Sequence features for peptidase C14.006: caspase-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

MERNUM	Species	Sequence length	Peptidase unit	Active site residues	Source
MER0690004	Acanthisitta chloris	426	140-422	H250, C293	GENBANK:XP_009074285
MER0267950	Ailuropoda melanoleuca	452	201-449	H277, C320	UNIPROT:G1LJ60
MER0267950	Ailuropoda melanoleuca	452	201-449	H277, C320	UNIPROT:G1LJ60
MER0263408	Alligator mississippiensis	403	141-402	H251, C294	GENBANK:XP_006268654
MER0307407	Alligator sinensis	426	140-422	H250, C293	GENBANK:XP_006020987
MER0327973	Anas platyrhynchos	426	140-422	H250, C293	UNIPROT:U3IAZ7
MER0327973	Anas platyrhynchos	426	140-422	H250, C293	UNIPROT:U3IAZ7
MER0687991	Apaloderma vittatum	445	159-441	H269, C312	GENBANK:XP_009872031
MER0686154	Aptenodytes forsteri	426	140-422	H250, C293	UNIPROT:A0A087RHC1
MER0686154	Aptenodytes forsteri	426	140-422	H250, C293	UNIPROT:A0A087RHC1
MER0685511	Aquila chrysaetos	426	140-422	H250, C293	GENBANK:XP_011586201
MER0556650	Astatotilapia burtoni	464	163-458	H275, C318	GENBANK:XP_005925327
MER0556652	Astatotilapia burtoni	525	224-519	H336, C379	GENBANK:XP_005925326
MER0365941	Astyanax mexicanus	463	159-381	H270, C313	GENBANK:XP_007249868
MER0396240	Balaenoptera acutorostrata	452	167-449	H277, C320	GENBANK:XP_007184744
MER0681506	Balearica regulorum	408	123-404	H232, C275	GENBANK:XP_010308307
MER0679153	Bison bison	452	167-449	H277, C320	GENBANK:XP_010832313
MER0433711	Bos grunniens	452	167-449	H277, C320	UNIPROT:L8J685
MER0433711	Bos grunniens	452	167-449	H277, C320	UNIPROT:L8J685
MER0056492	Bos taurus	452	167-449	H277, C320	UNIPROT:E1BJT6
MER0056492	Bos taurus	452	167-449	H277, C320	UNIPROT:E1BJT6
MER0137581	Branchiostoma floridae	360	85-357	H184, C227	GENBANK:EEA39196
MER0141562	Branchiostoma floridae	439	140-399	H258, C301	GENBANK:XP_002586743
MER0143828	Branchiostoma floridae	7154	5789-5934	N2390, H3298, N5889, T5932, S2433, C3341	GENBANK:EEA53292
MER0317973	Branchiostoma floridae	340	80-339	H162, C205	GENBANK:XP_002586740
MER0580857	Bubalus bubalis	452	167-449	H277, C320	GENBANK:XP_006071934
MER0678804	Buceros rhinoceros	426	140-422	H250, C293	UNIPROT:A0A091HDL7
MER0678804	Buceros rhinoceros	426	140-422	H250, C293	UNIPROT:A0A091HDL7
MER0317873	Callithrix jacchus	452	201-449	H277, C320	UNIPROT:F7I2T9
MER0317873	Callithrix jacchus	452	201-449	H277, C320	UNIPROT:F7I2T9
MER0696426	Callorhinchus milii	417	166-375	H238, C281	UNIPROT:V9KZT1
MER0696426	Callorhinchus milii	417	166-375	H238, C281	UNIPROT:V9KZT1
MER0581709	Calypte anna	420	134-416	H244, C287	UNIPROT:A0A091IBX0
MER0581709	Calypte anna	420	134-416	H244, C287	UNIPROT:A0A091IBX0
MER0677034	Camelus dromedarius	452	167-449	H277, C320	GENBANK:XP_010997662
MER0696297	Camelus ferus	444	192-429	H269, C312	UNIPROT:S9WQE9
MER0696297	Camelus ferus	444	192-429	H269, C312	UNIPROT:S9WQE9
MER0082638	Canis lupus familiaris	452	167-449	H277, C320	GENBANK:XP_848601
MER0559195	Capra hircus	435	150-432	H260, C303	GENBANK:XP_005679612
MER0676235	Cariama cristata	426	140-422	H250, C293	GENBANK:XP_009706668
MER0103860	Cavia porcellus	452	182-449	H277, C320	UNIPROT:H0VRM5
MER0103860	Cavia porcellus	452	182-449	H277, C320	UNIPROT:H0VRM5
MER0526202	Ceratotherium simum	452	167-449	H277, C320	GENBANK:XP_004430721
MER0587332	Cercopithecus sabaeus	431	146-428	H256, C299	GENBANK:XP_007981908
MER0696181	Cercopithecus sabaeus	453	201-417	H278, C321	GENBANK:-
MER0672571	Chaetura pelagica	426	140-422	H250, C293	GENBANK:XP_009996635
MER0696518	Channa striata	436	173-416	H245, C288	UNIPROT:A0A0E4G1T6
MER0696518	Channa striata	436	173-416	H245, C288	UNIPROT:A0A0E4G1T6
MER0671636	Charadrius vociferus	423	137-419	H247, C290	GENBANK:XP_009891089
MER0591451	Chelonia mydas	428	142-424	H252, C295	GENBANK:XP_007066518
MER0583472	Chinchilla lanigera	456	171-453	H281, C324	GENBANK:XP_005405427
MER0577593	Chrysemys picta	454	157-418	H267, C310	GENBANK:XP_008171732
MER0574718	Chrysochloris asiatica	451	166-447	H276, C319	GENBANK:XP_006861254
MER0148150	Ciona intestinalis	435	164-428	H248, C291	GENBANK:XP_002122917
MER0578776	Columba livia	426	140-422	H250, C293	GENBANK:XP_005506362
MER0573877	Condylura cristata	458	173-455	H283, C326	GENBANK:XP_004694462
MER0572853	Corvus brachyrhynchos	426	140-422	H250, C293	UNIPROT:A0A091EV21
MER0572853	Corvus brachyrhynchos	426	140-422	H250, C293	UNIPROT:A0A091EV21
MER0668030	Corvus cornix	426	140-422	H250, C293	GENBANK:XP_010394452
MER0137189	Cricetulus griseus	452	167-449	H277, C320	UNIPROT:B2CMK4
MER0137189	Cricetulus griseus	452	167-449	H277, C320	UNIPROT:B2CMK4
MER0665659	Cuculus canorus	426	140-422	H250, C293	UNIPROT:A0A091H297
MER0665659	Cuculus canorus	426	140-422	H250, C293	UNIPROT:A0A091H297
MER0568060	Cynoglossus semilaevis	445	138-438	H250, C293	GENBANK:XP_008320960
MER0049658	Danio rerio	435	118-429	H245, C288	GENBANK:ABG91569
MER0049658	Danio rerio	435	118-429	H245, C288	GENBANK:ABG91569
MER0599617	Echinops telfairi	454	169-451	H279, C322	GENBANK:XP_004714052
MER0664642	Egretta garzetta	426	140-422	H250, C293	UNIPROT:A0A091J5K9
MER0664642	Egretta garzetta	426	140-422	H250, C293	UNIPROT:A0A091J5K9
MER0564280	Eptesicus fuscus	452	167-449	H277, C320	GENBANK:XP_008152175
MER0098510	Equus caballus	452	167-449	H277, C320	UNIPROT:F6SXT6
MER0098510	Equus caballus	452	167-449	H277, C320	UNIPROT:F6SXT6
MER0562134	Equus przewalskii	462	177-459	H287, C330	GENBANK:XP_008536170
MER0660712	Esox lucius	443	142-439	H254, C297	GENBANK:XP_010883256
MER0658852	Eurypyga helias	429	143-425	H253, C296	GENBANK:XP_010154355
MER0559908	Falco cherrug	424	138-420	H248, C291	GENBANK:XP_005434368
MER0546065	Falco peregrinus	424	138-420	H248, C291	GENBANK:XP_005235430
MER0610815	Felis catus	451	167-448	H277, C320	UNIPROT:M3WPE3
MER0610815	Felis catus	451	167-448	H277, C320	UNIPROT:M3WPE3
MER0568513	Ficedula albicollis	406	120-402	H230, C273	GENBANK:XP_005038461
MER0657437	Fukomys damarensis	452	167-449	H277, C320	UNIPROT:A0A091CVH5
MER0657437	Fukomys damarensis	452	167-449	H277, C320	UNIPROT:A0A091CVH5
MER0655160	Fulmarus glacialis	382	140-382	H250, C293	GENBANK:XP_009583548
MER0002572	Gallus gallus	424	138-420	H248, C291	UNIPROT:F1NP15
MER0002572	Gallus gallus	424	138-420	H248, C291	UNIPROT:F1NP15
MER0002572	Gallus gallus	424	138-420	H248, C291	UNIPROT:F1NP15
MER0653944	Gavia stellata	426	140-422	H250, C293	GENBANK:XP_009806633
MER0559740	Geospiza fortis	426	140-422	H250, C293	GENBANK:XP_005430019
MER0696245	Gorilla gorilla	317	65-298	H142, C185	UNIPROT:G3QLZ6
MER0652623	Haliaeetus albicilla	434	148-430	H258, C301	GENBANK:XP_009910597
MER0651637	Haliaeetus leucocephalus	426	140-422	H250, C293	GENBANK:XP_010565918
MER0317869	Heterocephalus glaber	435	165-432	H260, C303	UNIPROT:G5C2L9
MER0317869	Heterocephalus glaber	435	165-432	H260, C303	UNIPROT:G5C2L9
MER0001644	Homo sapiens	452	167-449	H277, C320	PIR:A54821
MER0001644	Homo sapiens	452	167-449	H277, C320	PIR:A54821
MER0547679	Jaculus jaculus	452	167-449	H277, C320	GENBANK:XP_004661203
MER0649699	Larimichthys crocea	444	139-360	H251, C294	GENBANK:XP_010741737
MER0611157	Latimeria chalumnae	450	168-449	H278, C321	GENBANK:XP_006013688
MER0553879	Lepisosteus oculatus	421	135-417	H246, C289	GENBANK:XP_006642491
MER0696146	Lepisosteus oculatus	455	202-418	H280, C323	GENBANK:-
MER0549844	Lipotes vexillifer	452	167-449	H277, C320	GENBANK:XP_007466706
MER0320155	Macaca fascicularis	452	201-449	H277, C320	UNIPROT:G7P1H8
MER0320155	Macaca fascicularis	452	201-449	H277, C320	UNIPROT:G7P1H8
MER0317866	Macaca mulatta	452	201-449	H277, C320	UNIPROT:G7MN58
MER0317866	Macaca mulatta	452	201-449	H277, C320	UNIPROT:G7MN58
MER0696356	Macaca mulatta	348	96-329	H173, C216	UNIPROT:H9H3K3
MER0696467	Macaca mulatta	426	174-406	H251, C294	UNIPROT:H9H3K1
MER0647070	Manacus vitellinus	422	136-418	H246, C289	GENBANK:XP_008925418
MER0646433	Mandrillus leucophaeus	452	167-449	H277, C320	GENBANK:XP_011845271
MER0542400	Maylandia zebra	529	224-445	H336, C379	GENBANK:XP_004550818
MER0317876	Meleagris gallopavo	424	141-420	H248, C291	GENBANK:XP_003202669
MER0540669	Melopsittacus undulatus	420	134-416	H244, C287	GENBANK:XP_005144852
MER0643585	Mesitornis unicolor	426	140-422	H250, C293	UNIPROT:A0A091S9H7
MER0643585	Mesitornis unicolor	426	140-422	H250, C293	UNIPROT:A0A091S9H7
MER0544770	Mesocricetus auratus	452	167-449	H277, C320	GENBANK:XP_005083133
MER0538707	Microtus ochrogaster	452	167-449	H277, C320	GENBANK:XP_005363883
MER0181424	Monodelphis domestica	453	167-449	H277, C320	UNIPROT:F7BDP8
MER0181424	Monodelphis domestica	453	167-449	H277, C320	UNIPROT:F7BDP8
MER0000855	Mus musculus	452	167-452	H277, C320	GENBANK:-
MER0000855	Mus musculus	452	167-452	H277, C320	GENBANK:-
MER0317867	Mustela putorius	424	173-421	H249, C292	UNIPROT:M1EL54
MER0317867	Mustela putorius	424	173-421	H249, C292	UNIPROT:M1EL54
MER0613361	Myotis davidii	469	184-466	H294, C337	GENBANK:XP_006768044
MER0230910	Myotis lucifugus	452	167-449	H277, C320	UNIPROT:G1PRI6
MER0230910	Myotis lucifugus	452	167-449	H277, C320	UNIPROT:G1PRI6
MER0640467	Nannospalax galili	452	167-449	H277, C320	GENBANK:XP_008826840
MER0535155	Neolamprologus brichardi	529	224-445	H336, C379	GENBANK:XP_006802962
MER0535158	Neolamprologus brichardi	468	163-384	H275, C318	GENBANK:XP_006802965
MER0535159	Neolamprologus brichardi	525	224-519	H336, C379	GENBANK:XP_006802964
MER0638746	Nestor notabilis	420	134-416	H244, C287	GENBANK:XP_010011239
MER0635790	Nipponia nippon	426	140-422	H250, C293	UNIPROT:A0A091UM40
MER0635790	Nipponia nippon	426	140-422	H250, C293	UNIPROT:A0A091UM40
MER0256765	Nomascus leucogenys	452	201-449	H277, C320	UNIPROT:G1QSD1
MER0256765	Nomascus leucogenys	452	201-449	H277, C320	UNIPROT:G1QSD1
MER0532853	Octodon degus	452	167-449	H277, C320	GENBANK:XP_004629082
MER0531289	Odobenus rosmarus	452	167-449	H277, C320	GENBANK:XP_004414637
MER0696059	Oncorhynchus mykiss	485	232-449	H296, C339	UNIPROT:A0A060XF80
MER0696059	Oncorhynchus mykiss	485	232-449	H296, C339	UNIPROT:A0A060XF80
MER0696106	Oncorhynchus mykiss	371	185-303	H249, C292	UNIPROT:A0A060Y043
MER0696106	Oncorhynchus mykiss	371	185-303	H249, C292	UNIPROT:A0A060Y043
MER0696289	Ophiophagus hannah	429	176-414	H253, C296	UNIPROT:V8NKC1
MER0696289	Ophiophagus hannah	429	176-414	H253, C296	UNIPROT:V8NKC1
MER0634308	Opisthocomus hoazin	426	140-422	H250, C293	UNIPROT:A0A091VVQ5
MER0634308	Opisthocomus hoazin	426	140-422	H250, C293	UNIPROT:A0A091VVQ5
MER0529499	Orcinus orca	452	167-449	H277, C320	GENBANK:XP_004272158
MER0317938	Oreochromis niloticus	441	174-437	H252, C295	GENBANK:XP_003450677
MER0528553	Orycteropus afer	453	167-450	H277, C320	GENBANK:XP_007954778
MER0110115	Oryctolagus cuniculus	451	201-448	H277, C320	UNIPROT:G1SGX8
MER0110115	Oryctolagus cuniculus	451	201-448	H277, C320	UNIPROT:G1SGX8
MER0256381	Otolemur garnettii	435	184-432	H260, C303	GENBANK:XP_003791595
MER0619256	Ovis aries	457	167-454	H280, C325	GENBANK:XP_004008183
MER0405758	Pan paniscus	452	167-449	H277, C320	GENBANK:XP_003820590
MER0053501	Pan troglodytes	451	167-448	H277, C319	UNIPROT:H2QVJ4
MER0053501	Pan troglodytes	451	167-448	H277, C319	UNIPROT:H2QVJ4
MER0518256	Panthera tigris	451	167-448	H277, C320	GENBANK:XP_007090903
MER0516337	Pantholops hodgsonii	452	167-449	H277, C320	GENBANK:XP_005981926
MER0525692	Papio anubis	452	167-449	H277, C320	UNIPROT:A0A096MTV4
MER0525692	Papio anubis	452	167-449	H277, C320	UNIPROT:A0A096MTV4
MER0524749	Pelodiscus sinensis	428	142-424	H252, C295	GENBANK:XP_006127417
MER0632496	Phaethon lepturus	426	140-422	H250, C293	UNIPROT:A0A091TBG6
MER0632496	Phaethon lepturus	426	140-422	H250, C293	UNIPROT:A0A091TBG6
MER0696458	Phoenicopterus ruber	247	122-246	H200, C243	UNIPROT:A0A091UD55
MER0696458	Phoenicopterus ruber	247	122-246	H200, C243	UNIPROT:A0A091UD55
MER0521160	Physeter catodon	452	167-449	H277, C320	GENBANK:XP_007111111
MER0629658	Picoides pubescens	426	140-422	H250, C293	UNIPROT:A0A093GIX8
MER0629658	Picoides pubescens	426	140-422	H250, C293	UNIPROT:A0A093GIX8
MER0428880	Pipa carvalhoi	139	1-139	missing, C20	UNIPROT:G5E193
MER0428880	Pipa carvalhoi	139	1-139	missing, C20	UNIPROT:G5E193
MER0522572	Poecilia formosa	514	209-430	H321, C364	GENBANK:XP_007550154
MER0522576	Poecilia formosa	464	159-380	H271, C314	GENBANK:XP_007550156
MER0696613	Poecilia formosa	435	182-417	H246, C289	GENBANK:-
MER0513617	Poecilia reticulata	512	207-428	H319, C362	GENBANK:XP_008429698
MER0317874	Pongo abelii	452	201-449	H277, C320	UNIPROT:H2PNV7
MER0317874	Pongo abelii	452	201-449	H277, C320	UNIPROT:H2PNV7
MER0515346	Pteropus alecto	452	167-449	H277, C320	UNIPROT:L5KR92
MER0515346	Pteropus alecto	452	167-449	H277, C320	UNIPROT:L5KR92
MER0696375	Pygoscelis adeliae	426	172-390	H250, C293	UNIPROT:A0A093QS73
MER0696375	Pygoscelis adeliae	426	172-390	H250, C293	UNIPROT:A0A093QS73
MER0441450	Python bivittatus	428	142-423	H252, C295	GENBANK:XP_007425963
MER0002598	Rattus norvegicus	452	167-449	H277, C320	PIR:JC6507
MER0002598	Rattus norvegicus	452	167-449	H277, C320	PIR:JC6507
MER0559508	Rhinopithecus roxellana	452	167-449	H277, C320	GENBANK:XP_010377697
MER0512269	Saimiri boliviensis	452	167-449	H277, C320	GENBANK:XP_003929851
MER0393536	Sarcophilus harrisii	463	172-449	H277, C320	GENBANK:XP_003771755
MER0549485	Serinus canaria	426	140-422	H250, C293	GENBANK:XP_009100903
MER0469509	Stegastes partitus	463	160-459	H272, C315	GENBANK:XP_008296395
MER0484964	Struthio camelus	426	140-422	H250, C293	GENBANK:XP_009683457
MER0317865	Sus scrofa	452	201-449	H277, C320	GENBANK:XP_003134619
MER0267161	Takifugu rubripes	432	143-429	H255, C298	GENBANK:XP_003976201
MER0696395	Takifugu rubripes	431	179-412	H243, C286	UNIPROT:H2UKY4
MER0696559	Takifugu rubripes	397	183-301	H247, C290	UNIPROT:H2UKY6
MER1152430	Takifugu rubripes	436	136-436	H247, C290,	GENBANK:XP_029694628
MER0142313	Tetraodon nigroviridis	397	135-395	H247, C290	UNIPROT:Q4SNC6
MER0142313	Tetraodon nigroviridis	397	135-395	H247, C290	UNIPROT:Q4SNC6
MER0696195	Tetraodon nigroviridis	435	187-384	H250, C293	GENBANK:-
MER0474984	Tinamus guttatus	426	140-422	H250, C293	GENBANK:XP_010209837
MER0479633	Trichechus manatus	452	167-448	H277, C320	GENBANK:XP_004382421
MER0598280	Tupaia chinensis	452	167-449	H277, C320	UNIPROT:L9JAE6
MER0598280	Tupaia chinensis	452	167-449	H277, C320	UNIPROT:L9JAE6
MER0455085	Tyto alba	420	134-416	H244, C287	GENBANK:XP_009968311
MER0287517	Ursus maritimus	452	167-449	H277, C320	GENBANK:XP_008695521
MER0616467	Vicugna pacos	452	167-449	H277, C320	GENBANK:XP_006210119
MER0012123	Xenopus laevis	423	138-416	H245, C288	GENBANK:AAH72125
MER0012123	Xenopus laevis	423	138-416	H245, C288	GENBANK:AAH72125
MER0317856	Xenopus tropicalis	421	137-416	H246, C289	GENBANK:XP_002941266
MER0317856	Xenopus tropicalis	421	137-416	H246, C289	GENBANK:XP_002941266
MER0453011	Xiphophorus maculatus	430	129-426	H241, C284	GENBANK:XP_005798912
MER0696149	Xiphophorus maculatus	463	210-444	H274, C317	GENBANK:-
MER0449259	Zonotrichia albicollis	426	140-422	H250, C293	GENBANK:XP_005495024