$VAR1 = undef;

Summary for peptidase C14.006: caspase-2

Names
MEROPS Name	caspase-2
Other names	caspase-2L, caspase-2S, Ich-1, NEDD-2

Domain architecture

MEROPS Classification
Classification	Clan CD >> Subclan (none) >> Family C14 >> Subfamily A >> C14.006
Holotype	caspase-2 (Mus musculus), Uniprot accession P29594 (peptidase unit: 167-452), MERNUM MER0000855
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00430
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.55
Enzymology	BRENDA database
Proteolytic events	CutDB database (3 cleavages)
Activity status	human: active (Garcia-Calvo et al., 1999) mouse: active (by similarity) (Troy et al., 2003)
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Caspase_2
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	d/e/-/DGsa/-/-/- (based on 290 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	4	12	11	0	149	23	28	32
Pro	3	7	27	0	0	3	35	28
Ala	13	19	25	0	44	38	20	33
Val	18	17	36	0	5	53	19	14
Leu	20	18	29	0	2	40	28	13
Ile	7	6	6	0	0	15	9	8
Met	4	3	10	0	6	6	7	4
Phe	3	5	4	0	4	14	6	4
Tyr	3	4	6	0	2	17	4	3
Trp	1	0	1	0	1	2	2	0
Ser	19	26	31	0	66	18	35	40
Thr	12	16	33	0	1	15	23	13
Cys	3	2	6	0	3	5	5	7
Asn	4	7	8	0	2	7	11	8
Gln	4	18	9	0	1	8	9	16
Asp	80	11	3	290	0	3	13	24
Glu	31	60	10	0	1	10	13	29
Lys	0	0	0	0	0	5	10	7
Arg	0	0	0	0	1	2	5	1
His	0	5	6	0	1	5	7	5