$VAR1 = undef;

Summary for peptidase M10.009: matrix metallopeptidase-12

Names
MEROPS Name	matrix metallopeptidase-12
Other names	macrophage elastase, matrix metalloproteinase 12, metalloelastase, MMP-12

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M10 >> Subfamily A >> M10.009
Holotype	matrix metallopeptidase-12 (Mus musculus), Uniprot accession P34960 (peptidase unit: 91-272), MERNUM MER0001090
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00162
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.65
Enzymology	BRENDA database
Proteolytic events	CutDB database (94 cleavages)
Activity status	human: active (Shapiro et al., 2004) mouse: active (Shapiro et al., 1992)
Physiology	Role in turnover of extracellular matrix proteins.
Pharmaceutical relevance	Drug target for prevention of pathological tissue damage.
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/MMP12
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/pa/-/gl/-/-/- (based on 342 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	69	32	55	84	12	57	70	47
Pro	21	94	21	23	14	11	15	34
Ala	39	73	66	64	41	43	69	63
Val	27	19	11	9	29	22	17	18
Leu	25	30	45	9	93	22	22	27
Ile	5	5	5	2	15	12	6	16
Met	3	0	8	5	4	3	2	2
Phe	5	2	15	8	12	9	7	11
Tyr	4	1	7	4	17	8	10	5
Trp	1	1	1	2	2	10	4	0
Ser	13	16	10	13	17	26	28	25
Thr	12	9	10	10	10	16	19	13
Cys	3	4	3	10	13	4	2	5
Asn	12	5	7	19	6	6	3	8
Gln	12	10	21	7	8	16	8	8
Asp	10	4	8	5	15	9	8	8
Glu	14	7	15	18	8	19	20	21
Lys	23	11	21	27	17	27	12	15
Arg	23	9	5	17	4	17	15	13
His	5	3	6	6	4	4	4	2