shrimp) Protein Expr Purif (2013) 92, 183-189. PubMed Europe PubMed DOI
Zurawa-Janicka,D., Jarzab,M., Polit,A., Skorko-Glonek,J., Lesner,A., Gitlin,A., Gieldon,A., Ciarkowski,J., Glaza,P., Lubomska,A. and Lipinska,B. Temperature-induced changes of HtrA2(Omi) protease activity and structure Cell Stress Chaperones (2013) 18, 35-51. PubMed Europe PubMed DOI

2012

Fitzgerald,J.C., Camprubi,M.D., Dunn,L., Wu,H.C., Ip,N.Y., Kruger,R., Martins,L.M., Wood,N.W. and Plun-Favreau,H. Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function Cell Death Differ (2012) 19, 257-266. PubMed Europe PubMed DOI
Hu,Q., Li,B., Xu,R., Chen,D., Mu,C., Fei,E. and Wang,G. The protease Omi cleaves the mitogen-activated protein kinase kinase MEK1 to inhibit microglial activation Sci Signal (2012) 5, ra61-ra61. PubMed Europe PubMed DOI
Martins,L.M. HtrA2 peptidase [ISSN:978-0-12-407742-3] (2012) 3, 2571-2577. DOI
Plun-Favreau,H., Burchell,V.S., Holmstrom,K.M., Yao,Z., Deas,E., Cain,K., Fedele,V., Moisoi,N., Campanella,M., Miguel Martins,L., Wood,N.W., Gourine,A.V. and Abramov,A.Y. HtrA2 deficiency causes mitochondrial uncoupling through the F1F0-ATP synthase and consequent ATP depletion Cell Death Dis (2012) 3, e335-e335. PubMed Europe PubMed DOI PMC EPMC K
Shin,E.J., Kim,E.M., Lee,J.A., Rhim,H. and Hwang,O. Matrix metalloproteinase-3 is activated by HtrA2/Omi in dopaminergic cells: relevance to Parkinson's disease Neurochem Int (2012) 60, 249-256. PubMed Europe PubMed DOI

2011

Clausen,T., Kaiser,M., Huber,R. and Ehrmann,M. HTRA proteases: regulated proteolysis in protein quality control Nat Rev Mol Cell Biol (2011) 12, 152-162. PubMed Europe PubMed DOI V
Gerhardt,E., Graber,S., Szego,E.M., Moisoi,N., Martins,L.M., Outeiro,T.F. and Kermer,P. Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice PLoS ONE (2011) 6, e28855-e28855. PubMed Europe PubMed DOI PMC EPMC K I
Park,D.W., Nam,M.K. and Rhim,H. The serine protease HtrA2 cleaves UCH-L1 and inhibits its hydrolase activity: implication in the UCH-L1-mediated cell death Biochem Biophys Res Commun (2011) 415, 24-29. PubMed Europe PubMed DOI
Westerlund,M., Behbahani,H., Gellhaar,S., Forsell,C., Belin,A.C., Anvret,A., Zettergren,A., Nissbrandt,H., Lind,C., Sydow,O., Graff,C., Olson,L., Ankarcrona,M. and Galter,D. Altered enzymatic activity and allele frequency of OMI/HTRA2 in Alzheimer's disease FASEB J (2011) 25, 1345-1352. PubMed Europe PubMed DOI M

2010

Behbahani,H., Pavlov,P.F., Wiehager,B., Nishimura,T., Winblad,B. and Ankarcrona,M. Association of Omi/HtrA2 with gamma-secretase in mitochondria Neurochem Int (2010) 57, 668-675. PubMed Europe PubMed DOI
Chien,J. WT1 as a substrate of HtrA2: a potential pathway for therapeutic targeting by HtrA proteases Future Oncol (2010) 6, 1233-1235. PubMed Europe PubMed DOI T
Essafi,A. and Hastie,N.D. WT1 the oncogene: a tale of death and HtrA Mol Cell (2010) 37, 153-155. PubMed Europe PubMed DOI
Hartkamp,J., Carpenter,B. and Roberts,S.G. The Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/Omi Mol Cell (2010) 37, 159-171. PubMed Europe PubMed DOI
Hartkamp,J. and Roberts,S.G. HtrA2, taming the oncogenic activities of WT1 Cell Cycle (2010) 9, 2508-2514. PubMed Europe PubMed DOI
Kieper,N., Holmstrom,K.M., Ciceri,D., Fiesel,F.C., Wolburg,H., Ziviani,E., Whitworth,A.J., Martins,L.M., Kahle,P.J. and Kruger,R. Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1 Exp Cell Res (2010) 316, 1213-1224. PubMed Europe PubMed DOI K
Li,B., Hu,Q., Wang,H., Man,N., Ren,H., Wen,L., Nukina,N., Fei,E. and Wang,G. Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases Cell Death Differ (2010) 17, 1773-1784. PubMed Europe PubMed DOI
Vande Walle,L., Wirawan,E., Lamkanfi,M., Festjens,N., Verspurten,J., Saelens,X., Vanden Berghe,T. and Vandenabeele,P. The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal Cell Res (2010) 20, 421-433. PubMed Europe PubMed DOI

2009

Balakrishnan,M.P., Cilenti,L., Mashak,Z., Popat,P., Alnemri,E.S. and Zervos,A.S. THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death Am J Physiol Heart Circ Physiol (2009) 297, H643-H653. PubMed Europe PubMed DOI PMC EPMC
Bhuiyan,M.S. and Fukunaga,K. Mitochondrial serine protease HtrA2/Omi as a potential therapeutic target Curr Drug Targets (2009) 10, 372-383. PubMed Europe PubMed DOI V T
Chien,J., Campioni,M., Shridhar,V. and Baldi,A. HtrA serine proteases as potential therapeutic targets in cancer Curr Cancer Drug Targets (2009) 9, 451-468. PubMed Europe PubMed DOI T
Johnson,F. and Kaplitt,M.G. Novel mitochondrial substrates of omi indicate a new regulatory role in neurodegenerative disorders PLoS ONE (2009) 4, e7100-e7100. PubMed Europe PubMed DOI PMC EPMC
Kooistra,J., Milojevic,J., Melacini,G. and Ortega,J. A new function of human HtrA2 as an amyloid-beta oligomerization inhibitor J Alzheimers Dis (2009) 17, 281-294. PubMed Europe PubMed DOI
Liu,M.L., Liu,M.J., Shen,Y.F., Ryu,H., Kim,H.J., Klupsch,K., Downward,J. and Hong,S.T. Omi is a mammalian heat-shock protein that selectively binds and detoxifies oligomeric amyloid-beta J Cell Sci (2009) 122, 1917-1926. PubMed Europe PubMed DOI
Moisoi,N., Klupsch,K., Fedele,V., East,P., Sharma,S., Renton,A., Plun-Favreau,H., Edwards,R.E., Teismann,P., Esposti,M.D., Morrison,A.D., Wood,N.W., Downward,J. and Martins,L.M. Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response Cell Death Differ (2009) 16, 449-464. PubMed Europe PubMed DOI K
Park,H.M., Kim,G.Y., Nam,M.K., Seong,G.H., Han,C., Chung,K.C., Kang,S. and Rhim,H. The serine protease HtrA2/Omi cleaves Parkin and irreversibly inactivates its E3 ubiquitin ligase activity Biochem Biophys Res Commun (2009) 387, 537-542. PubMed Europe PubMed DOI

2008

Bhuiyan,M.S. and Fukunaga,K. Activation of HtrA2, a mitochondrial serine protease mediates apoptosis: current knowledge on HtrA2 mediated myocardial ischemia/reperfusion injury Cardiovasc Ther (2008) 26, 224-232. PubMed Europe PubMed DOI
Bogaerts,V., Nuytemans,K., Reumers,J., Pals,P., Engelborghs,S., Pickut,B., Corsmit,E., Peeters,K., Schymkowitz,J., De Deyn,P.P., Cras,P., Rousseau,F., Theuns,J. and Van Broeckhoven,C. Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease Hum Mutat (2008) 29, 832-840. PubMed Europe PubMed DOI M
Chao,J.R., Parganas,E., Boyd,K., Hong,C.Y., Opferman,J.T. and Ihle,J.N. Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons Nature (2008) 452, 98-102. PubMed Europe PubMed DOI
Kim,G.Y., Nam,M.K., Kim,S.S., Kim,H.Y., Lee,S.K. and Rhim,H. A simple and rapid strategy for the molecular cloning and monitoring of mouse HtrA2 serine protease Biotechnol Lett (2008) 30, 397-403. PubMed Europe PubMed DOI
Marabese,M., Mazzoletti,M., Vikhanskaya,F. and Broggini,M. HtrA2 enhances the apoptotic functions of p73 on bax Cell Death Differ (2008) 15, 849-858. PubMed Europe PubMed DOI
McCormick,A.L., Roback,L. and Mocarski,E.S. HtrA2/Omi terminates cytomegalovirus infection and is controlled by the viral mitochondrial inhibitor of apoptosis (vMIA) PLoS Pathog (2008) 4, e1000063-e1000063. PubMed Europe PubMed DOI PMC EPMC
Pruefer,F.G., Lizarraga,F., Maldonado,V. and Melendez-Zajgla,J. Participation of Omi Htra2 serine-protease activity in the apoptosis induced by cisplatin on SW480 colon cancer cells J Chemother (2008) 20, 348-354. PubMed Europe PubMed DOI
Vande Walle,L., Lamkanfi,M. and Vandenabeele,P. The mitochondrial serine protease HtrA2/Omi: an overview Cell Death Differ (2008) 15, 453-460. PubMed Europe PubMed DOI V
Whitworth,A.J., Lee,J.R., Ho,V.M., Flick,R., Chowdhury,R. and McQuibban,G.A. Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin Dis Model Mech (2008) 1, 168-174. PubMed Europe PubMed DOI PMC EPMC
Yun,J., Cao,J.H., Dodson,M.W., Clark,I.E., Kapahi,P., Chowdhury,R.B. and Guo,M. Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo J Neurosci (2008) 28, 14500-14510. PubMed Europe PubMed DOI PMC EPMC

2007

Alnemri,E.S. HtrA2 and Parkinson's disease: think PINK? Nat Cell Biol (2007) 9, 1227-1229. PubMed Europe PubMed DOI
Althaus,J., Siegelin,M.D., Dehghani,F., Cilenti,L., Zervos,A.S. and Rami,A. The serine protease Omi/HtrA2 is involved in XIAP cleavage and in neuronal cell death following focal cerebral ischemia/reperfusion Neurochem Int (2007) 50, 172-180. PubMed Europe PubMed DOI T I
Bhuiyan,M.S. and Fukunaga,K. Inhibition of HtrA2/Omi ameliorates heart dysfunction following ischemia/reperfusion injury in rat heart in vivo Eur J Pharmacol (2007) 557, 168-177. PubMed Europe PubMed DOI I
Huttunen,H.J., Guenette,S.Y., Peach,C., Greco,C., Xia,W., Kim,D.Y., Barren,C., Tanzi,R.E. and Kovacs,D.M. Htra2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation J Biol Chem (2007) 282, 28285-28295. PubMed Europe PubMed DOI
Kadomatsu,T., Mori,M. and Terada,K. Mitochondrial import of Omi: the definitive role of the putative transmembrane region and multiple processing sites in the amino-terminal segment Biochem Biophys Res Commun (2007) 361, 516-521. PubMed Europe PubMed DOI
Kuninaka,S., Iida,S.I., Hara,T., Nomura,M., Naoe,H., Morisaki,T., Nitta,M., Arima,Y., Mimori,T., Yonehara,S. and Saya,H. Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation Oncogene (2007) 26, 2395-2406. PubMed Europe PubMed DOI
Liu,M.J., Liu,M.L., Shen,Y.F., Kim,J.M., Lee,B.H., Lee,Y.S. and Hong,S.T. Transgenic mice with neuron-specific overexpression of HtrA2/Omi suggest a neuroprotective role for HtrA2/Omi Biochem Biophys Res Commun (2007) 362, 295-300. PubMed Europe PubMed DOI
Ma,S., Song,E., Gao,S., Tian,R. and Gao,Y. Rapid characterization of the binding property of HtrA2/Omi PDZ domain by validation screening of PDZ ligand library Sci China C Life Sci (2007) 50, 412-422. PubMed Europe PubMed DOI
Ma,X., Kalakonda,S., Srinivasula,S.M., Reddy,S.P., Platanias,L.C. and Kalvakolanu,D.V. GRIM-19 associates with the serine protease HtrA2 for promoting cell death Oncogene (2007) 26, 4842-4849. PubMed Europe PubMed DOI
Plun-Favreau,H., Klupsch,K., Moisoi,N., Gandhi,S., Kjaer,S., Frith,D., Harvey,K., Deas,E., Harvey,R.J., McDonald,N., Wood,N.W., Martins,L.M. and Downward,J. The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1 Nat Cell Biol (2007) 9, 1243-1252. PubMed Europe PubMed DOI
Vande Walle,L., Van Damme,P., Lamkanfi,M., Saelens,X., Vandekerckhove,J., Gevaert,K. and Vandenabeele,P. Proteome-wide identification of HtrA2/Omi substrates J Proteome Res (2007) 6, 1006-1015. PubMed Europe PubMed DOI P
Yang,L., Sun,M., Sun,X.M., Cheng,G.Z., Nicosia,S.V. and Cheng,J.Q. Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212 J Biol Chem (2007) 282, 10981-10987. PubMed Europe PubMed DOI
Zhang,Y., Appleton,B.A., Wu,P., Wiesmann,C. and Sidhu,S.S. Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain Protein Sci (2007) 16, 1738-1750. PubMed Europe PubMed DOI PMC EPMC

2006

[YEAR:15-1-2006]Hong,S.K., Cha,M.K. and Kim,I.H. Specific protein interaction of human Pag with Omi/HtrA2 and the activation of the protease activity of Omi/HtrA2 Free Radic Biol Med (15-1-2006) 40, 275-284. PubMed Europe PubMed DOI
Hu,X.Y., Xu,Y.M., Chen,X.C., Ping,H., Chen,Z.H. and Zeng,F.Q. Immunohistochemical analysis of Omi/HtrA2 expression in prostate cancer and benign prostatic hyperplasia APMIS (2006) 114, 893-898. PubMed Europe PubMed DOI
[YEAR:12-5-2006]Klupsch,K. and Downward,J. The protease inhibitor Ucf-101 induces cellular responses independently of its known target, HtrA2/Omi Cell Death Differ (12-5-2006) 13, 2157-2159. PubMed Europe PubMed DOI I
[YEAR:28-2-2006]Nam,M.K., Seong,Y.M., Park,H.J., Choi,J.Y., Kang,S. and Rhim,H. The homotrimeric structure of HtrA2 is indispensable for executing its serine protease activity Exp Mol Med (28-2-2006) 38, 36-43. PubMed Europe PubMed DOI
[YEAR:12-9-2006]Park,H.J., Kim,S.S., Seong,Y.M., Kim,K.H., Goo,H.G., Yoon,E.J., Min,d.S., Kang,S. and Rhim,H. Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease. Implications for the physiological function of HtrA2 in the mitochondria J Biol Chem (12-9-2006) 281, 34277-34287. PubMed Europe PubMed DOI

2005

[YEAR:28-9-2005]Cilenti,L., Kyriazis,G.A., Soundarapandian,M.M., Stratico,V., Yerkes,A., Park,K.M., Sheridan,A.M., Alnemri,E.S., Bonventre,J.V. and Zervos,A.S. Omi/HtrA2 protease mediates cisplatin-induced cell death in renal cells Am J Physiol Renal Physiol (28-9-2005) 288, F371-F379. PubMed Europe PubMed DOI I
[YEAR:4-1-2005]Liu,H.R., Gao,E., Hu,A., Tao,L., Qu,Y., Most,P., Koch,W.J., Christopher,T.A., Lopez,B.L., Alnemri,E.S., Zervos,A.S. and Ma,X.L. Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion Circulation (4-1-2005) 111, 90-96. PubMed Europe PubMed DOI I
[YEAR:31-8-2005]Liu,M.L., Liu,M.J., Kim,J.M., Kim,H.J., Kim,J.H. and Hong,S.T. HtrA2 interacts with A beta peptide but does not directly alter its production or degradation Mol Cells (31-8-2005) 20, 83-89. PubMed Europe PubMed
[YEAR:29-4-2005]Sekine,K., Hao,Y., Suzuki,Y., Takahashi,R., Tsuruo,T. and Naito,M. HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells Biochem Biophys Res Commun (29-4-2005) 330, 279-285. PubMed Europe PubMed DOI
[YEAR:16-6-2005]Strauss,K.M., Martins,L.M., Plun-Favreau,H., Marx,F.P., Kautzmann,S., Berg,D., Gasser,T., Wszolek,Z., Muller,T., Bornemann,A., Wolburg,H., Downward,J., Riess,O., Schulz,J.B. and Kruger,R. Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease Hum Mol Genet (16-6-2005) 14, 2099-2111. PubMed Europe PubMed DOI M

2004

[YEAR:26-3-2004]Blink,E., Maianski,N.A., Alnemri,E.S., Zervos,A.S., Roos,D. and Kuijpers,T.W. Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils Cell Death Differ (26-3-2004) 11, 937-939. PubMed Europe PubMed DOI
[YEAR:15-9-2004]Cilenti,L., Soundarapandian,M.M., Kyriazis,G.A., Stratico,V., Singh,S., Gupta,S., Bonventre,J.V., Alnemri,E.S. and Zervos,A.S. Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death J Biol Chem (15-9-2004) 279, 50295-50301. PubMed Europe PubMed DOI
Dingwall,C. and Holbrook,J.D. Human HtrA proteases [ISSN:0-12-079610-4] (2004) 2, 1476-1480. V
[YEAR:4-8-2004]Gupta,S., Singh,R., Datta,P., Zhang,Z., Orr,C., Lu,Z., Dubois,G., Zervos,A.S., Meisler,M.H., Srinivasula,S.M., Fernandes-Alnemri,T. and Alnemri,E.S. The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity J Biol Chem (4-8-2004) 279, 45844-45854. PubMed Europe PubMed DOI
Martins,L.M., Morrison,A., Klupsch,K., Fedele,V., Moisoi,N., Teismann,P., Abuin,A., Grau,E., Geppert,M., Livi,G.P., Creasy,C.L., Martin,A., Hargreaves,I., Heales,S.J., Okada,H., Brandner,S., Schulz,J.B., Mak,T. and Downward,J. Neuroprotective role of the reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice Mol Cell Biol (2004) 24, 9848-9862. PubMed Europe PubMed DOI PMC EPMC K
[YEAR:16-6-2004]Seong,Y.M., Choi,J.Y., Park,H.J., Kim,K.J., Ahn,S.G., Seong,G.H., Kim,I.K., Kang,S. and Rhim,H. Autocatalytic processing of HtrA2/Omi is essential for induction of caspase-dependent cell death through antagonizing XIAP J Biol Chem (16-6-2004) 279, 37588-37596. PubMed Europe PubMed DOI
Seong,Y.M., Park,H.J., Seong,G.H., Choi,J.Y., Yoon,S.J., Min,B.R., Kang,S. and Rhim,H. N-terminal truncation circumvents proteolytic degradation of the human HtrA2/Omi serine protease in Escherichia coli: rapid purification of a proteolytically active HtrA2/Omi Protein Expr Purif (2004) 33, 200-208. PubMed Europe PubMed DOI
[YEAR:7-11-2004]Suzuki,Y., Takahashi-Niki,K., Akagi,T., Hashikawa,T. and Takahashi,R. Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways Cell Death Differ (7-11-2004) 11, 208-216. PubMed Europe PubMed DOI
[YEAR:24-8-2004]Trencia,A., Fiory,F., Maitan,M.A., Vito,P., Barbagallo,A.P., Perfetti,A., Miele,C., Ungaro,P., Oriente,F., Cilenti,L., Zervos,A.S., Formisano,P. and Beguinot,F. Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15 J Biol Chem (24-8-2004) 279, 46566-46572. PubMed Europe PubMed DOI I
Zhang,X. and Chang,Z. Temperature dependent protease activity and structural properties of human HtrA2 protease Biochemistry (Mosc) (2004) 69, 687-692. PubMed Europe PubMed DOI

2003

[YEAR:28-3-2003]Cilenti,L., Lee,Y., Hess,S., Srinivasula,S., Park,K.M., Junqueira,D., Davis,H., Bonventre,J.V., Alnemri,E.S. and Zervos,A.S. Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2 J Biol Chem (28-3-2003) 278, 11489-11494. PubMed Europe PubMed DOI I
[YEAR:1-2-2003]Jin,S., Kalkum,M., Overholtzer,M., Stoffel,A., Chait,B.T. and Levine,A.J. CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals Genes Dev (1-2-2003) 17, 359-367. PubMed Europe PubMed DOI PMC EPMC
[YEAR:16-10-2003]Jones,J.M., Datta,P., Srinivasula,S.M., Ji,W., Gupta,S., Zhang,Z., Davies,E., Hajnoczky,G., Saunders,T.L., Van Keuren,M.L., Fernandes-Alnemri,T., Meisler,M.H. and Alnemri,E.S. Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice Nature (16-10-2003) 425, 721-727. PubMed Europe PubMed DOI M
Martins,L.M., Turk,B.E., Cowling,V., Borg,A., Jarrell,E.T., Cantley,L.C. and Downward,J. Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi J Biol Chem (2003) 278, 49417-49427. PubMed Europe PubMed DOI
Park,H.J., Choi,J.Y., Seong,Y.M., Han,C., Yoon,K., Kang,S. and Rhim,H. Antigenicity of the region encoded by exon8 of the human serine protease, HtrA2/Omi, is associated with its protein solubility Biotechnol Lett (2003) 25, 1597-1603. PubMed Europe PubMed DOI
[YEAR:22-8-2003]Srinivasula,S.M., Gupta,S., Datta,P., Zhang,Z., Hegde,R., Cheong,N., Fernandes-Alnemri,T. and Alnemri,E.S. Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2 J Biol Chem (22-8-2003) 278, 31469-31472. PubMed Europe PubMed DOI
[YEAR:15-6-2003]Yang,Q.H., Church-Hajduk,R., Ren,J., Newton,M.L. and Du,C. Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis Genes Dev (15-6-2003) 17, 1487-1496. PubMed Europe PubMed DOI PMC EPMC

2002

[YEAR:4-1-2002]Hegde,R., Srinivasula,S.M., Zhang,Z., Wassell,R., Mukattash,R., Cilenti,L., Dubois,G., Lazebnik,Y., Zervos,A.S., Fernandes-Alnemri,T. and Alnemri,E.S. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction J Biol Chem (4-1-2002) 277, 432-438. PubMed Europe PubMed DOI
Li,W., Srinivasula,S.M., Chai,J., Li,P., Wu,J.W., Zhang,Z., Alnemri,E.S. and Shi,Y. Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi Nat Struct Biol (2002) 9, 436-441. PubMed Europe PubMed DOI S
Martins,L.M. The serine protease Omi/HtrA2: a second mammalian protein with a Reaper-like function Cell Death Differ (2002) 9, 699-701. PubMed Europe PubMed DOI
[YEAR:4-1-2002]Martins,L.M., Iaccarino,I., Tenev,T., Gschmeissner,S., Totty,N.F., Lemoine,N.R., Savopoulos,J., Gray,C.W., Creasy,C.L., Dingwall,C. and Downward,J. The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif J Biol Chem (4-1-2002) 277, 439-444. PubMed Europe PubMed DOI
Silke,J. and Verhagen,A.M. Jekyll and Hyde; changing places, changing faces Cell Death Differ (2002) 9, 362-363. PubMed Europe PubMed DOI
[YEAR:1-4-2002]Silke,J., Hawkins,C.J., Ekert,P.G., Chew,J., Day,C.L., Pakusch,M., Verhagen,A.M. and Vaux,D.L. The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites J Cell Biol (1-4-2002) 157, 115-124. PubMed Europe PubMed DOI PMC EPMC
Van Loo,G., van Gurp,M., Depuydt,B., Srinivasula,S.M., Rodriguez,I., Alnemri,E.S., Gevaert,K., Vandekerckhove,J., Declercq,W. and Vandenabeele,P. The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity Cell Death Differ (2002) 9, 20-26. PubMed Europe PubMed DOI
[YEAR:4-1-2002]Verhagen,A.M., Silke,J., Ekert,P.G., Pakusch,M., Kaufmann,H., Connolly,L.M., Day,C.L., Tikoo,A., Burke,R., Wrobel,C., Moritz,R.L., Simpson,R.J. and Vaux,D.L. HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins J Biol Chem (4-1-2002) 277, 445-454. PubMed Europe PubMed DOI

2001

MacFarlane,M. OMInously, a mitochondrial serine protease is now unveiled as the third 'MAC' Trends Pharmacol Sci (2001) 22, 608-609. PubMed Europe PubMed
Suzuki,Y., Imai,Y., Nakayama,H., Takahashi,K., Takio,K. and Takahashi,R. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death Mol Cell (2001) 8, 613-621. PubMed Europe PubMed DOI

2000

[YEAR:15-9-2000]Faccio,L., Fusco,C., Viel,A. and Zervos,A.S. Tissue-specific splicing of Omi stress-regulated endoprotease leads to an inactive protease with a modified PDZ motif Genomics (15-9-2000) 68, 343-347. PubMed Europe PubMed DOI R
[YEAR:28-1-2000]Faccio,L., Fusco,C., Chen,A., Martinotti,S., Bonventre,J.V. and Zervos,A.S. Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia J Biol Chem (28-1-2000) 275, 2581-2588. PubMed Europe PubMed DOI
Gray,C.W., Ward,R.V., Karran,E., Turconi,S., Rowles,A., Viglienghi,D., Southan,C., Barton,A., Fantom,K.G., West,A., Savopoulos,J., Hassan,N.J., Clinkenbeard,H., Hanning,C., Amegadzie,B., Davis,J.B., Dingwall,C., Livi,G.P. and Creasy,C.L. Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response Eur J Biochem (2000) 267, 5699-5710. PubMed Europe PubMed DOI
Savopoulos,J.W., Carter,P.S., Turconi,S., Pettman,G.R., Karran,E.H., Gray,C.W., Ward,R.V., Jenkins,O. and Creasy,C.L. Expression, purification, and functional analysis of the human serine protease HtrA2 Protein Expr Purif (2000) 19, 227-234. PubMed Europe PubMed DOI E