| Activity |
|---|
| Catalytic type | Metallo |
| Peplist | Included in the Peplist with identifier PL00250 |
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.83
|
| Enzymology | BRENDA database |
| Proteolytic events | CutDB database (8 cleavages) |
| Physiology | Anthrax virulence determinant that inactivates mitogen-activated protein kinase kinase, so killing infected macrophages (Ascenzi et al., 2002). |
| Pharmaceutical relevance | Cytotoxic component of anthrax toxin. A urokinase-activated form is a potential antitumour agent (Liu et al., 2003). |
| Pathways |
KEGG | NOD-like receptor signaling pathway |
| Cleavage site specificity |
Explanations of how to interpret the
following cleavage site sequence logo and specificity matrix can be found here. |
|---|
| Cleavage pattern | kphr/p/lrt/pkr Liy/pq/l/- (based on 17 cleavages) |
