Sequence features for peptidase M10.009: matrix metallopeptidase-12

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

MERNUM Species Sequence length Peptidase unit Active site residues Metal ligands Source
MER1203226 Acinonyx jubatus 470 100-275 E220 H219, H223, H229 GENBANK:XP_014929426
MER0233936 Ailuropoda melanoleuca 407 69-235 E188 H187, H191, H197 UNIPROT:D2HIH4
MER0233936 Ailuropoda melanoleuca 407 69-235 E188 H187, H191, H197 UNIPROT:D2HIH4
MER1204216 Ailuropoda melanoleuca 164 56-164 missing missing, missing, missing GENBANK:XP_011216659
MER0290974 Anolis carolinensis 268 95-253 E209 H208, H212, H218 UNIPROT:G1KVT7
MER0290974 Anolis carolinensis 268 95-253 E209 H208, H212, H218 UNIPROT:G1KVT7
MER0403085 Balaenoptera acutorostrata 331 100-277 A220 H219, H223, H229 GENBANK:XP_007191301
MER0679452 Bison bison 471 99-277 E220 H219, H223, H229 GENBANK:XP_010837171
MER0190915 Bos grunniens 474 105-279 E224 H223, H227, H233 UNIPROT:L8J133
MER0190915 Bos grunniens 474 105-279 E224 H223, H227, H233 UNIPROT:L8J133
MER1203663 Bos indicus 471 101-275 E220 H219, H223, H229 GENBANK:XP_019830080
MER0112492 Bos taurus 611 267-447 E387 H386, H390, H396 GENBANK:XP_605366
MER1203792 Branchiostoma belcheri 267 81-243 E198 H197, H201, H207 GENBANK:XP_019641815
MER1205291 Branchiostoma belcheri 524 38-212 E156 H155, H159, H165 GENBANK:XP_019620812
MER1206243 Branchiostoma belcheri 1385 130-298 E243, H242, H246, H252, GENBANK:XP_019613997
MER0138255 Branchiostoma floridae 2357 117-277 E231 H230, H234, H240 GENBANK:XP_002227294
MER0290935 Callithrix jacchus 469 100-271 E219 H218, H222, H228 UNIPROT:F7IH65
MER0290935 Callithrix jacchus 469 100-271 E219 H218, H222, H228 UNIPROT:F7IH65
MER1203332 Camelus bactrianus 471 101-278 E220 H219, H223, H229 GENBANK:XP_010951489
MER0676321 Camelus dromedarius 471 100-268 E220 H219, H223, H229 GENBANK:XP_010976088
MER0826227 Camelus ferus 342 110-224 E178 H177, H181, H187 UNIPROT:S9WV40
MER0826227 Camelus ferus 342 110-224 E178 H177, H181, H187 UNIPROT:S9WV40
MER0053742 Canis lupus familiaris 601 231-410 E351 H350, H354, H360 GENBANK:XP_854594
MER1203673 Castor canadensis 471 101-264 E220 H219, H223, H229 GENBANK:XP_020023662
MER0825354 Castor fiber 471 111-267 E221 H220, H224, H230 UNIPROT:A0A0B5D1B3
MER0825354 Castor fiber 471 111-267 E221 H220, H224, H230 UNIPROT:A0A0B5D1B3
MER0103340 Cavia porcellus 464 104-258 E214 H213, H217, H223 GENBANK:XP_003472863
MER1203737 Cavia porcellus 468 108-262 E218 H217, H221, H227 GENBANK:XP_013010832
MER1203481 Cercocebus atys 470 109-263 E219 H218, H222, H228 GENBANK:XP_011921969
MER0591883 Chelonia mydas 263 98-257 E213 H212, H216, H222 UNIPROT:M7CBA3
MER0591883 Chelonia mydas 263 98-257 E213 H212, H216, H222 UNIPROT:M7CBA3
MER0670306 Colobus angolensis 470 99-276 E219 H218, H222, H228 GENBANK:XP_011782025
MER1203573 Dipodomys ordii 467 105-261 E217 H216, H220, H226 GENBANK:XP_012865313
MER1204011 Echinops telfairi 470 103-274 E220 H219, H223, H229 GENBANK:XP_012861701
MER1203266 Enhydra lutris 493 124-304 E243 H242, H246, H252 GENBANK:XP_022368855
MER1203308 Equus asinus 470 101-269 E220 H219, H223, H229 GENBANK:XP_014715497
MER0098644 Equus caballus 470 99-280 E220 H219, H223, H229 GENBANK:XP_001498924
MER0615803 Erinaceus europaeus 329 92-265 E211 H210, H214, H220 GENBANK:XP_007520732
MER0615814 Erinaceus europaeus 326 92-268 E211 H210, H214, H220 GENBANK:XP_007520807
MER0329337 Felis catus 470 100-275 E220 H219, H223, H229 UNIPROT:M3WEA4
MER0329337 Felis catus 470 100-275 E220 H219, H223, H229 UNIPROT:M3WEA4
MER1203256 Felis catus 417 47-222 E167 H166, H170, H176 GENBANK:XP_019666771
MER0656643 Fukomys damarensis 471 98-265 E219 H218, H222, H228 GENBANK:XP_010640358
MER0557642 Galeopterus variegatus 267 101-262 G216 H215, H219, H225 GENBANK:XP_008561265
MER0329580 Gorilla gorilla 470 105-263 E219 H218, H222, H228 GENBANK:XP_004052087
MER0290952 Heterocephalus glaber 403 34-197 E153 H152, H156, H162 UNIPROT:G5BUC6
MER0290952 Heterocephalus glaber 403 34-197 E153 H152, H156, H162 UNIPROT:G5BUC6
MER1203706 Heterocephalus glaber 469 105-263 E219 H218, H222, H228 GENBANK:XP_021104682
MER1205682 Hipposideros armiger 335 105-206 missing missing, missing, missing GENBANK:XP_019490265
MER0001089 Homo sapiens 470 98-279 E219 H218, H222, H228 PIR:A49499
MER0001089 Homo sapiens 470 98-279 E219 H218, H222, H228 PIR:A49499
MER0106433 Ictidomys tridecemlineatus 420 50-228 E170 H169, H173, H179 GENBANK:XP_005329151
MER1203377 Ictidomys tridecemlineatus 421 55-229 E170 H169, H173, H179 GENBANK:XP_013215689
MER0190815 Ixodes ricinus 353 98-275 E218 H217, H221, H227 GENBANK:JAA66366
MER0552771 Leptonychotes weddellii 470 99-281 E220 H219, H223, H229 GENBANK:XP_006741362
MER0825053 Lottia gigantea 504 125-284 E238 H237, H241, H247 UNIPROT:V4AU04
MER0825053 Lottia gigantea 504 125-284 E238 H237, H241, H247 UNIPROT:V4AU04
MER0103105 Loxodonta africana 470 106-274 E220 H219, H223, H229 GENBANK:XP_003415653
MER0290926 Macaca fascicularis 470 109-263 E219 H218, H222, H228 GENBANK:EHH56702
MER0113063 Macaca mulatta 470 98-279 E219 H218, H222, H228 UNIPROT:F6YVM2
MER0113063 Macaca mulatta 470 98-279 E219 H218, H222, H228 UNIPROT:F6YVM2
MER1203486 Macaca nemestrina 470 109-263 E219 H218, H222, H228 GENBANK:XP_011759865
MER0645620 Mandrillus leucophaeus 470 99-276 E219 H218, H222, H228 GENBANK:XP_011839797
MER1203446 Manis javanica 470 100-264 E220 H219, H223, H229 GENBANK:XP_017506048
MER1203435 Marmota marmota 469 104-278 E219 H218, H222, H228 GENBANK:XP_015345543
MER1203720 Meriones unguiculatus 462 101-256 E212 H211, H215, H221 GENBANK:XP_021508508
MER1203524 Mesocricetus auratus 461 100-269 E211 H210, H214, H220 GENBANK:XP_021086995
MER0539239 Microtus ochrogaster 463 91-274 E213 H212, H216, H222 GENBANK:XP_005346832
MER0112936 Monodelphis domestica 472 99-272 E218 H217, H221, H227 UNIPROT:F6SSU7
MER0112936 Monodelphis domestica 472 99-272 E218 H217, H221, H227 UNIPROT:F6SSU7
MER0826154 Monodelphis domestica 181 11-114 E67 H66, H70, H76 UNIPROT:F6PYT6
MER1203612 Mus caroli 473 112-281 E223 H222, H226, H232 GENBANK:XP_021027464
MER0001090 Mus musculus 462 91-272 E212 H211, H215, H221 PIR:A42401
MER0001090 Mus musculus 462 91-272 E212 H211, H215, H221 PIR:A42401
MER1203602 Mus pahari 473 112-281 E223 H222, H226, H232 GENBANK:XP_021061647
MER0290911 Mustela putorius 481 113-292 E232 H231, H235, H241 UNIPROT:G9KAW9
MER0290911 Mustela putorius 481 113-292 E232 H231, H235, H241 UNIPROT:G9KAW9
MER0627648 Nannospalax galili 474 99-278 E220 H219, H223, H229 GENBANK:XP_008828317
MER1203396 Neomonachus schauinslandi 470 101-264 E220 H219, H223, H229 GENBANK:XP_021552097
MER1204648 Neotoma lepida 200 101-199 missing missing, missing, missing GENBANK:OBS83455
MER0826308 Neovison vison 490 130-290 E240 H239, H243, H249 UNIPROT:U6CUQ2
MER0826308 Neovison vison 490 130-290 E240 H239, H243, H249 UNIPROT:U6CUQ2
MER0257248 Nomascus leucogenys 470 105-263 E219 H218, H222, H228 UNIPROT:G1R6D8
MER0257248 Nomascus leucogenys 470 105-263 E219 H218, H222, H228 UNIPROT:G1R6D8
MER1206163 Octopus bimaculoides 458 3-132 E90 H89, H93, H99 GENBANK:XP_014780006
MER0531351 Odobenus rosmarus 546 99-281 E220 H219, H223, H229 GENBANK:XP_004416050
MER1203361 Odobenus rosmarus 470 101-264 E220 H219, H223, H229 GENBANK:XP_012423403
MER1203515 Odocoileus virginianus 470 101-275 E220 H219, H223, H229 GENBANK:XP_020756029
MER0826233 Ophiophagus hannah 491 80-213 E189, E460 H188, H459, H192, H463, H469, H198 UNIPROT:V8NHQ9
MER0826233 Ophiophagus hannah 491 80-213 E189, E460 H188, H459, H192, H463, H469, H198 UNIPROT:V8NHQ9
MER0005066 Oryctolagus cuniculus 464 93-274 E214 H213, H217, H223 GENBANK:-
MER0005066 Oryctolagus cuniculus 464 93-274 E214 H213, H217, H223 GENBANK:-
MER0256284 Otolemur garnettii 473 99-276 E218 H217, H221, H227 GENBANK:XP_003781377
MER1203510 Ovis ammon musimon 470 103-275 E220 H219, H223, H229 GENBANK:XP_012008199
MER0329628 Ovis aries 470 103-275 E220 H219, H223, H229 UNIPROT:W5P4C9
MER0329628 Ovis aries 470 103-275 E220 H219, H223, H229 UNIPROT:W5P4C9
MER0397524 Pan paniscus 470 80-261 E201 D200, T204, T210 GENBANK:XP_003828422
MER0053260 Pan troglodytes 463 80-261 E201 H200, H204, H210 GENBANK:XP_508724
MER1203197 Panthera pardus 425 55-230 E175 H174, H178, H184 GENBANK:XP_019289243
MER0329585 Papio anubis 470 109-263 E219 H218, H222, H228 UNIPROT:A0A096NXM4
MER0329585 Papio anubis 470 109-263 E219 H218, H222, H228 UNIPROT:A0A096NXM4
MER1203491 Papio anubis 426 65-219 E175 H174, H178, H184 GENBANK:XP_017804393
MER1203490 Peromyscus maniculatus 462 98-256 E212 H211, H215, H221 GENBANK:XP_006983826
MER0520984 Physeter catodon 335 100-264 A220 H219, H223, H229 GENBANK:XP_007103873
MER1203480 Piliocolobus tephrosceles 470 105-263 E219 H218, H222, H228 GENBANK:XP_023063902
MER0290966 Pongo abelii 992 639-785 E223, E741 H740, H222, H744, H226, H750, H232 GENBANK:XP_003777921
MER1203503 Pongo abelii 470 105-263 E219 H218, H222, H228 GENBANK:XP_024111754
MER1203251 Propithecus coquereli 469 99-277 E218 H217, H221, H227 GENBANK:XP_012514630
MER0329648 Pteropus alecto 460 91-254 E210 H209, H213, H219 UNIPROT:L5KZT0
MER0329648 Pteropus alecto 460 91-254 E210 H209, H213, H219 UNIPROT:L5KZT0
MER0263672 Pteropus vampyrus 480 110-286 E230 H229, H233, H239 GENBANK:XP_011366408
MER0438614 Python bivittatus 198 42-195 E151 H150, H154, H160 GENBANK:XP_007443198
MER0003155 Rattus norvegicus 465 94-275 E215 H214, H218, H224 UNIPROT:Q63341
MER0003155 Rattus norvegicus 465 94-275 E215 H214, H218, H224 UNIPROT:Q63341
MER0003155 Rattus norvegicus 465 94-275 E215 H214, H218, H224 UNIPROT:Q63341
MER1203541 Rattus norvegicus 420 59-214 E170 H169, H173, H179 GENBANK:XP_017450909
MER1203516 Rhinolophus sinicus 446 76-255 E195 H194, H198, H204 GENBANK:XP_019572733
MER1203538 Rhinopithecus bieti 470 105-263 E219 H218, H222, H228 GENBANK:XP_017705580
MER0558649 Rhinopithecus roxellana 470 99-274 E219 H218, H222, H228 GENBANK:XP_010377366
MER1203664 Rousettus aegyptiacus 465 91-267 E210 H209, H213, H219 GENBANK:XP_015989512
MER0329670 Saimiri boliviensis 468 100-263 E219 H218, H222, H228 GENBANK:XP_003923815
MER0167763 Strongylocentrotus purpuratus 553 155-348 E257 H256, H260, H266 GENBANK:XP_791600
MER0167808 Strongylocentrotus purpuratus 555 139-325 E260 H259, H263, H269 GENBANK:XP_791616
MER0109382 Sus scrofa 466 98-276 E219 H218, H222, H228 UNIPROT:A6H560
MER0109382 Sus scrofa 466 98-276 E219 H218, H222, H228 UNIPROT:A6H560
MER1125708 Sus scrofa 466 98-277 E219 H218, H222, H228 UNIPROT:F1SV57
MER0190893 Tupaia chinensis 381 97-273 E217 H216, H220, H226 UNIPROT:L9KQ76
MER0190893 Tupaia chinensis 381 97-273 E217 H216, H220, H226 UNIPROT:L9KQ76
MER0084918 Ursus maritimus 493 122-302 E243 H242, H246, H252 GENBANK:XP_008688365