$VAR1 = undef;

Summary for peptidase S01.162: kallikrein-related peptidase 3

Names
MEROPS Name	kallikrein-related peptidase 3
Other names	APS g.p. [obs.] (Homo sapiens), hk3, kallikrein 3, kallikrein hK3, P-30 antigen, prostate-specific antigen, PSA, seminin, gamma-seminoprotein, KLK3 g.p. (Homo sapiens), semenogelase

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.162
Holotype	kallikrein-related peptidase 3 (Homo sapiens), Uniprot accession P07288 (peptidase unit: 25-260), MERNUM MER0000115
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00291
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.77
Enzymology	BRENDA database
Proteolytic events	CutDB database (37 cleavages)
Biotechnology	Used in detection and assessment of prostate cancer.
Pharmaceutical relevance	A potential drug target for prostatic and other cancers (Gygi et al., 2002).
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/KLK3
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	si/sq/-/yqrs/s/-/- (based on 86 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	5	2	0	0	4	7	6	10
Pro	1	3	5	0	0	1	3	5
Ala	7	4	1	0	4	0	0	3
Val	4	2	6	0	4	10	3	3
Leu	1	5	10	4	5	4	2	2
Ile	13	4	4	0	7	8	2	2
Met	1	0	0	2	1	0	1	0
Phe	0	0	6	2	1	0	0	0
Tyr	0	0	10	35	1	2	0	2
Trp	0	0	1	0	0	0	1	0
Ser	25	21	9	0	20	17	9	4
Thr	0	3	6	0	5	2	5	7
Cys	0	3	0	2	0	0	0	1
Asn	2	0	2	2	4	4	12	1
Gln	6	20	12	19	3	5	7	3
Asp	0	2	0	2	3	2	1	4
Glu	1	1	0	1	1	3	7	8
Lys	0	8	3	2	1	3	5	4
Arg	8	4	1	9	3	1	1	2
His	1	3	9	6	2	1	4	4

Human genetics
Gene symbol	Locus	Megabases	Ensembl	Entrez gene	Gene Cards	OMIM
KLK3	19q13.3-q13.4		ENSG00000142515	354	KLK3	176820