Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase S01.162: kallikrein-related peptidase 3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, R Splicing. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Baryshev,M. and Vjaters,E.
    Allele-Specific CG/CCWGG Methylation of the PSA Promoter Discriminates Aggressive, Indolent, and Benign Prostate Cell Lines and Is Involved in the Regulation of PSA Expression
    Int J Mol Sci26, PubMed  Europe PubMed DOI
  2. Cheng,A., Guo,S., Wang,Z., Lan,K., Liu,Z., Wang,Y., Chen,R. and Qin,G.
    High-performance affinity peptide sensor for prostate specific antigen detection
    Biomed Mater20, PubMed  Europe PubMed DOI
  3. Hoffmann,T.J., Graff,R.E., Madduri,R.K., Rodriguez,A.A., Cario,C.L., Feng,K., Jiang,Y., Wang,A., Klein,R.J., Pierce,B.L., Eggener,S., Tong,L., Blot,W., Long,J., Goss,L.B., Darst,B.F., Rebbeck,T., Lachance,J., Andrews,C., Adebiyi,A.O., Adusei,B., Aisuodionoe-Shadrach,O.I., Fernandez,P.W., Jalloh,M., Janivara,R., Chen,W.C., Mensah,J.E., Agalliu,I., Berndt,S.I., Shelley,J.P., Schaffer,K., Machiela,M.J., Freedman,N.D., Huang,W.Y., Li,S.A., Goodman,P.J., Till,C., Thompson,I., Lilja,H., Ranatunga,D.K., Presti,J., Van Den Eeden,S.K., Chanock,S.J., Mosley,J.D., Conti,D.V., Haiman,C.A., Justice,A.C., Kachuri,L. and Witte,J.S.
    Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups
    Nat Genet57, 334-344. PubMed  Europe PubMed DOI
  4. Huang,C.P., Hu,W.P., Yang,W., Lee,Z.J. and Chen,W.Y.
    In silico maturation of DNA aptamer against the prostate-specific antigen (PSA) and kinetic analysis
    Biochem Biophys Res Commun759, 151638-151638. PubMed  Europe PubMed DOI
  5. Kahveci,E.F., Colvin Zielen,A.M., Gibbs,W.J., McIntyre,C.A., Modi,R., Johnstonbaugh,H.Z., Washington Iv,T.H., Brown,V., Hockman,M.R., Rossman,N.R. and Jensen-Seaman,M.I.
    Comparative functional analyses of the prostate-specific KLK3 enzyme in primates reveals the impact of sexual selection
    Evolution PubMed  Europe PubMed DOI
    6. 2024
  6. Halldorsson,S., Hillringhaus,L., Hojer,C., Muranyi,A., Schraeml,M., Lange,M.S. and Tabares,G.
    Development of a first-in-class antibody and a specific assay for alpha-1,6-fucosylated prostate-specific antigen
    Sci Rep14, 16512-16512. PubMed  Europe PubMed DOI
  7. Hua,X., Zhao,T., Gui,X. and Jin,B.
    A NiFe PBA/AuNPs nanocomposite sensitive immunosensor for electrochemical detection of PSA
    Anal Methods16, 1923-1933. PubMed  Europe PubMed DOI
  8. Huang,Z., Zhao,L., Guo,Q., Fan,D., Ren,X., Wei,Q. and Wu,D.
    Controlled-Release Electrochemiluminescence Biosensor with Strong Self-On Effect by a Multiple Signal Amplification Strategy for Trace Detection of Prostate-Specific Antigen
    Anal Chem96, 6659-6665. PubMed  Europe PubMed DOI
  9. Miglione,A., Di Nardo,F., Cavalera,S., Serra,T., Baggiani,C., Cinti,S. and Anfossi,L.
    Merging Lateral Flow Immunoassay with Electroanalysis as a Novel Sensing Platform: Prostate Specific Antigen Detection as Case of Study
    Anal Chem96, 2297-2302. PubMed  Europe PubMed DOI
  10. Ouyang,M., Jia,M., Chang,Z., Wang,Y., Wang,K., Gao,X. and Tang,B.
    Precise prostate cancer diagnosis using fluorescent nanoprobes for detecting PSA and PSMA in serum
    Chem Commun (Camb)60, 5181-5184. PubMed  Europe PubMed DOI
  11. Peng,Y.F., Ma,L.Y. and Luo,M.
    Elevation of Serum Prostate-Specific Antigen Levels in Males With Pulmonary Embolism
    Clin Appl Thromb Hemost30, 10760296241250002-10760296241250002. PubMed  Europe PubMed DOI
  12. Shao,H., Zhao,L., Liu,Z. and Li,J.
    An epitope imprinted electrochemical sensor for highly sensitive and selective determination of prostate-specific antigen
    Mikrochim Acta191, 660-660. PubMed  Europe PubMed DOI
  13. Simanek,V., Vrzakova,R., Vitak,R., Jirasko,M., Furst,T., Topolcan,O., Pecen,L., Vurm,V. and Kucera,R.
    Preanalytical stability of molecular forms of prostate-specific antigen in serum samples (PSA, free PSA, [-2]proPSA) and their impact on fPSA/tPSA ratio and PHI
    Prostate84, 656-665. PubMed  Europe PubMed DOI
  14. Sklenarova,D., Hlavacek,A., Krivankova,J., Brandmeier,J.C., Weisova,J., Rihacek,M., Gorris,H.H., Skladal,P. and Farka,Z.
    Single-molecule microfluidic assay for prostate-specific antigen based on magnetic beads and upconversion nanoparticles
    Lab Chip24, 3536-3545. PubMed  Europe PubMed DOI
  15. Srinivasan,S., Kryza,T., Bock,N., Tse,B.W.C., Sokolowski,K.A., Janaththani,P., Fernando,A., Moya,L., Stephens,C., Dong,Y., Rohl,J., Alinezhad,S., Vela,I., Perry-Keene,J.L., Buzacott,K., Nica,R., Gago-Dominguez,M., Schleutker,J., Maier,C., Muir,K., Tangen,C.M., Gronberg,H., Pashayan,N., Albanes,D., Wolk,A., Stanford,J.L., Berndt,S.I., Mucci,L.A., Koutros,S., Cussenot,O., Sorensen,K.D., Grindedal,E.M., Travis,R.C., Haiman,C.A., MacInnis,R.J., Vega,A., Wiklund,F., Neal,D.E., Kogevinas,M., Penney,K.L., Nordestgaard,B.G., Brenner,H., John,E.M., Gamulin,M., Claessens,F., Melander,O., Dahlin,A., Stattin,P., Hallmans,G., Haggstrom,C., Johansson,R., Thysell,E., Ronn,A.C., Li,W., Brown,N., Dimeski,G., Shepherd,B., Dadaev,T., Brook,M.N., Spurdle,A.B., Stenman,U.H., Koistinen,H., Kote-Jarai,Z., Klein,R.J., Lilja,H., Ecker,R.C., Eeles,R., Clements,J. and Batra,J.
    A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer
    Nat Commun15, 9587-9587. PubMed  Europe PubMed DOI
  16. Vickers,A.J. and Lilja,H.
    Eight Misconceptions about Prostate-Specific Antigen
    Clin Chem70, 13-16. PubMed  Europe PubMed DOI
  17. Villalonga,A., Diaz,R., Ojeda,I., Sanchez,A., Mayol,B., Martinez-Ruiz,P., Villalonga,R. and Vilela,D.
    Sandwich-Type Electrochemical Aptasensor with Supramolecular Architecture for Prostate-Specific Antigen
    Molecules29, PubMed  Europe PubMed DOI
  18. Wu,D., Wang,B., Jiang,A., Dong,Y. and Jie,G.
    Dual-mode photoelectrochemical radar based on CdS quantum dot and Ce-MOF for detection of low-abundance disease-associated proteins
    Anal Chim Acta1306, 342585-342585. PubMed  Europe PubMed DOI
  19. Xia,N., Liu,G., Chen,Y., Wu,T., Liu,L., Yang,S. and Li,Y.
    Magnetically-assisted electrochemical immunoplatform for simultaneous detection of active and total prostate-specific antigen based on proteolytic reaction and sandwich affinity analysis
    Talanta270, 125534-125534. PubMed  Europe PubMed DOI
  20. Yan,D., Jiao,L., Chen,C., Jia,X., Li,R., Hu,L., Li,X., Zhai,Y., Strizhak,P.E., Zhu,Z., Tang,J. and Lu,X.
    p-d Orbital Hybridization-Engineered PdSn Nanozymes for a Sensitive Immunoassay
    Nano Lett24, 2912-2920. PubMed  Europe PubMed DOI
  21. Yeh,I.H., Shi,H.F., Darius,E., Lien,M.C., Lu,Y.C., Wang,C. and Liu,K.K.
    Plasmonic biochips with enhanced stability in harsh environments for the sensitive detection of prostate-specific antigen
    J Mater Chem B12, 1617-1623. PubMed  Europe PubMed DOI
  22. Yu,Y., Xie,H., Zhou,T., Zhang,H., Lu,C., Tao,R., Tang,Z. and Luo,J.
    Real-Time and Ultrasensitive Prostate-Specific Antigen Sensing Using Love-Mode Surface Acoustic Wave Immunosensor Based on MoS(2)@Cu(2)O-Au Nanocomposites
    Sensors (Basel)24, PubMed  Europe PubMed DOI
  23. Zhang,S., Tang,X., Zang,L. and Zhao,L.
    Carbon quantum dots(CQDs)-sensitized CdS/CuInS(2) heterojunction as a photoelectrochemical biosensing platform for highly sensitive detection of prostate-specific antigen
    Talanta272, 125811-125811. PubMed  Europe PubMed DOI
  24. Zikmundova,E., Sklenarova,D., Koci,E., Zatloukalova,T., Bacova,T., Makhneva,E., Holub,D., Machacova,E., Koprivova,H., Vytiskova,K., Porizka,P., Novotny,K., Skladal,P., Farka,Z. and Kaiser,J.
    Magnetic microbead-based upconversion immunoassay with laser-induced breakdown spectroscopy readout for the detection of prostate-specific antigen
    Mikrochim Acta191, 656-656. PubMed  Europe PubMed DOI
    25. 2023
  25. Basu,S., Das,D., Ansari,Z., Rana,N., Majhi,B., Patra,D., Kanungo,A., Morgan,D., Dutta,S. and Sen,K.
    A multispectroscopic approach for ultra-trace sensing of prostate specific antigen (PSA) by iron nanocomposite fabricated on graphene nanoplatelet
    Spectrochim Acta A Mol Biomol Spectrosc301, 122955-122955. PubMed  Europe PubMed DOI
  26. Chen,S., Tang,Q., Zeng,Y., Yang,Y., Zhu,T., Wang,H., Guo,L., Li,L. and Qian,Z.
    A novel fluorescence aptasensor based on PCN-223 as an efficient quencher for sensitive determination of prostate-specific antigen
    Mikrochim Acta190, 70-70. PubMed  Europe PubMed DOI
  27. Koistinen,H., Kovanen,R.M., Hollenberg,M.D., Dufour,A., Radisky,E.S., Stenman,U.H., Batra,J., Clements,J., Hooper,J.D., Diamandis,E., Schilling,O., Rannikko,A. and Mirtti,T.
    The roles of proteases in prostate cancer
    IUBMB Life75, 493-513. PubMed  Europe PubMed DOI  V
  28. Lehrer,S. and Rheinstein,P.H.
    Association of Kallikrein Related Peptidase 3 (KLK3) gene with dermatophytosis in the UK biobank cohort
    Mycoses66, 1050-1055. PubMed  Europe PubMed DOI
  29. Lehto,T.K., Kovanen,R.M., Lintula,S., Malen,A., Sturenberg,C., Erickson,A., Pulkka,O.P., Stenman,U.H., Diamandis,E.P., Rannikko,A., Mirtti,T. and Koistinen,H.
    Prognostic impact of kallikrein-related peptidase transcript levels in prostate cancer
    Int J Cancer153, 867-881. PubMed  Europe PubMed DOI
  30. Liang,H., Wang,X., Li,F., Xie,Y., Shen,J., Wang,X., Huang,Y., Lin,S., Chen,J., Zhang,L., Jiang,B., Xing,J. and Zhu,J.
    Label-free plasmonic metasensing of PSA and exosomes in serum for rapid high-sensitivity diagnosis of early prostate cancer
    Biosens Bioelectron235, 115380-115380. PubMed  Europe PubMed DOI
  31. Ning,H., Wu,H., Lyu,J. and Wu,F.
    Re: A low prostate-specific antigen predicts a worse outcome in high but not in low/intermediate-grade prostate cancer
    Eur J Cancer187, 144-146. PubMed  Europe PubMed DOI
  32. Stuardo-Parada,A., Lopez-Munoz,R., Villarroel-Espindola,F., Figueroa,C.D. and Ehrenfeld,P.
    Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer
    Med Oncol40, 224-224. PubMed  Europe PubMed DOI  V
  33. Wang,F., Gong,Y., Xu,Y., Ma,Z. and Han,H.
    Electrochemical sensing interface based on the oriented self-assembly of histidine labeled peptides induced by Ni(2+) for protease detection
    Biosens Bioelectron230, 115259-115259. PubMed  Europe PubMed DOI
  34. Wei,C., Chen,X., Ji,J., Xu,Y., He,X., Zhang,H., Mo,Z. and Wang,F.
    Urinary exosomal prostate-specific antigen is a noninvasive biomarker to detect prostate cancer: Not only old wine in new bottles
    Int J Cancer152, 1719-1727. PubMed  Europe PubMed DOI
  35. Zeng,Z., Tian,J., Ren,Z., Yang,Y., Gong,Q., Sun,R., Zhang,X., Liu,W. and Chen,C.
    Digital droplet immunoassay based on a microfluidic chip with magnetic beads for the detection of prostate-specific antigen
    J Sep Sci46, e2300471-e2300471. PubMed  Europe PubMed DOI
  36. Zhao,J., Ma,H., Liu,Y., Xu,B., Song,L., Han,X., Liu,R., He,C., Cheng,Z. and Zhao,B.
    SERS-based biosensor for detection of f-PSA%: Implications for the diagnosis of prostate cancer
    Talanta261, 124654-124654. PubMed  Europe PubMed DOI
    37. 2022
  37. Behyar,M.B., Farshchi,F. and Hasanzadeh,M.
    Sensitive recognition of prostate-specific antigen using biotinylated antibody encapsulated on D-penicillamine decorated wrinkled silicate nanoparticles (WSN): An innovative sandwich-type biosensor toward diagnosis of prostate cancer
    J Mol Recognit35, e2960-e2960. PubMed  Europe PubMed DOI  I
  38. Bott-Neto,J.L., Martins,T.S., Buscaglia,L.A., Machado,S.A.S. and Oliveira ON Jr
    Photocatalysis of TiO2 Sensitized with Graphitic Carbon Nitride and Electrodeposited Aryl Diazonium on Screen-Printed Electrodes to Detect Prostate Specific Antigen under Visible Light
    ACS Appl Mater Interfaces14, 22114-22121. PubMed  Europe PubMed DOI
  39. Bushira,F.A., Wang,P., Wang,Y., Hou,S., Diao,X., Li,H., Zheng,L. and Jin,Y.
    Plasmon-Boosted Fe, Co Dual Single-Atom Catalysts for Ultrasensitive Luminol-Dissolved O2 Electrochemiluminescence Detection of Prostate-Specific Antigen
    Anal Chem94, 9758-9765. PubMed  Europe PubMed DOI
  40. Cao,X., Liu,M., Zhao,M., Li,J., Xia,J., Zou,T. and Wang,Z.
    Synergetic PtNP@Co3O4 hollow nanopolyhedrals as peroxidase-like nanozymes for the dual-channel homogeneous biosensing of prostate-specific antigen
    Anal Bioanal Chem414, 1921-1932. PubMed  Europe PubMed DOI
  41. Chen,M., Han,R., Li,Y. and Luo,X.
    Nonfouling and ratiometric electrochemical detection of prostate specific antigen in whole serum
    Anal Chim Acta1224, 340191-340191. PubMed  Europe PubMed DOI
  42. Gao,X., Niu,T., Xia,Q., Hu,B., Zhao,Z., Feng,X., Yang,J., Tang,B. and Xu,K.
    Au-Se bonded nanoprobe for prostate specific antigen detection in serum
    Anal Chim Acta1210, 339852-339852. PubMed  Europe PubMed DOI
  43. Hui,N., Wang,J., Wang,D., Wang,P., Luo,X. and Lv,S.
    An ultrasensitive biosensor for prostate specific antigen detection in complex serum based on functional signal amplifier and designed peptides with both antifouling and recognizing capabilities
    Biosens Bioelectron200, 113921-113921. PubMed  Europe PubMed DOI
  44. Jiang,X., Pan,C., Wang,Q., Yin,Z., Han,X. and Tang,D.
    Glucose oxidase-encapsulated liposomes for amplified autofluorescence-free immunoassay of a prostate-specific antigen with photoluminescence of CePO(4):Tb nanocrystals
    Analyst147, 5680-5686. PubMed  Europe PubMed DOI
  45. Li,B., Guo,L., Chen,M., Guo,Y., Ge,L. and Kwok,H.F.
    Single-atom Pt-anchored Zn0.5Cd0.5S boosted photoelectrochemical immunoassay of prostate-specific antigen
    Biosens Bioelectron202, 114006-114006. PubMed  Europe PubMed DOI
  46. Li,M., Wang,Y., Hu,H., Feng,Y., Zhu,S., Li,C. and Feng,N.
    A dual-readout sandwich immunoassay based on biocatalytic perovskite nanocrystals for detection of prostate specific antigen
    Biosens Bioelectron203, 113979-113979. PubMed  Europe PubMed DOI
  47. Li,N., Wang,C., Chen,L., Ye,C. and Peng,Y.
    Ultrathin Covalent Organic Framework Nanosheets/Ti(3)C(2)T(x)-Based Photoelectrochemical Biosensor for Efficient Detection of Prostate-Specific Antigen
    Molecules27, PubMed  Europe PubMed DOI
  48. Liu,G., Guan,X., Li,B., Zhou,H., Kong,N. and Wang,H.
    Hemin-graphene oxide-gold nanoflower-assisted enhanced electrochemiluminescence immunosensor for determination of prostate-specific antigen
    Mikrochim Acta189, 297-297. PubMed  Europe PubMed DOI
  49. Luo,Z., Qin,D., Wu,Y., Meng,S., Mo,W. and Deng,B.
    An electrochemiluminescence immunosensor based on ABEI-GO-AgNPs as a double-amplified luminophore for the ultra-sensitive detection of prostate-specific antigen
    Colloids Surf B Biointerfaces218, 112718-112718. PubMed  Europe PubMed DOI
  50. Majd Shokorlou,Y. and Heidarzadeh,H.
    Multispectral plasmonic biosensors based on a Penta-supercell metamaterial for detection of prostate-specific antigen: Ultrasensitive in LC resonance mode
    Biosens Bioelectron217, 114722-114722. PubMed  Europe PubMed DOI
  51. Ozyurt,C., Uludag,I., Ince,B. and Sezginturk,M.K.
    Biosensing strategies for diagnosis of prostate specific antigen
    J Pharm Biomed Anal209, 114535-114535. PubMed  Europe PubMed DOI  V
  52. Shang,Q., Dong,H., Liu,S., Jiang,F., Li,Y., Wang,S., Liu,Q., Li,Y. and Tang,F.
    Sandwich-type electrochemical immunosensor based on nitrogen-doped porous carbon and nanoporous trimetallic nanozyme (PdAgCu) for determination of prostate specific antigen
    Mikrochim Acta189, 359-359. PubMed  Europe PubMed DOI
  53. Taghdisi,S.M., Ramezani,M., Alibolandi,M., Khademi,Z., Hajihasani,M.M., Alinezhad Nameghi,M., Khakshour Abdolabadi,A., Rahimi,H., Abnous,K. and Danesh,N.M.
    A highly sensitive fluorescent aptasensor for detection of prostate specific antigen based on the integration of a DNA structure and CRISPR-Cas12a
    Anal Chim Acta1219, 340031-340031. PubMed  Europe PubMed DOI
  54. Tang,X., Lu,C., Xu,X., Ding,Z., Li,H., Zhang,H., Wang,Y. and Li,C.
    A visible and near-infrared light dual responsive "signal-off" and "signal-on" photoelectrochemical aptasensor for prostate-specific antigen
    Biosens Bioelectron202, 113905-113905. PubMed  Europe PubMed DOI
  55. Wang,K., Xing,X., Ding,Y., Wen,X., Lu,Y., Wang,G., Wang,J., Zhao,H. and Hong,X.
    A dual-mode immunosensing strategy for prostate specific antigen detection: Integration of resonance Raman scattering and photoluminescence properties of ZnS:Mn(2+) nanoprobes
    Anal Chim Acta1205, 339775-339775. PubMed  Europe PubMed DOI
  56. Yu,J., Gao,G., Sun,B., Liang,L., Shen,Q., Zhang,Y. and Cao,H.
    Optimization of sensing-pad functionalizing strategy toward separative extended-gate FET biosensors for PSA detection
    J Pharm Biomed Anal211, 114597-114597. PubMed  Europe PubMed DOI
    57. 2021
  57. Kunnapuu,J., Bokharaie,H. and Jeltsch,M.
    Proteolytic Cleavages in the VEGF Family: Generating Diversity among Angiogenic VEGFs, Essential for the Activation of Lymphangiogenic VEGFs
    Biology (Basel)10, PubMed  Europe PubMed DOI
    58. 2020
  58. Gutkin,S., Green,O., Raviv,G., Shabat,D. and Portnoy,O.
    Powerful Chemiluminescence Probe for Rapid Detection of Prostate Specific Antigen Proteolytic Activity: Forensic Identification of Human Semen
    Bioconjug Chem PubMed  Europe PubMed DOI
  59. Nassir,A.M. and Kamel,H.F.M.
    Explication of the roles of prostate health index (PHI) and urokinase plasminogen activator (uPA) as diagnostic and predictor tools for prostate cancer in equivocal PSA range of 4-10 ng/mL
    Saudi J Biol Sci27, 1975-1984. PubMed  Europe PubMed DOI
  60. Vertosick,E.A., Haggstrom,C., Sjoberg,D.D., Hallmans,G., Johansson,R., Vickers,A.J., Stattin,P. and Lilja,H.
    Prespecified four kallikrein marker model (4Kscore) at age 50 or 60 for early detection of lethal prostate cancer in a large population-based cohort of asymptomatic men followed for 20 years
    J Urol101097JU0000000000001007-101097JU00000000101097JU. PubMed  Europe PubMed DOI
    61. 2019
  61. Jha,S.K., Rauniyar,K., Chronowska,E., Mattonet,K., Maina,E.W., Koistinen,H., Stenman,U.H., Alitalo,K. and Jeltsch,M.
    KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D
    elife8, PubMed  Europe PubMed DOI
  62. Moradi,A., Srinivasan,S., Clements,J. and Batra,J.
    Beyond the biomarker role: prostate-specific antigen (PSA) in the prostate cancer microenvironment
    Cancer Metastasis Rev38, 333-346. PubMed  Europe PubMed DOI
  63. Motamedi,R.K., Sarhangi,N., Afshari,M., Sattari,M., Jamaldini,S.H., Samzadeh,M., Mohsen Ziaei,S.A., Pourmand,G.R. and Hasanzad,M.
    Kallikarein-related peptidase 3 common genetic variant and the risk of prostate cancer
    J Cell Biochem120, 14822-14830. PubMed  Europe PubMed DOI  M
    64. 2018
  64. Kostova,M.B., Brennen,W.N., Lopez,D., Anthony,L., Wang,H., Platz,E. and Denmeade,S.R.
    PSA-alpha-2-Macroglobulin complex is enzymatically active in the serum of patients with advanced prostate cancer and can degrade circulating peptide hormones
    Prostate78, 819-829. PubMed  Europe PubMed DOI
  65. Nakajima,R., Novakova,Z., Tueckmantel,W., Motlova,L., Barinka,C. and Kozikowski,A.P.
    2-Aminoadipic acid-C(O)-glutamate based prostate-specific membrane antigen ligands for potential use as theranostics
    ACS Med Chem Lett9, 1099-1104. PubMed  Europe PubMed DOI  I
    66. 2016
  66. Karakosta,T.D., Soosaipillai,A., Diamandis,E.P., Batruch,I. and Drabovich,A.P.
    Quantification of human kallikrein-related peptidases in biological fluids by multiplatform targeted mass spectrometry assays
    Mol Cell Proteomics15, 2863-2876. PubMed  Europe PubMed DOI  A
  67. Sangster-Guity,N., Tu-Sekine,B., Raben,D.M., Denmeade,S.R. and Williams,S.A.
    Mutational analysis of prostate-specific antigen defines the intrinsic proteolytic activity of the proPSA zymogen
    Prostate76, 1203-1217. PubMed  Europe PubMed DOI
  68. Ylikangas,H., Mattsson,J.M., Stenman,U.H., Koistinen,H., Poso,A. and Lahtela-Kakkonen,M.
    Virtual screening of small drug-like compounds stimulating the enzymatic activity of kallikrein-related peptidase 3 (KLK3)
    ChemMedChem11, 2043-2049. PubMed  Europe PubMed DOI
    69. 2015
  69. Aloysius,H. and Hu,L.
    Targeted prodrug approaches for hormone refractory prostate cancer
    Med Res Rev35, 554-585. PubMed  Europe PubMed DOI
  70. Lebeau,A.M. and Denmeade,S.R.
    Protease-activated pore-forming peptides for the treatment and imaging of prostate cancer
    Mol Cancer Ther14, 659-668. PubMed  Europe PubMed DOI
    71. 2014
  71. Bremmer,S.C., McNeil,A.J. and Soellner,M.B.
    Enzyme-triggered gelation: targeting proteases with internal cleavage sites
    Chem Commun (Camb)50, 1691-1693. PubMed  Europe PubMed DOI  A
  72. Koistinen,H., Hekim,C., Wu,P., Narvanen,A. and Stenman,U.-H.
    Evaluation of peptides as protease inhibitors and stimulators
    Methods Mol Biol1088, 147-158. PubMed  Europe PubMed DOI
  73. Kojtari,A., Shah,V., Babinec,J.S., Yang,C. and Ji,H.F.
    Structure-based drug design of diphenyl alpha-aminoalkylphosphonates as prostate-specific antigen antagonists
    J Chem Inf Model54, 2967-2979. PubMed  Europe PubMed DOI  I
  74. Mattsson,J.M., Ravela,S., Hekim,C., Jonsson,M., Malm,J., Narvanen,A., Stenman,U.H. and Koistinen,H.
    Proteolytic activity of prostate-specific antigen (PSA) towards protein substrates and effect of peptides stimulating psa activity
    PLoS ONE9, e107819-e107819. PubMed  Europe PubMed DOI  P
  75. Mavridis,K., Avgeris,M. and Scorilas,A.
    Targeting kallikrein-related peptidases in prostate cancer
    Expert Opin Ther Targets18, 365-383. PubMed  Europe PubMed DOI
  76. Romanov,V., Whyard,T.C., Waltzer,W.C. and Gabig,T.G.
    A claudin 3 and claudin 4-targeted Clostridium perfringens protoxin is selectively cytotoxic to PSA-producing prostate cancer cells
    Cancer Lett351, 260-264. PubMed  Europe PubMed DOI
    77. 2013
  77. de Souza,L.R., Melo,M., Paschoalin,T., Carmona,A.K., Kondo,M., Hirata,I.Y., Blaber,M., Tersariol,I., Takatsuka,J., Juliano,M.A., Juliano,L., Gomes,R.A. and Puzer,L.
    Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin
    Biochem Biophys Res Commun433, 333-337. PubMed  Europe PubMed DOI
  78. Kostova,M.B., Rosen,D.M., Chen,Y., Mease,R.C. and Denmeade,S.R.
    Structural optimization, biological evaluation, and application of peptidomimetic prostate specific antigen inhibitors
    J Med Chem56, 4224-4235. PubMed  Europe PubMed DOI  I
  79. Koumandou,V.L. and Scorilas,A.
    Evolution of the plasma and tissue kallikreins, and their alternative splicing isoforms
    PLoS ONE8, e68074-e68074. PubMed  Europe PubMed DOI
  80. Lundwall,A.
    Old genes and new genes: The evolution of the kallikrein locus
    Thromb Haemost110, 469-475. PubMed  Europe PubMed DOI  V
  81. Meinander,K., Weisell,J., Pakkala,M., Tadd,A.C., Hekim,C., Kallionpaa,R., Widell,K., Stenman,U.H., Koistinen,H., Narvanen,A., Vepsalainen,J., Luthman,K. and Wallen,E.A.A.
    Pseudopeptides with a centrally positioned alkene-based disulphide bridge mimetic stimulate kallikrein-related peptidase 3 activity
    MedChemComm4, 549-553. DOI
  82. Rodriguez,S., Al-Ghamdi,O.A., Burrows,K., Guthrie,P.A., Lane,J.A., Davis,M., Marsden,G., Alharbi,K.K., Cox,A., Hamdy,F.C., Neal,D.E., Donovan,J.L. and Day,I.N.
    Very Low PSA Concentrations and Deletions of the KLK3 Gene
    Clin Chem59, 234-244. PubMed  Europe PubMed DOI  M
  83. Thorek,D.L., Evans,M.J., Carlsson,S.V., Ulmert,D. and Lilja,H.
    Prostate-specific kallikrein-related peptidases and their relation to prostate cancer biology and detection. Established relevance and emerging roles
    Thromb Haemost110, 484-492. PubMed  Europe PubMed DOI  V
  84. Vegvari,A., Sjodin,K., Rezeli,M., Malm,J., Lilja,H., Laurell,T. and Marko-Varga,G.
    Identification of a novel proteoform of prostate specific antigen (SNP-L132I) in clinical samples by multiple reaction monitoring
    Mol Cell Proteomics12, 2761-2773. PubMed  Europe PubMed DOI  A  M
  85. Zhu,L., Jaamaa,S., Af Hallstrom,T.M., Laiho,M., Sankila,A., Nordling,S., Stenman,U.H. and Koistinen,H.
    PSA forms complexes with alpha1-antichymotrypsin in prostate
    Prostate73, 219-226. PubMed  Europe PubMed DOI
    86. 2012
  86. Batra,J., O'Mara,T., Patnala,R., Lose,F. and Clements,J.A.
    Genetic polymorphisms in the human tissue kallikrein (KLK) locus and their implication in various malignant and non-malignant diseases
    Biol Chem393, 1365-1390. PubMed  Europe PubMed DOI  M
  87. Chao,J., Chai,K.X. and Chen,L.M.
    Kallikrein-related peptidase 3, the prostate-specific antigen
    [ISSN:978-0-12-407742-3]3, 2765-2768. DOI
  88. Clements,J.A., Hooper,J.D. and Dong,Y.
    The human tissue kallikrein and kallikrein-related peptidase family
    [ISSN:978-0-12-407742-3]3, 2747-2756. DOI
  89. Feng,T., Feng,D., Shi,W., Li,X. and Ma,H.
    A graphene oxide-peptide fluorescence sensor for proteolytically active prostate-specific antigen
    Mol Biosyst8, 1441-1445. PubMed  Europe PubMed DOI  A
  90. Manning,M.L., Kostova,M., Williams,S.A. and Denmeade,S.R.
    Trypsin-like proteolytic contamination of commercially available PSA purified from human seminal fluid
    Prostate72, 1233-1238. PubMed  Europe PubMed DOI
    91. 2011
  91. Cumming,A.P., Hopmans,S.N., Vukmirovic-Popovic,S. and Duivenvoorden,W.C.
    PSA affects prostate cancer cell invasion in vitro and induces an osteoblastic phenotype in bone in vivo
    Prostate Cancer Prostatic Dis14, 286-294. PubMed  Europe PubMed DOI
  92. Harkonen,H.H., Mattsson,J.M., Maatta,J.A., Stenman,U.H., Koistinen,H., Matero,S., Windshugel,B., Poso,A. and Lahtela-Kakkonen,M.
    The discovery of compounds that stimulate the activity of kallikrein-related peptidase 3 (KLK3)
    ChemMedChem6, 2170-2178. PubMed  Europe PubMed DOI
  93. O'Mara,T.A., Nagle,C.M., Batra,J., Kedda,M.A., Clements,J.A. and Spurdle,A.B.
    Kallikrein-related peptidase 3 (KLK3/PSA) single nucleotide polymorphisms and ovarian cancer survival
    Twin Res Hum Genet14, 323-327. PubMed  Europe PubMed DOI  M
  94. Penney,K.L., Schumacher,F.R., Kraft,P., Mucci,L.A., Sesso,H.D., Ma,J., Niu,Y., Cheong,J.K., Hunter,D.J., Stampfer,M.J. and Hsu,S.I.
    Association of KLK3 (PSA) genetic variants with prostate cancer risk and PSA levels
    Carcinogenesis32, 853-859. PubMed  Europe PubMed DOI  M
  95. Stura,E.A., Muller,B.H., Bossus,M., Michel,S., Jolivet-Reynaud,C. and Ducancel,F.
    Crystal structure of human prostate-specific antigen in a sandwich antibody complex
    J Mol Biol414, 530-544. PubMed  Europe PubMed DOI  S
  96. Williams,S.A., Jelinek,C.A., Litvinov,I., Cotter,R.J., Isaacs,J.T. and Denmeade,S.R.
    Enzymatically active prostate-specific antigen promotes growth of human prostate cancers
    Prostate71, 1595-1607. PubMed  Europe PubMed DOI  T
    97. 2010
  97. Andrade,D., Assis,D.M., Lima,A.R., Oliveira,J.R., Araujo,M.S., Blaber,S.I., Blaber,M., Juliano,M.A. and Juliano,L.
    Substrate specificity and inhibition of human kallikrein-related peptidase 3 (KLK3 or PSA) activated with sodium citrate and glycosaminoglycans
    Arch Biochem Biophys498, 74-82. PubMed  Europe PubMed DOI  P
  98. Lawrence,M.G., Lai,J. and Clements,J.A.
    Kallikreins on steroids: structure, function, and hormonal regulation of prostate-specific antigen and the extended kallikrein locus
    Endocr Rev31, 407-446. PubMed  Europe PubMed DOI
  99. Lebeau,A.M., Kostova,M., Craik,C.S. and Denmeade,S.R.
    Prostate-specific antigen: an overlooked candidate for the targeted treatment and selective imaging of prostate cancer
    Biol Chem391, 333-343. PubMed  Europe PubMed DOI  V  I
  100. Michal,K. and Stanislaw,R.
    [Prostate specific antigen in women]
    Ginekol Pol81, 704-707. PubMed  Europe PubMed
  101. Pakkala,M., Weisell,J., Hekim,C., Vepsalainen,J., Wallen,E.A., Stenman,U.H., Koistinen,H. and Narvanen,A.
    Mimetics of the disulfide bridge between the N- and C-terminal cysteines of the KLK3-stimulating peptide B-2
    Amino Acids39, 233-242. PubMed  Europe PubMed DOI
  102. Pavlopoulou,A., Pampalakis,G., Michalopoulos,I. and Sotiropoulou,G.
    Evolutionary history of tissue kallikreins
    PLoS ONE5, e13781-e13781. PubMed  Europe PubMed DOI
  103. Williams,S.A., Xu,Y., De Marzo,A.M., Isaacs,J.T. and Denmeade,S.R.
    Prostate-specific antigen (PSA) is activated by KLK2 in prostate cancer ex vivo models and in prostate-targeted PSA/KLK2 double transgenic mice
    Prostate70, 788-796. PubMed  Europe PubMed DOI
    104. 2009
  104. Lebeau,A.M., Singh,P., Isaacs,J.T. and Denmeade,S.R.
    Prostate-specific antigen is a "chymotrypsin-like" serine protease with unique P1 substrate specificity
    Biochemistry48, 3490-3496. PubMed  Europe PubMed DOI  P
  105. Lebeau,A.M., Banerjee,S.R., Pomper,M.G., Mease,R.C. and Denmeade,S.R.
    Optimization of peptide-based inhibitors of prostate-specific antigen (PSA) as targeted imaging agents for prostate cancer
    Bioorg Med Chem17, 4888-4893. PubMed  Europe PubMed DOI  I
  106. Mattsson,J.M., Laakkonen,P., Stenman,U.H. and Koistinen,H.
    Antiangiogenic properties of prostate-specific antigen (PSA)
    Scand J Clin Lab Invest69, 447-451. PubMed  Europe PubMed DOI
  107. Patane,S. and Marte,F.
    Prostate-specific antigen kallikrein: from prostate cancer to cardiovascular system
    Eur Heart J30, 1169-1170. PubMed  Europe PubMed DOI
  108. Singh,P., Lebeau,A.M., Lilja,H., Denmeade,S.R. and Isaacs,J.T.
    Molecular insights into substrate specificity of prostate specific antigen through structural modeling
    Proteins77, 984-993. PubMed  Europe PubMed DOI  P
  109. Stone,J.G., Rolston,R.K., Ueda,M., Lee,H.G., Richardson,S.L., Castellani,R.J., Perry,G. and Smith,M.A.
    Evidence for the novel expression of human kallikrein-related peptidase 3, prostate-specific antigen, in the brain
    Int J Clin Exp Pathol2, 267-274. PubMed  Europe PubMed
    110. 2008
  110. Alapont Alacreu,J.M., Navarro Rosales,S., Budia Alba,A., Espana Furio,F., Morera Martinez,F. and Jimenez Cruz,J.F.
    [PSA and hK2 in the diagnosis of prostate cancer]
    Actas Urol Esp32, 575-588. PubMed  Europe PubMed
  111. Clements,J.A.
    Reflections on the tissue kallikrein and kallikrein-related peptidase family - from mice to men - what have we learnt in the last two decades?
    Biol Chem389, 1447-1454. PubMed  Europe PubMed DOI  V
  112. Graeser,R., Chung,D.E., Esser,N., Moor,S., Schachtele,C., Unger,C. and Kratz,F.
    Synthesis and biological evaluation of an albumin-binding prodrug of doxorubicin that is cleaved by prostate-specific antigen (PSA) in a PSA-positive orthotopic prostate carcinoma model (LNCaP)
    Int J Cancer122, 1145-1154. PubMed  Europe PubMed DOI
  113. Koistinen,H., Narvanen,A., Pakkala,M., Hekim,C., Mattsson,J.M., Zhu,L., Laakkonen,P. and Stenman,U.H.
    Development of peptides specifically modulating the activity of KLK2 and KLK3
    Biol Chem389, 633-642. PubMed  Europe PubMed DOI
  114. Lebeau,A.M., Singh,P., Isaacs,J.T. and Denmeade,S.R.
    Potent and selective peptidyl boronic acid inhibitors of the serine protease prostate-specific antigen
    Chem Biol15, 665-674. PubMed  Europe PubMed DOI  I
  115. Menez,R., Michel,S., Muller,B.H., Bossus,M., Ducancel,F., Jolivet-Reynaud,C. and Stura,E.A.
    Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody
    J Mol Biol376, 1021-1033. PubMed  Europe PubMed DOI  S
  116. Singh,P., Williams,S.A., Shah,M.H., Lectka,T., Pritchard,G.J., Isaacs,J.T. and Denmeade,S.R.
    Mechanistic insights into the inhibition of prostate specific antigen by beta-lactam class compounds
    Proteins70, 1416-1428. PubMed  Europe PubMed DOI  I
  117. Waheed,A., Hassan,M.I., Etten,R.L. and Ahmad,F.
    Human seminal proteinase and prostate-specific antigen are the same protein
    J Biosci33, 195-207. PubMed  Europe PubMed DOI
    118. 2007
  118. Hassan,M.I., Kumar,V., Somvanshi,R.K., Dey,S., Singh,T.P. and Yadav,S.
    Structure-guided design of peptidic ligand for human prostate specific antigen
    J Pept Sci13, 849-855. PubMed  Europe PubMed DOI  I
  119. Jeong,S. and Lee,S.W.
    Expression and purification of recombinant active prostate-specific antigen from Escherichia coli
    J Microbiol Biotechnol17, 840-846. PubMed  Europe PubMed  E
  120. Lai,J., Kedda,M.A., Hinze,K., Smith,R.L., Yaxley,J., Spurdle,A.B., Morris,C.P., Harris,J. and Clements,J.A.
    PSA/KLK3 AREI promoter polymorphism alters androgen receptor binding and is associated with prostate cancer susceptibility
    Carcinogenesis28, 1032-1039. PubMed  Europe PubMed DOI
  121. Lawrence,M.G., Veveris-Lowe,T.L., Whitbread,A.K., Nicol,D.L. and Clements,J.A.
    Epithelial-mesenchymal transition in prostate cancer and the potential role of kallikrein serine proteases
    Cells Tissues Organs185, 111-115. PubMed  Europe PubMed DOI
  122. Steuber,T., Vickers,A.J., Serio,A.M., Vaisanen,V., Haese,A., Pettersson,K., Eastham,J.A., Scardino,P.T., Huland,H. and Lilja,H.
    Comparison of free and total forms of serum human kallikrein 2 and prostate-specific antigen for prediction of locally advanced and recurrent prostate cancer
    Clin Chem53, 233-240. PubMed  Europe PubMed DOI
  123. Wang,Z.J., Zhang,W., Wu,H.F. and Sui,Y.G.
    [Procaryotic expression, purification and identification of recombinant human prostate-specific antigen]
    Zhonghua Nan Ke Xue13, 1080-1083. PubMed  Europe PubMed  E
  124. Williams,S.A., Singh,P., Isaacs,J.T. and Denmeade,S.R.
    Does PSA play a role as a promoting agent during the initiation and/or progression of prostate cancer?
    Prostate67, 312-329. PubMed  Europe PubMed DOI  V
  125. Yonou,H., Horiguchi,Y., Ohno,Y., Namiki,K., Yoshioka,K., Ohori,M., Hatano,T. and Tachibana,M.
    Prostate-specific antigen stimulates osteoprotegerin production and inhibits receptor activator of nuclear factor-KappaB ligand expression by human osteoblasts
    Prostate67, 840-848. PubMed  Europe PubMed DOI
  126. Yoon,H., Laxmikanthan,G., Lee,J., Blaber,S.I., Rodriguez,A., Kogot,J.M., Scarisbrick,I.A. and Blaber,M.
    Activation profiles and regulatory cascades of the human kallikrein-related peptidases
    J Biol Chem282, 31852-31864. PubMed  Europe PubMed DOI  V
    127. 2006
  127. [YEAR:1-6-2006]Debela,M., Magdolen,V., Schechter,N., Valachova,M., Lottspeich,F., Craik,C.S., Choe,Y., Bode,W. and Goettig,P.
    Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences
    J Biol Chem281, 25678-25688. PubMed  Europe PubMed DOI  P
  128. [YEAR:9-5-2006]Kodak,J.A., Mann,D.L., Klyushnenkova,E.N. and Alexander,R.B.
    Activation of innate immunity by prostate specific antigen (PSA)
    Prostate66, 1592-1599. PubMed  Europe PubMed DOI
  129. Lundwall,A., Clauss,A. and Olsson,A.Y.
    Evolution of kallikrein-related peptidases in mammals and identification of a genetic locus encoding potential regulatory inhibitors
    Biol Chem387, 243-249. PubMed  Europe PubMed DOI
    130. 2005
  130. Jonsson,M., Linse,S., Frohm,B., Lundwall,A. and Malm,J.
    Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen
    Biochem J387, 447-453. PubMed  Europe PubMed DOI
  131. Kratz,F., Mansour,A., Soltau,J., Warnecke,A., Fichtner,I., Unger,C. and Drevs,J.
    Development of albumin-binding Doxorubicin prodrugs that are cleaved by prostate-specific antigen
    Arch Pharm (Weinheim)338, 462-472. PubMed  Europe PubMed DOI
  132. [YEAR:25-5-2005]Kurlender,L., Borgono,C., Michael,I.P., Obiezu,C., Elliott,M.B., Yousef,G.M. and Diamandis,E.P.
    A survey of alternative transcripts of human tissue kallikrein genes
    Biochim Biophys Acta1755, 1-14. PubMed  Europe PubMed DOI  R
  133. [YEAR:13-1-2005]Michael,I.P., Kurlender,L., Memari,N., Yousef,G.M., Du,D., Grass,L., Stephan,C., Jung,K. and Diamandis,E.P.
    Intron retention: a common splicing event within the human kallikrein gene family
    Clin Chem51, 506-515. PubMed  Europe PubMed DOI  R
  134. [YEAR:10-1-2005]Olsson,A.Y., Bjartell,A., Lilja,H. and Lundwall,A.
    Expression of prostate-specific antigen (PSA) and human glandular kallikrein 2 (hK2) in ileum and other extraprostatic tissues
    Int J Cancer113, 290-297. PubMed  Europe PubMed DOI
  135. Veveris-Lowe,T.L., Lawrence,M.G., Collard,R.L., Bui,L., Herington,A.C., Nicol,D.L. and Clements,J.A.
    Kallikrein 4 (hK4) and prostate-specific antigen (PSA) are associated with the loss of E-cadherin and an epithelial-mesenchymal transition (EMT)-like effect in prostate cancer cells
    Endocr Relat Cancer12, 631-643. PubMed  Europe PubMed DOI
  136. Volkel,T., Heidtmann,H.H., Muller,R. and Kontermann,R.E.
    Engineering of human coagulation factor X variants activated by prostate-specific antigen
    Mol Biotechnol29, 19-30. PubMed  Europe PubMed DOI
    137. 2004
  137. Chao,J.
    Human kallikrein 3, prostate-specific antigen
    [ISSN:0-12-079610-4]2, 1583-1585.  V
  138. Clements,J.A., Hooper,J.D., Odorico,D.M. and Dong,Y.
    The tissue kallikrein gene cluster
    [ISSN:0-12-079610-4]2, 1569-1577.  V
  139. [YEAR:1-10-2004]Kim,J. and Coetzee,G.A.
    Prostate specific antigen gene regulation by androgen receptor
    J Cell Biochem93, 233-241. PubMed  Europe PubMed DOI
  140. Pakkala,M., Jylhasalmi,A., Wu,P., Leinonen,J., Stenman,U.H., Santa,H., Vepsalainen,J., Perakyla,M. and Narvanen,A.
    Conformational and biochemical analysis of the cyclic peptides which modulate serine protease activity
    J Pept Sci10, 439-447. PubMed  Europe PubMed DOI
  141. Tsui,K.H., Wu,L., Chang,P.L., Hsieh,M.L. and Juang,H.H.
    Identifying the combination of the transcriptional regulatory sequences on prostate specific antigen and human glandular kallikrein genes
    J Urol172, 2029-2034. PubMed  Europe PubMed DOI
    142. 2003
  142. [YEAR:15-1-2003]Balk,S.P., Ko,Y.J. and Bubley,G.J.
    Biology of prostate-specific antigen
    J Clin Oncol21, 383-391. PubMed  Europe PubMed DOI
  143. Chakraborty,N.G., Stevens,R.L., Mehrotra,S., Laska,E., Taxel,P., Sporn,J.R., Schauer,P. and Albertsen,P.C.
    Recognition of PSA-derived peptide antigens by T cells from prostate cancer patients without any prior stimulation
    Cancer Immunol Immunother52, 497-505. PubMed  Europe PubMed DOI
  144. [YEAR:1-8-2003]Fortier,A.H., Holaday,J.W., Liang,H., Dey,C., Grella,D.K., Holland-Linn,J., Vu,H., Plum,S.M. and Nelson,B.J.
    Recombinant prostate specific antigen inhibits angiogenesis in vitro and in vivo
    Prostate56, 212-219. PubMed  Europe PubMed DOI
  145. [YEAR:1-1-2003]Gallardo-Williams,M.T., Maronpot,R.R., Wine,R.N., Brunssen,S.H. and Chapin,R.E.
    Inhibition of the enzymatic activity of prostate-specific antigen by boric acid and 3-nitrophenyl boronic acid
    Prostate54, 44-49. PubMed  Europe PubMed DOI  I
  146. Heuze-Vourc'h,N., Leblond,V. and Courty,Y.
    Complex alternative splicing of the hKLK3 gene coding for the tumor marker PSA (prostate-specific-antigen)
    Eur J Biochem270, 706-714. PubMed  Europe PubMed DOI
  147. Zhu,L., Leinonen,J., Zhang,W.M., Finne,P. and Stenman,U.H.
    Dual-label immunoassay for simultaneous measurement of prostate-specific antigen (PSA)-alpha1-antichymotrypsin complex together with free or total PSA
    Clin Chem49, 97-103. PubMed  Europe PubMed DOI  A
    148. 2002
  148. [YEAR:13-9-2002]Carvalho,A.L., Sanz,L., Barettino,D., Romero,A., Calvete,J.J. and Romao,M.J.
    Crystal structure of a prostate kallikrein isolated from stallion seminal plasma: a homologue of human PSA
    J Mol Biol322, 325-337. PubMed  Europe PubMed DOI  S
  149. Gygi,C.M., Leibovitch,I.Y., Adlington,R., Baldwin,J.E., Chen,B., Mccoull,W., Pritchard,G.J., Becker,G.W., Dixon,E.P., Little,S.P., Sutkowski,D.M., Teater,C. and Neubauer,B.L.
    Prostate-specific antigen (PSA)-mediated proliferation, androgenic regulation and inhibitory effects of LY312340 in HOS-TE85 (TE85) human osteosarcoma cells
    Anticancer Res22, 2725-2732. PubMed  Europe PubMed  I
  150. [YEAR:5-3-2002]Hsieh,M.C. and Cooperman,B.S.
    Inhibition of prostate-specific antigen (PSA) by alpha(1)-antichymotrypsin: salt-dependent activation mediated by a conformational change
    Biochemistry41, 2990-2997. PubMed  Europe PubMed DOI
  151. [YEAR:1-4-2002]Rehault,S., Brillard-Bourdet,M., Bourgeois,L., Frenette,G., Juliano,L., Gauthier,F. and Moreau,T.
    Design of new and sensitive fluorogenic substrates for human kallikrein hK3 (prostate-specific antigen) derived from semenogelin sequences
    Biochim Biophys Acta1596, 55-62. PubMed  Europe PubMed DOI  A
    152. 2001
  152. [YEAR:10-5-2001]Adlington,R.M., Baldwin,J.E., Becker,G.W., Chen,B., Cheng,L., Cooper,S.L., Hermann,R.B., Howe,T.J., Mccoull,W., McNulty,A.M., Neubauer,B.L. and Pritchard,G.J.
    Design, synthesis, and proposed active site binding analysis of monocyclic 2-azetidinone inhibitors of prostate specific antigen
    J Med Chem44, 1491-1508. PubMed  Europe PubMed DOI  I
  153. Clements,J., Hooper,J., Dong,Y. and Harvey,T.
    The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions
    Biol Chem382, 5-14. PubMed  Europe PubMed DOI  V
  154. [YEAR:1-7-2001]Denmeade,S.R., Lovgren,J., Khan,S.R., Lilja,H. and Isaacs,J.T.
    Activation of latent protease function of Pro-HK2, but not Pro-PSA, involves autoprocessing
    Prostate48, 122-126. PubMed  Europe PubMed DOI
  155. [YEAR:1-3-2001]Habeck,L.L., Belagaje,R.M., Becker,G.W., Hale,J.E., Churgay,L.M., Ulmer,M., Yang,X.Y., Shackelford,K.A., Richardson,J.M., Johnson,M.G. and Mendelsohn,L.G.
    Expression, purification, and characterization of active recombinant prostate-specific antigen in Pichia pastoris (yeast)
    Prostate46, 298-306. PubMed  Europe PubMed DOI
  156. [YEAR:2-10-2001]Huang,X., Knoell,C.T., Frey,G., Hazegh-Azam,M., Tashjian,A.H., Jr., Hedstrom,L., Abeles,R.H. and Timasheff,S.N.
    Modulation of recombinant human prostate-specific antigen: activation by Hofmeister salts and inhibition by azapeptides. Appendix: thermodynamic interpretation of the activation by concentrated salts
    Biochemistry40, 11734-11741. PubMed  Europe PubMed DOI  I
  157. [YEAR:15-9-2001]Mikolajczyk,S.D., Marker,K.M., Millar,L.S., Kumar,A., Saedi,M.S., Payne,J.K., Evans,C.L., Gasior,C.L., Linton,H.J., Carpenter,P. and Rittenhouse,H.G.
    A truncated precursor form of prostate-specific antigen is a more specific serum marker of prostate cancer
    Cancer Res61, 6958-6963. PubMed  Europe PubMed
  158. Rehault,S., Monget,P., Mazerbourg,S., Tremblay,R., Gutman,N., Gauthier,F. and Moreau,T.
    Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3
    Eur J Biochem268, 2960-2968. PubMed  Europe PubMed DOI
  159. [YEAR:13-2-2001]Takayama,T.K., Carter,C.A. and Deng,T.
    Activation of prostate-specific antigen precursor (pro-PSA) by prostin, a novel human prostatic serine protease identified by degenerate PCR
    Biochemistry40, 1679-1687. PubMed  Europe PubMed DOI
    160. 2000
  160. Diamandis,E.P., Yousef,G.M., Luo,L.Y., Magklara,A. and Obiezu,C.V.
    The new human kallikrein gene family: implications in carcinogenesis
    Trends Endocrinol Metab11, 54-60. PubMed  Europe PubMed DOI
  161. [YEAR:17-10-2000]Gan,L., Lee,I., Smith,R., Argonza-Barrett,R., Lei,H., McCuaig,J., Moss,P., Paeper,B. and Wang,K.
    Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region
    Gene257, 119-130. PubMed  Europe PubMed DOI
  162. Malatesta,M., Mannello,F., Luchetti,F., Marcheggiani,F., Condemi,L., Papa,S. and Gazzanelli,G.
    Prostate-specific antigen synthesis and secretion by human placenta: A physiological kallikrein source during pregnancy
    J Clin Endocrinol Metab85, 317-321. PubMed  Europe PubMed DOI
  163. [YEAR:1-10-2000]Malm,J., Hellman,J., Hogg,P. and Lilja,H.
    Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor
    Prostate45, 132-139. PubMed  Europe PubMed DOI  P  I
  164. [YEAR:1-11-2000]Mikolajczyk,S.D., Millar,L.S., Marker,K.M., Wang,T.J., Rittenhouse,H.G., Marks,L.S. and Slawin,K.M.
    Seminal plasma contains "BPSA," a molecular form of prostate-specific antigen that is associated with benign prostatic hyperplasia
    Prostate45, 271-276. PubMed  Europe PubMed DOI
  165. [YEAR:1-1-2000]Tanaka,T., Isono,T., Yoshiki,T., Yuasa,T. and Okada,Y.
    A novel form of prostate-specific antigen transcript produced by alternative splicing
    Cancer Res60, 56-59. PubMed  Europe PubMed  R
    166. 1999
  166. Heidtmann,H.H., Nettelbeck,D.M., Mingels,A., Jager,R., Welker,H.G. and Kontermann,R.E.
    Generation of angiostatin-like fragments from plasminogen by prostate-specific antigen
    Br J Cancer81, 1269-1273. PubMed  Europe PubMed DOI
  167. Leinonen,J., Leinimaa,M., Zhang,W.M., Piironen,T., Pettersson,K., Lilja,H., Dowell,B. and Stenman,U.H.
    Reactivity of anti-PSA monoclonal antibodies with recombinant human kallikrein-2
    Tumour Biol20 Suppl 1, 35-37. PubMed  Europe PubMed
  168. [YEAR:19-3-1999]Okabe,E., Kajihara,J., Usami,Y. and Hirano,K.
    The cleavage site specificity of human prostate specific antigen for insulin-like growth factor binding protein-3
    FEBS Lett447, 87-90. PubMed  Europe PubMed DOI
  169. Rae,F., Bulmer,B., Nicol,D. and Clements,J.
    The human tissue kallikreins (KLKs 1-3) and a novel KLK1 mRNA transcript are expressed in a renal cell carcinoma cDNA library
    Immunopharmacology45, 83-88. PubMed  Europe PubMed DOI
  170. Yang,C.F., Porter,E.S., Boths,J., Kanyi,D., Hsieh,M. and Cooperman,B.S.
    Design of synthetic hexapeptide substrates for prostate-specific antigen using single-position minilibraries
    J Pept Res54, 444-448. PubMed  Europe PubMed DOI  A  P
  171. Yousef,G.M., Luo,L.Y. and Diamandis,E.P.
    Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4
    Anticancer Res19, 2843-2852. PubMed  Europe PubMed
    172. 1998
  172. Catalona,W.J., Partin,A.W., Slawin,K.M., Brawer,M.K., Flanigan,R.C., Patel,A., Richie,J.P., deKernion,J.B., Walsh,P.C., Scardino,P.T., Lange,P.H., Subong,E.N., Parson,R.E., Gasior,G.H., Loveland,K.G. and Southwick,P.C.
    Use of the percentage of free prostate-specific antigen to enhance differentiation of prostate cancer from benign prostatic disease: a prospective multicenter clinical trial
    JAMA279, 1542-1547. PubMed  Europe PubMed DOI
  173. Wu,J.T., Lyons,B.W., Liu,G.H. and Wu,L.L.
    Production of milligram concentrations of free prostate specific antigen (fPSA) from LNCaP cell culture: Difference between fPSA from LNCaP cell and seminal plasma
    J Clin Lab Anal12, 6-13. PubMed  Europe PubMed DOI
    174. 1997
  174. Denmeade,S.R., Lou,W., Lovgren,J., Malm,J., Lilja,H. and Isaacs,J.T.
    Specific and efficient peptide substrates for assaying the proteolytic activity of prostate-specific antigen
    Cancer Res57, 4924-4930. PubMed  Europe PubMed  A  P
  175. [YEAR:14-11-1997]Deperthes,D., Marceau,F., Frenette,G., Lazure,C., Tremblay,R.R. and Dube,J.Y.
    Human kallikrein hK2 has low kininogenase activity while prostate-specific antigen (hK3) has none
    Biochim Biophys Acta1343, 102-106. PubMed  Europe PubMed DOI
  176. Lovgren,J., Rajakoski,K., Karp,M., Lundwall a and Lilja,H.
    Activation of the zymogen form of prostate-specific antigen by human glandular kallikrein 2
    Biochem Biophys Res Commun238, 549-555. PubMed  Europe PubMed DOI
  177. Nilsson,O., Peter,A., Andersson,I., Nilsson,K., Grundstrom,B. and Karlsson,B.
    Antigenic determinants of prostate-specific antigen (PSA) and development of assays specific for different forms of PSA
    Br J Cancer75, 789-797. PubMed  Europe PubMed  A
  178. [YEAR:22-8-1997]Takayama,T.K., Fujikawa,K. and Davie,E.W.
    Characterization of the precursor of prostate-specific antigen. Activation by trypsin and by human glandular kallikrein
    J Biol Chem272, 21582-21588. PubMed  Europe PubMed DOI
  179. Zhang,W.M., Leinonen,J., Kalkkinen,N. and Stenman,U.H.
    Prostate-specific antigen forms a complex with and cleaves alpha1-protease inhibitor in vitro
    Prostate33, 87-96. PubMed  Europe PubMed DOI
    180. 1996
  180. Piironen,T., Lovgren,J., Karp,M., Eerola,R., Lundwall,A., Dowell,B., Lovgren,T., Lilja,H. and Pettersson,K.
    Immunofluorometric assay for sensitive and specific measurement of human prostatic glandular kallikrein (hK2) in serum
    Clin Chem42, 1034-1041. PubMed  Europe PubMed  A
  181. Villoutreix,B.O., Lilja,H., Pettersson,K., Lovgren,T. and Teleman,O.
    Structural investigation of the alpha-1-antichymotrypsin:prostate-specific antigen complex by comparative model building
    Protein Sci5, 836-851. PubMed  Europe PubMed DOI
    182. 1995
  182. [YEAR:1-6-1995]Karr,J.F., Kantor,J.A., Hand,P.H., Eggensperger,D.L. and Schlom,J.
    The presence of prostate-specific antigen-related genes in primates and the expression of recombinant human prostate-specific antigen in a transfected murine cell line
    Cancer Res55, 2455-2462. PubMed  Europe PubMed
  183. Lilja,H.
    Regulation of the enzymatic activity of prostate-specific antigen and its reactions with extracellular protease inhibitors in prostate cancer
    Scand J Clin Lab Invest Suppl220, 47-56. PubMed  Europe PubMed
  184. [YEAR:24-8-1995]Lovgren,J., Piironen,T., Overmo,C., Dowell,B., Karp,M., Pettersson,K., Lilja,H. and Lundwall,A.
    Production of recombinant PSA and HK2 and analysis of their immunologic cross-reactivity
    Biochem Biophys Res Commun213, 888-895. PubMed  Europe PubMed DOI
  185. Malm,J. and Lilja,H.
    Biochemistry of prostate specific antigen, PSA
    Scand J Clin Lab Invest Suppl221, 15-22. PubMed  Europe PubMed
  186. Webber,M.M., Waghray,A. and Bello,D.
    Prostate-specific antigen, a serine protease, facilitates human prostate cancer cell invasion
    Clin Cancer Res1, 1089-1094. PubMed  Europe PubMed
  187. Zhang,W.M., Leinonen,J., Kalkkinen,N., Dowell,B. and Stenman,U.H.
    Purification and characterization of different molecular forms of prostate-specific antigen in human seminal fluid
    Clin Chem41, 1567-1573. PubMed  Europe PubMed
    188. 1994
  188. Fielder,P.J., Rosenfeld,R.G., Graves,H.C., Grandbois,K., Maack,C.A., Sawamura,S., Ogawa,Y., Sommer,A. and Cohen,P.
    Biochemical analysis of prostate specific antigen-proteolyzed insulin-like growth factor binding protein-3
    Growth Regul4, 164-172. PubMed  Europe PubMed  P
    189. 1993
  189. [YEAR:19-8-1993]Gauthier,E.R., Chapdelaine,P., Tremblay,R.R. and Dube,J.Y.
    Characterization of rhesus monkey prostate specific antigen cDNA
    Biochim Biophys Acta1174, 207-210. PubMed  Europe PubMed DOI
  190. Lilja,H.
    Structure, function, and regulation of the enzyme activity of prostate-specific antigen
    World J Urol11, 188-191. PubMed  Europe PubMed DOI
    191. 1992
  191. Cohen,P., Graves,H.C., Peehl,D.M., Kamarei,M., Giudice,L.C. and Rosenfeld,R.G.
    Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma
    J Clin Endocrinol Metab75, 1046-1053. PubMed  Europe PubMed DOI
    192. 1991
  192. Abrahamson,M., Buttle,D.J., Mason,R.W., Hansson,H., Grubb,A., Lilja,H. and Ohlsson,K.
    Regulation of cystatin C activity by serine proteinases
    Biomed Biochim Acta50, 587-593. PubMed  Europe PubMed
  193. [YEAR:25-4-1991]Catalona,W.J., Smith,D.S., Ratliff,T.L., Dodds,K.M., Coplen,D.E., Yuan,J.J., Petros,J.A. and Andriole,G.L.
    Measurement of prostate-specific antigen in serum as a screening test for prostate cancer
    N Engl J Med324, 1156-1161. PubMed  Europe PubMed DOI
  194. Chapdelaine,P., Gauthier,E., Ho-Kim,M.A., Bissonnette,L., Tremblay,R.R. and Dube,J.Y.
    Characterization and expression of the prostatic arginine esterase gene, a canine glandular kallikrein
    DNA Cell Biol10, 49-59. PubMed  Europe PubMed
    195. 1990
  195. Christensson,A., Laurell,C.B. and Lilja,H.
    Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors
    Eur J Biochem194, 755-763. PubMed  Europe PubMed
    196. 1989
  196. Digby,M., Zhang,X.Y. and Richards,R.I.
    Human prostate specific antigen (PSA) gene: structure and linkage to the kallikrein-like gene, hGK-1
    Nucleic Acids Res17, 2137-2137. PubMed  Europe PubMed
  197. Riegman,P.H., Vlietstra,R.J., Klaassen,P., van der Korput,J.A., Geurts van Kessel,A., Romijn,J.C. and Trapman,J.
    The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19
    FEBS Lett247, 123-126. PubMed  Europe PubMed DOI
    198. 1988
  198. McGee,R.S. and Herr,J.C.
    Human seminal vesicle-specific antigen is a substrate for prostate-specific antigen (or P-30)
    Biol Reprod39, 499-510. PubMed  Europe PubMed
    199. 1987
  199. [YEAR:16-6-1987]Dunbar,J.C. and Bradshaw,R.A.
    Amino acid sequence of guinea pig prostate kallikrein
    Biochemistry26, 3471-3478. PubMed  Europe PubMed
    200. 1986
  200. Watt,K.W., Lee,P.J., M'Timkulu,T., Chan,W.P. and Loor,R.
    Human prostate-specific antigen: structural and functional similarity with serine proteases
    Proc Natl Acad Sci U S A83, 3166-3170. PubMed  Europe PubMed
    201. 1985
  201. Dunbar,J.C. and Bradshaw,R.A.
    Nerve growth factor biosynthesis: isolation and characterization of a guinea pig prostate kallikrein
    J Cell Biochem29, 309-319. PubMed  Europe PubMed DOI
  202. Lilja,H.
    A kallikrein-like serine protease in prostatic fluid cleaves the predominant seminal vesicle protein
    J Clin Invest76, 1899-1903. PubMed  Europe PubMed DOI
    203. 1984
  203. [YEAR:17-9-1984]Ban,Y., Wang,M.C., Watt,K.W., Loor,R. and Chu,T.M.
    The proteolytic activity of human prostate-specific antigen
    Biochem Biophys Res Commun123, 482-488. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use