Structure for peptidase M34.001: anthrax lethal factor

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1J7N_B	Bacillus anthracis	2.30 Å	precursor
One monomer of the dimer is shown. The catalytic zinc is shown as a light grey CPK sphere. The zinc ligands are shown in ball-and-stick representation: His719, His723 and Glu768 in purple. Catalytic residues are shown in ball-and-stick representation: Glu720 in dark blue and Tyr761 in green.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Bacillus anthracis
precursor	2.30 Å	1J7N	1J7N	1J7N	1J7N	1J7N	1J7N	Pannifer et al., 2001
complex with N-terminus of mitogen-activated protein kinase kinase 2	3.90 Å	1JKY	1JKY	1JKY	1JKY	1JKY	1JKY	Pannifer et al., 2001
complex with NSC 12155 inhibitor	2.90 Å	1PWP	1PWP	1PWP	1PWP	1PWP	1PWP	Panchal et al., 2004
complex with thioacetyl-Tyr-Pro-Met-NH2 inhibitor	3.52 Å	1PWQ	1PWQ	1PWQ	1PWQ	1PWQ	1PWQ	Turk et al., 2004
complex with (3-(N-hydroxycarboxamido)-2-isobutylpropanoyl-Trp-methylamide inhibitor	2.70 Å	1PWU	1PWU	1PWU	1PWU	1PWU	1PWU	Turk et al., 2004
complex with peptide substrate	2.85 Å	1PWV	1PWV	1PWV	1PWV	1PWV	1PWV	Turk et al., 2004
complex with peptide substrate in presence of zinc	2.80 Å	1PWW	1PWW	1PWW	1PWW	1PWW	1PWW	Turk et al., 2004
complex with hydroxamate inhibitor (2R)-2-[(4-fluoro-3-methylphenyl)sulfonyl]amino-N-hydroxy-2-tetrahydro-2H-pyran-4-ylacetamide	2.30 Å	1YQY	1YQY	1YQY	1YQY	1YQY	1YQY	Shoop et al., 2005
mature peptidase	2.67 Å	1ZXV	1ZXV	1ZXV	1ZXV	1ZXV	1ZXV	Forino et al., 2005
mature peptidase	0.00 Å	2L0R	2L0R	2L0R	2L0R	2L0R	2L0R	Dalkas et al., 2010
mature peptidase	3.10 Å	3KWV	3KWV	3KWV	3KWV	3KWV	3KWV	Feld et al., 2010
mature peptidase	1.63 Å	4DV8	4DV8	4DV8	4DV8	4DV8	4DV8	Jiao et al., 2012
mature peptidase	2.20 Å	4PKQ	4PKQ	4PKQ	4PKQ	4PKQ	4PKQ	Maize et al., 2014
mature peptidase	2.20 Å	4PKR	4PKR	4PKR	4PKR	4PKR	4PKR	Maize et al., 2014
mature peptidase	2.30 Å	4PKS	4PKS	4PKS	4PKS	4PKS	4PKS	Maize et al., 2014
mature peptidase	2.40 Å	4PKT	4PKT	4PKT	4PKT	4PKT	4PKT	Maize et al., 2014
mature peptidase	2.40 Å	4PKU	4PKU	4PKU	4PKU	4PKU	4PKU	Maize et al., 2014
mature peptidase	2.50 Å	4PKV	4PKV	4PKV	4PKV	4PKV	4PKV	Maize et al., 2014
mature peptidase	1.75 Å	4PKW	4PKW	4PKW	4PKW	4PKW	4PKW	Maize et al., 2014
mature peptidase	2.65 Å	4WF6	4WF6	4WF6	4WF6	4WF6	4WF6	Kurbanov et al., 2015
mature peptidase	2.35 Å	4XM6	4XM6	4XM6	4XM6	4XM6	4XM6
mature peptidase	2.70 Å	4XM7	4XM7	4XM7	4XM7	4XM7	4XM7
mature peptidase	2.70 Å	4XM8	4XM8	4XM8	4XM8	4XM8	4XM8
mature peptidase	2.10 Å	5D1S	5D1S	5D1S	5D1S	5D1S	5D1S	Kurbanov et al., 2015
mature peptidase	2.20 Å	5D1T	5D1T	5D1T	5D1T	5D1T	5D1T	Kurbanov et al., 2015
mature peptidase	2.85 Å	5D1U	5D1U	5D1U	5D1U	5D1U	5D1U	Kurbanov et al., 2015