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Literature for peptidase S01.278: HtrA2 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Zheng,N., Li,K., Cao,J., Wang,Z., Zhang,L., Zhao,Z., He,J., Wang,Y., Zhu,X., Chen,Y., Meng,J., Zhao,D., Niu,M., Luo,H., Zhang,X., Sun,H. and Zhang,Y.W.
    Electrophysiology-based screening identifies neuronal HtrA serine peptidase 2 (HTRA2) as a synaptic plasticity regulator participating in tauopathy
    Transl Psychiatry15, 5-5. PubMed  Europe PubMed DOI
    2. 2024
  2. Aspholm,E.E., Lidman,J. and Burmann,B.M.
    Structural basis of substrate recognition and allosteric activation of the proapoptotic mitochondrial HtrA2 protease
    Nat Commun15, 4592-4592. PubMed  Europe PubMed DOI
  3. Baker,M.J., Blau,K.U., Anderson,A.J., Palmer,C.S., Fielden,L.F., Crameri,J.J., Milenkovic,D., Thorburn,D.R., Frazier,A.E., Langer,T. and Stojanovski,D.
    CLPB disaggregase dysfunction impacts the functional integrity of the proteolytic SPY complex
    J Cell Biol223, PubMed  Europe PubMed DOI
  4. Bi,P.Y., Killackey,S.A., Schweizer,L., Arnoult,D., Philpott,D.J. and Girardin,S.E.
    Cytosolic retention of HtrA2 during mitochondrial protein import stress triggers the DELE1-HRI pathway
    Commun Biol7, 391-391. PubMed  Europe PubMed DOI
  5. Liu,Q., Yan,X., Yuan,Y., Li,R., Zhao,Y., Fu,J., Wang,J. and Su,J.
    HTRA2/OMI-Mediated Mitochondrial Quality Control Alters Macrophage Polarization Affecting Systemic Chronic Inflammation
    Int J Mol Sci25, PubMed  Europe PubMed DOI  V
  6. Mudrale,S.P., Dutta,S., Natu,K., Chaudhari,P. and Bose,K.
    Comparative Analysis of Canine and Human HtrA2 to Delineate Its Role in Apoptosis and Cancer
    Biochem J481, 1603-1620. PubMed  Europe PubMed DOI
  7. Rosochowicz,M.A., Kulcenty,K. and Suchorska,W.M.
    Exploring the Role of HtrA Family Genes in Cancer: A Systematic Review
    Mol Diagn Ther28, 347-377. PubMed  Europe PubMed DOI  V
    8. 2023
  8. Nam,M.K., Seong,Y., Jeong,G.H., Yoo,S.A. and Rhim,H.
    HtrA2 regulates alpha-Synuclein-mediated mitochondrial reactive oxygen species production in the mitochondria of microglia
    Biochem Biophys Res Commun638, 84-93. PubMed  Europe PubMed DOI  K
  9. Nam,M.K., Shin,H.A., Yun,H., Yoo,S.A. and Rhim,H.
    Delayed hair cycle in mnd2 mutant mice lacking HtrA2 serine protease activity
    Biochem Biophys Res Commun641, 102-109. PubMed  Europe PubMed DOI
  10. Weiss,J., Heib,M., Korn,T., Hoyer,J., Fuchslocher Chico,J., Voigt,S., Koudelka,T., Tholey,A. and Adam,D.
    Protease-independent control of parthanatos by HtrA2/Omi
    Cell Mol Life Sci80, 258-258. PubMed  Europe PubMed DOI
    11. 2022
  11. Chakraborty,A., Bose,R. and Bose,K.
    Unraveling the Dichotomy of Enigmatic Serine Protease HtrA2
    Front Mol Biosci9, 824846-824846. PubMed  Europe PubMed DOI
  12. Nam,M.K., Moon,J.M., Kim,G.Y., Kim,S.M. and Rhim,H.
    The novel human HtrA2 ortholog in zebrafish: New molecular insight and challenges into the imbalance of homeostasis
    Gene819, 146263-146263. PubMed  Europe PubMed DOI
  13. Parui,A.L., Singh,N., Dutta,S. and Bose,K.
    Role of conserved regulatory loop residues in allosteric propagation of serine protease HtrA2
    Biochem Biophys Res Commun594, 63-68. PubMed  Europe PubMed DOI
  14. Parui,A.L., Mishra,V., Dutta,S., Bhaumik,P. and Bose,K.
    Inter-subunit crosstalk via PDZ synergistically governs allosteric activation of proapoptotic HtrA2
    Structure30, 1307-1320. PubMed  Europe PubMed DOI
  15. Parui,A.L., Singh,N., Dutta,S. and Bose,K.
    Corrigendum to "Role of conserved regulatory loop residues in allosteric propagation of serine protease HtrA2"
    Biochem Biophys Res Commun598, 138-138. PubMed  Europe PubMed DOI
  16. Toyama,Y., Harkness,R.W. and Kay,L.E.
    Structural basis of protein substrate processing by human mitochondrial high-temperature requirement A2 protease
    Proc Natl Acad Sci U S A119, e2203172119-e2203172119. PubMed  Europe PubMed DOI
  17. Wachoski-Dark,E., Zhao,T., Khan,A., Shutt,T.E. and Greenway,S.C.
    Mitochondrial Protein Homeostasis and Cardiomyopathy
    Int J Mol Sci23, PubMed  Europe PubMed DOI  V
    18. 2021
  18. Fantone,S., Giannubilo,S.R., Marzioni,D. and Tossetta,G.
    HTRA family proteins in pregnancy outcome
    Tissue Cell72, 101549-101549. PubMed  Europe PubMed DOI
  19. Kummari,R., Dutta,S., Patil,S., Mudrale,S.P. and Bose,K.
    Elucidating the role of GRIM-19 as a substrate and allosteric activator of pro-apoptotic serine protease HtrA2
    Biochem J478, 1241-1259. PubMed  Europe PubMed DOI
  20. Toyama,Y., Harkness,R.W., Lee,T.Y.T., Maynes,J.T. and Kay,L.E.
    Oligomeric assembly regulating mitochondrial HtrA2 function as examined by methyl-TROSY NMR
    Proc Natl Acad Sci U S A118, PubMed  Europe PubMed DOI
  21. Toyama,Y., Harkness,R.W. and Kay,L.E.
    Dissecting the role of interprotomer cooperativity in the activation of oligomeric high-temperature requirement A2 protein
    Proc Natl Acad Sci U S A118, PubMed  Europe PubMed DOI
    22. 2020
  22. Chung,H.J., Jamal,M.A.H.M. and Hong,S.T.
    The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi
    Sci Rep10, 5284-5284. PubMed  Europe PubMed DOI
  23. Nam,H.Y., Song,D., Eo,J., Choi,N.E., Hong,J.A., Hong,K.T., Lee,J.S., Seo,J. and Lee,J.
    Activity-Based Probes for the High Temperature Requirement A Serine Proteases
    ACS Chem Biol PubMed  Europe PubMed DOI
    24. 2019
  24. Chaganti,L.K., Dutta,S., Kuppili,R.R., Mandal,M. and Bose,K.
    Structural modeling and role of HAX-1 as a positive allosteric modulator of human serine protease HtrA2
    Biochem J476, 2965-2980. PubMed  Europe PubMed DOI
  25. Darreh-Shori,T., Rezaeianyazdi,S., Lana,E., Mitra,S., Gellerbring,A., Karami,A., Bogdanovic,N., Lithner,C.U., Winblad,B. and Behbahani,H.
    Increased active OMI/HTRA2 serine protease displays a positive correlation with cholinergic alterations in the Alzheimer's disease brain
    Mol Neurobiol56, 4601-4619. PubMed  Europe PubMed DOI
  26. Hu,Y., Bi,Y., Yao,D., Wang,P. and Li,Y.
    Omi/HtrA2 Protease associated cell apoptosis participates in blood-brain barrier dysfunction
    Front Mol Neurosci12, 48-48. PubMed  Europe PubMed DOI  I
  27. Hur,W., Kang,B.Y., Kim,S.M., Lee,G.W., Kim,J.H., Nam,M.K., Rhim,H. and Yoon,A.S.K.
    Serine protease HtrA2/Omi deficiency impairs mitochondrial homeostasis and promotes hepatic fibrogenesis via activation of hepatic stellate cells
    Cells8, PubMed  Europe PubMed DOI  M
  28. Su,X.J., Huang,L., Qu,Y. and Mu,D.
    Progress in research on the role of Omi/HtrA2 in neurological diseases
    Rev Neurosci30, 279-287. PubMed  Europe PubMed DOI
    29. 2018
  29. Gambardella,S., Ferese,R., Scala,S., Carboni,S., Biagioni,F., Emiliano,G., Zampatti,S., Modugno,N., Fabbiano,F., Fornai,F., Centonze,D. and Ruggieri,S.
    Mitochondrial serine protease HTRA2 p.G399S in a female with Di George syndrome and Parkinson's disease
    Parkinsons Dis2018, 5651435-5651435. PubMed  Europe PubMed DOI  M
  30. Kovacs-Nagy,R., Morin,G., Nouri,M.A., Brandau,O., Saadi,N.W., Nouri,M.A., van den Broek,F., Prokisch,H., Mayr,J.A. and Wortmann,S.B.
    HTRA2 Defect: a recognizable inborn error of metabolism with 3-methylglutaconic aciduria as discriminating feature characterized by neonatal movement disorder and epilepsy-report of 11 patients
    Neuropediatrics49, 373-378. PubMed  Europe PubMed DOI  M
  31. Rodrigue-Gervais,I.G., Doiron,K., Champagne,C., Mayes,L., Leiva-Torres,G.A., Vanie P Jr, Douglas,T., Vidal,S.M., Alnemri,E.S. and Saleh,M.
    The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes
    Sci Rep8, 8446-8446. PubMed  Europe PubMed DOI
  32. Sun,M.L., Sun,L.M. and Wang,Y.Q.
    Peptide selectivity between the PDZ domains of human pregnancy-related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen probes
    J Mol Recognit31, e2698-e2698. PubMed  Europe PubMed DOI  I
  33. Wagh,A.R. and Bose,K.
    Structural basis of inactivation of human counterpart of mouse motor neuron degeneration 2 mutant in serine protease HtrA2
    Biosci Rep38, PubMed  Europe PubMed DOI
  34. Xu,J., Jiao,K., Liu,X., Sun,Q., Wang,K., Xu,H., Zhang,S., Wu,Y., Wu,L., Liu,D., Wang,W. and Liu,H.
    Omi/HtrA2 participates in age-related autophagic deficiency in rat liver
    Aging Dis9, 1031-1042. PubMed  Europe PubMed DOI  K
    35. 2017
  35. Fu,K., Wang,Y., Guo,D., Wang,G. and Ren,H.
    Familial Parkinson's Disease-Associated L166P Mutant DJ-1 is Cleaved by Mitochondrial Serine Protease Omi/HtrA2
    Neurosci Bull33, 685-694. PubMed  Europe PubMed DOI  M
  36. Goo,H.G., Rhim,H. and Kang,S.
    Pathogenic role of serine protease HtrA2/Omi in neurodegenerative diseases
    Curr Protein Pept Sci18, 1-12. PubMed  Europe PubMed DOI
  37. Liu,X., Lei,J., Wang,K., Ma,L., Liu,D., Du,Y., Wu,Y., Zhang,S., Wang,W., Ma,X. and Liu,H.
    Mitochondrial Omi/HtrA2 promotes caspase activation through cleavage of HAX-1 in aging heart
    Rejuvenation Res20, 183-192. PubMed  Europe PubMed DOI  I
  38. M'Angale,P.G. and Staveley,B.E.
    The HtrA2 Drosophila model of Parkinson's disease is suppressed by the pro-survival Bcl-2 Buffy
    Genome60, 1-7. PubMed  Europe PubMed DOI  M
  39. Merski,M., Moreira,C., Abreu,R.M., Ramos,M.J., Fernandes,P.A., Martins,L.M., Pereira,P.J.B. and Macedo-Ribeiro,S.
    Molecular motion regulates the activity of the mitochondrial serine protease HtrA2
    Cell Death Dis8, e3119-e3119. PubMed  Europe PubMed DOI  S
  40. Olahova,M., Thompson,K., Hardy,S.A., Barbosa,I.A., Besse,A., Anagnostou,M.E., White,K., Davey,T., Simpson,M.A., Champion,M., Enns,G., Schelley,S., Lightowlers,R.N., Chrzanowska-Lightowlers,Z.M., McFarland,R., Deshpande,C., Bonnen,P.E. and Taylor,R.W.
    Pathogenic variants in HTRA2 cause an early-onset mitochondrial syndrome associated with 3-methylglutaconic aciduria
    J Inherit Metab Dis40, 121-130. PubMed  Europe PubMed DOI  M
  41. Zurawa-Janicka,D., Wenta,T., Jarzab,M., Skorko-Glonek,J., Glaza,P., Gieldon,A., Ciarkowski,J. and Lipinska,B.
    Structural insights into the activation mechanisms of human HtrA serine proteases
    Arch Biochem Biophys621, 6-23. PubMed  Europe PubMed DOI  V
    42. 2016
  42. Casadei,N., Sood,P., Ulrich,T., Fallier-Becker,P., Kieper,N., Helling,S., May,C., Glaab,E., Chen,J., Nuber,S., Wolburg,H., Marcus,K., Rapaport,D., Ott,T., Riess,O., Kruger,R. and Fitzgerald,J.C.
    Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2
    Hum Mol Genet25, 459-471. PubMed  Europe PubMed DOI  M
  43. Csizmadia,V., Hales,P., Tsu,C., Ma,J., Chen,J., Shah,P., Fleming,P., Senn,J.J., Kadambi,V.J., Dick,L. and Wolenski,F.S.
    Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi
    Toxicol Res5, 1619-1628. DOI  I
  44. Gibellini,L., DeBiasi,S., Nasi,M., Iannone,A., Cossarizza,A. and Pinti,M.
    Mitochondrial proteases as emerging pharmacological targets
    Curr Pharm Des22, 2679-2688. PubMed  Europe PubMed  T
  45. Gieldon,A., Zurawa-Janicka,D., Jarzab,M., Wenta,T., Golik,P., Dubin,G., Lipinska,B. and Ciarkowski,J.
    Distinct 3D architecture and dynamics of the human HtrA2(Omi) protease and its mutated variants
    PLoS ONE11, e0161526-e0161526. PubMed  Europe PubMed DOI  M  S
  46. Jarzab,M., Wenta,T., Zurawa-Janicka,D., Polit,A., Gieldon,A.J., Wysocka,M., Glaza,P., Skorko-Glonek,J., Ciarkowski,J., Lesner,A. and Lipinska,B.
    Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer
    Biochim Biophys Acta1864, 283-296. PubMed  Europe PubMed DOI
  47. Lee,S.H., Moon,Y.M., Seo,H.B., Kim,S.Y., Kim,E.K., Yi,J., Nam,M.K., Min,J.K., Park,S.H., Rhim,H. and Cho,M.L.
    HtrA2 suppresses autoimmune arthritis and regulates activation of STAT3
    Sci Rep6, 39393-39393. PubMed  Europe PubMed DOI
    48. 2015
  48. Chao,Y.X., Ng,E.Y., Foo,J.N., Liu,J., Zhao,Y. and Tan,E.K.
    Mitochondrial serine protease HTRA2 gene mutation in Asians with coexistent essential tremor and Parkinson disease
    Neurogenetics16, 241-242. PubMed  Europe PubMed DOI  M
  49. Lucotte,B., Tajhizi,M., Alkhatib,D., Samuelsson,E.-B., Wiehager,B., Schedin-Weiss,S., Sundstrom,E., Winblad,B., Tjernberg,L.O. and Behbahani,H.
    Stress conditions increase vimentin cleavage by Omi/HtrA2 protease in human primary neurons and differentiated neuroblastoma cells
    Mol Neurobiol52, 1077-1092. PubMed  Europe PubMed DOI  I
  50. Ma,Q., Hu,Q.S., Xu,R.J., Zhen,X.C. and Wang,G.H.
    Protease Omi facilitates neurite outgrowth in mouse neuroblastoma N2a cells by cleaving transcription factor E2F1
    Acta Pharmacol Sin36, 966-975. PubMed  Europe PubMed DOI
  51. Wu,J.Y., Li,M., Cao,L.J., Sun,M.L., Chen,D., Ren,H.G., Xia,Q., Tao,Z.T., Qin,Z.H., Hu,Q.S. and Wang,G.H.
    Protease Omi cleaving Hax-1 protein contributes to OGD/R-induced mitochondrial damage in neuroblastoma N2a cells and cerebral injury in MCAO mice
    Acta Pharmacol Sin36, 1043-1052. PubMed  Europe PubMed DOI
  52. Wysocka,M., Wojtysiak,A., Okonska,M., Gruba,N., Jarzab,M., Wenta,T., Lipinska,B., Grzywa,R., Sienczyk,M., Rolka,K. and Lesner,A.
    Design and synthesis of new substrates of HtrA2 protease
    Anal Biochem475, 44-52. PubMed  Europe PubMed DOI  A  P
    53. 2014
  53. Chen,Y.Y., Chuang,P.Y., Chen,C.P., Chiu,Y.H., Lo,H.F., Cheong,M.L., Huang,J.Y., Kuo,P.L. and Chen,H.
    Functional antagonism between high temperature requirement protein A (HtrA) family members regulates trophoblast invasion
    J Biol Chem289, 22958-22968. PubMed  Europe PubMed DOI
  54. Cilenti,L., Ambivero,C.T., Ward,N., Alnemri,E.S., Germain,D. and Zervos,A.S.
    Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy
    Biochim Biophys Acta1843, 1295-1307. PubMed  Europe PubMed DOI
  55. Patterson,V.L., Zullo,A.J., Koenig,C., Stoessel,S., Jo,H., Liu,X., Han,J., Choi,M., DeWan,A.T., Thomas,J.L., Kuan,C.Y. and Hoh,J.
    Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1
    PLoS ONE9, e115789-e115789. PubMed  Europe PubMed DOI  K
  56. Singh,N., D'Souza,A., Cholleti,A., Sastry,G.M. and Bose,K.
    Dual regulatory switch confers tighter control on HtrA2 proteolytic activity
    FEBS J281, 2456-2470. PubMed  Europe PubMed DOI
  57. Unal Gulsuner,H., Gulsuner,S., Mercan,F.N., Onat,O.E., Walsh,T., Shahin,H., Lee,M.K., Dogu,O., Kansu,T., Topaloglu,H., Elibol,B., Akbostanci,C., King,M.C., Ozcelik,T. and Tekinay,A.B.
    Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease
    Proc Natl Acad Sci U S A111, 18285-18290. PubMed  Europe PubMed DOI  M
  58. Xu,R., Hu,Q., Ma,Q., Liu,C. and Wang,G.
    The protease Omi regulates mitochondrial biogenesis through the GSK3beta/PGC-1alpha pathway
    Cell Death Dis5, e1373-e1373. PubMed  Europe PubMed DOI
    59. 2013
  59. Bejugam,P.R., Kuppili,R.R., Singh,N., Gadewal,N., Chaganti,L.K., Sastry,G.M. and Bose,K.
    Allosteric regulation of serine protease HtrA2 through novel non-canonical substrate binding pocket
    PLoS ONE8, e55416-e55416. PubMed  Europe PubMed DOI
  60. Goo,H.G., Jung,M.K., Han,S.S., Rhim,H. and Kang,S.
    HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA
    Biochim Biophys Acta1833, 1866-1875. PubMed  Europe PubMed DOI  K
  61. Kang,S., Fernandes-Alnemri,T. and Alnemri,E.S.
    A novel role for the mitochondrial HTRA2/OMI protease in aging
    Autophagy9, 420-421. PubMed  Europe PubMed DOI
  62. Kang,S., Louboutin,J.P., Datta,P., Landel,C.P., Martinez,D., Zervos,A.S., Strayer,D.S., Fernandes-Alnemri,T. and Alnemri,E.S.
    Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging
    Cell Death Differ20, 259-269. PubMed  Europe PubMed DOI  K
  63. Skorko-Glonek,J., Zurawa-Janicka,D., Koper,T., Jarzab,M., Figaj,D., Glaza,P. and Lipinska,B.
    HtrA protease family as therapeutic targets
    Curr Pharm Des19, 977-1009. PubMed  Europe PubMed  V
  64. Sun,H., Li,L., Zhou,F., Zhu,L., Ke,K., Tan,X., Xu,W., Rui,Y., Zheng,H., Zhou,Z. and Yang,H.
    The member of high temperature requirement family HtrA2 participates in neuronal apoptosis after intracerebral hemorrhage in adult rats
    J Mol Histol44, 369-379. PubMed  Europe PubMed DOI
  65. Suwannaboon,R., Phiwsaiya,K., Senapin,S., Khunrae,P. and Rattanarojpong,T.
    The identification and expression of the full-length HtrA2 gene from Penaeus monodon (black tiger shrimp)
    Protein Expr Purif92, 183-189. PubMed  Europe PubMed DOI
  66. Zurawa-Janicka,D., Jarzab,M., Polit,A., Skorko-Glonek,J., Lesner,A., Gitlin,A., Gieldon,A., Ciarkowski,J., Glaza,P., Lubomska,A. and Lipinska,B.
    Temperature-induced changes of HtrA2(Omi) protease activity and structure
    Cell Stress Chaperones18, 35-51. PubMed  Europe PubMed DOI
    67. 2012
  67. Fitzgerald,J.C., Camprubi,M.D., Dunn,L., Wu,H.C., Ip,N.Y., Kruger,R., Martins,L.M., Wood,N.W. and Plun-Favreau,H.
    Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function
    Cell Death Differ19, 257-266. PubMed  Europe PubMed DOI
  68. Hu,Q., Li,B., Xu,R., Chen,D., Mu,C., Fei,E. and Wang,G.
    The protease Omi cleaves the mitogen-activated protein kinase kinase MEK1 to inhibit microglial activation
    Sci Signal5, ra61-ra61. PubMed  Europe PubMed DOI
  69. Martins,L.M.
    HtrA2 peptidase
    [ISSN:978-0-12-407742-3]3, 2571-2577. DOI
  70. Plun-Favreau,H., Burchell,V.S., Holmstrom,K.M., Yao,Z., Deas,E., Cain,K., Fedele,V., Moisoi,N., Campanella,M., Miguel Martins,L., Wood,N.W., Gourine,A.V. and Abramov,A.Y.
    HtrA2 deficiency causes mitochondrial uncoupling through the F1F0-ATP synthase and consequent ATP depletion
    Cell Death Dis3, e335-e335. PubMed  Europe PubMed DOI  K
  71. Shin,E.J., Kim,E.M., Lee,J.A., Rhim,H. and Hwang,O.
    Matrix metalloproteinase-3 is activated by HtrA2/Omi in dopaminergic cells: relevance to Parkinson's disease
    Neurochem Int60, 249-256. PubMed  Europe PubMed DOI
    72. 2011
  72. Clausen,T., Kaiser,M., Huber,R. and Ehrmann,M.
    HTRA proteases: regulated proteolysis in protein quality control
    Nat Rev Mol Cell Biol12, 152-162. PubMed  Europe PubMed DOI  V
  73. Gerhardt,E., Graber,S., Szego,E.M., Moisoi,N., Martins,L.M., Outeiro,T.F. and Kermer,P.
    Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice
    PLoS ONE6, e28855-e28855. PubMed  Europe PubMed DOI  K  I
  74. Park,D.W., Nam,M.K. and Rhim,H.
    The serine protease HtrA2 cleaves UCH-L1 and inhibits its hydrolase activity: implication in the UCH-L1-mediated cell death
    Biochem Biophys Res Commun415, 24-29. PubMed  Europe PubMed DOI
  75. Westerlund,M., Behbahani,H., Gellhaar,S., Forsell,C., Belin,A.C., Anvret,A., Zettergren,A., Nissbrandt,H., Lind,C., Sydow,O., Graff,C., Olson,L., Ankarcrona,M. and Galter,D.
    Altered enzymatic activity and allele frequency of OMI/HTRA2 in Alzheimer's disease
    FASEB J25, 1345-1352. PubMed  Europe PubMed DOI  M
    76. 2010
  76. Behbahani,H., Pavlov,P.F., Wiehager,B., Nishimura,T., Winblad,B. and Ankarcrona,M.
    Association of Omi/HtrA2 with gamma-secretase in mitochondria
    Neurochem Int57, 668-675. PubMed  Europe PubMed DOI
  77. Chien,J.
    WT1 as a substrate of HtrA2: a potential pathway for therapeutic targeting by HtrA proteases
    Future Oncol6, 1233-1235. PubMed  Europe PubMed DOI  T
  78. Essafi,A. and Hastie,N.D.
    WT1 the oncogene: a tale of death and HtrA
    Mol Cell37, 153-155. PubMed  Europe PubMed DOI
  79. Hartkamp,J. and Roberts,S.G.
    HtrA2, taming the oncogenic activities of WT1
    Cell Cycle9, 2508-2514. PubMed  Europe PubMed DOI
  80. Hartkamp,J., Carpenter,B. and Roberts,S.G.
    The Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/Omi
    Mol Cell37, 159-171. PubMed  Europe PubMed DOI
  81. Kieper,N., Holmstrom,K.M., Ciceri,D., Fiesel,F.C., Wolburg,H., Ziviani,E., Whitworth,A.J., Martins,L.M., Kahle,P.J. and Kruger,R.
    Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1
    Exp Cell Res316, 1213-1224. PubMed  Europe PubMed DOI  K
  82. Li,B., Hu,Q., Wang,H., Man,N., Ren,H., Wen,L., Nukina,N., Fei,E. and Wang,G.
    Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases
    Cell Death Differ17, 1773-1784. PubMed  Europe PubMed DOI
  83. Vande Walle,L., Wirawan,E., Lamkanfi,M., Festjens,N., Verspurten,J., Saelens,X., Vanden Berghe,T. and Vandenabeele,P.
    The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal
    Cell Res20, 421-433. PubMed  Europe PubMed DOI
    84. 2009
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