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Literature for peptidase S01.212: plasma kallikrein

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Lee,D.K., Ghannam,A., Murugesan,N., Vincent,D., Dona,M., Cohn,D.M., Adatia,A., Smith,M.D., Audhya,P.K., Hampton,S.L. and Feener,E.P.
    A sensitive and specific assay to characterize plasma kallikrein activity in plasma from patients with hereditary angioedema
    World Allergy Organ J (2025) 18, 101135-101135. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Liu,H., Deng,Y., Liu,J., Wang,Z., Hu,X.Q., Duan,Y., Chen,Y. and Xie,Z.
    Plasma Kallikrein Inhibitors for Multiple Disorders: Current Advances and Perspectives
    J Med Chem (2025) PubMed  Europe PubMed DOI
  3. Lopez-Lera,A., Corvillo,F., Gonzalez-Sanchez,L., Melgosa,M. and Sanchez-Corral,P.
    Relevance of the interactions between the complement and contact coagulation systems on renal pathology
    Nefrologia (Engl Ed) (2025) , 501347-501347. PubMed  Europe PubMed DOI
    4. 2024
  4. Kearney,K.J., Spronk,H.M.H., Emsley,J., Key,N.S. and Philippou,H.
    Plasma Kallikrein as a Forgotten Clotting Factor
    Semin Thromb Hemost (2024) 50, 953-961. PubMed  Europe PubMed DOI  V
  5. Longhurst,H.J., Lindsay,K., Petersen,R.S., Fijen,L.M., Gurugama,P., Maag,D., Butler,J.S., Shah,M.Y., Golden,A., Xu,Y., Boiselle,C., Vogel,J.D., Abdelhady,A.M., Maitland,M.L., McKee,M.D., Seitzer,J., Han,B.W., Soukamneuth,S., Leonard,J., Sepp-Lorenzino,L., Clark,E.D., Lebwohl,D. and Cohn,D.M.
    CRISPR-Cas9 In Vivo Gene Editing of KLKB1 for Hereditary Angioedema
    N Engl J Med (2024) 390, 432-441. PubMed  Europe PubMed DOI
  6. Riedl,M.A., Bordone,L., Revenko,A., Newman,K.B. and Cohn,D.M.
    Clinical Progress in Hepatic Targeting for Novel Prophylactic Therapies in Hereditary Angioedema
    J Allergy Clin Immunol Pract (2024) 12, 911-918. PubMed  Europe PubMed DOI  K
    7. 2023
  7. Bedian,V., Biris,N., Omer,C., Chung,J.K., Fuller,J., Dagher,R., Chandran,S., Harwin,P., Kiselak,T., Violin,J., Nichols,A. and Bista,P.
    STAR-0215 is a Novel, Long-Acting Monoclonal Antibody Inhibitor of Plasma Kallikrein for the Potential Treatment of Hereditary Angioedema
    J Pharmacol Exp Ther (2023) 387, 214-225. PubMed  Europe PubMed DOI
  8. Li,C., Barroeta,A.B., Wong,S.S., Kim,H.J., Pathak,M., Dreveny,I., Meijers,J.C.M. and Emsley,J.
    Structures of factor XI and prekallikrein bound to domain 6 of high-molecular weight kininogen reveal alternate domain 6 conformations and exosites
    J Thromb Haemost (2023) 21, 2378-2389. PubMed  Europe PubMed DOI
  9. Motta,G., Juliano,L. and Chagas,J.R.
    Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond
    Front Physiol (2023) 14, 1188816-1188816. PubMed  Europe PubMed DOI  PMC  EPMC  V
    10. 2022
  10. Alfaro,E., Diaz-Garcia,E., Garcia-Tovar,S., Zamarron,E., Mangas,A., Galera,R., Nanwani-Nanwani,K., Perez-de-Diego,R., Lopez-Collazo,E., Garcia-Rio,F. and Cubillos-Zapata,C.
    Impaired Kallikrein-Kinin System in COVID-19 Patients' Severity
    Front Immunol (2022) 13, 909342-909342. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Davie,R.L., Edwards,H.J., Evans,D.M., Hodgson,S.T., Stocks,M.J., Smith,A.J., Rushbrooke,L.J., Pethen,S.J., Roe,M.B., Clark,D.E., McEwan,P.A. and Hampton,S.L.
    Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential Oral On-Demand Treatment for Hereditary Angioedema
    J Med Chem (2022) 65, 13629-13644. PubMed  Europe PubMed DOI  I
  12. Sohaei,D., Hollenberg,M., Janket,S.J., Diamandis,E.P., Poda,G. and Prassas,I.
    The therapeutic relevance of the Kallikrein-Kinin axis in SARS-cov-2-induced vascular pathology
    Crit Rev Clin Lab Sci (2022) , 1-16. PubMed  Europe PubMed DOI  V
  13. Wang,J.K., Li,Y., Zhao,X.L., Liu,Y.B., Tan,J., Xing,Y.Y., Adi,D., Wang,Y.T., Fu,Z.Y., Ma,Y.T., Liu,S.M., Liu,Y., Wang,Y., Shi,X.J., Lu,X.Y., Song,B.L. and Luo,J.
    Ablation of Plasma Prekallikrein Decreases Low-Density Lipoprotein Cholesterol by Stabilizing Low-Density Lipoprotein Receptor and Protects Against Atherosclerosis
    Circulation (2022) 145, 675-687. PubMed  Europe PubMed DOI
    14. 2021
  14. Giangreco,N.P., Lebreton,G., Restaino,S., Jane Farr,M., Zorn,E., Colombo,P.C., Patel,J., LeVine,R., Truby,L., Soni,R.K., Leprince,P., Kobashigawa,J., Tatonetti,N.P. and Fine,B.M.
    Plasma kallikrein predicts primary graft dysfunction after heart transplant
    J Heart Lung Transplant (2021) PubMed  Europe PubMed DOI
  15. Kearney,K.J., Butler,J., Posada,O.M., Wilson,C., Heal,S., Ali,M., Hardy,L., Ahnstrom,J., Gailani,D., Foster,R., Hethershaw,E., Longstaff,C. and Philippou,H.
    Kallikrein directly interacts with and activates Factor IX, resulting in thrombin generation and fibrin formation independent of Factor XI
    Proc Natl Acad Sci U S A (2021) 118 PubMed  Europe PubMed DOI
  16. Pihl,R., Jensen,R.K., Poulsen,E.C., Jensen,L., Hansen,A.G., Thogersen,I.B., Dobo,J., Gal,P., Andersen,G.R., Enghild,J.J. and Thiel,S.
    ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism
    Sci Adv (2021) 7 PubMed  Europe PubMed DOI  PMC  EPMC
  17. Wan,J., Vadaq,N., Konings,J., Jaeger,M., Kumar,V., de Laat,B., Joosten,L., Netea,M.G., van der Ven,A.J., DE Groot,P.G., de Mast,Q. and Roest,M.
    Kallikrein augments the anticoagulant function of the protein C system in thrombin generation
    J Thromb Haemost (2021) PubMed  Europe PubMed DOI
    18. 2020
  18. Chatterjee,P., Gheblawi,M., Wang,K., Vu,J., Kondaiah,P. and Oudit,G.Y.
    Interaction between the apelinergic system and ACE2 in the cardiovascular system: therapeutic implications
    Clin Sci (Lond) (2020) 134, 2319-2336. PubMed  Europe PubMed DOI  V
  19. Fang,C. and Schmaier,A.H.
    Novel anti-thrombotic mechanisms mediated by Mas receptor as result of balanced activities between the kallikrein/kinin and the renin-angiotensin systems
    Pharmacol Res (2020) 160, 105096-105096. PubMed  Europe PubMed DOI  PMC  EPMC  V
  20. Ivanov,I., Verhamme,I.M., Sun,M.F., Mohammed,B., Cheng,Q., Matafonov,A., Dickeson,S.K., Joseph,K., Kaplan,A.P. and Gailani,D.
    Protease activity in single-chain prekallikrein
    Blood (2020) 135, 558-567. PubMed  Europe PubMed DOI
  21. Meini,S., Zanichelli,A., Sbrojavacca,R., Iuri,F., Roberts,A.T., Suffritti,C. and Tascini,C.
    Understanding the Pathophysiology of COVID-19: Could the Contact System Be the Key?
    Front Immunol (2020) 11, 2014-2014. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Ponczek,M.B., Shamanaev,A., LaPlace,A., Dickeson,S.K., Srivastava,P., Sun,M.F., Gruber,A., Kastrup,C., Emsley,J. and Gailani,D.
    The evolution of factor XI and the kallikrein-kinin system
    Blood Adv (2020) 4, 6135-6147. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Xie,Z., Li,Z., Shao,Y. and Liao,C.
    Discovery and development of plasma kallikrein inhibitors for multiple diseases
    Eur J Med Chem (2020) 190, 112137-112137. PubMed  Europe PubMed DOI  I
    24. 2019
  24. Fischer,C., Lamer,T., Wang,W., McKinnie,S.M.K., Iturrioz,X., Llorens-Cortes,C., Oudit,G.Y. and Vederas,J.C.
    Plasma kallikrein cleaves and inactivates apelin-17: palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents
    Eur J Med Chem (2019) 166, 119-124. PubMed  Europe PubMed DOI
  25. Hwang,G., Johri,A., Ng,S. and Craig,T.
    A review of kallikrein inhibitor lanadelumab in hereditary angioedema
    Immunotherapy (2019) 11, 937-944. PubMed  Europe PubMed DOI
  26. Hwang,J.R., Hwang,G., Johri,A. and Craig,T.
    Oral plasma kallikrein inhibitor BCX7353 for treatment of hereditary angioedema
    Immunotherapy (2019) 11, 1439-1444. PubMed  Europe PubMed DOI  I
  27. Li,C., Voos,K.M., Pathak,M., Hall,G., McCrae,K.R., Dreveny,I., Li,R. and Emsley,J.
    Plasma Kallikrein Structure Reveals Apple Domain Disc Rotated Conformation Compared to Factor XI
    J Thromb Haemost (2019) 17, 759-770. PubMed  Europe PubMed DOI  S
  28. Partridge,J.R., Choy,R.M., Silva-Garcia,A., Yu,C., Li,Z., Sham,H. and Metcalf,B.
    Structures of full-length plasma kallikrein bound to highly specific inhibitors describe a new mode of targeted inhibition
    J Struct Biol (2019) 206, 170-182. PubMed  Europe PubMed DOI  S  I
  29. Salu,B.R., Pando,S.C., Brito,M.V., Medina,A.F., Odei-Addo,F., Frost,C., Naude,R., Sampaio,M.U., Emsley,J., Maffei,F.H.A. and Oliva,M.L.V.
    Improving the understanding of plasma kallikrein contribution to arterial thrombus formation using two plant protease inhibitors
    Platelets (2019) 30, 305-313. PubMed  Europe PubMed DOI
  30. Sun,J.K., Maturi,R.K., Boyer,D.S., Wells,J.A., Gonzalez,V.H., Tansley,R., Hernandez,H., Maetzel,A., Feener,E.P. and Aiello,L.P.
    One-time intravitreal injection of KVD001, a plasma kallikrein inhibitor, in patients with central-involved diabetic macular edema and reduced vision: an open-label phase 1B study
    Ophthalmol Retina (2019) 3, 1107-1109. PubMed  Europe PubMed DOI  I
  31. Wedi,B.
    Lanadelumab to treat hereditary angioedema
    Drugs Today (Barc) (2019) 55, 439-448. PubMed  Europe PubMed DOI
    32. 2018
  32. Aygoren-Pursun,E., Bygum,A., Grivcheva-Panovska,V., Magerl,M., Graff,J., Steiner,U.C., Fain,O., Huissoon,A., Kinaciyan,T., Farkas,H., Lleonart,R., Longhurst,H.J., Rae,W., Triggiani,M., Aberer,W., Cancian,M., Zanichelli,A., Smith,W.B., Baeza,M.L., Du-Thanh,A., Gompels,M., Gonzalez-Quevedo,T., Greve,J., Guilarte,M., Katelaris,C., Dobo,S., Cornpropst,M., Clemons,D., Fang,L., Collis,P., Sheridan,W., Maurer,M. and Cicardi,M.
    Oral plasma kallikrein inhibitor for prophylaxis in hereditary angioedema
    N Engl J Med (2018) 379, 352-362. PubMed  Europe PubMed DOI  I
  33. Irmscher,S., Doring,N., Halder,L.D., Jo,E.A.H., Kopka,I., Dunker,C., Jacobsen,I.D., Luo,S., Slevogt,H., Lorkowski,S., Beyersdorf,N., Zipfel,P.F. and Skerka,C.
    Kallikrein cleaves C3 and activates complement
    J Innate Immun (2018) 10, 94-105. PubMed  Europe PubMed DOI
  34. Riedl,M.A., Aygoren-Pursun,E., Baker,J., Farkas,H., Anderson,J., Bernstein,J.A., Bouillet,L., Busse,P., Manning,M., Magerl,M., Gompels,M., Huissoon,A.P., Longhurst,H., Lumry,W., Ritchie,B., Shapiro,R., Soteres,D., Banerji,A., Cancian,M., Johnston,D.T., Craig,T.J., Launay,D., Li,H.H., Liebhaber,M., Nickel,T., Offenberger,J., Rae,W., Schrijvers,R., Triggiani,M., Wedner,H.J., Dobo,S., Cornpropst,M., Clemons,D., Fang,L., Collis,P., Sheridan,W.P. and Maurer,M.
    Evaluation of avoralstat, an oral kallikrein inhibitor, in a phase 3 hereditary angioedema prophylaxis trial: the OPUS-2 study
    Allergy (2018) 73, 1871-1880. PubMed  Europe PubMed DOI  I
  35. Teufel,D.P., Bennett,G., Harrison,H., van Rietschoten,K., Pavan,S., Stace,C., Le Floch,F., Van Bergen,T., Vermassen,E., Barbeaux,P., Hu,T.T., Feyen,J.H.M. and Vanhove,M.
    Stable and long-lasting, novel bicyclic peptide plasma kallikrein inhibitors for the treatment of diabetic macular edema
    J Med Chem (2018) 61, 2823-2836. PubMed  Europe PubMed DOI  I
  36. Xu,M., Chen,Y., Xu,P., Andreasen,P.A., Jiang,L., Li,J. and Huang,M.
    Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217
    FEBS Lett (2018) 592, 2658-2667. PubMed  Europe PubMed DOI  S
    37. 2017
  37. Abdel-Magid,A.F.
    Plasma kallikrein inhibitors for the treatment of retinal vascular permeability associated with diabetic retinopathy and diabetic macular edema
    ACS Med Chem Lett (2017) 8, 776-777. PubMed  Europe PubMed DOI  PMC  EPMC  I
  38. Ivanov,I., Matafonov,A., Sun,M.F., Cheng,Q., Dickeson,S.K., Verhamme,I.M., Emsley,J. and Gailani,D.
    Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation
    Blood (2017) 129, 1527-1537. PubMed  Europe PubMed DOI
  39. Li,Z., Partridge,J., Silva-Garcia,A., Rademacher,P., Betz,A., Xu,Q., Sham,H., Hu,Y., Shan,Y., Liu,B., Zhang,Y., Shi,H., Xu,Q., Ma,X. and Zhang,L.
    Structure-guided design of novel, potent, and selective macrocyclic plasma kallikrein inhibitors
    ACS Med Chem Lett (2017) 8, 185-190. PubMed  Europe PubMed DOI  PMC  EPMC  I
  40. Simao,F., Ustunkaya,T., Clermont,A.C. and Feener,E.P.
    Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke
    Blood (2017) 129, 2280-2290. PubMed  Europe PubMed DOI
  41. Steen Burrell,K.A., Layzer,J. and Sullenger,B.A.
    A kallikrein-targeting RNA aptamer inhibits the intrinsic pathway of coagulation and reduces bradykinin release
    J Thromb Haemost (2017) 15, 1807-1817. PubMed  Europe PubMed DOI  I
  42. Xu,M.-M., Xu,P., Zhou,X.-L., Andreasen,P., Jiang,L.-G. and Huang,M.-D.
    Crystal structures of the serine protease domain of murine plasma kallikrein
    Jiegou Huaxue (2017) 36, 242-249. DOI  S
    43. 2016
  43. Clermont,A., Murugesan,N., Zhou,Q., Kita,T., Robson,P.A., Rushbrooke,L.J., Evans,D.M., Aiello,L.P. and Feener,E.P.
    Plasma kallikrein mediates vascular endothelial growth factor-induced retinal dysfunction and thickening
    Invest Ophthalmol Vis Sci (2016) 57, 2390-2399. PubMed  Europe PubMed DOI  PMC  EPMC  I
  44. Cornpropst,M., Collis,P., Collier,J., Babu,Y.S., Wilson,R., Zhang,J., Fang,L., Zong,J. and Sheridan,W.P.
    Safety, pharmacokinetics, and pharmacodynamics of avoralstat, an oral plasma kallikrein inhibitor: phase 1 study
    Allergy (2016) 71, 1676-1683. PubMed  Europe PubMed DOI  I
  45. Gittleman,H.R., Merkulova,A., Alhalabi,O., Stavrou,E.X., Veigl,M.L., Barnholtz-Sloan,J.S. and Schmaier,A.H.
    A cross-sectional study of KLKB1 and PRCP polymorphisms in patient samples with cardiovascular disease
    Front Med (Lausanne) (2016) 3, 17-17. PubMed  Europe PubMed DOI  PMC  EPMC  M
  46. Gras,J.
    Anti-KLKB1 (plasma kallikrein) MAb treatment of hereditary angioedema
    Drugs Future (2016) 41, 281-284. DOI
  47. Kokoye,Y., Ivanov,I., Cheng,Q., Matafonov,A., Dickeson,S.K., Mason,S., Sexton,D.J., Renne,T., McCrae,K., Feener,E.P. and Gailani,D.
    A comparison of the effects of factor XII deficiency and prekallikrein deficiency on thrombus formation
    Thromb Res (2016) 140, 118-124. PubMed  Europe PubMed DOI  M
  48. Kolte,D. and Shariat-Madar,Z.
    Plasma kallikrein inhibitors in cardiovascular disease: an innovative therapeutic approach
    Cardiol Rev (2016) 24, 99-109. PubMed  Europe PubMed DOI  I
    49. 2015
  49. Adamopoulos,P.G., Kontos,C.K., Papageorgiou,S.G., Pappa,V. and Scorilas,A.
    KLKB1 mRNA overexpression: a novel molecular biomarker for the diagnosis of chronic lymphocytic leukemia
    Clin Biochem (2015) 48, 849-854. PubMed  Europe PubMed DOI
  50. Renne,T.
    The vascular side of plasma kallikrein
    Blood (2015) 125, 589-590. PubMed  Europe PubMed DOI  K
  51. Xu,P., Xu,M., Jiang,L., Yang,Q., Luo,Z., Dauter,Z., Huang,M. and Andreasen,P.A.
    Design of specific serine protease inhibitors based on a versatile peptide scaffold: conversion of a urokinase inhibitor to a plasma kallikrein inhibitor
    J Med Chem (2015) 58, 8868-8876. PubMed  Europe PubMed DOI  I
    52. 2014
  52. Kenniston,J.A., Faucette,R.R., Martik,D., Comeau,S.R., Lindberg,A.P., Kopacz,K.J., Conley,G.P., Chen,J., Viswanathan,M., Kastrapeli,N., Cosic,J., Mason,S., DiLeo,M., Abendroth,J., Kuzmic,P., Ladner,R.C., Edwards,T.E., Tenhoor,C., Adelman,B.A., Nixon,A.E. and Sexton,D.J.
    Inhibition of plasma kallikrein by a highly specific active site blocking antibody
    J Biol Chem (2014) 289, 23596-23608. PubMed  Europe PubMed DOI
  53. Keum,J.S., Jaffa,M.A., Luttrell,L.M. and Jaffa,A.A.
    Novel mechanism of plasma prekallikrein (PK) activation by vascular smooth muscle cells: evidence of the presence of PK activator
    J Biol Regul Homeost Agents (2014) 28, 587-603. PubMed  Europe PubMed
  54. Schmaier,A.H.
    Physiologic activities of the contact activation system
    Thromb Res (2014) 133 Suppl 1, S41-S44. PubMed  Europe PubMed DOI  PMC  EPMC  K
  55. Wang,J., Matafonov,A., Madkhali,H., Mahdi,F., Watson,D., Schmaier,A.H., Gailani,D. and Shariat-Madar,Z.
    Prolylcarboxypeptidase independently activates plasma prekallikrein (Fletcher factor)
    Curr Mol Med (2014) 14, 1173-1185. PubMed  Europe PubMed
    56. 2013
  56. Bjorkqvist,J., Jamsa,A. and Renne,T.
    Plasma kallikrein: the bradykinin-producing enzyme
    Thromb Haemost (2013) 110, 399-407. PubMed  Europe PubMed DOI  V
  57. Koumandou,V.L. and Scorilas,A.
    Evolution of the plasma and tissue kallikreins, and their alternative splicing isoforms
    PLoS ONE (2013) 8, e68074-e68074. PubMed  Europe PubMed DOI  PMC  EPMC
  58. Wong,M.K. and Takei,Y.
    Lack of plasma kallikrein-kinin system cascade in teleosts
    PLoS ONE (2013) 8, e81057-e81057. PubMed  Europe PubMed DOI  PMC  EPMC
    59. 2012
  59. Baeriswyl,V., Rapley,H., Pollaro,L., Stace,C., Teufel,D., Walker,E., Chen,S., Winter,G., Tite,J. and Heinis,C.
    Bicyclic peptides with optimized ring size inhibit human plasma kallikrein and its orthologues while sparing paralogous proteases
    ChemMedChem (2012) 7, 1173-1176. PubMed  Europe PubMed DOI  I
  60. Bird,J.E., Smith,P.L., Wang,X., Schumacher,W.A., Barbera,F., Revelli,J.P. and Seiffert,D.
    Effects of plasma kallikrein deficiency on haemostasis and thrombosis in mice: murine ortholog of the Fletcher trait
    Thromb Haemost (2012) 107, 1141-1150. PubMed  Europe PubMed DOI  K
  61. Renne,T. and Gruber,A.
    Plasma kallikrein: novel functions for an old protease
    Thromb Haemost (2012) 107, 1012-1013. PubMed  Europe PubMed DOI
  62. Schmaier,A.H.
    Prekallikrein and plasma kallikrein
    [ISSN:978-0-12-407742-3] (2012) 3, 2885-2892. DOI
    63. 2011
  63. Kolte,D., Bryant,J., Holsworth,D., Wang,J., Akbari,P., Gibson,G. and Shariat-Madar,Z.
    Biochemical characterization of a novel high-affinity and specific plasma kallikrein inhibitor
    Br J Pharmacol (2011) 162, 1639-1649. PubMed  Europe PubMed DOI  I
  64. Revenko,A.S., Gao,D., Crosby,J.R., Bhattacharjee,G., Zhao,C., May,C., Gailani,D., Monia,B.P. and Macleod,A.R.
    Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding
    Blood (2011) 118, 5302-5311. PubMed  Europe PubMed DOI  K
    65. 2010
  65. Stoop,A.A., Joshi,R.V., Eggers,C.T. and Craik,C.S.
    Analysis of an engineered plasma kallikrein inhibitor and its effect on contact activation
    Biol Chem (2010) 391, 425-433. PubMed  Europe PubMed DOI
    66. 2009
  66. Abid,K., Rochat,B., Lassahn,P.G., Stocklin,R., Michalet,S., Brakch,N., Aubert,J.F., Vatansever,B., Tella,P., De Meester,I. and Grouzmann,E.
    Kinetic study of neuropeptide Y (NPY) proteolysis in blood and identification of NPY3-35: a new peptide generated by plasma kallikrein
    J Biol Chem (2009) 284, 24715-24724. PubMed  Europe PubMed DOI  PMC  EPMC  P
  67. Huang,W.Y., Wan,X. and Zhang,S.
    A novel chromogenic peptide for prekallikrein/kallikrein determination
    Clin Lab (2009) 55, 106-113. PubMed  Europe PubMed  A
    68. 2008
  68. Lima,A.R., Alves,F.M., Angelo,P.F., Andrade,D., Blaber,S.I., Blaber,M., Juliano,L. and Juliano,M.A.
    S(1)' and S(2)' subsite specificities of human plasma kallikrein and tissue kallikrein 1 for the hydrolysis of peptides derived from the bradykinin domain of human kininogen
    Biol Chem (2008) 389, 1487-1494. PubMed  Europe PubMed DOI  P
  69. Saito,A.
    Plasma kallikrein is activated on dermatan sulfate and cleaves factor H
    Biochem Biophys Res Commun (2008) 370, 646-650. PubMed  Europe PubMed DOI
  70. Schmaier,A.H.
    Assembly, activation, and physiologic influence of the plasma kallikrein/kinin system
    Int Immunopharmacol (2008) 8, 161-165. PubMed  Europe PubMed DOI  PMC  EPMC  V
  71. Stief,T.W.
    Kallikrein activates prothrombin
    Clin Appl Thromb Hemost (2008) 14, 97-98. PubMed  Europe PubMed DOI
    72. 2007
  72. Colman,R.
    Kallikrein-kinin system
     (2007) 9780521853767, 444-450. DOI  V
  73. Hooley,E., McEwan,P.A. and Emsley,J.
    Molecular modeling of the prekallikrein structure provides insights into high-molecular-weight kininogen binding and zymogen activation
    J Thromb Haemost (2007) 5, 2461-2466. PubMed  Europe PubMed DOI
  74. Sainz,I.M., Pixley,R.A. and Colman,R.W.
    Fifty years of research on the plasma kallikrein-kinin system: from protein structure and function to cell biology and in-vivo pathophysiology
    Thromb Haemost (2007) 98, 77-83. PubMed  Europe PubMed DOI  V
  75. Schmaier,A.H. and McCrae,K.R.
    The plasma kallikrein-kinin system: its evolution from contact activation
    J Thromb Haemost (2007) 5, 2323-2329. PubMed  Europe PubMed DOI  V
  76. Schneider,L., Lumry,W., Vegh,A., Williams,A.H. and Schmalbach,T.
    Critical role of kallikrein in hereditary angioedema pathogenesis: a clinical trial of ecallantide, a novel kallikrein inhibitor
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