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Literature for peptidase M12.210: ADAM10 peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Liu,Z., Williams,B., Wang,L., Clark,F.K., Vignogna,R.C., Fromme,J.C. and Liu,J.<br>Tetraspanin TSP-12 and SUP-17/ADAM10 exhibit cell type-specific codependence for trafficking through the Golgi<br>Proc Natl Acad Sci U S A (2026) 123, e2524916123-e2524916123. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Yu,Y., Babendreyer,A., Pabst,A., Michely,A., Tauscher,M., Martin,C., Kuhnel,M.P., Jonigk,D.D., Dusterhoft,S. and Ludwig,A.<br>ADAM10 and ADAM17 differently mediate induced pulmonary ACE release by either direct proteolysis or indirect upregulation protein synthesis<br>Biochim Biophys Acta Mol Cell Res (2026) 1873, 120112-120112. PubMed  Europe PubMed DOI
    3. 2025
  3. Baek,C.H., Kim,H., Moon,S.Y., Lee,E.K. and Yang,W.S.<br>AKT activation triggers Rab14-mediated ADAM10 translocation to the cell surface in human aortic endothelial cells<br>Sci Rep (2025) 15, 7448-7448. PubMed  Europe PubMed DOI  PMC  EPMC  K
  4. Murai,T., Masaki,Y. and Yasuhara,K.<br>Curcumin induces IL-6 receptor shedding via the ADAM10 proteinase<br>Biochem Biophys Res Commun (2025) 768, 151939-151939. PubMed  Europe PubMed DOI  I
  5. Targas,A.B.A., Victoriano,P.H.M., Garcia,M.B.B., Alexandre-Silva,V. and Cominetti,M.R.<br>Exploring the connection between dementia and cardiovascular risk with a focus on ADAM10<br>Biochim Biophys Acta Mol Basis Dis (2025) 1871, 167825-167825. PubMed  Europe PubMed DOI  V
  6. Yang,M., Lin,Y., He,Y., Liao,S., Qin,Y., Liu,L., He,J. and Shao,Y.<br>Tetraspanin-Mediated ADAM10 Regulation in Sepsis and Potential Therapeutic Implications<br>Front Biosci (Landmark Ed) (2025) 30, 39386-39386. PubMed  Europe PubMed DOI
    7. 2024
  7. Abdalla,A.M., Miao,Y., Ming,N. and Ouyang,C.<br>ADAM10 modulates the efficacy of T-cell-mediated therapy in solid tumors<br>Immunol Cell Biol (2024) PubMed  Europe PubMed DOI
  8. Alexandre-Silva,V. and Cominetti,M.R.<br>Unraveling the dual role of ADAM10: Bridging the gap between cancer and Alzheimer's disease<br>Mech Ageing Dev (2024) 219, 111928-111928. PubMed  Europe PubMed DOI  V
  9. Babendreyer,A., Kieselhorst,J., Rinkens,C., Lyashenko,A.M., Dusterhoft,S., Jahr,H., Craveiro,R.B., Wolf,M. and Ludwig,A.<br>Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation<br>Cell Commun Signal (2024) 22, 322-322. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Bar,J., Fanutza,T., Reimann,C.C., Seipold,L., Grohe,M., Bolter,J.R., Delfs,F., Bucher,M., Gee,C.E., Schweizer,M., Saftig,P. and Mikhaylova,M.<br>Non-canonical function of ADAM10 in presynaptic plasticity<br>Cell Mol Life Sci (2024) 81, 342-342. PubMed  Europe PubMed DOI
  11. Barbaud,A., Lascombe,I., Pechery,A., Arslan,S., Kleinclauss,F. and Fauconnet,S.<br>GW501516-Mediated Targeting of Tetraspanin 15 Regulates ADAM10-Dependent N-Cadherin Cleavage in Invasive Bladder Cancer Cells<br>Cells (2024) 13 PubMed  Europe PubMed DOI  PMC  EPMC
  12. de Oliveira,T.R., Manzine,P.R., Cominetti,M.R., Leite,O.D. and Faria,R.C.<br>Electrochemical magneto-immunoassay for detection of ADAM10 Alzheimer's biomarker using gold nanoparticles as label<br>Talanta (2024) 266, 125042-125042. PubMed  Europe PubMed DOI
  13. Drexhage,L.Z., Zhang,S., Dupont,M., Ragaller,F., Sjule,E., Cabezas-Caballero,J., Deimel,L.P., Robertson,H., Russell,R.A., Dushek,O., Sezgin,E., Karaji,N. and Sattentau,Q.J.<br>Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis<br>Nat Commun (2024) 15, 541-541. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Gharzia,F.G., Aljohmani,A., Beck,A., Philipp,S.E. and Yildiz,D.<br>Regulation of ADAM10 activity through microdomain-dependent intracellular calcium changes<br>Cell Commun Signal (2024) 22, 531-531. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Murai,T., Masaki,Y. and Yasuhara,K.<br>Curcumin Modulates the Membrane Raft Integrity via Phase Separation and Induces CD44 Shedding in Tumor Cells<br>Biochemistry (2024) PubMed  Europe PubMed DOI  I
  16. Rosenbaum,D. and Saftig,P.<br>New insights into the function and pathophysiology of the ectodomain sheddase A Disintegrin And Metalloproteinase 10 (ADAM10)<br>FEBS J (2024) 291, 2733-2766. PubMed  Europe PubMed DOI  V
    17. 2023
  17. Abraham,C.B., Xu,L., Pantelopulos,G.A. and Straub,J.E.<br>Characterizing the transmembrane domains of ADAM10 and BACE1 and the impact of membrane composition<br>Biophys J (2023) 122, 3999-4010. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Aguero-Rabes,P., Perez-Perez,J., Cremades-Jimeno,L., Garcia-Ayllon,M.S., Gea-Gonzalez,A., Sainz,M.J., Mahillo-Fernandez,I., Tellez,R., Cardaba,B., Saez-Valero,J. and Gomez-Tortosa,E.<br>ADAM10 Gene Variants in AD Patients and Their Relationship to CSF Protein Levels<br>Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC
  19. Alfano,D.N., Miller,M.J. and Bubeck Wardenburg,J.<br>Endothelial ADAM10 utilization defines a molecular pathway of vascular injury in mice with bacterial sepsis<br>J Clin Invest (2023) 133 PubMed  Europe PubMed DOI  PMC  EPMC
  20. Baek,C.H., Kim,H., Moon,S.Y. and Yang,W.S.<br>AMPK boosts ADAM10 shedding activity in human aortic endothelial cells by promoting Rab14-dependent ADAM10 cell surface translocation<br>Biochem Biophys Res Commun (2023) 675, 54-60. PubMed  Europe PubMed DOI  K
  21. Chen,Y.T., Lin,C.W., Chou,Y.E., Su,S.C., Chang,L.C., Lee,C.Y., Hsieh,M.J. and Yang,S.F.<br>Potential impact of ADAM-10 genetic variants with the clinical features of oral squamous cell carcinoma<br>J Cell Mol Med (2023) 27, 1144-1152. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Khezri,M.R., Mohebalizadeh,M. and Ghasemnejad-Berenji,M.<br>Therapeutic potential of ADAM10 modulation in Alzheimer's disease: a review of the current evidence<br>Cell Commun Signal (2023) 21, 60-60. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Liao,S., Lin,Y., Liu,L., Yang,S., Lin,Y., He,J. and Shao,Y.<br>ADAM10-a "multitasker" in sepsis: focus on its posttranslational target<br>Inflamm Res (2023) 72, 395-423. PubMed  Europe PubMed DOI  PMC  EPMC  V
  24. Lipper,C.H., Egan,E.D., Gabriel,K.H. and Blacklow,S.C.<br>Structural basis for membrane-proximal proteolysis of substrates by ADAM10<br>Cell (2023) 186, 3632-3641. PubMed  Europe PubMed DOI  PMC  EPMC
  25. Liu,S., Zhang,Z., Li,L., Yao,L., Ma,Z. and Li,J.<br>ADAM10- and gamma-secretase-dependent cleavage of the transmembrane protein PTPRT attenuates neurodegeneration in the mouse model of Alzheimer's disease<br>FASEB J (2023) 37, e22734-e22734. PubMed  Europe PubMed DOI
  26. Maas,S.L., Donners,M.M.P.C. and van der Vorst,E.P.C.<br>ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis?<br>Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC  V
  27. Overby,M., Serrano-Rodriguez,A., Dadras,S., Christiansen,A.K., Ozcelik,G., Lichtenthaler,S.F., Weick,J.P. and Muller,H.K.<br>Neuron-specific gene NSG1 binds to and positively regulates sortilin ectodomain shedding via a metalloproteinase-dependent mechanism<br>J Biol Chem (2023) 299, 105446-105446. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Pastore,F., Battistoni,M., Sollazzo,R., Renna,P., Paciello,F., Li Puma,D.D., Barone,E., Dagliyan,O., Ripoli,C. and Grassi,C.<br>A Bioengineering Strategy to Control ADAM10 Activity in Living Cells<br>Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC
  29. Saha,N., Baek,D.S., Mendoza,R.P., Robev,D., Xu,Y., Goldgur,Y., de la Cruz,M.J., de Stanchina,E., Janes,P.W., Xu,K., Dimitrov,D.S. and Nikolov,D.B.<br>Fully human monoclonal antibody targeting activated ADAM10 on colorectal cancer cells<br>Biomed Pharmacother (2023) 161, 114494-114494. PubMed  Europe PubMed DOI
    30. 2022
  30. Cai,C., Zhang,M., Liu,L., Zhang,H., Guo,Y., Lan,T., Xu,Y., Ma,P. and Li,S.<br>ADAM10-cleaved ephrin-A5 contributes to prostate cancer metastasis<br>Cell Death Dis (2022) 13, 453-453. PubMed  Europe PubMed DOI  PMC  EPMC  K
  31. Gul,C., Kilic,S. and Sehitoglu,M.H.<br>The importance of a disintegrin and metalloproteinase (ADAM)10 and ADAM17 in the pathogenesis of psoriasis<br>Clin Exp Dermatol (2022) 47, 1673-1678. PubMed  Europe PubMed DOI
  32. Hitschler,L. and Lang,T.<br>The transmembrane domain of the amyloid precursor protein is required for antiamyloidogenic processing by alpha-secretase ADAM10<br>J Biol Chem (2022) 298, 101911-101911. PubMed  Europe PubMed DOI  PMC  EPMC
  33. Jocher,G., Grass,V., Tschirner,S.K., Riepler,L., Breimann,S., Kaya,T., Oelsner,M., Hamad,M.S., Hofmann,L.I., Blobel,C.P., Schmidt-Weber,C.B., Gokce,O., Jakwerth,C.A., Trimpert,J., Kimpel,J., Pichlmair,A. and Lichtenthaler,S.F.<br>ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion<br>EMBO Rep (2022) 23, e54305-e54305. PubMed  Europe PubMed DOI
  34. Kirschke,S., Ogunsulire,I., Selvakumar,B., Schumacher,N., Sezin,T., Rose-John,S., Scheffold,A., Garbers,C. and Lokau,J.<br>The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo<br>J Biol Chem (2022) 298, 101910-101910. PubMed  Europe PubMed DOI  PMC  EPMC
  35. Klapproth,E., Witt,A., Klose,P., Wiedemann,J., Vavilthota,N., Kunzel,S.R., Kammerer,S., Gunscht,M., Sprott,D., Lesche,M., Rost,F., Dahl,A., Rauch,E., Kattner,L., Weber,S., Mirtschink,P., Kopaliani,I., Guan,K., Lorenz,K., Saftig,P., Wagner,M. and El-Armouche,A.<br>Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction<br>Nat Commun (2022) 13, 7648-7648. PubMed  Europe PubMed DOI  PMC  EPMC
  36. Koo,C.Z., Matthews,A.L., Harrison,N., Szyroka,J., Nieswandt,B., Gardiner,E.E., Poulter,N.S. and Tomlinson,M.G.<br>The Platelet Collagen Receptor GPVI Is Cleaved by Tspan15/ADAM10 and Tspan33/ADAM10 Molecular Scissors<br>Int J Mol Sci (2022) 23, 2440-2440. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Musardo,S., Therin,S., Pelucchi,S., D'Andrea,L., Stringhi,R., Ribeiro,A., Manca,A., Balducci,C., Pagano,J., Sala,C., Verpelli,C., Grieco,V., Edefonti,V., Forloni,G., Gardoni,F., Meli,G., Di Marino,D., Di Luca,M. and Marcello,E.<br>The development of ADAM10 endocytosis inhibitors for the treatment of Alzheimer's disease<br>Mol Ther (2022) 30, 2474-2490. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Reiss,K., Leitzke,S., Seidel,J., Sperrhacke,M. and Bhakdi,S.<br>Scramblases as Regulators of Proteolytic ADAM Function<br>Membranes (Basel) (2022) 12, 185-185. PubMed  Europe PubMed DOI  PMC  EPMC
  39. Sezin,T., Selvakumar,B. and Scheffold,A.<br>The role of A Disintegrin and Metalloproteinase (ADAM)-10 in T helper cell biology<br>Biochim Biophys Acta Mol Cell Res (2022) 1869, 119192-119192. PubMed  Europe PubMed DOI
  40. Shin,Y., Jo,K.S., Shin,M., Lee,D., Yeo,H., Song,Y. and Kang,S.W.<br>Role of redox-sensitive catalytic interaction with ADAM10 in mutant-selective extracellular shedding of prion protein<br>Redox Biol (2022) 56, 102456-102456. PubMed  Europe PubMed DOI  PMC  EPMC
  41. Wang,J.N. and Cao,X.J.<br>Targeting ADAM10 in Renal Diseases<br>Curr Mol Med (2022) PubMed  Europe PubMed DOI  V
  42. Werny,L., Grogro,A., Bickenbach,K., Bulck,C., Armbrust,F., Koudelka,T., Pathak,K., Scharfenberg,F., Sammel,M., Sheikhouny,F., Tholey,A., Linder,S. and Becker-Pauly,C.<br>MT1-MMP and ADAM10/17 exhibit a remarkable overlap of shedding properties<br>FEBS J (2022) 290, 93-111. PubMed  Europe PubMed DOI
    43. 2021
  43. Asada-Utsugi,M., Uemura,K., Kubota,M., Noda,Y., Tashiro,Y., Uemura,T.M., Yamakado,H., Urushitani,M., Takahashi,R., Hattori,S., Miyakawa,T., Ageta-Ishihara,N., Kobayashi,K., Kinoshita,M. and Kinoshita,A.<br>Mice with cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial learning tasks<br>Mol Brain (2021) 14, 23-23. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Chen,X., Zhang,Y. and Guan,X.<br>Simultaneous detection of multiple proteases using a non-array nanopore platform<br>Nanoscale (2021) 13, 13658-13664. PubMed  Europe PubMed DOI
  45. Harrison,N., Koo,C.Z. and Tomlinson,M.G.<br>Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential<br>Int J Mol Sci (2021) 22, 6707-6707. PubMed  Europe PubMed DOI  PMC  EPMC  V
  46. Lipper,C.H., Gabriel,K.H., Seegar,T.C.M., Durr,K.L., Tomlinson,M.G. and Blacklow,S.C.<br>Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site<br>Structure (2021) 30, 206-214. PubMed  Europe PubMed DOI
  47. Maitra,S., Sornjai,W., Smith,D.R. and Vincent,B.<br>Phenanthroline impairs betaAPP processing and expression, increases p53 protein levels and induces cell cycle arrest in human neuroblastoma cells<br>Brain Res Bull (2021) 170, 29-38. PubMed  Europe PubMed DOI  I
  48. Mattila,S.O., Tuhkanen,H.E., Lackman,J.J., Konzack,A., Morato,X., Argerich,J., Saftig,P., Ciruela,F. and Petaja-Repo,U.E.<br>GPR37 is processed in the N-terminal ectodomain by ADAM10 and furin<br>FASEB J (2021) 35, e21654-e21654. PubMed  Europe PubMed DOI
  49. Meyer-Schwesinger,C., Seipold,L. and Saftig,P.<br>Ectodomain shedding by ADAM proteases as a central regulator in kidney physiology and disease<br>Biochim Biophys Acta Mol Cell Res (2021) , 119165-119165. PubMed  Europe PubMed DOI
  50. Oclon,E. and Hrabia,A.<br>miRNA expression profile in chicken ovarian follicles throughout development and miRNA-mediated MMP expression<br>Theriogenology (2021) 160, 116-127. PubMed  Europe PubMed DOI
  51. Pereira Vatanabe,I., Peron,R., Mantellatto Grigoli,M., Pelucchi,S., De Cesare,G., Magalhaes,T., Manzine,P.R., Figueredo Balthazar,M.L., Di Luca,M., Marcello,E. and Cominetti,M.R.<br>ADAM10 Plasma and CSF Levels Are Increased in Mild Alzheimer's Disease<br>Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC
  52. Rahn,S. and Becker-Pauly,C.<br>Meprin and ADAM proteases as triggers of systemic inflammation in sepsis<br>FEBS Lett (2021) 596, 534-556. PubMed  Europe PubMed DOI
  53. Sachs,M., Wetzel,S., Reichelt,J., Sachs,W., Schebsdat,L., Zielinski,S., Seipold,L., Heintz,L., Muller,S.A., Kretz,O., Lindenmeyer,M., Wiech,T., Huber,T.B., Lullmann-Rauch,R., Lichtenthaler,S.F., Saftig,P. and Meyer-Schwesinger,C.<br>ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage<br>J Am Soc Nephrol (2021) 32, 1389-1408. PubMed  Europe PubMed DOI
  54. Seidel,J., Leitzke,S., Ahrens,B., Sperrhacke,M., Bhakdi,S. and Reiss,K.<br>Role of ADAM10 and ADAM17 in Regulating CD137 Function<br>Int J Mol Sci (2021) 22, 2730-2730. PubMed  Europe PubMed DOI  PMC  EPMC
  55. Seifert,A., Dusterhoft,S., Wozniak,J., Koo,C.Z., Tomlinson,M.G., Nuti,E., Rossello,A., Cuffaro,D., Yildiz,D. and Ludwig,A.<br>The metalloproteinase ADAM10 requires its activity to sustain surface expression<br>Cell Mol Life Sci (2021) 78, 715-732. PubMed  Europe PubMed DOI
  56. Thonda,S., Puttapaka,S.N., Kona,S.V. and Kalivendi,S.V.<br>Extracellular-Signal-Regulated Kinase Inhibition Switches APP Processing from beta- to alpha-Secretase under Oxidative Stress: Modulation of ADAM10 by SIRT1/NF-kappaB Signaling<br>ACS Chem Neurosci (2021) 12, 4175-4186. PubMed  Europe PubMed DOI
  57. Tosetti,F., Alessio,M., Poggi,A. and Zocchi,M.R.<br>ADAM10 Site-Dependent Biology: Keeping Control of a Pervasive Protease<br>Int J Mol Sci (2021) 22, 4969-4969. PubMed  Europe PubMed DOI  PMC  EPMC
  58. Zhang,X., Tang,L. and Zhang,Z.<br>ADAM10 and ADAM17 are degraded by lysosomal pathway via asparagine endopeptidase<br>Biochem Biophys Res Commun (2021) 537, 15-21. PubMed  Europe PubMed DOI
    59. 2020
  59. Aguero,P., Sainz,M.J., Garcia-Ayllon,M.S., Saez-Valero,J., Tellez,R., Guerrero-Lopez,R., Perez-Perez,J., Jimenez-Escrig,A. and Gomez-Tortosa,E.<br>alpha-Secretase nonsense mutation (ADAM10 Tyr167*) in familial Alzheimer's disease<br>Alzheimers Res Ther (2020) 12, 139-139. PubMed  Europe PubMed DOI  PMC  EPMC
  60. Andrews,L.P., Somasundaram,A., Moskovitz,J.M., Szymczak-Workman,A.L., Liu,C., Cillo,A.R., Lin,H., Normolle,D.P., Moynihan,K.D., Taniuchi,I., Irvine,D.J., Kirkwood,J.M., Lipson,E.J., Ferris,R.L., Bruno,T.C., Workman,C.J. and Vignali,D.A.A.<br>Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding<br>Sci Immunol (2020) 5 PubMed  Europe PubMed DOI
  61. Chung,H.K. and Lin,M.Z.<br>On the cutting edge: protease-based methods for sensing and controlling cell biology<br>Nat Methods (2020) PubMed  Europe PubMed DOI  V
  62. Escamilla-Ayala,A.A., Sannerud,R., Mondin,M., Poersch,K., Vermeire,W., Paparelli,L., Berlage,C., Koenig,M., Chavez-Gutierrez,L., Ulbrich,M.H., Munck,S., Mizuno,H. and Annaert,W.<br>Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/gamma-secretase at the cell surface<br>elife (2020) 9 PubMed  Europe PubMed DOI  PMC  EPMC
  63. Kim,N. and Lee,H.J.<br>Target Enzymes Considered for the Treatment of Alzheimer's Disease and Parkinson's Disease<br>Biomed Res Int (2020) 2020, 2010728-2010728. PubMed  Europe PubMed DOI  PMC  EPMC  V
  64. Li,B., Zhu,C., Dong,L., Qin,J., Xiang,W., Davidson,A.J., Feng,S., Wang,Y., Shen,X., Weng,C., Wang,C., Zhu,T., Teng,L., Wang,J., Englert,C., Chen,J. and Jiang,H.<br>ADAM10 mediates ectopic proximal tubule development and renal fibrosis through Notch signalling<br>J Pathol (2020) PubMed  Europe PubMed DOI
  65. Lu,W., Fei,A., Jiang,Y., Chen,L. and Wang,Y.<br>Tetraspanin CD9 interacts with alpha-secretase to enhance its oncogenic function in pancreatic cancer<br>Am J Transl Res (2020) 12, 5525-5537. PubMed  Europe PubMed  PMC  EPMC  K
  66. Mizuno,S., Yoda,M., Kimura,T., Shimoda,M., Akiyama,H., Chiba,K., Nakamura,M. and Horiuchi,K.<br>ADAM10 is indispensable for longitudinal bone growth in mice<br>Bone (2020) 134, 115273-115273. PubMed  Europe PubMed DOI
  67. Mori,T., Koyama,N., Yokoo,T., Segawa,T., Maeda,M., Sawmiller,D., Tan,J. and Town,T.<br>Gallic Acid is a Dual alpha/beta-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice<br>J Biol Chem (2020) PubMed  Europe PubMed DOI
  68. Scharfenberg,F., Helbig,A., Sammel,M., Benzel,J., Schlomann,U., Peters,F., Wichert,R., Bettendorff,M., Schmidt-Arras,D., Rose-John,S., Moali,C., Lichtenthaler,S.F., Pietrzik,C.U., Bartsch,J.W., Tholey,A. and Becker-Pauly,C.<br>Degradome of soluble ADAM10 and ADAM17 metalloproteases<br>Cell Mol Life Sci (2020) 77, 331-350. PubMed  Europe PubMed DOI  P
  69. Smith TM Jr, Tharakan,A. and Martin,R.K.<br>Targeting ADAM10 in cancer and autoimmunity<br>Front Immunol (2020) 11, 499-499. PubMed  Europe PubMed DOI  PMC  EPMC
    70. 2019
  70. Jarosz-Griffiths,H.H., Corbett,N.J., Rowland,H.A., Fisher,K., Jones,A.C., Baron,J., Howell,G.J., Cowley,S.A., Chintawar,S., Cader,M.Z., Kellett,K.A.B. and Hooper,N.M.<br>Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-beta oligomers<br>J Biol Chem (2019) 294, 7085-7097. PubMed  Europe PubMed DOI
  71. Saha,N., Robev,D., Himanen,J.P. and Nikolov,D.B.<br>ADAM proteases: emerging role and targeting of the non-catalytic domains<br>Cancer Lett (2019) 467, 50-57. PubMed  Europe PubMed DOI
  72. Wichert,R., Scharfenberg,F., Colmorgen,C., Koudelka,T., Schwarz,J., Wetzel,S., Potempa,B., Potempa,J., Bartsch,J.W., Sagi,I., Tholey,A., Saftig,P., Rose-John,S. and Becker-Pauly,C.<br>Meprin beta induces activities of a disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage<br>FASEB J (2019) 33, 11925-11940. PubMed  Europe PubMed DOI
    73. 2018
  73. Bao,X., Shi,J., Xie,F., Liu,Z., Yu,J., Chen,W., Zhang,Z. and Xu,Q.<br>Proteolytic release of the p75(NTR) intracellular domain by ADAM10 promotes metastasis and resistance to anoikis<br>Cancer Res (2018) 78, 2262-2276. PubMed  Europe PubMed DOI
  74. Brummer,T., Pigoni,M., Rossello,A., Wang,H., Noy,P.J., Tomlinson,M.G., Blobel,C.P. and Lichtenthaler,S.F.<br>The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation<br>FASEB J (2018) 32, 3560-3573. PubMed  Europe PubMed DOI
    75. 2017
  75. Matthews,A.L., Noy,P.J., Reyat,J.S. and Tomlinson,M.G.<br>Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: the emerging role of tetraspanins and rhomboids<br>Platelets (2017) 28, 333-341. PubMed  Europe PubMed DOI
  76. Seegar,T.C.M., Killingsworth,L.B., Saha,N., Meyer,P.A., Patra,D., Zimmerman,B., Janes,P.W., Rubinstein,E., Nikolov,D.B., Skiniotis,G., Kruse,A.C. and Blacklow,S.C.<br>Structural basis for regulated proteolysis by the alpha-secretase ADAM10<br>Cell (2017) 171, 1638-1648. PubMed  Europe PubMed DOI  S
  77. Wetzel,S., Seipold,L. and Saftig,P.<br>The metalloproteinase ADAM10: a useful therapeutic target?<br>Biochim Biophys Acta (2017) 1864, 2071-2081. PubMed  Europe PubMed DOI  T
    78. 2016
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