Sequence features for peptidase M10.009: matrix metallopeptidase-12

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

 

MERNUM Species Sequence length Peptidase unit Active site residues Metal ligands Source
MER1203226 Acinonyx jubatus 470 100-275 E220 H219, H223, H229 GENBANK:XP_014929426
MER0233936 Ailuropoda melanoleuca 407 69-235 E188 H187, H191, H197 UNIPROT:D2HIH4
MER0233936 Ailuropoda melanoleuca 407 69-235 E188 H187, H191, H197 UNIPROT:D2HIH4
MER1204216 Ailuropoda melanoleuca 164 56-164 missing missing, missing, missing GENBANK:XP_011216659
MER0290974 Anolis carolinensis 268 95-253 E209 H208, H212, H218 UNIPROT:G1KVT7
MER0290974 Anolis carolinensis 268 95-253 E209 H208, H212, H218 UNIPROT:G1KVT7
MER0403085 Balaenoptera acutorostrata 331 100-277 A220 H219, H223, H229 GENBANK:XP_007191301
MER0679452 Bison bison 471 99-277 E220 H219, H223, H229 GENBANK:XP_010837171
MER0190915 Bos grunniens 474 105-279 E224 H223, H227, H233 UNIPROT:L8J133
MER0190915 Bos grunniens 474 105-279 E224 H223, H227, H233 UNIPROT:L8J133
MER1203663 Bos indicus 471 101-275 E220 H219, H223, H229 GENBANK:XP_019830080
MER0112492 Bos taurus 611 267-447 E387 H386, H390, H396 GENBANK:XP_605366
MER1203792 Branchiostoma belcheri 267 81-243 E198 H197, H201, H207 GENBANK:XP_019641815
MER1205291 Branchiostoma belcheri 524 38-212 E156 H155, H159, H165 GENBANK:XP_019620812
MER1206243 Branchiostoma belcheri 1385 130-298 E243, H242, H246, H252, GENBANK:XP_019613997
MER0138255 Branchiostoma floridae 2357 117-277 E231 H230, H234, H240 GENBANK:XP_002227294
MER0290935 Callithrix jacchus 469 100-271 E219 H218, H222, H228 UNIPROT:F7IH65
MER0290935 Callithrix jacchus 469 100-271 E219 H218, H222, H228 UNIPROT:F7IH65
MER1203332 Camelus bactrianus 471 101-278 E220 H219, H223, H229 GENBANK:XP_010951489
MER0676321 Camelus dromedarius 471 100-268 E220 H219, H223, H229 GENBANK:XP_010976088
MER0826227 Camelus ferus 342 110-224 E178 H177, H181, H187 UNIPROT:S9WV40
MER0826227 Camelus ferus 342 110-224 E178 H177, H181, H187 UNIPROT:S9WV40
MER0053742 Canis lupus familiaris 601 231-410 E351 H350, H354, H360 GENBANK:XP_854594
MER1203673 Castor canadensis 471 101-264 E220 H219, H223, H229 GENBANK:XP_020023662
MER0825354 Castor fiber 471 111-267 E221 H220, H224, H230 UNIPROT:A0A0B5D1B3
MER0825354 Castor fiber 471 111-267 E221 H220, H224, H230 UNIPROT:A0A0B5D1B3
MER0103340 Cavia porcellus 464 104-258 E214 H213, H217, H223 GENBANK:XP_003472863
MER1203737 Cavia porcellus 468 108-262 E218 H217, H221, H227 GENBANK:XP_013010832
MER1203481 Cercocebus atys 470 109-263 E219 H218, H222, H228 GENBANK:XP_011921969
MER0591883 Chelonia mydas 263 98-257 E213 H212, H216, H222 UNIPROT:M7CBA3
MER0591883 Chelonia mydas 263 98-257 E213 H212, H216, H222 UNIPROT:M7CBA3
MER0670306 Colobus angolensis 470 99-276 E219 H218, H222, H228 GENBANK:XP_011782025
MER1203573 Dipodomys ordii 467 105-261 E217 H216, H220, H226 GENBANK:XP_012865313
MER1204011 Echinops telfairi 470 103-274 E220 H219, H223, H229 GENBANK:XP_012861701
MER1203266 Enhydra lutris 493 124-304 E243 H242, H246, H252 GENBANK:XP_022368855
MER1203308 Equus asinus 470 101-269 E220 H219, H223, H229 GENBANK:XP_014715497
MER0098644 Equus caballus 470 99-280 E220 H219, H223, H229 GENBANK:XP_001498924
MER0615803 Erinaceus europaeus 329 92-265 E211 H210, H214, H220 GENBANK:XP_007520732
MER0615814 Erinaceus europaeus 326 92-268 E211 H210, H214, H220 GENBANK:XP_007520807
MER0329337 Felis catus 470 100-275 E220 H219, H223, H229 UNIPROT:M3WEA4
MER0329337 Felis catus 470 100-275 E220 H219, H223, H229 UNIPROT:M3WEA4
MER1203256 Felis catus 417 47-222 E167 H166, H170, H176 GENBANK:XP_019666771
MER0656643 Fukomys damarensis 471 98-265 E219 H218, H222, H228 GENBANK:XP_010640358
MER0557642 Galeopterus variegatus 267 101-262 G216 H215, H219, H225 GENBANK:XP_008561265
MER0329580 Gorilla gorilla 470 105-263 E219 H218, H222, H228 GENBANK:XP_004052087
MER0290952 Heterocephalus glaber 403 34-197 E153 H152, H156, H162 UNIPROT:G5BUC6
MER0290952 Heterocephalus glaber 403 34-197 E153 H152, H156, H162 UNIPROT:G5BUC6
MER1203706 Heterocephalus glaber 469 105-263 E219 H218, H222, H228 GENBANK:XP_021104682
MER1205682 Hipposideros armiger 335 105-206 missing missing, missing, missing GENBANK:XP_019490265
MER0001089 Homo sapiens 470 98-279 E219 H218, H222, H228 PIR:A49499
MER0001089 Homo sapiens 470 98-279 E219 H218, H222, H228 PIR:A49499
MER0106433 Ictidomys tridecemlineatus 420 50-228 E170 H169, H173, H179 GENBANK:XP_005329151
MER1203377 Ictidomys tridecemlineatus 421 55-229 E170 H169, H173, H179 GENBANK:XP_013215689
MER0190815 Ixodes ricinus 353 98-275 E218 H217, H221, H227 GENBANK:JAA66366
MER0552771 Leptonychotes weddellii 470 99-281 E220 H219, H223, H229 GENBANK:XP_006741362
MER0825053 Lottia gigantea 504 125-284 E238 H237, H241, H247 UNIPROT:V4AU04
MER0825053 Lottia gigantea 504 125-284 E238 H237, H241, H247 UNIPROT:V4AU04
MER0103105 Loxodonta africana 470 106-274 E220 H219, H223, H229 GENBANK:XP_003415653
MER0290926 Macaca fascicularis 470 109-263 E219 H218, H222, H228 GENBANK:EHH56702
MER0113063 Macaca mulatta 470 98-279 E219 H218, H222, H228 UNIPROT:F6YVM2
MER0113063 Macaca mulatta 470 98-279 E219 H218, H222, H228 UNIPROT:F6YVM2
MER1203486 Macaca nemestrina 470 109-263 E219 H218, H222, H228 GENBANK:XP_011759865
MER0645620 Mandrillus leucophaeus 470 99-276 E219 H218, H222, H228 GENBANK:XP_011839797
MER1203446 Manis javanica 470 100-264 E220 H219, H223, H229 GENBANK:XP_017506048
MER1203435 Marmota marmota 469 104-278 E219 H218, H222, H228 GENBANK:XP_015345543
MER1203720 Meriones unguiculatus 462 101-256 E212 H211, H215, H221 GENBANK:XP_021508508
MER1203524 Mesocricetus auratus 461 100-269 E211 H210, H214, H220 GENBANK:XP_021086995
MER0539239 Microtus ochrogaster 463 91-274 E213 H212, H216, H222 GENBANK:XP_005346832
MER0112936 Monodelphis domestica 472 99-272 E218 H217, H221, H227 UNIPROT:F6SSU7
MER0112936 Monodelphis domestica 472 99-272 E218 H217, H221, H227 UNIPROT:F6SSU7
MER0826154 Monodelphis domestica 181 11-114 E67 H66, H70, H76 UNIPROT:F6PYT6
MER1203612 Mus caroli 473 112-281 E223 H222, H226, H232 GENBANK:XP_021027464
MER0001090 Mus musculus 462 91-272 E212 H211, H215, H221 PIR:A42401
MER0001090 Mus musculus 462 91-272 E212 H211, H215, H221 PIR:A42401
MER1203602 Mus pahari 473 112-281 E223 H222, H226, H232 GENBANK:XP_021061647
MER0290911 Mustela putorius 481 113-292 E232 H231, H235, H241 UNIPROT:G9KAW9
MER0290911 Mustela putorius 481 113-292 E232 H231, H235, H241 UNIPROT:G9KAW9
MER0627648 Nannospalax galili 474 99-278 E220 H219, H223, H229 GENBANK:XP_008828317
MER1203396 Neomonachus schauinslandi 470 101-264 E220 H219, H223, H229 GENBANK:XP_021552097
MER1204648 Neotoma lepida 200 101-199 missing missing, missing, missing GENBANK:OBS83455
MER0826308 Neovison vison 490 130-290 E240 H239, H243, H249 UNIPROT:U6CUQ2
MER0826308 Neovison vison 490 130-290 E240 H239, H243, H249 UNIPROT:U6CUQ2
MER0257248 Nomascus leucogenys 470 105-263 E219 H218, H222, H228 UNIPROT:G1R6D8
MER0257248 Nomascus leucogenys 470 105-263 E219 H218, H222, H228 UNIPROT:G1R6D8
MER1206163 Octopus bimaculoides 458 3-132 E90 H89, H93, H99 GENBANK:XP_014780006
MER0531351 Odobenus rosmarus 546 99-281 E220 H219, H223, H229 GENBANK:XP_004416050
MER1203361 Odobenus rosmarus 470 101-264 E220 H219, H223, H229 GENBANK:XP_012423403
MER1203515 Odocoileus virginianus 470 101-275 E220 H219, H223, H229 GENBANK:XP_020756029
MER0826233 Ophiophagus hannah 491 80-213 E460, E189 H459, H188, H463, H192, H469, H198 UNIPROT:V8NHQ9
MER0826233 Ophiophagus hannah 491 80-213 E460, E189 H459, H188, H463, H192, H469, H198 UNIPROT:V8NHQ9
MER0005066 Oryctolagus cuniculus 464 93-274 E214 H213, H217, H223 GENBANK:-
MER0005066 Oryctolagus cuniculus 464 93-274 E214 H213, H217, H223 GENBANK:-
MER0256284 Otolemur garnettii 473 99-276 E218 H217, H221, H227 GENBANK:XP_003781377
MER1203510 Ovis ammon musimon 470 103-275 E220 H219, H223, H229 GENBANK:XP_012008199
MER0329628 Ovis aries 470 103-275 E220 H219, H223, H229 UNIPROT:W5P4C9
MER0329628 Ovis aries 470 103-275 E220 H219, H223, H229 UNIPROT:W5P4C9
MER0397524 Pan paniscus 470 80-261 E201 D200, T204, T210 GENBANK:XP_003828422
MER0053260 Pan troglodytes 463 80-261 E201 H200, H204, H210 GENBANK:XP_508724
MER1203197 Panthera pardus 425 55-230 E175 H174, H178, H184 GENBANK:XP_019289243
MER0329585 Papio anubis 470 109-263 E219 H218, H222, H228 UNIPROT:A0A096NXM4
MER0329585 Papio anubis 470 109-263 E219 H218, H222, H228 UNIPROT:A0A096NXM4
MER1203491 Papio anubis 426 65-219 E175 H174, H178, H184 GENBANK:XP_017804393
MER1203490 Peromyscus maniculatus 462 98-256 E212 H211, H215, H221 GENBANK:XP_006983826
MER0520984 Physeter catodon 335 100-264 A220 H219, H223, H229 GENBANK:XP_007103873
MER1203480 Piliocolobus tephrosceles 470 105-263 E219 H218, H222, H228 GENBANK:XP_023063902
MER0290966 Pongo abelii 992 639-785 E223, E741 H740, H222, H226, H744, H232, H750 GENBANK:XP_003777921
MER1203503 Pongo abelii 470 105-263 E219 H218, H222, H228 GENBANK:XP_024111754
MER1203251 Propithecus coquereli 469 99-277 E218 H217, H221, H227 GENBANK:XP_012514630
MER0329648 Pteropus alecto 460 91-254 E210 H209, H213, H219 UNIPROT:L5KZT0
MER0329648 Pteropus alecto 460 91-254 E210 H209, H213, H219 UNIPROT:L5KZT0
MER0263672 Pteropus vampyrus 480 110-286 E230 H229, H233, H239 GENBANK:XP_011366408
MER0438614 Python bivittatus 198 42-195 E151 H150, H154, H160 GENBANK:XP_007443198
MER0003155 Rattus norvegicus 465 94-275 E215 H214, H218, H224 UNIPROT:Q63341
MER0003155 Rattus norvegicus 465 94-275 E215 H214, H218, H224 UNIPROT:Q63341
MER0003155 Rattus norvegicus 465 94-275 E215 H214, H218, H224 UNIPROT:Q63341
MER1203541 Rattus norvegicus 420 59-214 E170 H169, H173, H179 GENBANK:XP_017450909
MER1203516 Rhinolophus sinicus 446 76-255 E195 H194, H198, H204 GENBANK:XP_019572733
MER1203538 Rhinopithecus bieti 470 105-263 E219 H218, H222, H228 GENBANK:XP_017705580
MER0558649 Rhinopithecus roxellana 470 99-274 E219 H218, H222, H228 GENBANK:XP_010377366
MER1203664 Rousettus aegyptiacus 465 91-267 E210 H209, H213, H219 GENBANK:XP_015989512
MER0329670 Saimiri boliviensis 468 100-263 E219 H218, H222, H228 GENBANK:XP_003923815
MER0167763 Strongylocentrotus purpuratus 553 155-348 E257 H256, H260, H266 GENBANK:XP_791600
MER0167808 Strongylocentrotus purpuratus 555 139-325 E260 H259, H263, H269 GENBANK:XP_791616
MER0109382 Sus scrofa 466 98-276 E219 H218, H222, H228 UNIPROT:A6H560
MER0109382 Sus scrofa 466 98-276 E219 H218, H222, H228 UNIPROT:A6H560
MER1125708 Sus scrofa 466 98-277 E219 H218, H222, H228 UNIPROT:F1SV57
MER0190893 Tupaia chinensis 381 97-273 E217 H216, H220, H226 UNIPROT:L9KQ76
MER0190893 Tupaia chinensis 381 97-273 E217 H216, H220, H226 UNIPROT:L9KQ76
MER0084918 Ursus maritimus 493 122-302 E243 H242, H246, H252 GENBANK:XP_008688365