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Literature for peptidase M10.009: matrix metallopeptidase-12

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Dorjay Tamang,J.S., Banerjee,S., Baidya,S.K., Das,S., Ghosh,B., Jha,T. and Adhikari,N.
    An overview of matrix metalloproteinase-12 in multiple disease conditions, potential selective inhibitors, and drug designing strategies
    Eur J Med Chem283, 117154-117154. PubMed  Europe PubMed DOI  V
  2. Sun,C., Deng,H., Wang,Q., Long,Y., Li,T., Song,C. and Han,C.
    The roles of HOXB9 and MMP12 in proliferation, migration, and invasion of human laryngeal cancer cells LCC and TU212
    Biochem Biophys Res Commun752, 151391-151391. PubMed  Europe PubMed DOI
  3. Zhou,S., Yang,Y., Qi,F., Sun,W., Zhang,D., Lu,Z. and Chen,Y.
    ADAMDEC1 promotes the malignant progression of cholangiocarcinoma by regulating NF-kappaB signaling pathway
    Sci Rep15, 817-817. PubMed  Europe PubMed DOI
    4. 2024
  4. Arosa,L., Camba-Gomez,M., Lorenzo-Martin,L.F., Clavain,L., Lopez,M. and Conde-Aranda,J.
    RNA Expression of MMP12 Is Strongly Associated with Inflammatory Bowel Disease and Is Regulated by Metabolic Pathways in RAW 264.7 Macrophages
    Int J Mol Sci25, PubMed  Europe PubMed DOI
  5. Buerger,M., Amor,M., Akhmetshina,A., Bianco,V., Perfler,B., Zebisch,A., Weichhart,T. and Kratky,D.
    Limited Alleviation of Lysosomal Acid Lipase Deficiency by Deletion of Matrix Metalloproteinase 12
    Int J Mol Sci25, PubMed  Europe PubMed DOI
  6. Han,D., Yu,F. and Zheng,L.
    Causal effect of serum matrix metalloproteinase levels on venous thromboembolism: a Mendelian randomization study
    Epidemiol Healthe2024046-e2024046. PubMed  Europe PubMed DOI
  7. Hanai,S., Nakagomi,D., Suzuki,K., Nakajima,H. and Furuya,F.
    Renal protective roles of macrophage matrix metalloproteinase-12 in mice with obstructed kidneys
    Int J Exp Pathol105, 193-201-201. PubMed  Europe PubMed DOI
    8. 2023
  8. Lin,B., Ser,H.L., Wang,L., Li,J., Chan,K.G., Lee,L.H. and Tan,L.T.
    The Emerging Role of MMP12 in the Oral Environment
    Int J Mol Sci24, PubMed  Europe PubMed DOI  V
  9. Tamang,J.S.D., Banerjee,S., Baidya,S.K., Ghosh,B., Adhikari,N. and Jha,T.
    Employing comparative QSAR techniques for the recognition of dibenzofuran and dibenzothiophene derivatives toward MMP-12 inhibition
    J Biomol Struct Dyn1-17. PubMed  Europe PubMed DOI
    10. 2022
  10. Chalise,U., Becirovic-Agic,M., Konfrst,S.R., Rodriguez-Paar,J.R., Cook,L.M. and Lindsey,M.L.
    MMP-12 polarizes neutrophil signalome towards an apoptotic signature
    J Proteomics264, 104636-104636. PubMed  Europe PubMed DOI
  11. Fan,D., Zheng,C., Wu,W., Chen,Y., Chen,D., Hu,X., Shen,C., Chen,M., Li,R. and Chen,Y.
    MMP9 SNP and MMP SNP-SNP interactions increase the risk for ischemic stroke in the Han Hakka population
    Brain Behav12, e2473-e2473. PubMed  Europe PubMed DOI
  12. Lee,M.R., Chen,Y.L., Wu,C.W., Chen,L.C., Chang,L.Y., Chen,J.Y., Huang,Y.T., Wang,J.Y., Shih,J.Y. and Yu,C.J.
    Toll-like receptor and matrix metalloproteinase single-nucleotide polymorphisms, haplotypes, and polygenic risk score differentiated between tuberculosis disease and infection
    Int J Infect Dis125, 61-66. PubMed  Europe PubMed DOI  M
  13. Ravanetti,L., Dekker,T., Guo,L., Dijkhuis,A., Dierdorp,B.S., Diamant,Z., Florquin,S. and Lutter,R.
    Efficacy of FP-025: A novel matrix metalloproteinase-12 (MMP-12) inhibitor in murine allergic asthma
    Allergy PubMed  Europe PubMed DOI  I
  14. Spix,B., Butz,E.S., Chen,C.C., Rosato,A.S., Tang,R., Jeridi,A., Kudrina,V., Plesch,E., Wartenberg,P., Arlt,E., Briukhovetska,D., Ansari,M., Gunsel,G.G., Conlon,T.M., Wyatt,A., Wetzel,S., Teupser,D., Holdt,L.M., Ectors,F., Boekhoff,I., Boehm,U., Garcia-Anoveros,J., Saftig,P., Giera,M., Kobold,S., Schiller,H.B., Zierler,S., Gudermann,T., Wahl-Schott,C., Bracher,F., Yildirim,A.O., Biel,M. and Grimm,C.
    Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice
    Nat Commun13, 318-318. PubMed  Europe PubMed DOI
  15. Yi,C., Liu,J., Deng,W., Luo,C., Qi,J., Chen,M. and Xu,H.
    Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis
    J Neuroinflammation19, 78-78. PubMed  Europe PubMed DOI  I
    16. 2021
  16. Abd-Elaziz,K., Voors-Pette,C., Wang,K.L., Pan,S., Lee,Y., Mao,J., Li,Y., Chien,B., Lau,D. and Diamant,Z.
    First-in-Man Safety, Tolerability, and Pharmacokinetics of a Novel and Highly Selective Inhibitor of Matrix Metalloproteinase-12, FP-025: Results from Two Randomized Studies in Healthy Subjects
    Clin Drug Investig41, 65-76. PubMed  Europe PubMed DOI  I
  17. Bassiouni,W., Ali,M.A.M. and Schulz,R.
    Multifunctional intracellular matrix metalloproteinases: implications in disease
    FEBS J288, 7162-7182. PubMed  Europe PubMed DOI  V
  18. Chakraborty,S., Sampath,D., Yu Lin,M.O., Bilton,M., Huang,C.K., Nai,M.H., Njah,K., Goy,P.A., Wang,C.C., Guccione,E., Lim,C.T. and Hong,W.
    Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing
    Nat Commun12, 6349-6349. PubMed  Europe PubMed DOI
  19. Makino,A., Shibata,T., Nagayasu,M., Hosoya,I., Nishimura,T., Nakano,C., Nagata,K., Ito,T., Takahashi,Y. and Nakamura,S.
    RSV infection-elicited high MMP-12-producing macrophages exacerbate allergic airway inflammation with neutrophil infiltration
    iScience24, 103201-103201. PubMed  Europe PubMed DOI  I
  20. Nighot,M., Ganapathy,A.S., Saha,K., Suchanec,E., Castillo,E., Gregory,A., Shapiro,S., Ma,T. and Nighot,P.
    Matrix Metalloproteinase MMP-12 promotes macrophage transmigration across intestinal epithelial tight junctions and increases severity of experimental colitis
    J Crohns Colitis15, 1751-1765. PubMed  Europe PubMed DOI
    21. 2020
  21. Baggio,C., Velazquez,J.V., Fragai,M., Nordgren,T.M. and Pellecchia,M.
    Therapeutic Targeting of MMP-12 for the Treatment of Chronic Obstructive Pulmonary Disease
    J Med Chem63, 12911-12920. PubMed  Europe PubMed DOI
  22. Boytard,L., Hadi,T., Silvestro,M., Qu,H., Kumpfbeck,A., Sleiman,R., Fils,K.H., Alebrahim,D., Boccalatte,F., Kugler,M., Corsica,A., Gelb,B.E., Jacobowitz,G., Miller,G., Bellini,C., Oakes,J., Silvestre,J.S., Zangi,L. and Ramkhelawon,B.
    Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages
    Nat Commun11, 4311-4311. PubMed  Europe PubMed DOI
  23. Chen,S., Xie,J., Zhao,K., Ren,L., Deng,Y., Xie,X., Chen,S., Xu,H., Long,X. and Liu,E.
    LPS aggravates lung inflammation induced by RSV by promoting the ERK-MMP-12 signaling pathway in mice
    Respir Res21, 193-193. PubMed  Europe PubMed DOI  I
  24. Feldreich,T., Nowak,C., Carlsson,A.C., Ostgren,C.J., Nystrom,F.H., Sundstrom,J., Carrero-Roig,J.J., Leppert,J., Hedberg,P., Giedraitis,V., Lind,L., Cordeiro,A. and Arnlov,J.
    The association between plasma proteomics and incident cardiovascular disease identifies MMP-12 as a promising cardiovascular risk marker in patients with chronic kidney disease
    Atherosclerosis307, 11-15. PubMed  Europe PubMed DOI
  25. Gaddi,G.M., Gisonno,R.A., Rosu,S.A., Cortez,M.F., Finarelli,G.S., Ramella,N.A. and Tricerri,M.A.
    Data regarding the sensibility to proteolysis of a natural apolipoprotein A-I mutant
    Data Brief31, 105960-105960. PubMed  Europe PubMed DOI
  26. Gona,K., Toczek,J., Ye,Y., Sanzida,N., Golbazi,A., Boodagh,P., Salarian,M., Jung,J.J., Rajendran,S., Kukreja,G., Wu,T.L., Devel,L. and Sadeghi,M.M.
    Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging
    J Med Chem63, 15037-15049. PubMed  Europe PubMed DOI  I
  27. Lee,K.B., Dunn,Z.S., Lopez,T., Mustafa,Z. and Ge,X.
    Generation of highly selective monoclonal antibodies inhibiting a recalcitrant protease using decoy designs
    Biotechnol Bioeng117, 3664-3676. PubMed  Europe PubMed DOI
  28. Yang,H., Zhang,C., Wu,J., Xiao,W., Xie,X., Zeng,Z., Chen,K., Wang,W., An,X., Tang,W. and Huang,Q.
    Association of matrix metalloproteinase-12 polymorphisms with chronic obstructive pulmonary disease risk: A protocol for systematic review and meta analysis
    Medicine (Baltimore)99, e21543-e21543. PubMed  Europe PubMed DOI
    29. 2019
  29. Toczek,J., Bordenave,T., Gona,K., Kim,H.Y., Beau,F., Georgiadis,D., Correia,I., Ye,Y., Razavian,M., Jung,J.J., Lequin,O., Dive,V., Sadeghi,M.M. and Devel,L.
    Novel matrix metalloproteinase 12 selective radiotracers for vascular molecular imaging
    J Med Chem62, 9743-9752. PubMed  Europe PubMed DOI  L
    30. 2018
  30. Chelluboina,B., Nalamolu,K.R., Klopfenstein,J.D., Pinson,D.M., Wang,D.Z., Vemuganti,R. and Veeravalli,K.K.
    MMP-12, a promising therapeutic target for neurological diseases
    Mol Neurobiol55, 1405-1409. PubMed  Europe PubMed DOI  T  V
  31. Cuffaro,D., Camodeca,C., D'Andrea,F., Piragine,E., Testai,L., Calderone,V., Orlandini,E., Nuti,E. and Rossello,A.
    Matrix metalloproteinase-12 inhibitors: synthesis, structure-activity relationships and intestinal absorption of novel sugar-based biphenylsulfonamide carboxylates
    Bioorg Med Chem26, 5804-5815. PubMed  Europe PubMed DOI  I
  32. Hagimori,M., Temma,T., Kudo,S., Sano,K., Kondo,N. and Mukai,T.
    Synthesis of radioiodinated probes targeted toward matrix metalloproteinase-12
    Bioorg Med Chem Lett28, 193-195. PubMed  Europe PubMed DOI  L
  33. Nuti,E., Cuffaro,D., Bernardini,E., Camodeca,C., Panelli,L., Chaves,S., Ciccone,L., Tepshi,L., Vera,L., Orlandini,E., Nencetti,S., Stura,E.A., Santos,M.A., Dive,V. and Rossello,A.
    Development of thioaryl-based matrix metalloproteinase-12 inhibitors with alternative zinc-binding groups: synthesis, potentiometric, NMR, and crystallographic studies
    J Med Chem61, 4421-4435. PubMed  Europe PubMed DOI  I
  34. Vinet,J., Costa,A.M., Salinas-Navarro,M., Leo,G., Moons,L., Arckens,L. and Biagini,G.
    A hydroxypyrone-based inhibitor of metalloproteinase-12 displays neuroprotective properties in both status epilepticus and optic nerve crush animal models
    Int J Mol Sci19, PubMed  Europe PubMed DOI  I
  35. Zhang,G., Li,W., Guo,Y., Li,D., Liu,Y. and Xu,S.
    MMP Gene polymorphisms, MMP-1 -1607 1G/2G, -519 A/G, and MMP-12 -82 A/G, and ischemic stroke: a meta-analysis
    J Stroke Cerebrovasc Dis27, 140-152. PubMed  Europe PubMed DOI  M
    36. 2017
  36. Dandachi,N., Kelly,N.J., Wood,J.P., Burton,C.L., Radder,J.E., Leme,A.S., Gregory,A.D. and Shapiro,S.D.
    Macrophage elastase induces TRAIL-mediated tumor cell death through its carboxy-terminal domain
    Am J Respir Crit Care Med196, 353-363. PubMed  Europe PubMed DOI
  37. Rouanet-Mehouas,C., Czarny,B., Beau,F., Cassar-Lajeunesse,E., Stura,E.A., Dive,V. and Devel,L.
    Zinc-metalloproteinase inhibitors: evaluation of the complex role played by the zinc-binding group on potency and selectivity
    J Med Chem60, 403-414. PubMed  Europe PubMed DOI  I
    38. 2016
  38. Bordenave,T., Helle,M., Beau,F., Georgiadis,D., Tepshi,L., Bernes,M., Ye,Y., Levenez,L., Poquet,E., Nozach,H., Razavian,M., Toczek,J., Stura,E.A., Dive,V., Sadeghi,M.M. and Devel,L.
    Synthesis, and in vitro and in vivo evaluation of MMP-12 selective optical probes
    Bioconjug Chem27, 2407-2417. PubMed  Europe PubMed DOI  L  I
  39. Lamort,A.S., Gravier,R., Laffitte,A., Juliano,L., Zani,M.L. and Moreau,T.
    New insights into the substrate specificity of macrophage elastase MMP-12
    Biol Chem397, 469-484. PubMed  Europe PubMed DOI  A  P
  40. Nuti,E., Cuffaro,D., D'Andrea,F., Rosalia,L., Tepshi,L., Fabbi,M., Carbotti,G., Ferrini,S., Santamaria,S., Camodeca,C., Ciccone,L., Orlandini,E., Nencetti,S., Stura,E.A., Dive,V. and Rossello,A.
    Sugar-based arylsulfonamide carboxylates as selective and water-soluble matrix metalloproteinase-12 inhibitors
    ChemMedChem11, 1626-1637. PubMed  Europe PubMed DOI  I
    41. 2015
  41. Aerts,J., Vandenbroucke,R.E., Dera,R., Balusu,S., Van Wonterghem,E., Moons,L., Libert,C., Dehaen,W. and Arckens,L.
    Synthesis and validation of a hydroxypyrone-based, potent, and specific matrix metalloproteinase-12 inhibitor with anti-inflammatory activity in vitro and in vivo
    Mediators Inflamm2015, 510679-510679. PubMed  Europe PubMed DOI  I
  42. Chelluboina,B., Klopfenstein,J.D., Pinson,D.M., Wang,D.Z., Vemuganti,R. and Veeravalli,K.K.
    Matrix metalloproteinase-12 induces blood-brain barrier damage after focal cerebral ischemia
    Stroke46, 3523-3531. PubMed  Europe PubMed DOI
  43. Chen,S.S., Song,J., Tu,X.Y., Zhao,J.H. and Ye,X.Q.
    The association between MMP-12 82 A/G polymorphism and susceptibility to various malignant tumors: a meta-analysis
    Int J Clin Exp Med8, 10845-10854. PubMed  Europe PubMed  M
  44. Hitaoka,S., Chuman,H. and Yoshizawa,K.
    A QSAR study on the inhibition mechanism of matrix metalloproteinase-12 by arylsulfone analogs based on molecular orbital calculations
    Org Biomol Chem13, 793-806. PubMed  Europe PubMed DOI  I
  45. Nakagomi,D., Suzuki,K., Meguro,K., Hosokawa,J., Tamachi,T., Takatori,H., Suto,A., Matsue,H., Ohara,O., Nakayama,T., Shimada,S. and Nakajima,H.
    Matrix metalloproteinase 12 is produced by M2 macrophages and plays important roles in the development of contact hypersensitivity
    J Allergy Clin Immunol135, 1397-1400. PubMed  Europe PubMed DOI
    46. 2014
  46. Bellac,C.L., Dufour,A., Krisinger,M.J., Loonchanta,A., Starr,A.E., auf dem Keller,U., Lange,P.F., Goebeler,V., Kappelhoff,R., Butler,G.S., Burtnick,L.D., Conway,E.M., Roberts,C.R. and Overall,C.M.
    Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis
    Cell Rep9, 618-632. PubMed  Europe PubMed DOI  P
  47. Borrotti,M., De March,D., Slanzi,D. and Poli,I.
    Designing lead optimisation of MMP-12 inhibitors
    Comput Math Methods Med2014, 258627-258627. PubMed  Europe PubMed DOI  I
  48. Dandachi,N.G. and Shapiro,S.D.
    A protean protease: MMP-12 fights viruses as a protease and a transcription factor
    Nat Med20, 470-472. PubMed  Europe PubMed DOI
  49. Koppisetti,R.K., Fulcher,Y.G., Jurkevich,A., Prior,S.H., Xu,J., Lenoir,M., Overduin,M. and Van Doren,S.R.
    Ambidextrous binding of cell and membrane bilayers by soluble matrix metalloproteinase-12
    Nat Commun5, 5552-5552. PubMed  Europe PubMed DOI
  50. Lim,N.H., Meinjohanns,E., Bou-Gharios,G., Gompels,L.L., Nuti,E., Rossello,A., Devel,L., Dive,V., Meldal,M. and Nagase,H.
    In vivo imaging of matrix metalloproteinase 12 and matrix metalloproteinase 13 activities in the mouse model of collagen-induced arthritis
    Arthritis Rheum66, 589-598. PubMed  Europe PubMed DOI  L  I
  51. Marchant,D.J., Bellac,C.L., Moraes,T.J., Wadsworth,S.J., Dufour,A., Butler,G.S., Bilawchuk,L.M., Hendry,R.G., Robertson,A.G., Cheung,C.T., Ng,J., Ang,L., Luo,Z., Heilbron,K., Norris,M.J., Duan,W., Bucyk,T., Karpov,A., Devel,L., Georgiadis,D., Hegele,R.G., Luo,H., Granville,D.J., Dive,V., McManus,B.M. and Overall,C.M.
    A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity
    Nat Med20, 493-502. PubMed  Europe PubMed
  52. Shamsara,J. and Shahir-Sadr,A.
    A predictive HQSAR model for a series of tricycle core containing MMP-12 inhibitors with dibenzofuran ring
    Int J Med Chem2014, 630807-630807. PubMed  Europe PubMed DOI  I
  53. Zhang,H., Wang,Y. and Xu,F.
    Impact of the subtle differences in MMP-12 structure on Glide-based molecular docking for pose prediction of inhibitors
    J Mol Struct1076, 153-159. DOI  I
    54. 2013
  54. Czarny,B., Stura,E.A., Devel,L., Vera,L., Cassar-Lajeunesse,E., Beau,F., Calderone,V., Fragai,M., Luchinat,C. and Dive,V.
    Molecular determinants of a selective matrix metalloprotease-12 inhibitor: Insights from crystallography and thermodynamic studies
    J Med Chem56, 1149-1159. PubMed  Europe PubMed DOI  S  I
  55. Gossas,T., Nordstrom,H., Xu,M.H., Sun,Z.H., Lin,G.Q., Wallberg,H. and Danielson,U.H.
    The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors-characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors
    MedChemComm4, 432-442. DOI  I
  56. Nury,C., Bregant,S., Czarny,B., Berthon,F., Cassar-Lajeunesse,E. and Dive,V.
    Detection of endogenous matrix metalloprotease-12 active form with a novel broad spectrum activity-based probe
    J Biol Chem288, 5636-5644. PubMed  Europe PubMed DOI  L
    57. 2012
  57. Kaynar,M. and Shapiro,S.D.
    Matrix metallopeptidase-12/macrophage elastase
    [ISSN:978-0-12-407744-7]3, 800-804. DOI
  58. Kovacs,H., Agback,T. and Isaksson,J.
    Probing water-protein contacts in a MMP-12/CGS27023A complex by nuclear magnetic resonance spectroscopy
    J Biomol NMR53, 85-92. PubMed  Europe PubMed DOI  I
  59. Li,J., Wang,J.J., Peng,Q., Chen,C., Humphrey,M.B., Heinecke,J. and Zhang,S.X.
    Macrophage metalloelastase (MMP-12) deficiency mitigates retinal inflammation and pathological angiogenesis in ischemic retinopathy
    PLoS ONE7, e52699-e52699. PubMed  Europe PubMed DOI  K
  60. Patel,T.R., Butler,G., McFarlane,A., Xie,I., Overall,C.M. and Stetefeld,J.
    Site specific cleavage mediated by MMPs regulates function of agrin
    PLoS ONE7, e43669-e43669. PubMed  Europe PubMed DOI  P
  61. Santamaria,S., Nuti,E., Cercignani,G., Marinelli,L., La Pietra,V., Novellino,E. and Rossello,A.
    N-O-Isopropyl sulfonamido-based hydroxamates: kinetic characterisation of a series of MMP-12/MMP-13 dual target inhibitors
    Biochem Pharmacol84, 813-820. PubMed  Europe PubMed DOI  I
    62. 2011
  62. Fulcher,Y.G. and Van Doren,S.R.
    Remote exosites of the catalytic domain of matrix metalloproteinase-12 enhance elastin degradation
    Biochemistry50, 9488-9499. PubMed  Europe PubMed DOI
  63. Haq,I., Lowrey,G.E., Kalsheker,N. and Johnson,S.R.
    Matrix metalloproteinase-12 (MMP-12) SNP affects MMP activity, lung macrophage infiltration and protects against emphysema in COPD
    Thorax66, 970-976. PubMed  Europe PubMed DOI  M
  64. Johnson,J.L., Devel,L., Czarny,B., George,S.J., Jackson,C.L., Rogakos,V., Beau,F., Yiotakis,A., Newby,A.C. and Dive,V.
    A selective matrix metalloproteinase-12 inhibitor retards atherosclerotic plaque development in apolipoprotein E-knockout mice
    Arterioscler Thromb Vasc Biol31, 528-535. PubMed  Europe PubMed DOI  I
  65. Magnussen,H., Watz,H., Kirsten,A., Wang,M., Wray,H., Samuelsson,V., Mo,J. and Kay,R.
    Safety and tolerability of an oral MMP-9 and -12 inhibitor, AZD1236, in patients with moderate-to-severe COPD: a randomised controlled 6-week trial
    Pulm Pharmacol Ther24, 563-570. PubMed  Europe PubMed DOI  I
  66. Pickett,S.D., Green,D.V.S., Hunt,D.L., Pardoe,D.A. and Hughes,I.
    Automated lead optimization of MMP-12 inhibitors using a genetic algorithm
    ACS Med Chem Lett2, 28-33. PubMed  Europe PubMed DOI  I
    67. 2010
  67. Devel,L., Garcia,S., Czarny,B., Beau,F., Lajeunesse,E., Vera,L., Georgiadis,D., Stura,E. and Dive,V.
    Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation
    J Biol Chem285, 35900-35909. PubMed  Europe PubMed DOI  I
  68. Heinz,A., Jung,M.C., Duca,L., Sippl,W., Taddese,S., Ihling,C., Rusciani,A., Jahreis,G., Weiss,A.S., Neubert,R.H. and Schmelzer,C.E.
    Degradation of tropoelastin by matrix metalloproteinases - cleavage site specificities and release of matrikines
    FEBS J277, 1939-1956. PubMed  Europe PubMed DOI  P
  69. Liang,X., Arunima,A., Zhao,Y., Bhaskaran,R., Shende,A., Byrne,T.S., Fleeks,J., Palmier,M.O. and Van Doren,S.R.
    Apparent tradeoff of higher activity in MMP-12 for enhanced stability and flexibility in MMP-3
    Biophys J99, 273-283. PubMed  Europe PubMed DOI
  70. Madala,S.K., Pesce,J.T., Ramalingam,T.R., Wilson,M.S., Minnicozzi,S., Cheever,A.W., Thompson,R.W., Mentink-Kane,M.M. and Wynn,T.A.
    Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis
    J Immunol184, 3955-3963. PubMed  Europe PubMed DOI  K
  71. Margheri,F., Serrati,S., Lapucci,A., Chilla,A., Bazzichi,L., Bombardieri,S., Kahaleh,B., Calorini,L., Bianchini,F., Fibbi,G. and Del Rosso,M.
    Modulation of the angiogenic phenotype of normal and systemic sclerosis endothelial cells by gain-loss of function of pentraxin 3 and matrix metalloproteinase 12
    Arthritis Rheum62, 2488-2498. PubMed  Europe PubMed DOI
  72. Mukhopadhyay,S., Sypek,J., Tavendale,R., Gartner,U., Winter,J., Li,W., Page,K., Fleming,M., Brady,J., O'Toole,M., Macgregor,D.F., Goldman,S., Tam,S., Abraham,W., Williams,C., Miller,D.K. and Palmer,C.N.
    Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults
    J Allergy Clin Immunol126, 70-76. PubMed  Europe PubMed DOI  T
  73. Taddese,S., Jung,M.C., Ihling,C., Heinz,A., Neubert,R.H. and Schmelzer,C.E.
    MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III
    Biochim Biophys Acta1804, 731-739. PubMed  Europe PubMed DOI  P
    74. 2009
  74. Crouser,E.D., Culver,D.A., Knox,K.S., Julian,M.W., Shao,G., Abraham,S., Liyanarachchi,S., Macre,J.E., Wewers,M.D., Gavrilin,M.A., Ross,P., Abbas,A. and Eng,C.
    Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis
    Am J Respir Crit Care Med179, 929-938. PubMed  Europe PubMed DOI  T
  75. Dwivedi,A., Slater,S.C. and George,S.J.
    MMP-9 and -12 cause N-cadherin shedding and thereby beta-catenin signalling and vascular smooth muscle cell proliferation
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  76. Garbacki,N., Di Valentin,E., Piette,J., Cataldo,D., Crahay,C. and Colige,A.
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