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Literature for peptidase M34.001: anthrax lethal factor

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, M Mutation, P Specificity, I Inhibitor, E Expression, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2020
  1. Greaney,A.J., Portley,M.K., O'Mard,D., Crown,D., Maier,N.K., Mendenhall,M.A., Mayer-Barber,K.D., Leppla,S.H. and Moayeri,M.
    Frontline Science: Anthrax lethal toxin-induced, NLRP1-mediated IL-1beta release is a neutrophil and PAD4-dependent event
    J Leukoc Biol PubMed  Europe PubMed DOI
  2. Lo,S.Y., Goulet,D.L., Fraaz,U. and Siemann,S.
    Effect of pH and denaturants on the fold and metal status of anthrax lethal factor
    Arch Biochem Biophys692, 108547-108547. PubMed  Europe PubMed DOI
  3. Mendenhall,M.A., Liu,S., Portley,M.K., O'Mard,D., Fattah,R., Szabo,R., Bugge,T.H., Khillan,J.S., Leppla,S.H. and Moayeri,M.
    Anthrax lethal factor cleaves regulatory subunits of phosphoinositide-3 kinase to contribute to toxin lethality
    Nat Microbiol PubMed  Europe PubMed DOI
    4. 2019
  4. Sandstrom,A., Mitchell,P.S., Goers,L., Mu,E.W., Lesser,C.F. and Vance,R.E.
    Functional degradation: a mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes
    Science364, eaau1330-eaau1330. PubMed  Europe PubMed DOI
  5. Saxena,M., Nandi,S. and Saxena,A.K.
    QSAR and molecular docking studies of lethal factor protease inhibitors against Bacillus anthracis
    SAR QSAR Environ Res30, 715-731. PubMed  Europe PubMed DOI  I
  6. Turk,B.E.
    Exceptionally selective substrate targeting by the metalloprotease anthrax lethal factor
    Adv Exp Med Biol1111, 189-203. PubMed  Europe PubMed DOI  P  S
    7. 2018
  7. Bi,T., Li,Y., Shekhtman,A. and Camarero,J.A.
    In-cell production of a genetically-encoded library based on the theta-defensin RTD-1 using a bacterial expression system
    Bioorg Med Chem26, 1212-1219. PubMed  Europe PubMed DOI  I
  8. Lahousse,M., Park,H.C., Lee,S.C., Ha,N.R., Jung,I.P., Schlesinger,S.R., Shackelford,K., Yoon,M.Y. and Kim,S.K.
    Inhibition of anthrax lethal factor by ssDNA aptamers
    Arch Biochem Biophys646, 16-23. PubMed  Europe PubMed DOI  I
  9. Suryadi,K. and Shine,N.
    Design and use of a novel substrate for simple, rapid, and specific early detection of anthrax infection
    PLoS ONE13, e0207084-e0207084. PubMed  Europe PubMed DOI  A
  10. Young,C.J., Richard,K., Beruar,A., Lo,S.Y. and Siemann,S.
    An investigation of the pH dependence of copper-substituted anthrax lethal factor and its mechanistic implications
    J Inorg Biochem182, 1-8. PubMed  Europe PubMed DOI
    11. 2017
  11. Gallegos-Candela,M., Boyer,A.E., Woolfitt,A.R., Brumlow,J., Lins,R.C., Quinn,C.P., Hoffmaster,A.R., Meister,G. and Barr,J.R.
    Validated MALDI-TOF-MS method for anthrax lethal factor provides early diagnosis and evaluation of therapeutics
    Anal Biochem543, 97-107. PubMed  Europe PubMed DOI  A
  12. Goldberg,A.B., Cho,E., Miller,C.J., Lou,H.J. and Turk,B.E.
    Identification of a substrate-selective exosite within the metalloproteinase anthrax lethal factor
    J Biol Chem292, 814-825. PubMed  Europe PubMed DOI  P
  13. Li,Y., Gould,A., Aboye,T., Bi,T., Breindel,L., Shekhtman,A. and Camarero,J.A.
    Full sequence amino acid scanning of theta-defensin RTD-1 yields a potent anthrax lethal factor protease inhibitor
    J Med Chem60, 1916-1927. PubMed  Europe PubMed DOI
    14. 2016
  14. Goldberg,A.B. and Turk,B.E.
    Inhibitors of the metalloproteinase anthrax lethal factor
    Curr Top Med Chem16, 2350-2358. PubMed  Europe PubMed  V  I
  15. Kolesnikov,A.V., Kozyr,A.V., Ryabko,A.K. and Shemyakin,I.G.
    Ultrasensitive detection of protease activity of anthrax and botulinum toxins by a new PCR-based assay
    Pathog Dis74, ftv112- PubMed  Europe PubMed DOI  A
  16. Young,C.J. and Siemann,S.
    Highly dynamic metal exchange in anthrax lethal factor involves the occupation of an inhibitory metal binding site
    Chem Commun (Camb)52, 11748-11751. PubMed  Europe PubMed DOI
    17. 2015
  17. Kong,Q., Song,Y., Mu,M., Han,X., Si,C. and Li,F.
    Effects of metalloprotease anthrax lethal factor on its peptide-based inhibitor R9LF-1
    Mol Cell Biochem406, 293-299. PubMed  Europe PubMed DOI  I
  18. Kurbanov,E.K., Chiu,T.-L., Solberg,J., Francis,S., Maize,K.M., Fernandez,J., Johnson,R.L., Hawkinson,J.E., Walters,M.A., Finzel,B.C. and Amin,E.A.
    Probing the S2' subsite of the anthrax toxin lethal factor using novel N-alkylated hydroxamates
    J Med Chem58, 8723-8733. PubMed  Europe PubMed DOI
  19. Maize,K.M., Kurbanov,E.K., Johnson,R.L., Amin,E.A. and Finzel,B.C.
    Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor
    FEBS Lett589, 3836-3841. PubMed  Europe PubMed DOI  S  I
    20. 2014
  20. Antonelli,A.C., Zhang,Y., Golub,L.M., Johnson,F. and Simon,S.R.
    Inhibition of anthrax lethal factor by curcumin and chemically modified curcumin derivatives
    J Enzyme Inhib Med Chem29, 663-669. PubMed  Europe PubMed DOI  I
  21. Gomez-Jeria,J.S.
    A density functional study of the inhibition of the anthrax lethal factor toxin by quinoline-based small molecules related to aminoquinuride (NSC 12155)
    Res J Pharm , Biol Chem Sci5, 780-792.  I
  22. Hutt,J.A., Lovchik,J.A., Drysdale,M., Sherwood,R.L., Brasel,T., Lipscomb,M.F. and Lyons,C.R.
    Lethal factor, but not edema factor, is required to cause fatal anthrax in cynomolgus macaques after pulmonary spore challenge
    Am J Pathol184, 3205-3216. PubMed  Europe PubMed DOI
  23. Kumar,B.V., Malik,S., Grandhi,P., Dayam,R. and Sarma,J.A.
    Anthrax lethal factor inhibitors as potential countermeasure of the infection
    Curr Top Med Chem14, 1977-1989. PubMed  Europe PubMed  V
  24. Liao,H.-S., Liu,H.-L., Chen,W.-H. and Ho,Y.
    Structure-based pharmacophore modeling and virtual screening to identify novel inhibitors for anthrax lethal factor
    Med Chem Res23, 3725-3732. DOI  I
  25. Lo,S.Y., Sabel,C.E., Webb,M.I., Walsby,C.J. and Siemann,S.
    High metal substitution tolerance of anthrax lethal factor and characterization of its active copper-substituted analogue
    J Inorg Biochem140, 12-22. PubMed  Europe PubMed DOI
  26. Maize,K.M., Zhang,X. and Amin,E.A.
    Statistical analysis, optimization, and prioritization of virtual screening parameters for zinc enzymes including the anthrax toxin lethal factor
    Curr Top Med Chem14, 2105-2114. PubMed  Europe PubMed  I
  27. Maize,K.M., Kurbanov,E.K., De La Mora-Rey,T., Geders,T.W., Hwang,D.-J., Walters,M.A., Johnson,R.L., Amin,E.A. and Finzel,B.C.
    Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding
    Acta Crystallogr Sect D Biol Crystallogr70, 2813-2822. PubMed  Europe PubMed DOI  S
  28. Williams,J.D., Khan,A.R., Cardinale,S.C., Butler,M.M., Bowlin,T.L. and Peet,N.P.
    Small molecule inhibitors of anthrax lethal factor toxin
    Bioorg Med Chem22, 419-434. PubMed  Europe PubMed DOI  I
    29. 2013
  29. Hurley,M.M. and Sellers,M.S.
    Prediction of protein-peptide interactions: application of the XPairIt API to anthrax lethal factor and substrates
    Progr Biomed Opt Imaging Proc SPIE8719, DOI  P
  30. Lu,H., Catania,J., Baranji,K., Feng,J., Gu,M., Lathey,J., Sweeny,D., Sanford,H., Sapru,K., Patamawenu,T., Chen,J.H., Ng,A., Fesseha,Z., Kluepfel-Stahl,S., Minang,J. and Alleva,D.
    Characterization of the native form of anthrax lethal factor for use in the toxin neutralization assay
    Clin Vaccine Immunol20, 986-997. PubMed  Europe PubMed DOI
  31. Moayeri,M., Crown,D., Jiao,G.S., Kim,S., Johnson,A., Leysath,C. and Leppla,S.H.
    Small-molecule inhibitors of lethal factor protease activity protect against anthrax infection
    Antimicrob Agents Chemother57, 4139-4145. PubMed  Europe PubMed DOI  I
  32. Montpellier,L.H. and Siemann,S.
    Effect of pH on the catalytic function and zinc content of native and immobilized anthrax lethal factor
    FEBS Lett587, 317-321. PubMed  Europe PubMed DOI
    33. 2012
  33. Bannwarth,L., Goldberg,A.B., Chen,C. and Turk,B.E.
    Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening
    Chem Biol19, 875-882. PubMed  Europe PubMed DOI  I
  34. Calugi,C., Trabocchi,A., Lalli,C. and Guarna,A.
    d-Proline-based peptidomimetic inhibitors of anthrax lethal factor
    Eur J Med Chem56, 96-107. PubMed  Europe PubMed DOI  I
  35. Gould,A., Li,Y., Majumder,S., Garcia,A.E., Carlsson,P., Shekhtman,A. and Camarero,J.A.
    Recombinant production of rhesus theta-defensin-1 (RTD-1) using a bacterial expression system
    Mol Biosyst8, 1359-1365. PubMed  Europe PubMed DOI  E
  36. Hellmich,K.A., Levinsohn,J.L., Fattah,R., Newman,Z.L., Maier,N., Sastalla,I., Liu,S., Leppla,S.H. and Moayeri,M.
    Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages
    PLoS ONE7, e49741-e49741. PubMed  Europe PubMed DOI  P
  37. Jiao,G.S., Kim,S., Moayeri,M., Crown,D., Thai,A., Cregar-Hernandez,L., McKasson,L., Sankaran,B., Lehrer,A., Wong,T., Johns,L., Margosiak,S.A., Leppla,S.H. and Johnson,A.T.
    Antidotes to anthrax lethal factor intoxication. Part 3: evaluation of core structures and further modifications to the C2-side chain
    Bioorg Med Chem Lett22, 2242-2246. PubMed  Europe PubMed DOI  I
  38. Leppla,S.H.
    Anthrax lethal factor
    [ISSN:978-0-12-407744-7]3, 1257-1261. DOI
  39. Levinsohn,J.L., Newman,Z.L., Hellmich,K.A., Fattah,R., Getz,M.A., Liu,S., Sastalla,I., Leppla,S.H. and Moayeri,M.
    Anthrax lethal factor cleavage of nlrp1 is required for activation of the inflammasome
    PLoS Pathog8, e1002638-e1002638. PubMed  Europe PubMed DOI
  40. Liu,T., Milia,E., Warburton,R.R., Hill,N.S., Gaestel,M. and Kayyali,U.S.
    Anthrax lethal toxin disrupts the endothelial permeability barrier through blocking p38 signaling
    J Cell Physiol227, 1438-1445. PubMed  Europe PubMed DOI
  41. Park,H.C., Sung,S.R., Lim,S.M., Lee,J.S., Kim,S.K. and Yoon,M.Y.
    Proteolytic assay-based screening identifies a potent inhibitor of anthrax lethal factor
    Microb Pathog53, 109-112. PubMed  Europe PubMed DOI  I
    42. 2011
  42. Bagramyan,K. and Kalkum,M.
    Ultrasensitive detection of Botulinum neurotoxins and anthrax lethal factor in biological samples by ALISSA
    Methods Mol Biol739, 23-36. PubMed  Europe PubMed DOI  A
  43. Kim,J., Park,H.C., Gedi,V., Park,H.Y., Roberts,A.G., Atkins,W.M. and Yoon,M.Y.
    Yeast-hybrid based high-throughput assay for identification of anthrax lethal factor inhibitors
    Biochem Biophys Res Commun404, 517-522. PubMed  Europe PubMed DOI  I
  44. Kim,S., Jiao,G.S., Moayeri,M., Crown,D., Cregar-Hernandez,L., McKasson,L., Margosiak,S.A., Leppla,S.H. and Johnson,A.T.
    Antidotes to anthrax lethal factor intoxication. Part 2: structural modifications leading to improved in vivo efficacy
    Bioorg Med Chem Lett21, 2030-2033. PubMed  Europe PubMed DOI  I
  45. Kuklenyik,Z., Boyer,A.E., Lins,R., Quinn,C.P., Gallegos-Candela,M., Woolfitt,A., Pirkle,J.L. and Barr,J.R.
    Comparison of MALDI-TOF-MS and HPLC-ESI-MS/MS for endopeptidase activity-based quantification of anthrax lethal factor in serum
    Anal Chem83, 1760-1765. PubMed  Europe PubMed DOI  A
  46. Li,F., Terzyan,S. and Tang,J.
    Subsite specificity of anthrax lethal factor and its implications for inhibitor development
    Biochem Biophys Res Commun407, 400-405. PubMed  Europe PubMed DOI  P
  47. Sabel,C.E., Carbone,R., Dabous,J.R., Lo,S.Y. and Siemann,S.
    Preparation and characterization of cobalt-substituted anthrax lethal factor
    Biochem Biophys Res Commun416, 106-110. PubMed  Europe PubMed DOI
  48. Smith,C.R., Smith,G.K., Yang,Z., Xu,D. and Guo,H.
    Quantum mechanical/molecular mechanical study of anthrax lethal factor catalysis
    Theor Chem Acc128, 83-90. DOI
  49. Thomas,J., Epshtein,Y., Chopra,A., Ordog,B., Ghassemi,M., Christman,J.W., Nattel,S., Cook,J.L. and Levitan,I.
    Anthrax lethal factor activates K(+) channels to induce IL-1beta secretion in macrophages
    J Immunol186, 5236-5243. PubMed  Europe PubMed DOI
    50. 2010
  50. Alfano,R.W., Leppla,S.H., Liu,S., Bugge,T.H., Ortiz,J.M., Lairmore,T.C., Duesbery,N.S., Mitchell,I.C., Nwariaku,F. and Frankel,A.E.
    Inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin in an orthotopic model of anaplastic thyroid carcinoma
    Mol Cancer Ther9, 190-201. PubMed  Europe PubMed DOI  U
  51. Cao,S., Guo,A., Wu,G., Liu,Z., Chen,W., Feng,C., Zhang,C.C. and Chen,H.
    Residue histidine 669 is essential for the catalytic activity of Bacillus anthracis lethal factor
    J Bacteriol192, 5799-5805. PubMed  Europe PubMed DOI
  52. Dalkas,G.A., Chasapis,C.T., Gkazonis,P.V., Bentrop,D. and Spyroulias,G.A.
    Conformational dynamics of the anthrax lethal factor catalytic center
    Biochemistry49, 10767-10769. PubMed  Europe PubMed DOI  S
  53. Fang,H., Sun,C., Xu,L., Owen,R.J., Auth,R.D., Snoy,P.J. and Frucht,D.M.
    Neutrophil elastase mediates pathogenic effects of anthrax lethal toxin in the murine intestinal tract
    J Immunol185, 5463-5467. PubMed  Europe PubMed DOI
  54. Gkazonis,P.V., Dalkas,G.A., Chasapis,C.T., Vlamis-Gardikas,A., Bentrop,D. and Spyroulias,G.A.
    Purification and biophysical characterization of the core protease domain of anthrax lethal factor
    Biochem Biophys Res Commun396, 643-647. PubMed  Europe PubMed DOI  E
  55. Ha,S.D., Ham,B., Mogridge,J., Saftig,P., Lin,S. and Kim,S.O.
    Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm
    J Biol Chem285, 2120-2129. PubMed  Europe PubMed DOI
  56. Jiao,G.S., Kim,S., Moayeri,M., Cregar-Hernandez,L., McKasson,L., Margosiak,S.A., Leppla,S.H. and Johnson,A.T.
    Antidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy
    Bioorg Med Chem Lett20, 6850-6853. PubMed  Europe PubMed DOI  I
  57. Newman,Z.L., Printz,M.P., Liu,S., Crown,D., Breen,L., Miller-Randolph,S., Flodman,P., Leppla,S.H. and Moayeri,M.
    Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1
    PLoS Pathog6, e1000906-e1000906. PubMed  Europe PubMed DOI
  58. Ngai,S., Batty,S., Liao,K.C. and Mogridge,J.
    An anthrax lethal factor mutant that is defective at causing pyroptosis retains proapoptotic activity
    FEBS J277, 119-127. PubMed  Europe PubMed DOI
  59. Sabel,C.E., St-Denis,S., Neureuther,J.M., Carbone,R. and Siemann,S.
    Alkaline earth metals are not required for the restoration of the apoform of anthrax lethal factor to its holoenzyme state
    Biochem Biophys Res Commun403, 209-213. PubMed  Europe PubMed DOI
  60. Yuan,H., Johnson,S.L., Chen,L.H., Wei,J. and Pellecchia,M.
    A novel pharmacophore model for the design of anthrax lethal factor inhibitors
    Chem Biol Drug Des76, 263-268. PubMed  Europe PubMed DOI  I
    61. 2009
  61. Agrawal,A., de Oliveira,C.A., Cheng,Y., Jacobsen,J.A., McCammon,J.A. and Cohen,S.M.
    Thioamide hydroxypyrothiones supersede amide hydroxypyrothiones in potency against anthrax lethal factor
    J Med Chem52, 1063-1074. PubMed  Europe PubMed DOI  I
  62. Alfano,R.W., Leppla,S.H., Liu,S., Bugge,T.H., Meininger,C.J., Lairmore,T.C., Mulne,A.F., Davis,S.H., Duesbery,N.S. and Frankel,A.E.
    Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis
    Mol Cancer Res7, 452-461. PubMed  Europe PubMed DOI  U
  63. Chen,Z., Moayeri,M., Crown,D., Emerson,S., Gorshkova,I., Schuck,P., Leppla,S.H. and Purcell,R.H.
    Novel chimpanzee/human monoclonal antibodies that neutralize anthrax lethal factor, and evidence for possible synergy with anti-protective antigen antibody
    Infect Immun77, 3902-3908. PubMed  Europe PubMed DOI
  64. Chun-Fan,F., Gao-Bing,W., Sha,C., Zi-Duo,L. and Yu-Zhi,H.
    Screening and activity analysis of lethal factor mutants-K518E and L519C from Bacillus anthracis
    Prog Biochem Biophys36, 1306-1312. DOI  M
  65. Dalkas,G.A., Papakyriakou,A., Vlamis-Gardikas,A. and Spyroulias,G.A.
    Insights into the anthrax lethal factor-substrate interaction and selectivity using docking and molecular dynamics simulations
    Protein Sci18, 1774-1785. PubMed  Europe PubMed DOI  P  S
  66. Johnson,S.L., Chen,L.H., Barile,E., Emdadi,A., Sabet,M., Yuan,H., Wei,J., Guiney,D. and Pellecchia,M.
    Structure-activity relationship studies of a novel series of anthrax lethal factor inhibitors
    Bioorg Med Chem17, 3352-3368. PubMed  Europe PubMed DOI  I
  67. Joshi,M., Ebalunode,J.O. and Briggs,J.M.
    Computational insights into the interaction of the anthrax lethal factor with the N-terminal region of its substrates
    Proteins75, 323-335. PubMed  Europe PubMed DOI  P
  68. Kang,Z., Webster Marketon,J.I., Johnson,A. and Sternberg,E.M.
    Bacillus anthracis lethal toxin represses MMTV promoter activity through transcription factors
    J Mol Biol389, 595-605. PubMed  Europe PubMed DOI
  69. Lebrun,I., Marques-Porto,R., Pereira,A.S., Pereira,A. and Perpetuo,E.A.
    Bacterial toxins: an overview on bacterial proteases and their action as virulence factors
    Mini Rev Med Chem9, 820-828. PubMed  Europe PubMed DOI  V
  70. Moayeri,M. and Leppla,S.H.
    Cellular and systemic effects of anthrax lethal toxin and edema toxin
    Mol Aspects Med30, 439-455. PubMed  Europe PubMed DOI
  71. Nguyen,M.L., Crowe,S.R., Kurella,S., Teryzan,S., Cao,B., Ballard,J.D., James,J.A. and Farris,A.D.
    Sequential B-cell epitopes of Bacillus anthracis lethal factor bind lethal toxin-neutralizing antibodies
    Infect Immun77, 162-169. PubMed  Europe PubMed DOI
  72. Thoren,K.L., Worden,E.J., Yassif,J.M. and Krantz,B.A.
    Lethal factor unfolding is the most force-dependent step of anthrax toxin translocation
    Proc Natl Acad Sci U S A106, 21555-21560. PubMed  Europe PubMed DOI
  73. Tonello,F. and Montecucco,C.
    The anthrax lethal factor and its MAPK kinase-specific metalloprotease activity
    Mol Aspects Med30, 431-438. PubMed  Europe PubMed DOI  V  I
  74. Zakharova,M.Y., Kuznetsov,N.A., Dubiley,S.A., Kozyr,A.V., Fedorova,O.S., Chudakov,D.M., Knorre,D.G., Shemyakin,I.G., Gabibov,A.G. and Kolesnikov,A.V.
    Substrate recognition of anthrax lethal factor examined by combinatorial and pre-steady-state kinetic approaches
    J Biol Chem284, 17902-17913. PubMed  Europe PubMed DOI
    75. 2008
  75. Alfano,R.W., Leppla,S.H., Liu,S., Bugge,T.H., Herlyn,M., Smalley,K.S., Bromberg-White,J.L., Duesbery,N.S. and Frankel,A.E.
    Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells
    Mol Cancer Ther7, 1218-1226. PubMed  Europe PubMed DOI  U
  76. Alfano,R.W., Leppla,S.H., Liu,S., Bugge,T.H., Duesbery,N.S. and Frankel,A.E.
    Potent inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin: implications for broad anti-tumor efficacy
    Cell Cycle7, 745-749. PubMed  Europe PubMed
  77. Bromberg-White,J.L. and Duesbery,N.S.
    Biological and biochemical characterization of anthrax lethal factor, a proteolytic inhibitor of MEK signaling pathways
    Methods Enzymol438, 355-365. PubMed  Europe PubMed DOI  V
  78. Cao,S., Liu,Z., Guo,A., Li,Y., Zhang,C., Gaobing,W., Chunfang,F., Tan,Y. and Chen,H.
    Efficient production and characterization of Bacillus anthracis lethal factor and a novel inactive mutant rLFm-Y236F
    Protein Expr Purif59, 25-30. PubMed  Europe PubMed DOI
  79. Dalkas,G.A., Papakyriakou,A., Vlamis-Gardikas,A. and Spyroulias,G.A.
    Low molecular weight inhibitors of the protease anthrax lethal factor
    Mini Rev Med Chem8, 290-306. PubMed  Europe PubMed DOI  V  I
  80. Gaddis,B.D., Rubert Perez,C.M. and Chmielewski,J.
    Inhibitors of anthrax lethal factor based upon N-oleoyldopamine
    Bioorg Med Chem Lett18, 2467-2470. PubMed  Europe PubMed DOI  I
  81. Gupta,P.K., Moayeri,M., Crown,D., Fattah,R.J. and Leppla,S.H.
    Role of N-terminal amino acids in the potency of anthrax lethal factor
    PLoS ONE3, e3130-e3130. PubMed  Europe PubMed DOI  E
  82. Hong,R., Magistrato,A. and Carloni,P.
    Anthrax lethal factor investigated by molecular simulations
    J Chem Theory Comput4, 1745-1756. PubMed  Europe PubMed DOI
  83. Johnson,S.L., Chen,L.H., Harbach,R., Sabet,M., Savinov,A., Cotton,N.J., Strongin,A., Guiney,D. and Pellecchia,M.
    Rhodanine derivatives as selective protease inhibitors against bacterial toxins
    Chem Biol Drug Des71, 131-139. PubMed  Europe PubMed DOI  I
  84. Kim,J., Park,H., Myung-Hyun,J., Han,S.H., Chung,H., Lee,J.S., Park,J.S. and Yoon,M.Y.
    The effects of anthrax lethal factor on the macrophage proteome: potential activity on nitric oxide synthases
    Arch Biochem Biophys472, 58-64. PubMed  Europe PubMed DOI
  85. Turk,B.E.
    Discovery and development of anthrax lethal factor metalloproteinase inhibitors
    Curr Pharm Biotechnol9, 24-33. PubMed  Europe PubMed DOI  V  I
  86. Verma,A., Wagner,L., Stibitz,S., Nguyen,N., Guerengomba,F. and Burns,D.L.
    Role of the N-terminal amino acid of Bacillus anthracis lethal factor in lethal toxin cytotoxicity and its effect on the lethal toxin neutralization assay
    Clin Vaccine Immunol15, 1737-1741. PubMed  Europe PubMed DOI
  87. Wickliffe,K.E., Leppla,S.H. and Moayeri,M.
    Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome
    Cell Microbiol10, 332-343. PubMed  Europe PubMed DOI
  88. Zakharova,M.Y., Dubiley,S.A., Chudakov,D.M., Gabibov,A.G., Shemyakin,I.G. and Kolesnikov,A.V.
    Substrate specificity of the anthrax lethal factor
    Dokl Biochem Biophys418, 14-17. PubMed  Europe PubMed DOI  P
    89. 2007
  89. Boyer,A.E., Quinn,C.P., Woolfitt,A.R., Pirkle,J.L., McWilliams,L.G., Stamey,K.L., Bagarozzi,D.A., Hart,J.C., Jr. and Barr,J.R.
    Detection and quantification of anthrax lethal factor in serum by mass spectrometry
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