$VAR1 = undef;

Summary for peptidase S01.212: plasma kallikrein

Names
MEROPS Name	plasma kallikrein
Other names	alpha-kallikrein, beta-kallikrein, Fletcher factor, follipsin (Sus scropha), IRCM-serine protease 1, kallidinogenase, kallikrein 3 [obs.], kallikrein B1, kininogenin, serum kallikrein, KLKB1 g.p. (Homo sapiens) (activated), prekallikrein (activated)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.212
Holotype	plasma kallikrein (Homo sapiens), Uniprot accession P03952 (peptidase unit: 391-628), MERNUM MER0000203
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00306
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.34
Enzymology	BRENDA database
Proteolytic events	CutDB database (11 cleavages)
Activity status	human: active (Colman, 2004) mouse: active (Seidah et al., 1990)
Physiology	Liberates bradykinin from kininogen. Also plays other roles in blood coagulation and inflammation. Thought to contribute to maturation of the ovarian follicle and ovulation.
Pathways	KEGG	Complement and coagulation cascades
Other databases	TREEFAM	http://www.treefam.org/family/TF343687
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/k/RK-/-/g/gfl (based on 40 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	4	3	1	0	1	7	13	9
Pro	1	4	1	0	0	4	2	0
Ala	0	1	1	0	2	0	0	0
Val	3	0	0	0	4	6	0	2
Leu	3	7	2	0	1	0	1	6
Ile	0	0	0	0	1	2	0	1
Met	1	3	3	0	1	1	0	0
Phe	2	3	6	0	0	2	2	6
Tyr	4	1	0	0	7	3	3	1
Trp	0	0	2	0	0	0	0	2
Ser	8	1	0	0	5	1	1	2
Thr	2	1	5	0	2	0	0	0
Cys	1	0	0	0	0	0	0	0
Asn	0	0	0	0	1	1	1	0
Gln	0	3	3	0	0	1	3	0
Asp	2	2	0	0	0	1	2	0
Glu	1	2	1	0	0	1	1	1
Lys	1	1	9	11	2	0	1	0
Arg	0	3	1	29	6	1	1	2
His	0	1	2	0	1	1	1	0