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Structure for peptidase M10.009: matrix metallopeptidase-12

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

PDB Organism Resolution Comment
1JK3 Homo sapiens 1.09 Å mature
The catalytic zinc is shown as a light grey CPK sphere. Structural calcium ions are shown as yellow CPK spheres. The zinc ligands are shown in ball-and-stick representation: His218, His222 and His228 in purple. The catalytic Glu219 (mutated to Ala) is shown in blue.
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TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
Homo sapiens
mature  peptidase 2.60 Å 1JIZ 1JIZ 1JIZ 1JIZ 1JIZ 1JIZ Nar et al., 2001
mature  peptidase 1.09 Å 1JK3 1JK3 1JK3 1JK3 1JK3 1JK3 Lang et al., 2001
ternary enzyme-product-inhibitor complexes of human mmp12 2.15 Å 1OS2 1OS2 1OS2 1OS2 1OS2 1OS2 Bertini et al., 2003
binary enzyme-product complexes of human mmp12 1.85 Å 1OS9 1OS9 1OS9 1OS9 1OS9 1OS9 Bertini et al., 2003
catalytic domain; complex with the inhibitor NNGH 1.34 Å 1RMZ 1RMZ 1RMZ 1RMZ 1RMZ 1RMZ Bertini et al., 2005
complex with 2-(1,3-dioxo-1,3- dihydro-2h-isoindol-2-yl)ethyl-4-(4-ethoxy[1,1-biphenyl]-4- yl)-4-oxobutanoic acid 2.00 Å 1ROS 1ROS 1ROS 1ROS 1ROS 1ROS Morales et al., 2004
complex with 2-(1,3-dioxo-1,3- dihydro-2h-isoindol-2-yl)ethyl-4-(4-ethoxy[1,1-biphenyl]-4- yl)-4-oxobutanoic acid 2.20 Å 1UTT 1UTT 1UTT 1UTT 1UTT 1UTT Morales et al., 2004
complex with (2R)-3-([4-[(pyri din-4-yl)phenyl]-thien-2-ylcarboxamido)(phenyl)propanoic acid 2.50 Å 1UTZ 1UTZ 1UTZ 1UTZ 1UTZ 1UTZ Morales et al., 2004
catalytic domain; complex with acetohydroxamic acid 1.03 Å 1Y93 1Y93 1Y93 1Y93 1Y93 1Y93 Bertini et al., 2005
mature  peptidase 0.00 Å 1YCM 1YCM 1YCM 1YCM 1YCM 1YCM Bertini et al., 2005
mature  peptidase 0.00 Å 1Z3J 1Z3J 1Z3J 1Z3J 1Z3J 1Z3J Bertini et al., 2005
complex with acetohydroxamic acid and (1S,5S,7R)-N~7~-(biphenyl-4-ylmethyl)-N~3~-hydroxy-6,8-dioxa-3-azabicyclo[3.2.1]octane-3,7-dicarboxamide 1.32 Å 2HU6 2HU6 2HU6 2HU6 2HU6 2HU6 Mannino et al., 2006
mature  peptidase 0.00 Å 2JXY 2JXY 2JXY 2JXY 2JXY 2JXY Bertini et al., 2008
mature  peptidase 0.00 Å 2K2G 2K2G 2K2G 2K2G 2K2G 2K2G Markus et al., 2008
mature  peptidase 0.00 Å 2K9C 2K9C 2K9C 2K9C 2K9C 2K9C Balayssac et al., 2008
mature  peptidase 0.00 Å 2KRJ 2KRJ 2KRJ 2KRJ 2KRJ 2KRJ Bertini et al., 2010
mature  peptidase 0.00 Å 2MLR 2MLR 2MLR 2MLR 2MLR 2MLR Koppisetti et al., 2014
mature  peptidase 0.00 Å 2MLS 2MLS 2MLS 2MLS 2MLS 2MLS Koppisetti et al., 2014
uninhibited form of human mmp-12 1.24 Å 2OXU 2OXU 2OXU 2OXU 2OXU 2OXU Bertini et al., 2006
complex with the peptide iag 1.15 Å 2OXW 2OXW 2OXW 2OXW 2OXW 2OXW Bertini et al., 2006
complex with two peptides pqg and iag 1.90 Å 2OXZ 2OXZ 2OXZ 2OXZ 2OXZ 2OXZ Bertini et al., 2006
mature  peptidase 0.00 Å 2POJ 2POJ 2POJ 2POJ 2POJ 2POJ Bhaskaran et al., 2007
does a fast nuclear magnetic resonance spectroscopy- and x-ray crystallography hybrid approach provide reliable structural information of ligand-protein complexes? a case stud 2.00 Å 2W0D 2W0D 2W0D 2W0D 2W0D 2W0D Isaksson et al., 2009
mature  peptidase 2.00 Å 2WO8 2WO8 2WO8 2WO8 2WO8 2WO8 Holmes et al., 2009
mature  peptidase 1.70 Å 2WO9 2WO9 2WO9 2WO9 2WO9 2WO9 Holmes et al., 2009
mature  peptidase 2.30 Å 2WOA 2WOA 2WOA 2WOA 2WOA 2WOA Holmes et al., 2009
mature  peptidase 0.00 Å 2Z2D 2Z2D 2Z2D 2Z2D 2Z2D 2Z2D
mature  peptidase 3.00 Å 3BA0 3BA0 3BA0 3BA0 3BA0 3BA0 Bertini et al., 2008
catalytic domain; complex with the inhibitor (r)-2-(biphenyl-4- ylsulfonamido)-4-methylpentanoic acid 1.90 Å 3EHX 3EHX 3EHX 3EHX 3EHX 3EHX Bertini et al., 2003
catalytic domain; complex with the inhibitor (r)-2-(4- methoxyphenylsulfonamido)propanoic acid 1.90 Å 3EHY 3EHY 3EHY 3EHY 3EHY 3EHY Bertini et al., 2003
catalytic domain; complex with the inhibitor (s)-n-(2,3-dihydroxypropyl)-4- methoxy-n-(2-nitroso-2-oxoethyl)benzenesulfonamide 1.70 Å 3F15 3F15 3F15 3F15 3F15 3F15 Bertini et al., 2003
catalytic domain; complex with the inhibitor (r)-n-(3-hydroxy-1-nitroso-1- oxopropan-2-yl)-4-methoxybenzenesulfonamide 1.16 Å 3F16 3F16 3F16 3F16 3F16 3F16 Bertini et al., 2003
catalytic domain; complex with the inhibitor n-(2-nitroso-2-oxoethyl) biphenyl-4-sulfonamide 1.10 Å 3F17 3F17 3F17 3F17 3F17 3F17 Bertini et al., 2003
catalytic domain; complex with the inhibitor 4-fluoro-n-(2-hydroxyethyl)-n- (2-nitroso-2-oxoethyl)benzenesulfonamide 1.13 Å 3F18 3F18 3F18 3F18 3F18 3F18 Bertini et al., 2003
catalytic domain; complex with the inhibitor 4-fluoro-n-(2-nitroso-2- oxoethyl)benzenesulfonamide 1.13 Å 3F19 3F19 3F19 3F19 3F19 3F19 Bertini et al., 2003
catalytic domain; complex with the inhibitor n-(2-nitroso-2-oxoethyl) benzenesulfonamide 1.25 Å 3F1A 3F1A 3F1A 3F1A 3F1A 3F1A Bertini et al., 2003
mature  peptidase 1.80 Å 3LIK 3LIK 3LIK 3LIK 3LIK 3LIK Devel et al., 2010
mature  peptidase 1.80 Å 3LIL 3LIL 3LIL 3LIL 3LIL 3LIL Devel et al., 2010
mature  peptidase 1.90 Å 3LIR 3LIR 3LIR 3LIR 3LIR 3LIR Devel et al., 2010
mature  peptidase 1.31 Å 3LJG 3LJG 3LJG 3LJG 3LJG 3LJG Devel et al., 2010
mature  peptidase 1.80 Å 3LK8 3LK8 3LK8 3LK8 3LK8 3LK8 Bertini et al., 2007
mature  peptidase 1.80 Å 3LKA 3LKA 3LKA 3LKA 3LKA 3LKA Borsi et al., 2010
mature  peptidase 1.81 Å 3N2U 3N2U 3N2U 3N2U 3N2U 3N2U Attolino et al., 2010
mature  peptidase 1.55 Å 3N2V 3N2V 3N2V 3N2V 3N2V 3N2V Attolino et al., 2010
mature  peptidase 1.80 Å 3NX7 3NX7 3NX7 3NX7 3NX7 3NX7 Bertini et al., 2007
mature  peptidase 1.81 Å 3RTS 3RTS 3RTS 3RTS 3RTS 3RTS
mature  peptidase 1.82 Å 3RTT 3RTT 3RTT 3RTT 3RTT 3RTT
mature  peptidase 1.59 Å 3TS4 3TS4 3TS4 3TS4 3TS4 3TS4 Devel et al., 2012
mature  peptidase 2.00 Å 3TSK 3TSK 3TSK 3TSK 3TSK 3TSK Devel et al., 2012
mature  peptidase 1.30 Å 3UVC 3UVC 3UVC 3UVC 3UVC 3UVC
mature  peptidase 1.63 Å 4EFS 4EFS 4EFS 4EFS 4EFS 4EFS Devel et al., 2012
mature  peptidase 1.15 Å 4GQL 4GQL 4GQL 4GQL 4GQL 4GQL Czarny et al., 2013
mature  peptidase 1.50 Å 4GR0 4GR0 4GR0 4GR0 4GR0 4GR0 Czarny et al., 2013
mature  peptidase 1.49 Å 4GR3 4GR3 4GR3 4GR3 4GR3 4GR3 Czarny et al., 2013
mature  peptidase 1.30 Å 4GR8 4GR8 4GR8 4GR8 4GR8 4GR8 Czarny et al., 2013
mature  peptidase 2.00 Å 4GUY 4GUY 4GUY 4GUY 4GUY 4GUY
mature  peptidase 1.43 Å 4H30 4H30 4H30 4H30 4H30 4H30 Antoni et al., 2013
mature  peptidase 2.16 Å 4H49 4H49 4H49 4H49 4H49 4H49 Antoni et al., 2013
mature  peptidase 1.50 Å 4H76 4H76 4H76 4H76 4H76 4H76 Antoni et al., 2013
mature  peptidase 1.59 Å 4H84 4H84 4H84 4H84 4H84 4H84 Antoni et al., 2013
mature  peptidase 1.70 Å 4I03 4I03 4I03 4I03 4I03 4I03 Antoni et al., 2013
mature  peptidase 1.90 Å 4IJO 4IJO 4IJO 4IJO 4IJO 4IJO Udi et al., 2013
catalytic domain; complex with a carboxylate inhibitor related to rxp470 1.30 Å 5CXA 5CXA 5CXA 5CXA 5CXA 5CXA
mutated catalytic domain; complex with rxp470 1.30 Å 5CZM 5CZM 5CZM 5CZM 5CZM 5CZM
mutated catalytic domain; complex with an hydroxamate analogue of rxp470 1.20 Å 5D2B 5D2B 5D2B 5D2B 5D2B 5D2B
double mutant catalytic domain; complex with an hydroxamate analogue of rxp470 1.31 Å 5D3C 5D3C 5D3C 5D3C 5D3C 5D3C
catalytic domain; complex with a selective sugar-conjugated arylsulfonamide carboxylate water-soluble inhibitor (dc27). 2.45 Å 5I0L 5I0L 5I0L 5I0L 5I0L 5I0L
catalytic domain; complex with a selective sugar-conjugated triazole-linked carboxylate chelating water-soluble inhibitor (dc24). 2.30 Å 5I2Z 5I2Z 5I2Z 5I2Z 5I2Z 5I2Z
catalytic domain; complex with a selective sugar-conjugated thiourea-linked carboxylate zinc-chelator water-soluble inhibitor (dc31). 2.17 Å 5I3M 5I3M 5I3M 5I3M 5I3M 5I3M
catalytic domain; complex with a selective sugar-conjugated triazole-linked carboxylate chelator water-soluble inhibitor (dc32). 1.95 Å 5I43 5I43 5I43 5I43 5I43 5I43
catalytic domain; complex with a selective sugar-conjugated triazole-linked carboxylate zinc-chelator water-soluble inhibitor (dc28). 2.05 Å 5I4O 5I4O 5I4O 5I4O 5I4O 5I4O
complex with rxp470.1 conjugated with fluorophore cy5,5 in space group p21212. 2.07 Å 5L79 5L79 5L79 5L79 5L79 5L79
Lys421Ala mutant; complex with rxp470.1 conjugated with fluorophore cy5,5 in space group p21. 1.80 Å 5L7F 5L7F 5L7F 5L7F 5L7F 5L7F
catalytic domain; complex with the inhibitor nngh 1.34 Å 5LAB 5LAB 5LAB 5LAB 5LAB 5LAB
complex with 3-(5-(1,2-dithiolan-3-yl)pentanamido) propane-1-sulfonate 1.80 Å 5N5J 5N5J 5N5J 5N5J 5N5J 5N5J
complex with 5-(1,2-dithiolan-3-yl)-n-(3- hydroxypropyl)pentanamide 1.80 Å 5N5K 5N5K 5N5K 5N5K 5N5K 5N5K
complex with inhibitor be7. 1.20 Å 6EKN 6EKN 6EKN 6EKN 6EKN 6EKN
complex with inhibitor be4. 1.49 Å 6ELA 6ELA 6ELA 6ELA 6ELA 6ELA
complex with hydroxamate inhibitor lp168. 1.59 Å 6ENM 6ENM 6ENM 6ENM 6ENM 6ENM
complex with carboxylic inhibitor lp165. 1.30 Å 6EOX 6EOX 6EOX 6EOX 6EOX 6EOX

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