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Literature for peptidase M10.009: matrix metallopeptidase-12

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: S Structure, A Assay, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Dorjay Tamang,J.S., Banerjee,S., Baidya,S.K., Das,S., Ghosh,B., Jha,T. and Adhikari,N.
    An overview of matrix metalloproteinase-12 in multiple disease conditions, potential selective inhibitors, and drug designing strategies
    Eur J Med Chem (2025) 283, 117154-117154. PubMed  Europe PubMed DOI  V
  2. Sun,C., Deng,H., Wang,Q., Long,Y., Li,T., Song,C. and Han,C.
    The roles of HOXB9 and MMP12 in proliferation, migration, and invasion of human laryngeal cancer cells LCC and TU212
    Biochem Biophys Res Commun (2025) 752, 151391-151391. PubMed  Europe PubMed DOI
  3. Zhou,S., Yang,Y., Qi,F., Sun,W., Zhang,D., Lu,Z. and Chen,Y.
    ADAMDEC1 promotes the malignant progression of cholangiocarcinoma by regulating NF-kappaB signaling pathway
    Sci Rep (2025) 15, 817-817. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2024
  4. Arosa,L., Camba-Gomez,M., Lorenzo-Martin,L.F., Clavain,L., Lopez,M. and Conde-Aranda,J.
    RNA Expression of MMP12 Is Strongly Associated with Inflammatory Bowel Disease and Is Regulated by Metabolic Pathways in RAW 264.7 Macrophages
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  5. Buerger,M., Amor,M., Akhmetshina,A., Bianco,V., Perfler,B., Zebisch,A., Weichhart,T. and Kratky,D.
    Limited Alleviation of Lysosomal Acid Lipase Deficiency by Deletion of Matrix Metalloproteinase 12
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  6. Han,D., Yu,F. and Zheng,L.
    Causal effect of serum matrix metalloproteinase levels on venous thromboembolism: a Mendelian randomization study
    Epidemiol Health (2024) , e2024046-e2024046. PubMed  Europe PubMed DOI
  7. Hanai,S., Nakagomi,D., Suzuki,K., Nakajima,H. and Furuya,F.
    Renal protective roles of macrophage matrix metalloproteinase-12 in mice with obstructed kidneys
    Int J Exp Pathol (2024) 105, 193-201-201. PubMed  Europe PubMed DOI
    8. 2023
  8. Lin,B., Ser,H.L., Wang,L., Li,J., Chan,K.G., Lee,L.H. and Tan,L.T.
    The Emerging Role of MMP12 in the Oral Environment
    Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC  V
  9. Port,H., Hausgaard,C.M., He,Y., Maksymowych,W.P., Wichuk,S., Sinkeviciute,D., Bay-Jensen,A.C. and Holm Nielsen,S.
    A novel biomarker of MMP-cleaved cartilage intermediate layer protein-1 is elevated in patients with rheumatoid arthritis, ankylosing spondylitis and osteoarthritis
    Sci Rep (2023) 13, 21717-21717. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Tamang,J.S.D., Banerjee,S., Baidya,S.K., Ghosh,B., Adhikari,N. and Jha,T.
    Employing comparative QSAR techniques for the recognition of dibenzofuran and dibenzothiophene derivatives toward MMP-12 inhibition
    J Biomol Struct Dyn (2023) , 1-17. PubMed  Europe PubMed DOI
    11. 2022
  11. Chalise,U., Becirovic-Agic,M., Konfrst,S.R., Rodriguez-Paar,J.R., Cook,L.M. and Lindsey,M.L.
    MMP-12 polarizes neutrophil signalome towards an apoptotic signature
    J Proteomics (2022) 264, 104636-104636. PubMed  Europe PubMed DOI
  12. Fan,D., Zheng,C., Wu,W., Chen,Y., Chen,D., Hu,X., Shen,C., Chen,M., Li,R. and Chen,Y.
    MMP9 SNP and MMP SNP-SNP interactions increase the risk for ischemic stroke in the Han Hakka population
    Brain Behav (2022) 12, e2473-e2473. PubMed  Europe PubMed DOI
  13. Lee,M.R., Chen,Y.L., Wu,C.W., Chen,L.C., Chang,L.Y., Chen,J.Y., Huang,Y.T., Wang,J.Y., Shih,J.Y. and Yu,C.J.
    Toll-like receptor and matrix metalloproteinase single-nucleotide polymorphisms, haplotypes, and polygenic risk score differentiated between tuberculosis disease and infection
    Int J Infect Dis (2022) 125, 61-66. PubMed  Europe PubMed DOI  M
  14. Ravanetti,L., Dekker,T., Guo,L., Dijkhuis,A., Dierdorp,B.S., Diamant,Z., Florquin,S. and Lutter,R.
    Efficacy of FP-025: A novel matrix metalloproteinase-12 (MMP-12) inhibitor in murine allergic asthma
    Allergy (2022) PubMed  Europe PubMed DOI  I
  15. Spix,B., Butz,E.S., Chen,C.C., Rosato,A.S., Tang,R., Jeridi,A., Kudrina,V., Plesch,E., Wartenberg,P., Arlt,E., Briukhovetska,D., Ansari,M., Gunsel,G.G., Conlon,T.M., Wyatt,A., Wetzel,S., Teupser,D., Holdt,L.M., Ectors,F., Boekhoff,I., Boehm,U., Garcia-Anoveros,J., Saftig,P., Giera,M., Kobold,S., Schiller,H.B., Zierler,S., Gudermann,T., Wahl-Schott,C., Bracher,F., Yildirim,A.O., Biel,M. and Grimm,C.
    Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice
    Nat Commun (2022) 13, 318-318. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Yi,C., Liu,J., Deng,W., Luo,C., Qi,J., Chen,M. and Xu,H.
    Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis
    J Neuroinflammation (2022) 19, 78-78. PubMed  Europe PubMed DOI  PMC  EPMC  I
    17. 2021
  17. Abd-Elaziz,K., Voors-Pette,C., Wang,K.L., Pan,S., Lee,Y., Mao,J., Li,Y., Chien,B., Lau,D. and Diamant,Z.
    First-in-Man Safety, Tolerability, and Pharmacokinetics of a Novel and Highly Selective Inhibitor of Matrix Metalloproteinase-12, FP-025: Results from Two Randomized Studies in Healthy Subjects
    Clin Drug Investig (2021) 41, 65-76. PubMed  Europe PubMed DOI  I
  18. Bassiouni,W., Ali,M.A.M. and Schulz,R.
    Multifunctional intracellular matrix metalloproteinases: implications in disease
    FEBS J (2021) 288, 7162-7182. PubMed  Europe PubMed DOI  V
  19. Chakraborty,S., Sampath,D., Yu Lin,M.O., Bilton,M., Huang,C.K., Nai,M.H., Njah,K., Goy,P.A., Wang,C.C., Guccione,E., Lim,C.T. and Hong,W.
    Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing
    Nat Commun (2021) 12, 6349-6349. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Makino,A., Shibata,T., Nagayasu,M., Hosoya,I., Nishimura,T., Nakano,C., Nagata,K., Ito,T., Takahashi,Y. and Nakamura,S.
    RSV infection-elicited high MMP-12-producing macrophages exacerbate allergic airway inflammation with neutrophil infiltration
    iScience (2021) 24, 103201-103201. PubMed  Europe PubMed DOI  PMC  EPMC  I
  21. Nighot,M., Ganapathy,A.S., Saha,K., Suchanec,E., Castillo,E., Gregory,A., Shapiro,S., Ma,T. and Nighot,P.
    Matrix Metalloproteinase MMP-12 promotes macrophage transmigration across intestinal epithelial tight junctions and increases severity of experimental colitis
    J Crohns Colitis (2021) 15, 1751-1765. PubMed  Europe PubMed DOI
    22. 2020
  22. Baggio,C., Velazquez,J.V., Fragai,M., Nordgren,T.M. and Pellecchia,M.
    Therapeutic Targeting of MMP-12 for the Treatment of Chronic Obstructive Pulmonary Disease
    J Med Chem (2020) 63, 12911-12920. PubMed  Europe PubMed DOI
  23. Boytard,L., Hadi,T., Silvestro,M., Qu,H., Kumpfbeck,A., Sleiman,R., Fils,K.H., Alebrahim,D., Boccalatte,F., Kugler,M., Corsica,A., Gelb,B.E., Jacobowitz,G., Miller,G., Bellini,C., Oakes,J., Silvestre,J.S., Zangi,L. and Ramkhelawon,B.
    Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages
    Nat Commun (2020) 11, 4311-4311. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Chen,S., Xie,J., Zhao,K., Ren,L., Deng,Y., Xie,X., Chen,S., Xu,H., Long,X. and Liu,E.
    LPS aggravates lung inflammation induced by RSV by promoting the ERK-MMP-12 signaling pathway in mice
    Respir Res (2020) 21, 193-193. PubMed  Europe PubMed DOI  PMC  EPMC  I
  25. Feldreich,T., Nowak,C., Carlsson,A.C., Ostgren,C.J., Nystrom,F.H., Sundstrom,J., Carrero-Roig,J.J., Leppert,J., Hedberg,P., Giedraitis,V., Lind,L., Cordeiro,A. and Arnlov,J.
    The association between plasma proteomics and incident cardiovascular disease identifies MMP-12 as a promising cardiovascular risk marker in patients with chronic kidney disease
    Atherosclerosis (2020) 307, 11-15. PubMed  Europe PubMed DOI
  26. Gaddi,G.M., Gisonno,R.A., Rosu,S.A., Cortez,M.F., Finarelli,G.S., Ramella,N.A. and Tricerri,M.A.
    Data regarding the sensibility to proteolysis of a natural apolipoprotein A-I mutant
    Data Brief (2020) 31, 105960-105960. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Gona,K., Toczek,J., Ye,Y., Sanzida,N., Golbazi,A., Boodagh,P., Salarian,M., Jung,J.J., Rajendran,S., Kukreja,G., Wu,T.L., Devel,L. and Sadeghi,M.M.
    Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging
    J Med Chem (2020) 63, 15037-15049. PubMed  Europe PubMed DOI  I
  28. Lee,K.B., Dunn,Z.S., Lopez,T., Mustafa,Z. and Ge,X.
    Generation of highly selective monoclonal antibodies inhibiting a recalcitrant protease using decoy designs
    Biotechnol Bioeng (2020) 117, 3664-3676. PubMed  Europe PubMed DOI
  29. Yang,H., Zhang,C., Wu,J., Xiao,W., Xie,X., Zeng,Z., Chen,K., Wang,W., An,X., Tang,W. and Huang,Q.
    Association of matrix metalloproteinase-12 polymorphisms with chronic obstructive pulmonary disease risk: A protocol for systematic review and meta analysis
    Medicine (Baltimore) (2020) 99, e21543-e21543. PubMed  Europe PubMed DOI  PMC  EPMC
    30. 2019
  30. Toczek,J., Bordenave,T., Gona,K., Kim,H.Y., Beau,F., Georgiadis,D., Correia,I., Ye,Y., Razavian,M., Jung,J.J., Lequin,O., Dive,V., Sadeghi,M.M. and Devel,L.
    Novel matrix metalloproteinase 12 selective radiotracers for vascular molecular imaging
    J Med Chem (2019) 62, 9743-9752. PubMed  Europe PubMed DOI  L
    31. 2018
  31. Chelluboina,B., Nalamolu,K.R., Klopfenstein,J.D., Pinson,D.M., Wang,D.Z., Vemuganti,R. and Veeravalli,K.K.
    MMP-12, a promising therapeutic target for neurological diseases
    Mol Neurobiol (2018) 55, 1405-1409. PubMed  Europe PubMed DOI  T  V
  32. Cuffaro,D., Camodeca,C., D'Andrea,F., Piragine,E., Testai,L., Calderone,V., Orlandini,E., Nuti,E. and Rossello,A.
    Matrix metalloproteinase-12 inhibitors: synthesis, structure-activity relationships and intestinal absorption of novel sugar-based biphenylsulfonamide carboxylates
    Bioorg Med Chem (2018) 26, 5804-5815. PubMed  Europe PubMed DOI  I
  33. Hagimori,M., Temma,T., Kudo,S., Sano,K., Kondo,N. and Mukai,T.
    Synthesis of radioiodinated probes targeted toward matrix metalloproteinase-12
    Bioorg Med Chem Lett (2018) 28, 193-195. PubMed  Europe PubMed DOI  L
  34. Nuti,E., Cuffaro,D., Bernardini,E., Camodeca,C., Panelli,L., Chaves,S., Ciccone,L., Tepshi,L., Vera,L., Orlandini,E., Nencetti,S., Stura,E.A., Santos,M.A., Dive,V. and Rossello,A.
    Development of thioaryl-based matrix metalloproteinase-12 inhibitors with alternative zinc-binding groups: synthesis, potentiometric, NMR, and crystallographic studies
    J Med Chem (2018) 61, 4421-4435. PubMed  Europe PubMed DOI  I
  35. Vinet,J., Costa,A.M., Salinas-Navarro,M., Leo,G., Moons,L., Arckens,L. and Biagini,G.
    A hydroxypyrone-based inhibitor of metalloproteinase-12 displays neuroprotective properties in both status epilepticus and optic nerve crush animal models
    Int J Mol Sci (2018) 19 PubMed  Europe PubMed DOI  I
  36. Zhang,G., Li,W., Guo,Y., Li,D., Liu,Y. and Xu,S.
    MMP Gene polymorphisms, MMP-1 -1607 1G/2G, -519 A/G, and MMP-12 -82 A/G, and ischemic stroke: a meta-analysis
    J Stroke Cerebrovasc Dis (2018) 27, 140-152. PubMed  Europe PubMed DOI  M
    37. 2017
  37. Dandachi,N., Kelly,N.J., Wood,J.P., Burton,C.L., Radder,J.E., Leme,A.S., Gregory,A.D. and Shapiro,S.D.
    Macrophage elastase induces TRAIL-mediated tumor cell death through its carboxy-terminal domain
    Am J Respir Crit Care Med (2017) 196, 353-363. PubMed  Europe PubMed DOI
  38. Rouanet-Mehouas,C., Czarny,B., Beau,F., Cassar-Lajeunesse,E., Stura,E.A., Dive,V. and Devel,L.
    Zinc-metalloproteinase inhibitors: evaluation of the complex role played by the zinc-binding group on potency and selectivity
    J Med Chem (2017) 60, 403-414. PubMed  Europe PubMed DOI  I
    39. 2016
  39. Bordenave,T., Helle,M., Beau,F., Georgiadis,D., Tepshi,L., Bernes,M., Ye,Y., Levenez,L., Poquet,E., Nozach,H., Razavian,M., Toczek,J., Stura,E.A., Dive,V., Sadeghi,M.M. and Devel,L.
    Synthesis, and in vitro and in vivo evaluation of MMP-12 selective optical probes
    Bioconjug Chem (2016) 27, 2407-2417. PubMed  Europe PubMed DOI  L  I
  40. Lamort,A.S., Gravier,R., Laffitte,A., Juliano,L., Zani,M.L. and Moreau,T.
    New insights into the substrate specificity of macrophage elastase MMP-12
    Biol Chem (2016) 397, 469-484. PubMed  Europe PubMed DOI  A  P
  41. Nuti,E., Cuffaro,D., D'Andrea,F., Rosalia,L., Tepshi,L., Fabbi,M., Carbotti,G., Ferrini,S., Santamaria,S., Camodeca,C., Ciccone,L., Orlandini,E., Nencetti,S., Stura,E.A., Dive,V. and Rossello,A.
    Sugar-based arylsulfonamide carboxylates as selective and water-soluble matrix metalloproteinase-12 inhibitors
    ChemMedChem (2016) 11, 1626-1637. PubMed  Europe PubMed DOI  I
    42. 2015
  42. Aerts,J., Vandenbroucke,R.E., Dera,R., Balusu,S., Van Wonterghem,E., Moons,L., Libert,C., Dehaen,W. and Arckens,L.
    Synthesis and validation of a hydroxypyrone-based, potent, and specific matrix metalloproteinase-12 inhibitor with anti-inflammatory activity in vitro and in vivo
    Mediators Inflamm (2015) 2015, 510679-510679. PubMed  Europe PubMed DOI  PMC  EPMC  I
  43. Chelluboina,B., Klopfenstein,J.D., Pinson,D.M., Wang,D.Z., Vemuganti,R. and Veeravalli,K.K.
    Matrix metalloproteinase-12 induces blood-brain barrier damage after focal cerebral ischemia
    Stroke (2015) 46, 3523-3531. PubMed  Europe PubMed DOI
  44. Chen,S.S., Song,J., Tu,X.Y., Zhao,J.H. and Ye,X.Q.
    The association between MMP-12 82 A/G polymorphism and susceptibility to various malignant tumors: a meta-analysis
    Int J Clin Exp Med (2015) 8, 10845-10854. PubMed  Europe PubMed  PMC  EPMC  M
  45. Hitaoka,S., Chuman,H. and Yoshizawa,K.
    A QSAR study on the inhibition mechanism of matrix metalloproteinase-12 by arylsulfone analogs based on molecular orbital calculations
    Org Biomol Chem (2015) 13, 793-806. PubMed  Europe PubMed DOI  I
  46. Nakagomi,D., Suzuki,K., Meguro,K., Hosokawa,J., Tamachi,T., Takatori,H., Suto,A., Matsue,H., Ohara,O., Nakayama,T., Shimada,S. and Nakajima,H.
    Matrix metalloproteinase 12 is produced by M2 macrophages and plays important roles in the development of contact hypersensitivity
    J Allergy Clin Immunol (2015) 135, 1397-1400. PubMed  Europe PubMed DOI
    47. 2014
  47. Bellac,C.L., Dufour,A., Krisinger,M.J., Loonchanta,A., Starr,A.E., auf dem Keller,U., Lange,P.F., Goebeler,V., Kappelhoff,R., Butler,G.S., Burtnick,L.D., Conway,E.M., Roberts,C.R. and Overall,C.M.
    Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis
    Cell Rep (2014) 9, 618-632. PubMed  Europe PubMed DOI  P
  48. Borrotti,M., De March,D., Slanzi,D. and Poli,I.
    Designing lead optimisation of MMP-12 inhibitors
    Comput Math Methods Med (2014) 2014, 258627-258627. PubMed  Europe PubMed DOI  PMC  EPMC  I
  49. Dandachi,N.G. and Shapiro,S.D.
    A protean protease: MMP-12 fights viruses as a protease and a transcription factor
    Nat Med (2014) 20, 470-472. PubMed  Europe PubMed DOI
  50. Koppisetti,R.K., Fulcher,Y.G., Jurkevich,A., Prior,S.H., Xu,J., Lenoir,M., Overduin,M. and Van Doren,S.R.
    Ambidextrous binding of cell and membrane bilayers by soluble matrix metalloproteinase-12
    Nat Commun (2014) 5, 5552-5552. PubMed  Europe PubMed DOI  PMC  EPMC
  51. Lim,N.H., Meinjohanns,E., Bou-Gharios,G., Gompels,L.L., Nuti,E., Rossello,A., Devel,L., Dive,V., Meldal,M. and Nagase,H.
    In vivo imaging of matrix metalloproteinase 12 and matrix metalloproteinase 13 activities in the mouse model of collagen-induced arthritis
    Arthritis Rheum (2014) 66, 589-598. PubMed  Europe PubMed DOI  L  I
  52. Marchant,D.J., Bellac,C.L., Moraes,T.J., Wadsworth,S.J., Dufour,A., Butler,G.S., Bilawchuk,L.M., Hendry,R.G., Robertson,A.G., Cheung,C.T., Ng,J., Ang,L., Luo,Z., Heilbron,K., Norris,M.J., Duan,W., Bucyk,T., Karpov,A., Devel,L., Georgiadis,D., Hegele,R.G., Luo,H., Granville,D.J., Dive,V., McManus,B.M. and Overall,C.M.
    A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity
    Nat Med (2014) 20, 493-502. PubMed  Europe PubMed
  53. Shamsara,J. and Shahir-Sadr,A.
    A predictive HQSAR model for a series of tricycle core containing MMP-12 inhibitors with dibenzofuran ring
    Int J Med Chem (2014) 2014, 630807-630807. PubMed  Europe PubMed DOI  PMC  EPMC  I
  54. Zhang,H., Wang,Y. and Xu,F.
    Impact of the subtle differences in MMP-12 structure on Glide-based molecular docking for pose prediction of inhibitors
    J Mol Struct (2014) 1076, 153-159. DOI  I
    55. 2013
  55. Czarny,B., Stura,E.A., Devel,L., Vera,L., Cassar-Lajeunesse,E., Beau,F., Calderone,V., Fragai,M., Luchinat,C. and Dive,V.
    Molecular determinants of a selective matrix metalloprotease-12 inhibitor: Insights from crystallography and thermodynamic studies
    J Med Chem (2013) 56, 1149-1159. PubMed  Europe PubMed DOI  S  I
  56. Gossas,T., Nordstrom,H., Xu,M.H., Sun,Z.H., Lin,G.Q., Wallberg,H. and Danielson,U.H.
    The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors-characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors
    MedChemComm (2013) 4, 432-442. DOI  I
  57. Nury,C., Bregant,S., Czarny,B., Berthon,F., Cassar-Lajeunesse,E. and Dive,V.
    Detection of endogenous matrix metalloprotease-12 active form with a novel broad spectrum activity-based probe
    J Biol Chem (2013) 288, 5636-5644. PubMed  Europe PubMed DOI  L
    58. 2012
  58. Kaynar,M. and Shapiro,S.D.
    Matrix metallopeptidase-12/macrophage elastase
    [ISSN:978-0-12-407744-7] (2012) 3, 800-804. DOI
  59. Kovacs,H., Agback,T. and Isaksson,J.
    Probing water-protein contacts in a MMP-12/CGS27023A complex by nuclear magnetic resonance spectroscopy
    J Biomol NMR (2012) 53, 85-92. PubMed  Europe PubMed DOI  I
  60. Li,J., Wang,J.J., Peng,Q., Chen,C., Humphrey,M.B., Heinecke,J. and Zhang,S.X.
    Macrophage metalloelastase (MMP-12) deficiency mitigates retinal inflammation and pathological angiogenesis in ischemic retinopathy
    PLoS ONE (2012) 7, e52699-e52699. PubMed  Europe PubMed DOI  PMC  EPMC  K
  61. Patel,T.R., Butler,G., McFarlane,A., Xie,I., Overall,C.M. and Stetefeld,J.
    Site specific cleavage mediated by MMPs regulates function of agrin
    PLoS ONE (2012) 7, e43669-e43669. PubMed  Europe PubMed DOI  PMC  EPMC  P
  62. Santamaria,S., Nuti,E., Cercignani,G., Marinelli,L., La Pietra,V., Novellino,E. and Rossello,A.
    N-O-Isopropyl sulfonamido-based hydroxamates: kinetic characterisation of a series of MMP-12/MMP-13 dual target inhibitors
    Biochem Pharmacol (2012) 84, 813-820. PubMed  Europe PubMed DOI  I
    63. 2011
  63. Fulcher,Y.G. and Van Doren,S.R.
    Remote exosites of the catalytic domain of matrix metalloproteinase-12 enhance elastin degradation
    Biochemistry (2011) 50, 9488-9499. PubMed  Europe PubMed DOI
  64. Haq,I., Lowrey,G.E., Kalsheker,N. and Johnson,S.R.
    Matrix metalloproteinase-12 (MMP-12) SNP affects MMP activity, lung macrophage infiltration and protects against emphysema in COPD
    Thorax (2011) 66, 970-976. PubMed  Europe PubMed DOI  M
  65. Johnson,J.L., Devel,L., Czarny,B., George,S.J., Jackson,C.L., Rogakos,V., Beau,F., Yiotakis,A., Newby,A.C. and Dive,V.
    A selective matrix metalloproteinase-12 inhibitor retards atherosclerotic plaque development in apolipoprotein E-knockout mice
    Arterioscler Thromb Vasc Biol (2011) 31, 528-535. PubMed  Europe PubMed DOI  I
  66. Magnussen,H., Watz,H., Kirsten,A., Wang,M., Wray,H., Samuelsson,V., Mo,J. and Kay,R.
    Safety and tolerability of an oral MMP-9 and -12 inhibitor, AZD1236, in patients with moderate-to-severe COPD: a randomised controlled 6-week trial
    Pulm Pharmacol Ther (2011) 24, 563-570. PubMed  Europe PubMed DOI  I
  67. Pickett,S.D., Green,D.V.S., Hunt,D.L., Pardoe,D.A. and Hughes,I.
    Automated lead optimization of MMP-12 inhibitors using a genetic algorithm
    ACS Med Chem Lett (2011) 2, 28-33. PubMed  Europe PubMed DOI  I
    68. 2010
  68. Devel,L., Garcia,S., Czarny,B., Beau,F., Lajeunesse,E., Vera,L., Georgiadis,D., Stura,E. and Dive,V.
    Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation
    J Biol Chem (2010) 285, 35900-35909. PubMed  Europe PubMed DOI  I
  69. Heinz,A., Jung,M.C., Duca,L., Sippl,W., Taddese,S., Ihling,C., Rusciani,A., Jahreis,G., Weiss,A.S., Neubert,R.H. and Schmelzer,C.E.
    Degradation of tropoelastin by matrix metalloproteinases - cleavage site specificities and release of matrikines
    FEBS J (2010) 277, 1939-1956. PubMed  Europe PubMed DOI  P
  70. Liang,X., Arunima,A., Zhao,Y., Bhaskaran,R., Shende,A., Byrne,T.S., Fleeks,J., Palmier,M.O. and Van Doren,S.R.
    Apparent tradeoff of higher activity in MMP-12 for enhanced stability and flexibility in MMP-3
    Biophys J (2010) 99, 273-283. PubMed  Europe PubMed DOI
  71. Madala,S.K., Pesce,J.T., Ramalingam,T.R., Wilson,M.S., Minnicozzi,S., Cheever,A.W., Thompson,R.W., Mentink-Kane,M.M. and Wynn,T.A.
    Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis
    J Immunol (2010) 184, 3955-3963. PubMed  Europe PubMed DOI  K
  72. Margheri,F., Serrati,S., Lapucci,A., Chilla,A., Bazzichi,L., Bombardieri,S., Kahaleh,B., Calorini,L., Bianchini,F., Fibbi,G. and Del Rosso,M.
    Modulation of the angiogenic phenotype of normal and systemic sclerosis endothelial cells by gain-loss of function of pentraxin 3 and matrix metalloproteinase 12
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