Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M12.210: ADAM10 peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Baek,C.H., Kim,H., Moon,S.Y., Lee,E.K. and Yang,W.S.
    AKT activation triggers Rab14-mediated ADAM10 translocation to the cell surface in human aortic endothelial cells
    Sci Rep15, 7448-7448. PubMed  Europe PubMed DOI  K
  2. Murai,T., Masaki,Y. and Yasuhara,K.
    Curcumin induces IL-6 receptor shedding via the ADAM10 proteinase
    Biochem Biophys Res Commun768, 151939-151939. PubMed  Europe PubMed DOI  I
    3. 2024
  3. Abdalla,A.M., Miao,Y., Ming,N. and Ouyang,C.
    ADAM10 modulates the efficacy of T-cell-mediated therapy in solid tumors
    Immunol Cell Biol PubMed  Europe PubMed DOI
  4. Alexandre-Silva,V. and Cominetti,M.R.
    Unraveling the dual role of ADAM10: Bridging the gap between cancer and Alzheimer's disease
    Mech Ageing Dev219, 111928-111928. PubMed  Europe PubMed DOI  V
  5. Babendreyer,A., Kieselhorst,J., Rinkens,C., Lyashenko,A.M., Dusterhoft,S., Jahr,H., Craveiro,R.B., Wolf,M. and Ludwig,A.
    Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation
    Cell Commun Signal22, 322-322. PubMed  Europe PubMed DOI
  6. Bar,J., Fanutza,T., Reimann,C.C., Seipold,L., Grohe,M., Bolter,J.R., Delfs,F., Bucher,M., Gee,C.E., Schweizer,M., Saftig,P. and Mikhaylova,M.
    Non-canonical function of ADAM10 in presynaptic plasticity
    Cell Mol Life Sci81, 342-342. PubMed  Europe PubMed DOI
  7. Barbaud,A., Lascombe,I., Pechery,A., Arslan,S., Kleinclauss,F. and Fauconnet,S.
    GW501516-Mediated Targeting of Tetraspanin 15 Regulates ADAM10-Dependent N-Cadherin Cleavage in Invasive Bladder Cancer Cells
    Cells13, PubMed  Europe PubMed DOI
  8. de Oliveira,T.R., Manzine,P.R., Cominetti,M.R., Leite,O.D. and Faria,R.C.
    Electrochemical magneto-immunoassay for detection of ADAM10 Alzheimer's biomarker using gold nanoparticles as label
    Talanta266, 125042-125042. PubMed  Europe PubMed DOI
  9. Drexhage,L.Z., Zhang,S., Dupont,M., Ragaller,F., Sjule,E., Cabezas-Caballero,J., Deimel,L.P., Robertson,H., Russell,R.A., Dushek,O., Sezgin,E., Karaji,N. and Sattentau,Q.J.
    Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis
    Nat Commun15, 541-541. PubMed  Europe PubMed DOI
  10. Gharzia,F.G., Aljohmani,A., Beck,A., Philipp,S.E. and Yildiz,D.
    Regulation of ADAM10 activity through microdomain-dependent intracellular calcium changes
    Cell Commun Signal22, 531-531. PubMed  Europe PubMed DOI
  11. Murai,T., Masaki,Y. and Yasuhara,K.
    Curcumin Modulates the Membrane Raft Integrity via Phase Separation and Induces CD44 Shedding in Tumor Cells
    Biochemistry PubMed  Europe PubMed DOI  I
  12. Rosenbaum,D. and Saftig,P.
    New insights into the function and pathophysiology of the ectodomain sheddase A Disintegrin And Metalloproteinase 10 (ADAM10)
    FEBS J291, 2733-2766. PubMed  Europe PubMed DOI  V
    13. 2023
  13. Abraham,C.B., Xu,L., Pantelopulos,G.A. and Straub,J.E.
    Characterizing the transmembrane domains of ADAM10 and BACE1 and the impact of membrane composition
    Biophys J122, 3999-4010. PubMed  Europe PubMed DOI
  14. Aguero-Rabes,P., Perez-Perez,J., Cremades-Jimeno,L., Garcia-Ayllon,M.S., Gea-Gonzalez,A., Sainz,M.J., Mahillo-Fernandez,I., Tellez,R., Cardaba,B., Saez-Valero,J. and Gomez-Tortosa,E.
    ADAM10 Gene Variants in AD Patients and Their Relationship to CSF Protein Levels
    Int J Mol Sci24, PubMed  Europe PubMed DOI
  15. Alfano,D.N., Miller,M.J. and Bubeck Wardenburg,J.
    Endothelial ADAM10 utilization defines a molecular pathway of vascular injury in mice with bacterial sepsis
    J Clin Invest133, PubMed  Europe PubMed DOI
  16. Baek,C.H., Kim,H., Moon,S.Y. and Yang,W.S.
    AMPK boosts ADAM10 shedding activity in human aortic endothelial cells by promoting Rab14-dependent ADAM10 cell surface translocation
    Biochem Biophys Res Commun675, 54-60. PubMed  Europe PubMed DOI  K
  17. Chen,Y.T., Lin,C.W., Chou,Y.E., Su,S.C., Chang,L.C., Lee,C.Y., Hsieh,M.J. and Yang,S.F.
    Potential impact of ADAM-10 genetic variants with the clinical features of oral squamous cell carcinoma
    J Cell Mol Med27, 1144-1152. PubMed  Europe PubMed DOI
  18. Khezri,M.R., Mohebalizadeh,M. and Ghasemnejad-Berenji,M.
    Therapeutic potential of ADAM10 modulation in Alzheimer's disease: a review of the current evidence
    Cell Commun Signal21, 60-60. PubMed  Europe PubMed DOI
  19. Liao,S., Lin,Y., Liu,L., Yang,S., Lin,Y., He,J. and Shao,Y.
    ADAM10-a "multitasker" in sepsis: focus on its posttranslational target
    Inflamm Res72, 395-423. PubMed  Europe PubMed DOI  V
  20. Lipper,C.H., Egan,E.D., Gabriel,K.H. and Blacklow,S.C.
    Structural basis for membrane-proximal proteolysis of substrates by ADAM10
    Cell186, 3632-3641. PubMed  Europe PubMed DOI
  21. Liu,S., Zhang,Z., Li,L., Yao,L., Ma,Z. and Li,J.
    ADAM10- and gamma-secretase-dependent cleavage of the transmembrane protein PTPRT attenuates neurodegeneration in the mouse model of Alzheimer's disease
    FASEB J37, e22734-e22734. PubMed  Europe PubMed DOI
  22. Maas,S.L., Donners,M.M.P.C. and van der Vorst,E.P.C.
    ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis?
    Int J Mol Sci24, PubMed  Europe PubMed DOI  V
  23. Pastore,F., Battistoni,M., Sollazzo,R., Renna,P., Paciello,F., Li Puma,D.D., Barone,E., Dagliyan,O., Ripoli,C. and Grassi,C.
    A Bioengineering Strategy to Control ADAM10 Activity in Living Cells
    Int J Mol Sci24, PubMed  Europe PubMed DOI
  24. Saha,N., Baek,D.S., Mendoza,R.P., Robev,D., Xu,Y., Goldgur,Y., de la Cruz,M.J., de Stanchina,E., Janes,P.W., Xu,K., Dimitrov,D.S. and Nikolov,D.B.
    Fully human monoclonal antibody targeting activated ADAM10 on colorectal cancer cells
    Biomed Pharmacother161, 114494-114494. PubMed  Europe PubMed DOI
    25. 2022
  25. Gul,C., Kilic,S. and Sehitoglu,M.H.
    The importance of a disintegrin and metalloproteinase (ADAM)10 and ADAM17 in the pathogenesis of psoriasis
    Clin Exp Dermatol47, 1673-1678. PubMed  Europe PubMed DOI
  26. Hitschler,L. and Lang,T.
    The transmembrane domain of the amyloid precursor protein is required for antiamyloidogenic processing by alpha-secretase ADAM10
    J Biol Chem298, 101911-101911. PubMed  Europe PubMed DOI
  27. Jocher,G., Grass,V., Tschirner,S.K., Riepler,L., Breimann,S., Kaya,T., Oelsner,M., Hamad,M.S., Hofmann,L.I., Blobel,C.P., Schmidt-Weber,C.B., Gokce,O., Jakwerth,C.A., Trimpert,J., Kimpel,J., Pichlmair,A. and Lichtenthaler,S.F.
    ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion
    EMBO Rep23, e54305-e54305. PubMed  Europe PubMed DOI
  28. Kirschke,S., Ogunsulire,I., Selvakumar,B., Schumacher,N., Sezin,T., Rose-John,S., Scheffold,A., Garbers,C. and Lokau,J.
    The metalloprotease ADAM10 generates soluble interleukin-2 receptor alpha (sCD25) in vivo
    J Biol Chem298, 101910-101910. PubMed  Europe PubMed DOI
  29. Koo,C.Z., Matthews,A.L., Harrison,N., Szyroka,J., Nieswandt,B., Gardiner,E.E., Poulter,N.S. and Tomlinson,M.G.
    The Platelet Collagen Receptor GPVI Is Cleaved by Tspan15/ADAM10 and Tspan33/ADAM10 Molecular Scissors
    Int J Mol Sci23, 2440-2440. PubMed  Europe PubMed DOI
  30. Musardo,S., Therin,S., Pelucchi,S., D'Andrea,L., Stringhi,R., Ribeiro,A., Manca,A., Balducci,C., Pagano,J., Sala,C., Verpelli,C., Grieco,V., Edefonti,V., Forloni,G., Gardoni,F., Meli,G., Di Marino,D., Di Luca,M. and Marcello,E.
    The development of ADAM10 endocytosis inhibitors for the treatment of Alzheimer's disease
    Mol Ther30, 2474-2490. PubMed  Europe PubMed DOI
  31. Reiss,K., Leitzke,S., Seidel,J., Sperrhacke,M. and Bhakdi,S.
    Scramblases as Regulators of Proteolytic ADAM Function
    Membranes (Basel)12, 185-185. PubMed  Europe PubMed DOI
  32. Sezin,T., Selvakumar,B. and Scheffold,A.
    The role of A Disintegrin and Metalloproteinase (ADAM)-10 in T helper cell biology
    Biochim Biophys Acta Mol Cell Res1869, 119192-119192. PubMed  Europe PubMed DOI
  33. Shin,Y., Jo,K.S., Shin,M., Lee,D., Yeo,H., Song,Y. and Kang,S.W.
    Role of redox-sensitive catalytic interaction with ADAM10 in mutant-selective extracellular shedding of prion protein
    Redox Biol56, 102456-102456. PubMed  Europe PubMed DOI
  34. Wang,J.N. and Cao,X.J.
    Targeting ADAM10 in Renal Diseases
    Curr Mol Med PubMed  Europe PubMed DOI  V
  35. Werny,L., Grogro,A., Bickenbach,K., Bulck,C., Armbrust,F., Koudelka,T., Pathak,K., Scharfenberg,F., Sammel,M., Sheikhouny,F., Tholey,A., Linder,S. and Becker-Pauly,C.
    MT1-MMP and ADAM10/17 exhibit a remarkable overlap of shedding properties
    FEBS J290, 93-111. PubMed  Europe PubMed DOI
    36. 2021
  36. Asada-Utsugi,M., Uemura,K., Kubota,M., Noda,Y., Tashiro,Y., Uemura,T.M., Yamakado,H., Urushitani,M., Takahashi,R., Hattori,S., Miyakawa,T., Ageta-Ishihara,N., Kobayashi,K., Kinoshita,M. and Kinoshita,A.
    Mice with cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial learning tasks
    Mol Brain14, 23-23. PubMed  Europe PubMed DOI
  37. Chen,X., Zhang,Y. and Guan,X.
    Simultaneous detection of multiple proteases using a non-array nanopore platform
    Nanoscale13, 13658-13664. PubMed  Europe PubMed DOI
  38. Harrison,N., Koo,C.Z. and Tomlinson,M.G.
    Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential
    Int J Mol Sci22, 6707-6707. PubMed  Europe PubMed DOI  V
  39. Lipper,C.H., Gabriel,K.H., Seegar,T.C.M., Durr,K.L., Tomlinson,M.G. and Blacklow,S.C.
    Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site
    Structure30, 206-214. PubMed  Europe PubMed DOI
  40. Maitra,S., Sornjai,W., Smith,D.R. and Vincent,B.
    Phenanthroline impairs betaAPP processing and expression, increases p53 protein levels and induces cell cycle arrest in human neuroblastoma cells
    Brain Res Bull170, 29-38. PubMed  Europe PubMed DOI  I
  41. Mattila,S.O., Tuhkanen,H.E., Lackman,J.J., Konzack,A., Morato,X., Argerich,J., Saftig,P., Ciruela,F. and Petaja-Repo,U.E.
    GPR37 is processed in the N-terminal ectodomain by ADAM10 and furin
    FASEB J35, e21654-e21654. PubMed  Europe PubMed DOI
  42. Meyer-Schwesinger,C., Seipold,L. and Saftig,P.
    Ectodomain shedding by ADAM proteases as a central regulator in kidney physiology and disease
    Biochim Biophys Acta Mol Cell Res119165-119165. PubMed  Europe PubMed DOI
  43. Oclon,E. and Hrabia,A.
    miRNA expression profile in chicken ovarian follicles throughout development and miRNA-mediated MMP expression
    Theriogenology160, 116-127. PubMed  Europe PubMed DOI
  44. Pereira Vatanabe,I., Peron,R., Mantellatto Grigoli,M., Pelucchi,S., De Cesare,G., Magalhaes,T., Manzine,P.R., Figueredo Balthazar,M.L., Di Luca,M., Marcello,E. and Cominetti,M.R.
    ADAM10 Plasma and CSF Levels Are Increased in Mild Alzheimer's Disease
    Int J Mol Sci22, PubMed  Europe PubMed DOI
  45. Rahn,S. and Becker-Pauly,C.
    Meprin and ADAM proteases as triggers of systemic inflammation in sepsis
    FEBS Lett596, 534-556. PubMed  Europe PubMed DOI
  46. Sachs,M., Wetzel,S., Reichelt,J., Sachs,W., Schebsdat,L., Zielinski,S., Seipold,L., Heintz,L., Muller,S.A., Kretz,O., Lindenmeyer,M., Wiech,T., Huber,T.B., Lullmann-Rauch,R., Lichtenthaler,S.F., Saftig,P. and Meyer-Schwesinger,C.
    ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage
    J Am Soc Nephrol32, 1389-1408. PubMed  Europe PubMed DOI
  47. Seidel,J., Leitzke,S., Ahrens,B., Sperrhacke,M., Bhakdi,S. and Reiss,K.
    Role of ADAM10 and ADAM17 in Regulating CD137 Function
    Int J Mol Sci22, 2730-2730. PubMed  Europe PubMed DOI
  48. Seifert,A., Dusterhoft,S., Wozniak,J., Koo,C.Z., Tomlinson,M.G., Nuti,E., Rossello,A., Cuffaro,D., Yildiz,D. and Ludwig,A.
    The metalloproteinase ADAM10 requires its activity to sustain surface expression
    Cell Mol Life Sci78, 715-732. PubMed  Europe PubMed DOI
  49. Thonda,S., Puttapaka,S.N., Kona,S.V. and Kalivendi,S.V.
    Extracellular-Signal-Regulated Kinase Inhibition Switches APP Processing from beta- to alpha-Secretase under Oxidative Stress: Modulation of ADAM10 by SIRT1/NF-kappaB Signaling
    ACS Chem Neurosci12, 4175-4186. PubMed  Europe PubMed DOI
  50. Tosetti,F., Alessio,M., Poggi,A. and Zocchi,M.R.
    ADAM10 Site-Dependent Biology: Keeping Control of a Pervasive Protease
    Int J Mol Sci22, 4969-4969. PubMed  Europe PubMed DOI
  51. Zhang,X., Tang,L. and Zhang,Z.
    ADAM10 and ADAM17 are degraded by lysosomal pathway via asparagine endopeptidase
    Biochem Biophys Res Commun537, 15-21. PubMed  Europe PubMed DOI
    52. 2020
  52. Aguero,P., Sainz,M.J., Garcia-Ayllon,M.S., Saez-Valero,J., Tellez,R., Guerrero-Lopez,R., Perez-Perez,J., Jimenez-Escrig,A. and Gomez-Tortosa,E.
    alpha-Secretase nonsense mutation (ADAM10 Tyr167*) in familial Alzheimer's disease
    Alzheimers Res Ther12, 139-139. PubMed  Europe PubMed DOI
  53. Andrews,L.P., Somasundaram,A., Moskovitz,J.M., Szymczak-Workman,A.L., Liu,C., Cillo,A.R., Lin,H., Normolle,D.P., Moynihan,K.D., Taniuchi,I., Irvine,D.J., Kirkwood,J.M., Lipson,E.J., Ferris,R.L., Bruno,T.C., Workman,C.J. and Vignali,D.A.A.
    Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding
    Sci Immunol5, PubMed  Europe PubMed DOI
  54. Chung,H.K. and Lin,M.Z.
    On the cutting edge: protease-based methods for sensing and controlling cell biology
    Nat Methods PubMed  Europe PubMed DOI  V
  55. Escamilla-Ayala,A.A., Sannerud,R., Mondin,M., Poersch,K., Vermeire,W., Paparelli,L., Berlage,C., Koenig,M., Chavez-Gutierrez,L., Ulbrich,M.H., Munck,S., Mizuno,H. and Annaert,W.
    Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/gamma-secretase at the cell surface
    elife9, PubMed  Europe PubMed DOI
  56. Kim,N. and Lee,H.J.
    Target Enzymes Considered for the Treatment of Alzheimer's Disease and Parkinson's Disease
    Biomed Res Int2020, 2010728-2010728. PubMed  Europe PubMed DOI  V
  57. Li,B., Zhu,C., Dong,L., Qin,J., Xiang,W., Davidson,A.J., Feng,S., Wang,Y., Shen,X., Weng,C., Wang,C., Zhu,T., Teng,L., Wang,J., Englert,C., Chen,J. and Jiang,H.
    ADAM10 mediates ectopic proximal tubule development and renal fibrosis through Notch signalling
    J Pathol PubMed  Europe PubMed DOI
  58. Lu,W., Fei,A., Jiang,Y., Chen,L. and Wang,Y.
    Tetraspanin CD9 interacts with alpha-secretase to enhance its oncogenic function in pancreatic cancer
    Am J Transl Res12, 5525-5537. PubMed  Europe PubMed  K
  59. Mizuno,S., Yoda,M., Kimura,T., Shimoda,M., Akiyama,H., Chiba,K., Nakamura,M. and Horiuchi,K.
    ADAM10 is indispensable for longitudinal bone growth in mice
    Bone134, 115273-115273. PubMed  Europe PubMed DOI
  60. Mori,T., Koyama,N., Yokoo,T., Segawa,T., Maeda,M., Sawmiller,D., Tan,J. and Town,T.
    Gallic Acid is a Dual alpha/beta-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice
    J Biol Chem PubMed  Europe PubMed DOI
  61. Scharfenberg,F., Helbig,A., Sammel,M., Benzel,J., Schlomann,U., Peters,F., Wichert,R., Bettendorff,M., Schmidt-Arras,D., Rose-John,S., Moali,C., Lichtenthaler,S.F., Pietrzik,C.U., Bartsch,J.W., Tholey,A. and Becker-Pauly,C.
    Degradome of soluble ADAM10 and ADAM17 metalloproteases
    Cell Mol Life Sci77, 331-350. PubMed  Europe PubMed DOI  P
  62. Smith TM Jr, Tharakan,A. and Martin,R.K.
    Targeting ADAM10 in cancer and autoimmunity
    Front Immunol11, 499-499. PubMed  Europe PubMed DOI
    63. 2019
  63. Jarosz-Griffiths,H.H., Corbett,N.J., Rowland,H.A., Fisher,K., Jones,A.C., Baron,J., Howell,G.J., Cowley,S.A., Chintawar,S., Cader,M.Z., Kellett,K.A.B. and Hooper,N.M.
    Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-beta oligomers
    J Biol Chem294, 7085-7097. PubMed  Europe PubMed DOI
  64. Saha,N., Robev,D., Himanen,J.P. and Nikolov,D.B.
    ADAM proteases: emerging role and targeting of the non-catalytic domains
    Cancer Lett467, 50-57. PubMed  Europe PubMed DOI
  65. Wichert,R., Scharfenberg,F., Colmorgen,C., Koudelka,T., Schwarz,J., Wetzel,S., Potempa,B., Potempa,J., Bartsch,J.W., Sagi,I., Tholey,A., Saftig,P., Rose-John,S. and Becker-Pauly,C.
    Meprin beta induces activities of a disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage
    FASEB J33, 11925-11940. PubMed  Europe PubMed DOI
    66. 2018
  66. Bao,X., Shi,J., Xie,F., Liu,Z., Yu,J., Chen,W., Zhang,Z. and Xu,Q.
    Proteolytic release of the p75(NTR) intracellular domain by ADAM10 promotes metastasis and resistance to anoikis
    Cancer Res78, 2262-2276. PubMed  Europe PubMed DOI
  67. Brummer,T., Pigoni,M., Rossello,A., Wang,H., Noy,P.J., Tomlinson,M.G., Blobel,C.P. and Lichtenthaler,S.F.
    The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation
    FASEB J32, 3560-3573. PubMed  Europe PubMed DOI
    68. 2017
  68. Matthews,A.L., Noy,P.J., Reyat,J.S. and Tomlinson,M.G.
    Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: the emerging role of tetraspanins and rhomboids
    Platelets28, 333-341. PubMed  Europe PubMed DOI
  69. Seegar,T.C.M., Killingsworth,L.B., Saha,N., Meyer,P.A., Patra,D., Zimmerman,B., Janes,P.W., Rubinstein,E., Nikolov,D.B., Skiniotis,G., Kruse,A.C. and Blacklow,S.C.
    Structural basis for regulated proteolysis by the alpha-secretase ADAM10
    Cell171, 1638-1648. PubMed  Europe PubMed DOI  S
  70. Wetzel,S., Seipold,L. and Saftig,P.
    The metalloproteinase ADAM10: a useful therapeutic target?
    Biochim Biophys Acta1864, 2071-2081. PubMed  Europe PubMed DOI  T
    71. 2016
  71. Atapattu,L., Saha,N., Chheang,C., Eissman,M.F., Xu,K., Vail,M.E., Hii,L., Llerena,C., Liu,Z., Horvay,K., Abud,H.E., Kusebauch,U., Moritz,R.L., Ding,B.S., Cao,Z., Rafii,S., Ernst,M., Scott,A.M., Nikolov,D.B., Lackmann,M. and Janes,P.W.
    An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth
    J Exp Med213, 1741-1757. PubMed  Europe PubMed DOI
  72. Camodeca,C., Nuti,E., Tepshi,L., Boero,S., Tuccinardi,T., Stura,E.A., Poggi,A., Zocchi,M.R. and Rossello,A.
    Discovery of a new selective inhibitor of a disintegrin and metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models
    Eur J Med Chem111, 193-201. PubMed  Europe PubMed DOI  I
  73. Franke,M., Schroder,J., Monhasery,N., Ackfeld,T., Hummel,T.M., Rabe,B., Garbers,C., Becker-Pauly,C., Floss,D.M. and Scheller,J.
    Human and murine Interleukin 23 receptors are novel substrates for a disintegrin and metalloproteases ADAM10 and ADAM17
    J Biol Chem291, 10551-10561. PubMed  Europe PubMed DOI
  74. Lokau,J., Nitz,R., Agthe,M., Monhasery,N., Aparicio-Siegmund,S., Schumacher,N., Wolf,J., Moller-Hackbarth,K., Waetzig,G.H., Grotzinger,J., Muller-Newen,G., Rose-John,S., Scheller,J. and Garbers,C.
    Proteolytic cleavage governs interleukin-11 trans-signaling
    Cell Rep14, 1761-1773. PubMed  Europe PubMed DOI  P
  75. Moss,M.L., Minond,D., Yoneyama,T., Hansen,H.P., Vujanovic,N. and Rasmussen,F.H.
    An improved fluorescent substrate for assaying soluble and membrane-associated ADAM family member activities
    Anal Biochem507, 13-17. PubMed  Europe PubMed DOI  A
  76. Orme,J.J., Du,Y., Vanarsa,K., Mayeux,J., Li,L., Mutwally,A., Arriens,C., Min,S., Hutcheson,J., Davis,L.S., Chong,B.F., Satterthwaite,A.B., Wu,T. and Mohan,C.
    Heightened cleavage of Axl receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE
    Clin Immunol169, 58-68. PubMed  Europe PubMed DOI  T
  77. Riethmueller,S., Ehlers,J.C., Lokau,J., Dusterhoft,S., Knittler,K., Dombrowsky,G., Grotzinger,J., Rabe,B., Rose-John,S. and Garbers,C.
    Cleavage site localization differentially controls interleukin-6 receptor proteolysis by ADAM10 and ADAM17
    Sci Rep6, 25550-25550. PubMed  Europe PubMed DOI  P
    78. 2015
  78. Chen,A.C., Kim,S., Shepardson,N., Patel,S., Hong,S. and Selkoe,D.J.
    Physical and functional interaction between the alpha- and gamma-secretases: a new model of regulated intramembrane proteolysis
    J Cell Biol211, 1157-1176. PubMed  Europe PubMed DOI
  79. Maretzky,T., Evers,A., Le Gall,S., Alabi,R.O., Speck,N., Reiss,K. and Blobel,C.P.
    The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding
    J Biol Chem290, 7416-7425. PubMed  Europe PubMed DOI
  80. Mizuno,S., Yoda,M., Shimoda,M., Tohmonda,T., Okada,Y., Toyama,Y., Takeda,S., Nakamura,M., Matsumoto,M. and Horiuchi,K.
    A disintegrin and metalloprotease 10 (ADAM10) is indispensable for maintenance of the muscle satellite cell pool
    J Biol Chem290, 28456-28464. PubMed  Europe PubMed DOI  K
  81. Saftig,P. and Lichtenthaler,S.F.
    The alpha secretase ADAM10: a metalloprotease with multiple functions in the brain
    Prog Neurobiol135, 1-20. PubMed  Europe PubMed DOI  V
  82. van der Vorst,E.P., Jeurissen,M., Wolfs,I.M., Keijbeck,A., Theodorou,K., Wijnands,E., Schurgers,L., Weber,S., Gijbels,M.J., Hamers,A.A., Dreymueller,D., Rose-John,S., de Winther,M.P., Ludwig,A., Saftig,P., Biessen,E.A. and Donners,M.M.
    Myeloid a disintegrin and metalloproteinase domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis
    Am J Pathol185, 1145-1155. PubMed  Europe PubMed DOI  K
  83. Wong,E., Maretzky,T., Peleg,Y., Blobel,C.P. and Sagi,I.
    The functional maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 requires processing at a newly identified proprotein convertase (PC) cleavage site
    J Biol Chem290, 12135-12146. PubMed  Europe PubMed DOI
    84. 2014
  84. Faber,T.W., Pullen,N.A., Fernando,J.F., Kolawole,E.M., McLeod,J.J., Taruselli,M., Williams,K.L., Rivera,K.O., Barnstein,B.O., Conrad,D.H. and Ryan,J.J.
    ADAM10 is required for SCF-induced mast cell migration
    Cell Immunol290, 80-88. PubMed  Europe PubMed DOI  K
  85. Groot,A.J., Habets,R., Yahyanejad,S., Hodin,C.M., Reiss,K., Saftig,P., Theys,J. and Vooijs,M.
    Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins
    Mol Cell Biol34, 2822-2832. PubMed  Europe PubMed DOI
  86. Herzog,C., Haun,R.S., Ludwig,A., Shah,S.V. and Kaushal,G.P.
    ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A
    J Biol Chem289, 13308-13322. PubMed  Europe PubMed DOI
  87. Prox,J. and Saftig,P.
    ADAM10: alpha-secretase in Alzheimer disease and regulator in neurobiology
    Neuroforum20, 212-220.
  88. Pruessmeyer,J., Hess,F.M., Alert,H., Groth,E., Pasqualon,T., Schwarz,N., Nyamoya,S., Kollert,J., van der Vorst,E., Donners,M., Martin,C., Uhlig,S., Saftig,P., Dreymueller,D. and Ludwig,A.
    Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space
    Blood123, 4077-4088. PubMed  Europe PubMed DOI
  89. Raikwar,N.S., Liu,K.Z. and Thomas,C.P.
    N-Terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domain
    PLoS ONE9, e112794-e112794. PubMed  Europe PubMed DOI
  90. Sonderegger,P. and Matsumoto-Miyai,K.
    Activity-controlled proteolytic cleavage at the synapse
    Trends Neurosci37, 413-423. PubMed  Europe PubMed DOI
    91. 2013
  91. Isozaki,T., Rabquer,B.J., Ruth,J.H., Haines,G.K., III and Koch,A.E.
    ADAM-10 is overexpressed in rheumatoid arthritis synovial tissue and mediates angiogenesis
    Arthritis Rheum65, 98-108. PubMed  Europe PubMed DOI
  92. Miller,M.A., Meyer,A.S., Beste,M.T., Lasisi,Z., Reddy,S., Jeng,K.W., Chen,C.H., Han,J., Isaacson,K., Griffith,L.G. and Lauffenburger,D.A.
    ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling
    Proc Natl Acad Sci U S A110, E2074-E2083. PubMed  Europe PubMed DOI
  93. Moller-Hackbarth,K., Dewitz,C., Schweigert,O., Trad,A., Garbers,C., Rose-John,S. and Scheller,J.
    A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3 (Tim-3)
    J Biol Chem288, 34529-34544. PubMed  Europe PubMed DOI
  94. Prox,J., Bernreuther,C., Altmeppen,H., Grendel,J., Glatzel,M., D'Hooge,R., Stroobants,S., Ahmed,T., Balschun,D., Willem,M., Lammich,S., Isbrandt,D., Schweizer,M., Horre,K., De Strooper,B. and Saftig,P.
    Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions
    J Neurosci33, 12915-12928. PubMed  Europe PubMed DOI  K
    95. 2012
  95. Endres,K. and Fahrenholz,F.
    Regulation of alpha-secretase ADAM10 expression and activity
    Exp Brain Res217, 343-352. PubMed  Europe PubMed DOI  U
  96. Endres,K. and Fahrenholz,F.
    The role of the anti-amyloidogenic secretase ADAM10 in shedding the APP-like proteins
    Curr Alzheimer Res9, 157-164. PubMed  Europe PubMed DOI
  97. Postina,R. and Fahrenholz,F.
    ADAM10, myelin-associated metalloendopeptidase
    [ISSN:978-0-12-407744-7]3, 1108-1114. DOI
    98. 2011
  98. Altmeppen,H.C., Prox,J., Puig,B., Kluth,M.A., Bernreuther,C., Thurm,D., Jorissen,E., Petrowitz,B., Bartsch,U., De Strooper,B., Saftig,P. and Glatzel,M.
    Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo
    Mol Neurodegener6, 36-36. PubMed  Europe PubMed DOI  K
  99. Bouillot,S., Tillet,E., Carmona,G., Prandini,M.H., Gauchez,A.S., Hoffmann,P., Alfaidy,N., Cand,F. and Huber,P.
    Protocadherin-12 cleavage is a regulated process mediated by ADAM10 protein: evidence of shedding up-regulation in pre-eclampsia
    J Biol Chem286, 15195-15204. PubMed  Europe PubMed DOI
  100. Cong,R., Li,Y. and Biemesderfer,D.
    A disintegrin and metalloprotease 10 activity sheds the ectodomain of the amyloid precursor-like protein 2 and regulates protein expression in proximal tubule cells
    Am J Physiol Cell Physiol300, C1366-C1374. PubMed  Europe PubMed DOI
  101. Esteve,P., Sandonis,A., Cardozo,M., Malapeira,J., Ibanez,C., Crespo,I., Marcos,S., Gonzalez-Garcia,S., Toribio,M.L., Arribas,J., Shimono,A., Guerrero,I. and Bovolenta,P.
    SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis
    Nat Neurosci14, 562-569. PubMed  Europe PubMed DOI
  102. Garbers,C., Janner,N., Chalaris,A., Moss,M.L., Floss,D.M., Meyer,D., Koch-Nolte,F., Rose-John,S. and Scheller,J.
    Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding
    J Biol Chem286, 14804-14811. PubMed  Europe PubMed DOI
  103. Hogl,S., Kuhn,P.H., Colombo,A. and Lichtenthaler,S.F.
    Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and gamma-secretase
    PLoS ONE6, e21337-e21337. PubMed  Europe PubMed DOI  P
  104. Laws,S.M., Eckart,K., Friedrich,P., Kurz,A., Forstl,H. and Riemenschneider,M.
    Lack of evidence to support the association of polymorphisms within the alpha- and beta-secretase genes (ADAM10/BACE1) with Alzheimer's disease
    Neurobiol Aging32, 541-543. PubMed  Europe PubMed DOI  M
  105. Lichtenthaler,S.F.
    alpha-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potential
    J Neurochem116, 10-21. PubMed  Europe PubMed DOI
  106. Mathews,J.A., Ford,J., Norton,S., Kang,D., Dellinger,A., Gibb,D.R., Ford,A.Q., Massay,H., Kepley,C.L., Scherle,P., Keegan,A.D. and Conrad,D.H.
    A potential new target for asthma therapy: A Disintegrin and Metalloprotease 10 (ADAM10) involvement in murine experimental asthma
    Allergy66, 1193-1200. PubMed  Europe PubMed DOI
  107. Saftig,P. and Reiss,K.
    The "A Disintegrin And Metalloproteases" ADAM10 and ADAM17: novel drug targets with therapeutic potential?
    Eur J Cell Biol90, 527-535. PubMed  Europe PubMed DOI
  108. Schelter,F., Grandl,M., Seubert,B., Schaten,S., Hauser,S., Gerg,M., Boccaccio,C., Comoglio,P. and Kruger,A.
    Tumor cell-derived Timp-1 is necessary for maintaining metastasis-promoting Met-signaling via inhibition of Adam-10
    Clin Exp Metastasis28, 793-802. PubMed  Europe PubMed DOI
  109. Sulis,M.L., Saftig,P. and Ferrando,A.A.
    Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL
    Leukemia25, 1564-1569. PubMed  Europe PubMed DOI
  110. Weber,S., Niessen,M.T., Prox,J., Lullmann-Rauch,R., Schmitz,A., Schwanbeck,R., Blobel,C.P., Jorissen,E., De Strooper,B., Niessen,C.M. and Saftig,P.
    The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling
    Development138, 495-505. PubMed  Europe PubMed DOI  K
    111. 2010
  111. Endres,K. and Fahrenholz,F.
    Upregulation of the alpha-secretase ADAM10 - risk or reason for hope?
    FEBS J277, 1585-1596. PubMed  Europe PubMed DOI  V
  112. Fahrenholz,F., Tippmann,F. and Endres,K.
    Retinoids as a perspective in treatment of Alzheimer's disease
    Neurodegener Dis7, 190-192. PubMed  Europe PubMed DOI  U
  113. Fahrenholz,F.
    The close link between retinoid signalling and the alpha-secretase ADAM10 and its potential for treating Alzheimer's disease (commentary on Jarvis et al.)
    Eur J Neurosci32, 1245-1245. PubMed  Europe PubMed
  114. Gibb,D.R., El Shikh,M., Kang,D.J., Rowe,W.J., El Sayed,R., Cichy,J., Yagita,H., Tew,J.G., Dempsey,P.J., Crawford,H.C. and Conrad,D.H.
    ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo
    J Exp Med207, 623-635. PubMed  Europe PubMed DOI
  115. Jorissen,E., Prox,J., Bernreuther,C., Weber,S., Schwanbeck,R., Serneels,L., Snellinx,A., Craessaerts,K., Thathiah,A., Tesseur,I., Bartsch,U., Weskamp,G., Blobel,C.P., Glatzel,M., De Strooper,B. and Saftig,P.
    The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex
    J Neurosci30, 4833-4844. PubMed  Europe PubMed DOI  K
  116. Kim,J., Lilliehook,C., Dudak,A., Prox,J., Saftig,P., Federoff,H.J. and Lim,S.T.
    Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10)
    J Biol Chem285, 22919-22926. PubMed  Europe PubMed DOI
  117. Kuhn,P.H., Wang,H., Dislich,B., Colombo,A., Zeitschel,U., Ellwart,J.W., Kremmer,E., Rossner,S. and Lichtenthaler,S.F.
    ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons
    EMBO J29, 3020-3032. PubMed  Europe PubMed DOI
  118. Mathews,J.A., Gibb,D.R., Chen,B.H., Scherle,P. and Conrad,D.H.
    CD23 sheddase A disintegrin and metalloproteinase 10 (ADAM10) is also required for CD23 sorting into B cell-derived exosomes
    J Biol Chem285, 37531-37541. PubMed  Europe PubMed DOI
  119. Mendelson,K., Swendeman,S., Saftig,P. and Blobel,C.P.
    Stimulation of platelet-derived growth factor receptor beta (PDGFRbeta) activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor (EGFR) signaling pathways
    J Biol Chem285, 25024-25032. PubMed  Europe PubMed DOI
  120. Rose,A.A., Annis,M.G., Dong,Z., Pepin,F., Hallett,M., Park,M. and Siegel,P.M.
    ADAM10 releases a soluble form of the GPNMB/osteoactivin extracellular domain with angiogenic properties
    PLoS ONE5, e12093-e12093. PubMed  Europe PubMed DOI
  121. Schelter,F., Kobuch,J., Moss,M.L., Becherer,J.D., Comoglio,P.M., Boccaccio,C. and Kruger,A.
    A disintegrin and metalloproteinase-10 (ADAM-10) mediates DN30 antibody-induced shedding of the met surface receptor
    J Biol Chem285, 26335-26340. PubMed  Europe PubMed DOI
  122. Wilke,G.A. and Bubeck Wardenburg,J.
    Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury
    Proc Natl Acad Sci U S A107, 13473-13478. PubMed  Europe PubMed DOI
  123. Xu,Q., Liu,X., Chen,W. and Zhang,Z.
    Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference
    J Transl Med8, 136-136. PubMed  Europe PubMed DOI
  124. Zhang,C., Tian,L., Chi,C., Wu,X., Yang,X., Han,M., Xu,T., Zhuang,Y. and Deng,K.
    Adam10 is essential for early embryonic cardiovascular development
    Dev Dyn239, 2594-2602. PubMed  Europe PubMed DOI  K
    125. 2009
  125. Anderegg,U., Eichenberg,T., Parthaune,T., Haiduk,C., Saalbach,A., Milkova,L., Ludwig,A., Grosche,J., Averbeck,M., Gebhardt,C., Voelcker,V., Sleeman,J.P. and Simon,J.C.
    ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells
    J Invest Dermatol129, 1471-1482. PubMed  Europe PubMed DOI
  126. Bloch,L., Sineshchekova,O., Reichenbach,D., Reiss,K., Saftig,P., Kuro-o,M. and Kaether,C.
    Klotho is a substrate for alpha-, beta- and gamma-secretase
    FEBS Lett583, 3221-3224. PubMed  Europe PubMed DOI
  127. Bozkulak,E.C. and Weinmaster,G.
    Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling
    Mol Cell Biol29, 5679-5695. PubMed  Europe PubMed DOI
  128. Burns,D.M., Li,Y.L., Shi,E., He,C., Xu,M., Zhuo,J., Zhang,C., Qian,D.Q., Li,Y., Wynn,R., Covington,M.B., Katiyar,K., Marando,C.A., Fridman,J.S., Scherle,P., Friedman,S., Metcalf,B. and Yao,W.
    Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition
    Bioorg Med Chem Lett19, 3525-3530. PubMed  Europe PubMed DOI  I
  129. Caescu,C.I., Jeschke,G.R. and Turk,B.E.
    Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10
    Biochem J424, 79-88. PubMed  Europe PubMed DOI  P
  130. Franzke,C.W., Bruckner-Tuderman,L. and Blobel,C.P.
    Shedding of collagen XVII/BP180 in skin depends on both ADAM10 and ADAM9
    J Biol Chem284, 23386-23396. PubMed  Europe PubMed DOI  I
  131. Freese,C., Garratt,A.N., Fahrenholz,F. and Endres,K.
    The effects of alpha-secretase ADAM10 on the proteolysis of neuregulin-1
    FEBS J276, 1568-1580. PubMed  Europe PubMed DOI
  132. Hata,S., Fujishige,S., Araki,Y., Kato,N., Araseki,M., Nishimura,M., Hartmann,D., Saftig,P., Fahrenholz,F., Taniguchi,M., Urakami,K., Akatsu,H., Martins,R.N., Yamamoto,K., Maeda,M., Yamamoto,T., Nakaya,T., Gandy,S. and Suzuki,T.
    Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction
    J Biol Chem284, 36024-36033. PubMed  Europe PubMed DOI
  133. Soundararajan,R., Sayat,R., Robertson,G.S. and Marignani,P.A.
    Triptolide: an inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells
    Cancer Biol Ther8, 2054-2062. PubMed  Europe PubMed  I
  134. Stamenkovic,I. and Yu,Q.
    Shedding light on proteolytic cleavage of CD44: the responsible sheddase and functional significance of shedding
    J Invest Dermatol129, 1321-1324. PubMed  Europe PubMed DOI
  135. Tippmann,F., Hundt,J., Schneider,A., Endres,K. and Fahrenholz,F.
    Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin
    FASEB J23, 1643-1654. PubMed  Europe PubMed DOI  U  I
  136. Tousseyn,T., Thathiah,A., Jorissen,E., Raemaekers,T., Konietzko,U., Reiss,K., Maes,E., Snellinx,A., Serneels,L., Nyabi,O., Annaert,W., Saftig,P., Hartmann,D. and De Strooper,B.
    ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase
    J Biol Chem284, 11738-11747. PubMed  Europe PubMed DOI
  137. van Tetering,G., van Diest,P., Verlaan,I., van der Wall,E., Kopan,R. and Vooijs,M.
    Metalloprotease ADAM10 is required for Notch1 site 2 cleavage
    J Biol Chem284, 31018-31027. PubMed  Europe PubMed DOI
    138. 2008
  138. Bell,K.F., Zheng,L., Fahrenholz,F. and Cuello,A.C.
    ADAM-10 over-expression increases cortical synaptogenesis
    Neurobiol Aging29, 554-565. PubMed  Europe PubMed DOI
  139. Dehmel,T., Goebel,H.H., Hartung,H.P., Lehmann,H., Wiendl,H. and Kieseier,B.C.
    The metalloproteinase-disintegrin ADAM10 is exclusively expressed by type I muscle fibers
    Muscle Nerve38, 1049-1051. PubMed  Europe PubMed DOI
  140. Deuss,M., Reiss,K. and Hartmann,D.
    Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17
    Curr Alzheimer Res5, 187-201. PubMed  Europe PubMed DOI  K  V
  141. Postina,R.
    A closer look at alpha-secretase
    Curr Alzheimer Res5, 179-186. PubMed  Europe PubMed DOI
  142. Rapti,M., Atkinson,S.J., Lee,M.H., Trim,A., Moss,M. and Murphy,G.
    The isolated N-terminal domains of TIMP-1 and TIMP-3 are insufficient for ADAM10 inhibition
    Biochem J411, 433-439. PubMed  Europe PubMed DOI
  143. Schulz,B., Pruessmeyer,J., Maretzky,T., Ludwig,A., Blobel,C.P., Saftig,P. and Reiss,K.
    ADAM10 regulates endothelial permeability and T-cell transmigration by proteolysis of vascular endothelial cadherin
    Circ Res102, 1192-1201. PubMed  Europe PubMed DOI
  144. Tian,L., Wu,X., Chi,C., Han,M., Xu,T. and Zhuang,Y.
    ADAM10 is essential for proteolytic activation of Notch during thymocyte development
    Int Immunol20, 1181-1187. PubMed  Europe PubMed DOI  K
    145. 2007
  145. Arima,T., Enokida,H., Kubo,H., Kagara,I., Matsuda,R., Toki,K., Nishimura,H., Chiyomaru,T., Tatarano,S., Idesako,T., Nishiyama,K. and Nakagawa,M.
    Nuclear translocation of ADAM-10 contributes to the pathogenesis and progression of human prostate cancer
    Cancer Sci98, 1720-1726. PubMed  Europe PubMed DOI
  146. [YEAR:1-1-2007]Carey,B.W., Kim,D.Y. and Kovacs,D.M.
    Presenilin/gamma-secretase and alpha-secretase-like peptidases cleave human MHC Class I proteins
    Biochem J401, 121-127. PubMed  Europe PubMed DOI
  147. Fahrenholz,F.
    Alpha-secretase as a therapeutic target
    Curr Alzheimer Res4, 412-417. PubMed  Europe PubMed DOI  U
  148. Gardiner,E.E., Karunakaran,D., Shen,Y., Arthur,J.F., Andrews,R.K. and Berndt,M.C.
    Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases
    J Thromb Haemost5, 1530-1537. PubMed  Europe PubMed DOI
  149. Kirkin,V., Cahuzac,N., Guardiola-Serrano,F., Huault,S., Luckerath,K., Friedmann,E., Novac,N., Wels,W.S., Martoglio,B., Hueber,A.O. and Zornig,M.
    The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells
    Cell Death Differ14, 1678-1687. PubMed  Europe PubMed DOI
  150. Lemieux,G.A., Blumenkron,F., Yeung,N., Zhou,P., Williams,J., Grammer,A.C., Petrovich,R., Lipsky,P.E., Moss,M.L. and Werb,Z.
    The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10
    J Biol Chem282, 14836-14844. PubMed  Europe PubMed DOI
  151. Moss,M.L., Bomar,M., Liu,Q., Sage,H., Dempsey,P., Lenhart,P.M., Gillispie,P.A., Stoeck,A., Wildeboer,D., Bartsch,J.W., Palmisano,R. and Zhou,P.
    The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events
    J Biol Chem282, 35712-35721. PubMed  Europe PubMed DOI
  152. Moss,M.L. and Rasmussen,F.H.
    Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening
    Anal Biochem366, 144-148. PubMed  Europe PubMed DOI  A  I
  153. Muraguchi,T., Takegami,Y., Ohtsuka,T., Kitajima,S., Chandana,E.P., Omura,A., Miki,T., Takahashi,R., Matsumoto,N., Ludwig,A., Noda,M. and Takahashi,C.
    RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity
    Nat Neurosci10, 838-845. PubMed  Europe PubMed DOI
    154. 2006
  154. Fahrenholz,F. and Postina,R.
    alpha-Secretase activation - an approach to Alzheimer's disease therapy
    Neurodegener Dis3, 255-261. PubMed  Europe PubMed DOI  U
  155. [YEAR:19-4-2006]Obregon,D.F., Rezai-Zadeh,K., Bai,Y., Sun,N., Hou,H., Ehrhart,J., Zeng,J., Mori,T., Arendash,G.W., Shytle,D., Town,T. and Tan,J.
    ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein
    J Biol Chem281, 16419-16427. PubMed  Europe PubMed DOI
  156. [YEAR:2-6-2006]Reiss,K., Maretzky,T., Haas,I.G., Schulte,M., Ludwig,A., Frank,M. and Saftig,P.
    Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion
    J Biol Chem281, 21735-21744. PubMed  Europe PubMed DOI
  157. [YEAR:30-9-2006]Schmitt,U., Hiemke,C., Fahrenholz,F. and Schroeder,A.
    Over-expression of two different forms of the alpha-secretase ADAM10 affects learning and memory in mice
    Behav Brain Res175, 278-284. PubMed  Europe PubMed DOI  U
  158. Weskamp,G., Ford,J.W., Sturgill,J., Martin,S., Docherty,A.J., Swendeman,S., Broadway,N., Hartmann,D., Saftig,P., Umland,S., Sehara-Fujisawa,A., Black,R.A., Ludwig,A., Becherer,J.D., Conrad,D.H. and Blobel,C.P.
    ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23
    Nat Immunol7, 1293-1298. PubMed  Europe PubMed DOI
    159. 2005
  159. [YEAR:21-10-2005]Janes,P.W., Saha,N., Barton,W.A., Kolev,M.V., Wimmer-Kleikamp,S.H., Nievergall,E., Blobel,C.P., Himanen,J.P., Lackmann,M. and Nikolov,D.B.
    Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans
    Cell123, 291-304. PubMed  Europe PubMed DOI
  160. [YEAR:21-10-2005]Mancia,F. and Shapiro,L.
    ADAM and Eph: how ephrin-signaling cells become detached
    Cell123, 185-187. PubMed  Europe PubMed DOI
  161. [YEAR:1-6-2005]Manilay,J.O., Anderson,A.C., Kang,C. and Robey,E.A.
    Impairment of thymocyte development by dominant-negative Kuzbanian (ADAM-10) is rescued by the Notch ligand, Delta-1
    J Immunol174, 6732-6741. PubMed  Europe PubMed
  162. Maretzky,T., Reiss,K., Ludwig,A., Buchholz,J., Scholz,F., Proksch,E., De Strooper,B., Hartmann,D. and Saftig,P.
    ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation
    Proc Natl Acad Sci U S A102, 9182-9187. PubMed  Europe PubMed DOI
  163. Reiss,K., Maretzky,T., Ludwig,A., Tousseyn,T., De Strooper,B., Hartmann,D. and Saftig,P.
    ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling
    EMBO J24, 742-752. PubMed  Europe PubMed DOI
  164. [YEAR:21-1-2005]Sanderson,M.P., Erickson,S.N., Gough,P.J., Garton,K.J., Wille,P.T., Raines,E.W., Dunbar,A.J. and Dempsey,P.J.
    ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx
    J Biol Chem280, 1826-1837. PubMed  Europe PubMed DOI
    165. 2004
  165. Allinson,T.M., Parkin,E.T., Condon,T.P., Schwager,S.L., Sturrock,E.D., Turner,A.J. and Hooper,N.M.
    The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein
    Eur J Biochem271, 2539-2547. PubMed  Europe PubMed DOI
  166. Hinkle,C.L., Sunnarborg,S.W., Loiselle,D., Parker,C.E., Stevenson,M., Russell,W.E. and Lee,D.C.
    Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency
    J Biol Chem279, 24179-24188. PubMed  Europe PubMed DOI
  167. Postina,R., Schroeder,A., Dewachter,I., Bohl,J., Schmitt,U., Kojro,E., Prinzen,C., Endres,K., Hiemke,C., Blessing,M., Flamez,P., Dequenne,A., Godaux,E., Van Leuven,F. and Fahrenholz,F.
    A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
    J Clin Invest113, 1456-1464. PubMed  Europe PubMed DOI
  168. Postina,R. and Fahrenholz,F.
    ADAM10, myelin-associated metalloendopeptidase
    [ISSN:0-12-079610-4]2, 751-753.  V
  169. [YEAR:1-3-2004]Sahin,U., Weskamp,G., Kelly,K., Zhou,H.M., Higashiyama,S., Peschon,J., Hartmann,D., Saftig,P. and Blobel,C.P.
    Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
    J Cell Biol164, 769-779. PubMed  Europe PubMed DOI
  170. Wolfsberg,T.G. and White,J.M.
    ADAM metalloproteinases
    [ISSN:0-12-079610-4]2, 709-714.  V
    171. 2003
  171. [YEAR:31-1-2003]Asai,M., Hattori,C., Szabo,B., Sasagawa,N., Maruyama,K., Tanuma,S. and Ishiura,S.
    Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase
    Biochem Biophys Res Commun301, 231-235. PubMed  Europe PubMed DOI
  172. [YEAR:1-4-2003]Hall,R.J. and Erickson,C.A.
    ADAM 10: an active metalloprotease expressed during avian epithelial morphogenesis
    Dev Biol256, 146-159. PubMed  Europe PubMed DOI
  173. [YEAR:15-8-2003]Hundhausen,C., Misztela,D., Berkhout,T.A., Broadway,N., Saftig,P., Reiss,K., Hartmann,D., Fahrenholz,F., Postina,R., Matthews,V., Kallen,K.J., Rose-John,S. and Ludwig,A.
    The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion
    Blood102, 1186-1195. PubMed  Europe PubMed DOI  I
  174. Kieseier,B.C., Pischel,H., Neuen-Jacob,E., Tourtellotte,W.W. and Hartung,H.P.
    ADAM-10 and ADAM-17 in the inflamed human CNS
    Glia42, 398-405. PubMed  Europe PubMed DOI
  175. [YEAR:26-6-2003]Plamont,M.A., Chasseigneaux,S., Delasnerie-Laupretre,N., Beaudry,P., Peoc'h,K. and Laplanche,J.L.
    Variation at the ADAM10 gene locus is not associated with Creutzfeldt-Jakob disease
    Neurosci Lett344, 132-134. PubMed  Europe PubMed DOI  M
  176. [YEAR:24-6-2003]Six,E., Ndiaye,D., Laabi,Y., Brou,C., Gupta-Rossi,N., Israel,A. and Logeat,F.
    The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase
    Proc Natl Acad Sci U S A100, 7638-7643. PubMed  Europe PubMed DOI
    177. 2002
  177. [YEAR:1-10-2002]Hartmann,D., De Strooper,B., Serneels,L., Craessaerts,K., Herreman,A., Annaert,W., Umans,L., Lubke,T., Lena Illert,A., von Figura,K. and Saftig,P.
    The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts
    Hum Mol Genet11, 2615-2624. PubMed  Europe PubMed  K
  178. Hooper,N.M. and Turner,A.J.
    The search for alpha-secretase and its potential as a therapeutic approach to Alzheimer s disease
    Curr Med Chem9, 1107-1119. PubMed  Europe PubMed  I
  179. Lemjabbar,H. and Basbaum,C.
    Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells
    Nat Med8, 41-46. PubMed  Europe PubMed DOI
  180. [YEAR:22-7-2002]Yan,Y., Shirakabe,K. and Werb,Z.
    The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors
    J Cell Biol158, 221-226. PubMed  Europe PubMed DOI
    181. 2001
  181. Anders,A., Gilbert,S., Garten,W., Postina,R. and Fahrenholz,F.
    Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases
    FASEB J15, 1837-1839. PubMed  Europe PubMed
  182. Chubinskaya,S., Mikhail,R., Deutsch,A. and Tindal,M.H.
    ADAM-10 protein is present in human articular cartilage primarily in the membrane-bound form and is upregulated in osteoarthritis and in response to IL-1alpha in bovine nasal cartilage
    J Histochem Cytochem49, 1165-1176. PubMed  Europe PubMed
  183. [YEAR:24-8-2001]Esler,W.P. and Wolfe,M.S.
    A portrait of Alzheimer secretases - new features and familiar faces
    Science293, 1449-1454. PubMed  Europe PubMed DOI
  184. [YEAR:8-5-2001]Kojro,E., Gimpl,G., Lammich,S., Marz,W. and Fahrenholz,F.
    Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-secretase ADAM 10
    Proc Natl Acad Sci U S A98, 5815-5820. PubMed  Europe PubMed DOI
  185. [YEAR:12-11-2001]Mechtersheimer,S., Gutwein,P., Agmon-Levin,N., Stoeck,A., Oleszewski,M., Riedle,S., Postina,R., Fahrenholz,F., Fogel,M., Lemmon,F. and Altevogt,P.
    Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins
    J Cell Biol155, 661-673. PubMed  Europe PubMed DOI  K
    186. 2000
  186. [YEAR:19-5-2000]Amour,A., Knight,C.G., Webster,A., Slocombe,P.M., Stephens,P.E., Knauper,V., Docherty,A.J. and Murphy,G.
    The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3
    FEBS Lett473, 275-279. PubMed  Europe PubMed DOI
  187. Fahrenholz,F., Gilbert,S., Kojro,E., Lammich,S. and Postina,R.
    Alpha-secretase activity of the disintegrin metalloprotease ADAM 10. Influences of domain structure
    Ann N Y Acad Sci920, 215-222. PubMed  Europe PubMed
  188. [YEAR:28-1-2000]Skovronsky,D.M., Moore,D.B., Milla,M.E., Doms,R.W. and Lee,V.M.
    Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-Golgi network
    J Biol Chem275, 2568-2575. PubMed  Europe PubMed DOI
    189. 1999
  189. Dallas,D.J., Genever,P.G., Patton,A.J., Millichip,M.I., McKie,N. and Skerry,T.M.
    Localization of ADAM10 and notch receptors in bone
    Bone25, 9-15. PubMed  Europe PubMed DOI
  190. [YEAR:30-3-1999]Lammich,S., Kojro,E., Postina,R., Gilbert,S., Pfeiffer,R., Jasionowski,M., Haass,C. and Fahrenholz,F.
    Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease
    Proc Natl Acad Sci U S A96, 3922-3927. PubMed  Europe PubMed DOI
  191. [YEAR:1-1-1999]Qi,H., Rand,M.D., Wu,X., Sestan,N., Wang,W., Rakic,P., Xu,T. and Artavanis-Tsakonas,S.
    Processing of the Notch ligand Delta by the metalloprotease Kuzbanian
    Science283, 91-94. PubMed  Europe PubMed DOI
    192. 1998
  192. Black,R.A. and White,J.M.
    ADAMs: focus on the protease domain
    Curr Opin Cell Biol10, 654-659. PubMed  Europe PubMed DOI
  193. Lendahl,U.
    A growing family of Notch ligands
    Bioessays20, 103-107. PubMed  Europe PubMed DOI
  194. Liedtke,W., Cannella,B., Mazzaccaro,R.J., Clements,J.M., Miller,K.M., Wucherpfennig,K.W., Gearing,A.J. and Raine,C.S.
    Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors
    Ann Neurol44, 35-46. PubMed  Europe PubMed DOI
  195. Yavari,R., Adida,C., Bray-Ward,P., Brines,M. and Xu,T.
    Human metalloprotease-disintegrin Kuzbanian regulates sympathoadrenal cell fate in development and neoplasia
    Hum Mol Genet7, 1161-1167. PubMed  Europe PubMed DOI
    196. 1997
  196. [YEAR:25-7-1997]Pan,D. and Rubin,G.M.
    Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis
    Cell90, 271-280. PubMed  Europe PubMed DOI
  197. Rosendahl,M.S., Ko,S.C., Long,D.L., Brewer,M.T., Rosenzweig,B., Hedl,E., Anderson,L., Pyle,S.M., Moreland,J., Meyers,M.A., Kohno,T., Lyons,D. and Lichenstein,H.S.
    Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases
    J Biol Chem272, 24588-24593. PubMed  Europe PubMed DOI
  198. [YEAR:15-12-1997]Yamazaki,K., Mizui,Y., Sagane,K. and Tanaka,I.
    Assignment of a disintegrin and metalloproteinase domain 10 (Adam10) gene to mouse chromosome 9
    Genomics46, 528-529. PubMed  Europe PubMed DOI
  199. [YEAR:15-10-1997]Yamazaki,K., Mizui,Y. and Tanaka,I.
    Radiation hybrid mapping of human ADAM10 gene to chromosome 15
    Genomics45, 457-459. PubMed  Europe PubMed DOI
    200. 1996
  200. Howard,L., Lu,X., Mitchell,S., Griffiths,S. and Glynn,P.
    Molecular cloning of MADM: A catalytically active mammalian disintegrin-metalloprotease expressed in various cell types
    Biochem J317, 45-50. PubMed  Europe PubMed
    201. 1992
  201. Chantry,A., Gregson,N. and Glynn,P.
    Degradation of myelin basic protein by a membrane-associated metalloprotease: neural distribution of the enzyme
    Neurochem Res17, 861-867. PubMed  Europe PubMed DOI
    202. 1990
  202. Chantry,A. and Glynn,P.
    A novel metalloproteinase originally isolated from brain myelin membranes is present in many tissues
    Biochem J268, 245-248. PubMed  Europe PubMed
    203. 1989
  203. Chantry,A., Gregson,N.A. and Glynn,P.
    A novel metalloproteinase associated with brain myelin membranes. Isolation and characterization
    J Biol Chem264, 21603-21607. PubMed  Europe PubMed
    204. 1988
  204. Chantry,A., Earl,C., Groome,N. and Glynn,P.
    Metalloendoprotease cleavage of 18.2- and 14.1-kilodalton basic proteins dissociating from rodent myelin membranes generates 10.0- and 5.9-kilodalton C-terminal fragments
    J Neurochem50, 688-694. PubMed  Europe PubMed
  205. Groome,N., Chantry,A., Earl,C., Newcombe,J., Keen,J., Findlay,J. and Glynn,P.
    A new epitope on human myelin basic protein arising from cleavage by a metalloendoprotease associated with brain myelin membranes
    J Neuroimmunol19, 77-88. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use