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Literature for peptidase M10.009: matrix metallopeptidase-12

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Dorjay Tamang,J.S., Banerjee,S., Baidya,S.K., Das,S., Ghosh,B., Jha,T. and Adhikari,N.<br>An overview of matrix metalloproteinase-12 in multiple disease conditions, potential selective inhibitors, and drug designing strategies<br>Eur J Med Chem (2025) 283, 117154-117154. PubMed  Europe PubMed DOI  V
  2. Sun,C., Deng,H., Wang,Q., Long,Y., Li,T., Song,C. and Han,C.<br>The roles of HOXB9 and MMP12 in proliferation, migration, and invasion of human laryngeal cancer cells LCC and TU212<br>Biochem Biophys Res Commun (2025) 752, 151391-151391. PubMed  Europe PubMed DOI
  3. Zhou,S., Yang,Y., Qi,F., Sun,W., Zhang,D., Lu,Z. and Chen,Y.<br>ADAMDEC1 promotes the malignant progression of cholangiocarcinoma by regulating NF-kappaB signaling pathway<br>Sci Rep (2025) 15, 817-817. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2024
  4. Arosa,L., Camba-Gomez,M., Lorenzo-Martin,L.F., Clavain,L., Lopez,M. and Conde-Aranda,J.<br>RNA Expression of MMP12 Is Strongly Associated with Inflammatory Bowel Disease and Is Regulated by Metabolic Pathways in RAW 264.7 Macrophages<br>Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  5. Buerger,M., Amor,M., Akhmetshina,A., Bianco,V., Perfler,B., Zebisch,A., Weichhart,T. and Kratky,D.<br>Limited Alleviation of Lysosomal Acid Lipase Deficiency by Deletion of Matrix Metalloproteinase 12<br>Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  6. Han,D., Yu,F. and Zheng,L.<br>Causal effect of serum matrix metalloproteinase levels on venous thromboembolism: a Mendelian randomization study<br>Epidemiol Health (2024) , e2024046-e2024046. PubMed  Europe PubMed DOI
  7. Hanai,S., Nakagomi,D., Suzuki,K., Nakajima,H. and Furuya,F.<br>Renal protective roles of macrophage matrix metalloproteinase-12 in mice with obstructed kidneys<br>Int J Exp Pathol (2024) 105, 193-201-201. PubMed  Europe PubMed DOI
    8. 2023
  8. Lin,B., Ser,H.L., Wang,L., Li,J., Chan,K.G., Lee,L.H. and Tan,L.T.<br>The Emerging Role of MMP12 in the Oral Environment<br>Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC  V
  9. Port,H., Hausgaard,C.M., He,Y., Maksymowych,W.P., Wichuk,S., Sinkeviciute,D., Bay-Jensen,A.C. and Holm Nielsen,S.<br>A novel biomarker of MMP-cleaved cartilage intermediate layer protein-1 is elevated in patients with rheumatoid arthritis, ankylosing spondylitis and osteoarthritis<br>Sci Rep (2023) 13, 21717-21717. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Tamang,J.S.D., Banerjee,S., Baidya,S.K., Ghosh,B., Adhikari,N. and Jha,T.<br>Employing comparative QSAR techniques for the recognition of dibenzofuran and dibenzothiophene derivatives toward MMP-12 inhibition<br>J Biomol Struct Dyn (2023) , 1-17. PubMed  Europe PubMed DOI
    11. 2022
  11. Chalise,U., Becirovic-Agic,M., Konfrst,S.R., Rodriguez-Paar,J.R., Cook,L.M. and Lindsey,M.L.<br>MMP-12 polarizes neutrophil signalome towards an apoptotic signature<br>J Proteomics (2022) 264, 104636-104636. PubMed  Europe PubMed DOI
  12. Fan,D., Zheng,C., Wu,W., Chen,Y., Chen,D., Hu,X., Shen,C., Chen,M., Li,R. and Chen,Y.<br>MMP9 SNP and MMP SNP-SNP interactions increase the risk for ischemic stroke in the Han Hakka population<br>Brain Behav (2022) 12, e2473-e2473. PubMed  Europe PubMed DOI
  13. Lee,M.R., Chen,Y.L., Wu,C.W., Chen,L.C., Chang,L.Y., Chen,J.Y., Huang,Y.T., Wang,J.Y., Shih,J.Y. and Yu,C.J.<br>Toll-like receptor and matrix metalloproteinase single-nucleotide polymorphisms, haplotypes, and polygenic risk score differentiated between tuberculosis disease and infection<br>Int J Infect Dis (2022) 125, 61-66. PubMed  Europe PubMed DOI  M
  14. Ravanetti,L., Dekker,T., Guo,L., Dijkhuis,A., Dierdorp,B.S., Diamant,Z., Florquin,S. and Lutter,R.<br>Efficacy of FP-025: A novel matrix metalloproteinase-12 (MMP-12) inhibitor in murine allergic asthma<br>Allergy (2022) PubMed  Europe PubMed DOI  I
  15. Spix,B., Butz,E.S., Chen,C.C., Rosato,A.S., Tang,R., Jeridi,A., Kudrina,V., Plesch,E., Wartenberg,P., Arlt,E., Briukhovetska,D., Ansari,M., Gunsel,G.G., Conlon,T.M., Wyatt,A., Wetzel,S., Teupser,D., Holdt,L.M., Ectors,F., Boekhoff,I., Boehm,U., Garcia-Anoveros,J., Saftig,P., Giera,M., Kobold,S., Schiller,H.B., Zierler,S., Gudermann,T., Wahl-Schott,C., Bracher,F., Yildirim,A.O., Biel,M. and Grimm,C.<br>Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice<br>Nat Commun (2022) 13, 318-318. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Yi,C., Liu,J., Deng,W., Luo,C., Qi,J., Chen,M. and Xu,H.<br>Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis<br>J Neuroinflammation (2022) 19, 78-78. PubMed  Europe PubMed DOI  PMC  EPMC  I
    17. 2021
  17. Abd-Elaziz,K., Voors-Pette,C., Wang,K.L., Pan,S., Lee,Y., Mao,J., Li,Y., Chien,B., Lau,D. and Diamant,Z.<br>First-in-Man Safety, Tolerability, and Pharmacokinetics of a Novel and Highly Selective Inhibitor of Matrix Metalloproteinase-12, FP-025: Results from Two Randomized Studies in Healthy Subjects<br>Clin Drug Investig (2021) 41, 65-76. PubMed  Europe PubMed DOI  I
  18. Bassiouni,W., Ali,M.A.M. and Schulz,R.<br>Multifunctional intracellular matrix metalloproteinases: implications in disease<br>FEBS J (2021) 288, 7162-7182. PubMed  Europe PubMed DOI  V
  19. Chakraborty,S., Sampath,D., Yu Lin,M.O., Bilton,M., Huang,C.K., Nai,M.H., Njah,K., Goy,P.A., Wang,C.C., Guccione,E., Lim,C.T. and Hong,W.<br>Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing<br>Nat Commun (2021) 12, 6349-6349. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Makino,A., Shibata,T., Nagayasu,M., Hosoya,I., Nishimura,T., Nakano,C., Nagata,K., Ito,T., Takahashi,Y. and Nakamura,S.<br>RSV infection-elicited high MMP-12-producing macrophages exacerbate allergic airway inflammation with neutrophil infiltration<br>iScience (2021) 24, 103201-103201. PubMed  Europe PubMed DOI  PMC  EPMC  I
  21. Nighot,M., Ganapathy,A.S., Saha,K., Suchanec,E., Castillo,E., Gregory,A., Shapiro,S., Ma,T. and Nighot,P.<br>Matrix Metalloproteinase MMP-12 promotes macrophage transmigration across intestinal epithelial tight junctions and increases severity of experimental colitis<br>J Crohns Colitis (2021) 15, 1751-1765. PubMed  Europe PubMed DOI
    22. 2020
  22. Baggio,C., Velazquez,J.V., Fragai,M., Nordgren,T.M. and Pellecchia,M.<br>Therapeutic Targeting of MMP-12 for the Treatment of Chronic Obstructive Pulmonary Disease<br>J Med Chem (2020) 63, 12911-12920. PubMed  Europe PubMed DOI
  23. Boytard,L., Hadi,T., Silvestro,M., Qu,H., Kumpfbeck,A., Sleiman,R., Fils,K.H., Alebrahim,D., Boccalatte,F., Kugler,M., Corsica,A., Gelb,B.E., Jacobowitz,G., Miller,G., Bellini,C., Oakes,J., Silvestre,J.S., Zangi,L. and Ramkhelawon,B.<br>Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages<br>Nat Commun (2020) 11, 4311-4311. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Chen,S., Xie,J., Zhao,K., Ren,L., Deng,Y., Xie,X., Chen,S., Xu,H., Long,X. and Liu,E.<br>LPS aggravates lung inflammation induced by RSV by promoting the ERK-MMP-12 signaling pathway in mice<br>Respir Res (2020) 21, 193-193. PubMed  Europe PubMed DOI  PMC  EPMC  I
  25. Feldreich,T., Nowak,C., Carlsson,A.C., Ostgren,C.J., Nystrom,F.H., Sundstrom,J., Carrero-Roig,J.J., Leppert,J., Hedberg,P., Giedraitis,V., Lind,L., Cordeiro,A. and Arnlov,J.<br>The association between plasma proteomics and incident cardiovascular disease identifies MMP-12 as a promising cardiovascular risk marker in patients with chronic kidney disease<br>Atherosclerosis (2020) 307, 11-15. PubMed  Europe PubMed DOI
  26. Gaddi,G.M., Gisonno,R.A., Rosu,S.A., Cortez,M.F., Finarelli,G.S., Ramella,N.A. and Tricerri,M.A.<br>Data regarding the sensibility to proteolysis of a natural apolipoprotein A-I mutant<br>Data Brief (2020) 31, 105960-105960. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Gona,K., Toczek,J., Ye,Y., Sanzida,N., Golbazi,A., Boodagh,P., Salarian,M., Jung,J.J., Rajendran,S., Kukreja,G., Wu,T.L., Devel,L. and Sadeghi,M.M.<br>Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging<br>J Med Chem (2020) 63, 15037-15049. PubMed  Europe PubMed DOI  I
  28. Lee,K.B., Dunn,Z.S., Lopez,T., Mustafa,Z. and Ge,X.<br>Generation of highly selective monoclonal antibodies inhibiting a recalcitrant protease using decoy designs<br>Biotechnol Bioeng (2020) 117, 3664-3676. PubMed  Europe PubMed DOI
  29. Yang,H., Zhang,C., Wu,J., Xiao,W., Xie,X., Zeng,Z., Chen,K., Wang,W., An,X., Tang,W. and Huang,Q.<br>Association of matrix metalloproteinase-12 polymorphisms with chronic obstructive pulmonary disease risk: A protocol for systematic review and meta analysis<br>Medicine (Baltimore) (2020) 99, e21543-e21543. PubMed  Europe PubMed DOI  PMC  EPMC
    30. 2019
  30. Toczek,J., Bordenave,T., Gona,K., Kim,H.Y., Beau,F., Georgiadis,D., Correia,I., Ye,Y., Razavian,M., Jung,J.J., Lequin,O., Dive,V., Sadeghi,M.M. and Devel,L.<br>Novel matrix metalloproteinase 12 selective radiotracers for vascular molecular imaging<br>J Med Chem (2019) 62, 9743-9752. PubMed  Europe PubMed DOI  L
    31. 2018
  31. Chelluboina,B., Nalamolu,K.R., Klopfenstein,J.D., Pinson,D.M., Wang,D.Z., Vemuganti,R. and Veeravalli,K.K.<br>MMP-12, a promising therapeutic target for neurological diseases<br>Mol Neurobiol (2018) 55, 1405-1409. PubMed  Europe PubMed DOI  T  V
  32. Cuffaro,D., Camodeca,C., D'Andrea,F., Piragine,E., Testai,L., Calderone,V., Orlandini,E., Nuti,E. and Rossello,A.<br>Matrix metalloproteinase-12 inhibitors: synthesis, structure-activity relationships and intestinal absorption of novel sugar-based biphenylsulfonamide carboxylates<br>Bioorg Med Chem (2018) 26, 5804-5815. PubMed  Europe PubMed DOI  I
  33. Hagimori,M., Temma,T., Kudo,S., Sano,K., Kondo,N. and Mukai,T.<br>Synthesis of radioiodinated probes targeted toward matrix metalloproteinase-12<br>Bioorg Med Chem Lett (2018) 28, 193-195. PubMed  Europe PubMed DOI  L
  34. Nuti,E., Cuffaro,D., Bernardini,E., Camodeca,C., Panelli,L., Chaves,S., Ciccone,L., Tepshi,L., Vera,L., Orlandini,E., Nencetti,S., Stura,E.A., Santos,M.A., Dive,V. and Rossello,A.<br>Development of thioaryl-based matrix metalloproteinase-12 inhibitors with alternative zinc-binding groups: synthesis, potentiometric, NMR, and crystallographic studies<br>J Med Chem (2018) 61, 4421-4435. PubMed  Europe PubMed DOI  I
  35. Vinet,J., Costa,A.M., Salinas-Navarro,M., Leo,G., Moons,L., Arckens,L. and Biagini,G.<br>A hydroxypyrone-based inhibitor of metalloproteinase-12 displays neuroprotective properties in both status epilepticus and optic nerve crush animal models<br>Int J Mol Sci (2018) 19 PubMed  Europe PubMed DOI  I
  36. Zhang,G., Li,W., Guo,Y., Li,D., Liu,Y. and Xu,S.<br>MMP Gene polymorphisms, MMP-1 -1607 1G/2G, -519 A/G, and MMP-12 -82 A/G, and ischemic stroke: a meta-analysis<br>J Stroke Cerebrovasc Dis (2018) 27, 140-152. PubMed  Europe PubMed DOI  M
    37. 2017
  37. Dandachi,N., Kelly,N.J., Wood,J.P., Burton,C.L., Radder,J.E., Leme,A.S., Gregory,A.D. and Shapiro,S.D.<br>Macrophage elastase induces TRAIL-mediated tumor cell death through its carboxy-terminal domain<br>Am J Respir Crit Care Med (2017) 196, 353-363. PubMed  Europe PubMed DOI
  38. Rouanet-Mehouas,C., Czarny,B., Beau,F., Cassar-Lajeunesse,E., Stura,E.A., Dive,V. and Devel,L.<br>Zinc-metalloproteinase inhibitors: evaluation of the complex role played by the zinc-binding group on potency and selectivity<br>J Med Chem (2017) 60, 403-414. PubMed  Europe PubMed DOI  I
    39. 2016
  39. Bordenave,T., Helle,M., Beau,F., Georgiadis,D., Tepshi,L., Bernes,M., Ye,Y., Levenez,L., Poquet,E., Nozach,H., Razavian,M., Toczek,J., Stura,E.A., Dive,V., Sadeghi,M.M. and Devel,L.<br>Synthesis, and in vitro and in vivo evaluation of MMP-12 selective optical probes<br>Bioconjug Chem (2016) 27, 2407-2417. PubMed  Europe PubMed DOI  L  I
  40. Lamort,A.S., Gravier,R., Laffitte,A., Juliano,L., Zani,M.L. and Moreau,T.<br>New insights into the substrate specificity of macrophage elastase MMP-12<br>Biol Chem (2016) 397, 469-484. PubMed  Europe PubMed DOI  A  P
  41. Nuti,E., Cuffaro,D., D'Andrea,F., Rosalia,L., Tepshi,L., Fabbi,M., Carbotti,G., Ferrini,S., Santamaria,S., Camodeca,C., Ciccone,L., Orlandini,E., Nencetti,S., Stura,E.A., Dive,V. and Rossello,A.<br>Sugar-based arylsulfonamide carboxylates as selective and water-soluble matrix metalloproteinase-12 inhibitors<br>ChemMedChem (2016) 11, 1626-1637. PubMed  Europe PubMed DOI  I
    42. 2015
  42. Aerts,J., Vandenbroucke,R.E., Dera,R., Balusu,S., Van Wonterghem,E., Moons,L., Libert,C., Dehaen,W. and Arckens,L.<br>Synthesis and validation of a hydroxypyrone-based, potent, and specific matrix metalloproteinase-12 inhibitor with anti-inflammatory activity in vitro and in vivo<br>Mediators Inflamm (2015) 2015, 510679-510679. PubMed  Europe PubMed DOI  PMC  EPMC  I
  43. Chelluboina,B., Klopfenstein,J.D., Pinson,D.M., Wang,D.Z., Vemuganti,R. and Veeravalli,K.K.<br>Matrix metalloproteinase-12 induces blood-brain barrier damage after focal cerebral ischemia<br>Stroke (2015) 46, 3523-3531. PubMed  Europe PubMed DOI
  44. Chen,S.S., Song,J., Tu,X.Y., Zhao,J.H. and Ye,X.Q.<br>The association between MMP-12 82 A/G polymorphism and susceptibility to various malignant tumors: a meta-analysis<br>Int J Clin Exp Med (2015) 8, 10845-10854. PubMed  Europe PubMed  PMC  EPMC  M
  45. Hitaoka,S., Chuman,H. and Yoshizawa,K.<br>A QSAR study on the inhibition mechanism of matrix metalloproteinase-12 by arylsulfone analogs based on molecular orbital calculations<br>Org Biomol Chem (2015) 13, 793-806. PubMed  Europe PubMed DOI  I
  46. Nakagomi,D., Suzuki,K., Meguro,K., Hosokawa,J., Tamachi,T., Takatori,H., Suto,A., Matsue,H., Ohara,O., Nakayama,T., Shimada,S. and Nakajima,H.<br>Matrix metalloproteinase 12 is produced by M2 macrophages and plays important roles in the development of contact hypersensitivity<br>J Allergy Clin Immunol (2015) 135, 1397-1400. PubMed  Europe PubMed DOI
    47. 2014
  47. Bellac,C.L., Dufour,A., Krisinger,M.J., Loonchanta,A., Starr,A.E., auf dem Keller,U., Lange,P.F., Goebeler,V., Kappelhoff,R., Butler,G.S., Burtnick,L.D., Conway,E.M., Roberts,C.R. and Overall,C.M.<br>Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis<br>Cell Rep (2014) 9, 618-632. PubMed  Europe PubMed DOI  P
  48. Borrotti,M., De March,D., Slanzi,D. and Poli,I.<br>Designing lead optimisation of MMP-12 inhibitors<br>Comput Math Methods Med (2014) 2014, 258627-258627. PubMed  Europe PubMed DOI  PMC  EPMC  I
  49. Dandachi,N.G. and Shapiro,S.D.<br>A protean protease: MMP-12 fights viruses as a protease and a transcription factor<br>Nat Med (2014) 20, 470-472. PubMed  Europe PubMed DOI
  50. Koppisetti,R.K., Fulcher,Y.G., Jurkevich,A., Prior,S.H., Xu,J., Lenoir,M., Overduin,M. and Van Doren,S.R.<br>Ambidextrous binding of cell and membrane bilayers by soluble matrix metalloproteinase-12<br>Nat Commun (2014) 5, 5552-5552. PubMed  Europe PubMed DOI  PMC  EPMC
  51. Lim,N.H., Meinjohanns,E., Bou-Gharios,G., Gompels,L.L., Nuti,E., Rossello,A., Devel,L., Dive,V., Meldal,M. and Nagase,H.<br>In vivo imaging of matrix metalloproteinase 12 and matrix metalloproteinase 13 activities in the mouse model of collagen-induced arthritis<br>Arthritis Rheum (2014) 66, 589-598. PubMed  Europe PubMed DOI  L  I
  52. Marchant,D.J., Bellac,C.L., Moraes,T.J., Wadsworth,S.J., Dufour,A., Butler,G.S., Bilawchuk,L.M., Hendry,R.G., Robertson,A.G., Cheung,C.T., Ng,J., Ang,L., Luo,Z., Heilbron,K., Norris,M.J., Duan,W., Bucyk,T., Karpov,A., Devel,L., Georgiadis,D., Hegele,R.G., Luo,H., Granville,D.J., Dive,V., McManus,B.M. and Overall,C.M.<br>A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity<br>Nat Med (2014) 20, 493-502. PubMed  Europe PubMed
  53. Shamsara,J. and Shahir-Sadr,A.<br>A predictive HQSAR model for a series of tricycle core containing MMP-12 inhibitors with dibenzofuran ring<br>Int J Med Chem (2014) 2014, 630807-630807. PubMed  Europe PubMed DOI  PMC  EPMC  I
  54. Zhang,H., Wang,Y. and Xu,F.<br>Impact of the subtle differences in MMP-12 structure on Glide-based molecular docking for pose prediction of inhibitors<br>J Mol Struct (2014) 1076, 153-159. DOI  I
    55. 2013
  55. Czarny,B., Stura,E.A., Devel,L., Vera,L., Cassar-Lajeunesse,E., Beau,F., Calderone,V., Fragai,M., Luchinat,C. and Dive,V.<br>Molecular determinants of a selective matrix metalloprotease-12 inhibitor: Insights from crystallography and thermodynamic studies<br>J Med Chem (2013) 56, 1149-1159. PubMed  Europe PubMed DOI  S  I
  56. Gossas,T., Nordstrom,H., Xu,M.H., Sun,Z.H., Lin,G.Q., Wallberg,H. and Danielson,U.H.<br>The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors-characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors<br>MedChemComm (2013) 4, 432-442. DOI  I
  57. Nury,C., Bregant,S., Czarny,B., Berthon,F., Cassar-Lajeunesse,E. and Dive,V.<br>Detection of endogenous matrix metalloprotease-12 active form with a novel broad spectrum activity-based probe<br>J Biol Chem (2013) 288, 5636-5644. PubMed  Europe PubMed DOI  L
    58. 2012
  58. Kaynar,M. and Shapiro,S.D.<br>Matrix metallopeptidase-12/macrophage elastase<br>[ISSN:978-0-12-407744-7] (2012) 3, 800-804. DOI
  59. Kovacs,H., Agback,T. and Isaksson,J.<br>Probing water-protein contacts in a MMP-12/CGS27023A complex by nuclear magnetic resonance spectroscopy<br>J Biomol NMR (2012) 53, 85-92. PubMed  Europe PubMed DOI  I
  60. Li,J., Wang,J.J., Peng,Q., Chen,C., Humphrey,M.B., Heinecke,J. and Zhang,S.X.<br>Macrophage metalloelastase (MMP-12) deficiency mitigates retinal inflammation and pathological angiogenesis in ischemic retinopathy<br>PLoS ONE (2012) 7, e52699-e52699. PubMed  Europe PubMed DOI  PMC  EPMC  K
  61. Patel,T.R., Butler,G., McFarlane,A., Xie,I., Overall,C.M. and Stetefeld,J.<br>Site specific cleavage mediated by MMPs regulates function of agrin<br>PLoS ONE (2012) 7, e43669-e43669. PubMed  Europe PubMed DOI  PMC  EPMC  P
  62. Santamaria,S., Nuti,E., Cercignani,G., Marinelli,L., La Pietra,V., Novellino,E. and Rossello,A.<br>N-O-Isopropyl sulfonamido-based hydroxamates: kinetic characterisation of a series of MMP-12/MMP-13 dual target inhibitors<br>Biochem Pharmacol (2012) 84, 813-820. PubMed  Europe PubMed DOI  I
    63. 2011
  63. Fulcher,Y.G. and Van Doren,S.R.<br>Remote exosites of the catalytic domain of matrix metalloproteinase-12 enhance elastin degradation<br>Biochemistry (2011) 50, 9488-9499. PubMed  Europe PubMed DOI
  64. Haq,I., Lowrey,G.E., Kalsheker,N. and Johnson,S.R.<br>Matrix metalloproteinase-12 (MMP-12) SNP affects MMP activity, lung macrophage infiltration and protects against emphysema in COPD<br>Thorax (2011) 66, 970-976. PubMed  Europe PubMed DOI  M
  65. Johnson,J.L., Devel,L., Czarny,B., George,S.J., Jackson,C.L., Rogakos,V., Beau,F., Yiotakis,A., Newby,A.C. and Dive,V.<br>A selective matrix metalloproteinase-12 inhibitor retards atherosclerotic plaque development in apolipoprotein E-knockout mice<br>Arterioscler Thromb Vasc Biol (2011) 31, 528-535. PubMed  Europe PubMed DOI  I
  66. Magnussen,H., Watz,H., Kirsten,A., Wang,M., Wray,H., Samuelsson,V., Mo,J. and Kay,R.<br>Safety and tolerability of an oral MMP-9 and -12 inhibitor, AZD1236, in patients with moderate-to-severe COPD: a randomised controlled 6-week trial<br>Pulm Pharmacol Ther (2011) 24, 563-570. PubMed  Europe PubMed DOI  I
  67. Pickett,S.D., Green,D.V.S., Hunt,D.L., Pardoe,D.A. and Hughes,I.<br>Automated lead optimization of MMP-12 inhibitors using a genetic algorithm<br>ACS Med Chem Lett (2011) 2, 28-33. PubMed  Europe PubMed DOI  I
    68. 2010
  68. Devel,L., Garcia,S., Czarny,B., Beau,F., Lajeunesse,E., Vera,L., Georgiadis,D., Stura,E. and Dive,V.<br>Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation<br>J Biol Chem (2010) 285, 35900-35909. PubMed  Europe PubMed DOI  I
  69. Heinz,A., Jung,M.C., Duca,L., Sippl,W., Taddese,S., Ihling,C., Rusciani,A., Jahreis,G., Weiss,A.S., Neubert,R.H. and Schmelzer,C.E.<br>Degradation of tropoelastin by matrix metalloproteinases - cleavage site specificities and release of matrikines<br>FEBS J (2010) 277, 1939-1956. PubMed  Europe PubMed DOI  P
  70. Liang,X., Arunima,A., Zhao,Y., Bhaskaran,R., Shende,A., Byrne,T.S., Fleeks,J., Palmier,M.O. and Van Doren,S.R.<br>Apparent tradeoff of higher activity in MMP-12 for enhanced stability and flexibility in MMP-3<br>Biophys J (2010) 99, 273-283. PubMed  Europe PubMed DOI
  71. Madala,S.K., Pesce,J.T., Ramalingam,T.R., Wilson,M.S., Minnicozzi,S., Cheever,A.W., Thompson,R.W., Mentink-Kane,M.M. and Wynn,T.A.<br>Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis<br>J Immunol (2010) 184, 3955-3963. PubMed  Europe PubMed DOI  K
  72. Margheri,F., Serrati,S., Lapucci,A., Chilla,A., Bazzichi,L., Bombardieri,S., Kahaleh,B., Calorini,L., Bianchini,F., Fibbi,G. and Del Rosso,M.<br>Modulation of the angiogenic phenotype of normal and systemic sclerosis endothelial cells by gain-loss of function of pentraxin 3 and matrix metalloproteinase 12<br>Arthritis Rheum (2010) 62, 2488-2498. PubMed  Europe PubMed DOI
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