$VAR1 = undef;

Summary for peptidase M12.210: ADAM10 peptidase

Names
MEROPS Name	ADAM10 peptidase
Other names	ADAM10, alpha-secretase, myelin-associated disintegrin metalloproteinase, MADM, mammalian kuzbanian protein

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.210
Holotype	ADAM10 peptidase (Bos taurus), Uniprot accession Q10741 (peptidase unit: 202-456), MERNUM MER0001139
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00192
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.81
Enzymology	BRENDA database
Proteolytic events	CutDB database (18 cleavages)
Physiology	Myelin-degrading activity.
Knockout	ADAM 10-deficient mouse embryos die at day 9.5 with multiple defects of the developing central nervous system, somites, and cardiovascular system (Hartmann et al., 2002).
Pharmaceutical relevance	Potential drug target for demyelinating disease. May play an important role in Notch signalling (Hartmann et al., 2002).
Pathways	KEGG	Alzheimer's disease
	KEGG	Epithelial cell signaling in Helicobacter pylori infection
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/ADAM10
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/alv/-/s/- (based on 155 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	6	3	7	8	3	5	29	6
Pro	7	18	0	14	0	2	2	9
Ala	3	34	32	40	8	21	21	11
Val	10	13	6	2	26	19	8	14
Leu	15	6	18	4	52	9	5	5
Ile	5	6	3	3	9	17	4	4
Met	1	6	12	4	3	0	1	1
Phe	6	8	0	5	2	2	4	5
Tyr	8	6	0	6	7	4	1	3
Trp	0	5	0	1	0	0	0	0
Ser	18	19	8	1	14	17	37	19
Thr	10	7	3	8	7	17	10	9
Cys	1	0	2	0	0	0	2	0
Asn	4	1	2	1	2	1	1	3
Gln	7	6	20	7	7	11	8	13
Asp	5	0	9	1	2	0	9	12
Glu	12	2	17	5	2	5	8	20
Lys	9	5	10	15	3	15	2	9
Arg	12	4	4	23	4	7	1	3
His	14	5	1	7	1	3	2	6