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Literature for peptidase C14.006: caspase-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: S Structure, A Assay, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Dorstyn,L., Lim,Y., Scanlan,J., McLennan,E., De Bellis,D., Katschner,M., Finnie,J., Emery-Corbin,S., Yousef,J., Dagley,L.F., Kok,C.H., Shah,S.S., Takahashi,C., Febbraio,M.A. and Kumar,S.
    Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice
    Sci Adv (2026) 12, eaeb2571-eaeb2571. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2025
  2. Zamaraev,A.V., Volik,P.I., Nilov,D.K., Turkina,M.V., Egorshina,A.Y., Gorbunova,A.S., Iarovenko,S.I., Zhivotovsky,B. and Kopeina,G.S.
    Correction: Requirement for Serine-384 in Caspase-2 processing and activity
    Cell Death Dis (2025) 16, 911-911. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Amason,M.E., Li,L., Harvest,C.K., Lacey,C.A. and Miao,E.A.
    Validation of the Intermolecular Disulfide Bond in Caspase-2
    Biology (Basel) (2024) 13 PubMed  Europe PubMed DOI  PMC  EPMC
  4. Dawar,S., Benitez,M.C., Lim,Y., Dite,T.A., Yousef,J.M., Thio,N., Garciaz,S., Jackson,T.D., Milne,J.V., Dagley,L.F., Phillips,W.A., Kumar,S. and Clemons,N.J.
    Caspase-2 protects against ferroptotic cell death
    Cell Death Dis (2024) 15, 182-182. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Ge,Y., Zhou,L., Fu,Y., He,L., Chen,Y., Li,D., Xie,Y., Yang,J., Wu,H., Dai,H., Peng,Z., Zhang,Y., Yi,S., Wu,B., Zhang,X., Zhang,Y., Ying,W., Cui,C.P., Liu,C.H. and Zhang,L.
    Caspase-2 is a condensate-mediated deubiquitinase in protein quality control
    Nat Cell Biol (2024) 26, 1943-1957. PubMed  Europe PubMed DOI
  6. Rizzotto,D., Vigorito,V., Rieder,P., Gallob,F., Moretta,G.M., Soratroi,C., Riley,J.S., Bellutti,F., Veli,S.L., Mattivi,A., Lohmuller,M., Herzog,S., Bornhauser,B.C., Jacotot,E.D., Villunger,A. and Fava,L.L.
    Caspase-2 kills cells with extra centrosomes
    Sci Adv (2024) 10, eado6607-eado6607. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Shah,R.B., Li,Y., Yu,H., Kini,E. and Sidi,S.
    Stepwise phosphorylation and SUMOylation of PIDD1 drive PIDDosome assembly in response to DNA repair failure
    Nat Commun (2024) 15, 9195-9195. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Uctepe,E., Vona,B., Esen,F.N., Sonmez,F.M., Smol,T., Tumer,S., Mancilar,H., Geylan Durgun,D.E., Boute,O., Moghbeli,M., Ghayoor Karimiani,E., Hashemi,N., Bakhshoodeh,B., Kim,H.G., Maroofian,R. and Yesilyurt,A.
    Bi-allelic truncating variants in CASP2 underlie a neurodevelopmental disorder with lissencephaly
    Eur J Hum Genet (2024) 32, 52-60. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Volik,P.I., Zamaraev,A.V., Egorshina,A.Y., Pervushin,N.V., Kapusta,A.A., Tyurin-Kuzmin,P.A., Lipatova,A.V., Kaehne,T., Lavrik,I.N., Zhivotovsky,B. and Kopeina,G.S.
    Ally or traitor: the dual role of p62 in caspase-2 regulation
    Cell Death Dis (2024) 15, 827-827. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Zeng,M., Wang,K., Wu,Q., Ding,J., Xie,D., Qi,X. and Shao,F.
    Dissecting caspase-2-mediated cell death: from intrinsic PIDDosome activation to chemical modulation
    Protein Cell (2024) PubMed  Europe PubMed DOI
    11. 2023
  11. Cuellar,M.E., Yang,M., Karavadhi,S., Zhang,Y.Q., Zhu,H., Sun,H., Shen,M., Hall,M.D., Patnaik,S., Ashe,K.H., Walters,M.A. and Pockes,S.
    An electrophilic fragment screening for the development of small molecules targeting caspase-2
    Eur J Med Chem (2023) 259, 115632-115632. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Pockes,S., Walters,M.A. and Ashe,K.H.
    Targeting caspase-2 interactions with tau in Alzheimer's disease and related dementias
    Transl Res (2023) 254, 34-40. PubMed  Europe PubMed DOI  PMC  EPMC  V
    13. 2022
  13. Bosc,E., Anastasie,J., Soualmia,F., Coric,P., Kim,J.Y., Wang,L.Q., Lacin,G., Zhao,K., Patel,R., Duplus,E., Tixador,P., Sproul,A.A., Brugg,B., Reboud-Ravaux,M., Troy,C.M., Shelanski,M.L., Bouaziz,S., Karin,M., El Amri,C. and Jacotot,E.D.
    Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics
    Cell Death Dis (2022) 13, 959-959. PubMed  Europe PubMed DOI  PMC  EPMC  I
  14. Bresinsky,M., Strasser,J.M., Vallaster,B., Liu,P., McCue,W.M., Fuller,J., Hubmann,A., Singh,G., Nelson,K.M., Cuellar,M.E., Wilmot,C.M., Finzel,B.C., Ashe,K.H., Walters,M.A. and Pockes,S.
    Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314
    ACS Pharmacol Transl Sci (2022) 5, 20-40. PubMed  Europe PubMed DOI  PMC  EPMC  I
  15. Bresinsky,M., Strasser,J.M., Hubmann,A., Vallaster,B., McCue,W.M., Fuller,J., Singh,G., Nelson,K.M., Cuellar,M.E., Finzel,B.C., Ashe,K.H., Walters,M.A. and Pockes,S.
    Characterization of caspase-2 inhibitors based on specific sites of caspase-2-mediated proteolysis
    Arch Pharm (Weinheim) (2022) 355, e2200095-e2200095. PubMed  Europe PubMed DOI
  16. Geng,S., Gu,L., Zhong,L., Xu,T. and Sun,Y.
    Genomic organization, evolution and functional characterization of caspase-2 and caspase-8 in miiuy croaker (Miichthys miiuy)
    Dev Comp Immunol (2022) 127, 104308-104308. PubMed  Europe PubMed DOI
  17. Jiang,L. and Li,J.
    lncRNA GMDSAS1 upregulates IL6, TNFalpha and IL1beta, and induces apoptosis in human monocytic THP1 cells via miR965p/caspase 2 signaling
    Mol Med Rep (2022) 25 PubMed  Europe PubMed DOI  PMC  EPMC  K
  18. Lingg,N., Kross,C., Engele,P., Ohlknecht,C., Koppl,C., Fischer,A., Lier,B., Loibl,J., Sprenger,B., Liu,J., Scheidl,P., Berkemeyer,M., Buchinger,W., Brocard,C., Striedner,G., Oostenbrink,C., Schneider,R., Jungbauer,A. and Cserjan-Puschmann,M.
    CASPON platform technology: Ultrafast circularly permuted caspase-2 cleaves tagged fusion proteins before all 20 natural amino acids at the N-terminus
    N Biotechnol (2022) 71, 37-46. PubMed  Europe PubMed DOI
  19. Luo,H., Ye,G., Liu,Y., Huang,D., Luo,Q., Chen,W. and Qi,Z.
    miR-150-3p enhances neuroprotective effects of neural stem cell exosomes after hypoxic-ischemic brain injury by targeting CASP2
    Neurosci Lett (2022) 779, 136635-136635. PubMed  Europe PubMed DOI
  20. Steuer,E.L., Kemper,L.J., Hlynialuk,C.J.W., Leinonen-Wright,K., Montonye,M.L., Lapcinski,I.P., Forster,C.L., Ashe,K.H. and Liu,P.
    Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia
    J Neurosci (2022) 42, 4737-4754. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Weiler,E.S., Szabo,T.G., Garcia-Carpio,I. and Villunger,A.
    PIDD1 in cell cycle control, sterile inflammation and cell death
    Biochem Soc Trans (2022) 50, 813-824. PubMed  Europe PubMed DOI  V
  22. Zhao,Y., Dhani,S. and Zhivotovsky,B.
    Unveiling caspase-2 regulation by non-coding RNAs
    Cell Death Dis (2022) 13, 834-834. PubMed  Europe PubMed DOI  PMC  EPMC  V
    23. 2021
  23. Kopeina,G.S. and Zhivotovsky,B.
    Caspase-2 as a Master Regulator of Genomic Stability
    Trends Cell Biol (2021) PubMed  Europe PubMed DOI
  24. Lim,Y., Dorstyn,L. and Kumar,S.
    The p53-caspase-2 axis in the cell cycle and DNA damage response
    Exp Mol Med (2021) 53, 517-527. PubMed  Europe PubMed DOI  V
  25. Liu,P. and Ashe,K.H.
    The molecular implications of a caspase-2-mediated site-specific tau cleavage in tauopathies
    Neural Regen Res (2021) 16, 1774-1775. PubMed  Europe PubMed DOI
  26. Ochiai,A., Sawaguchi,S., Memezawa,S., Seki,Y., Morimoto,T., Oizumi,H., Ohbuchi,K., Yamamoto,M., Mizoguchi,K., Miyamoto,Y. and Yamauchi,J.
    Knockdown of Golgi Stress-Responsive Caspase-2 Ameliorates HLD17-Associated AIMP2 Mutant-Mediated Inhibition of Oligodendroglial Cell Morphological Differentiation
    Neurochem Res (2021) PubMed  Europe PubMed DOI  K
  27. Ozdemir,A., Ibisoglu,B., Simay Demir,Y.D., Benhur,E., Valipour,F. and Ark,M.
    A novel proteolytic cleavage of ROCK 1 in cell death: Not only by caspases 3 and 7 but also by caspase 2
    Biochem Biophys Res Commun (2021) 547, 118-124. PubMed  Europe PubMed DOI
    28. 2020
  28. Brown-Suedel,A.N. and Bouchier-Hayes,L.
    Caspase-2 Substrates: To Apoptosis, Cell Cycle Control, and Beyond
    Front Cell Dev Biol (2020) 8, 610022-610022. PubMed  Europe PubMed DOI  PMC  EPMC  V
  29. Cserjan-Puschmann,M., Lingg,N., Engele,P., Kross,C., Loibl,J., Fischer,A., Bacher,F., Frank,A.C., Ohlknecht,C., Brocard,C., Oostenbrink,C., Berkemeyer,M., Schneider,R., Striedner,G. and Jungbauer,A.
    Production of Circularly Permuted Caspase-2 for Affinity Fusion-Tag Removal: Cloning, Expression in Escherichia coli, Purification, and Characterization
    Biomolecules (2020) 10 PubMed  Europe PubMed DOI
  30. Fu,S., Ding,M., Wang,J., Yin,X., Zhou,E., Kong,L., Tu,X., Guo,Z., Wang,A., Huang,Y. and Ye,J.
    Identification and functional characterization of three caspases in Takifugu obscurus in response to bacterial infection
    Fish Shellfish Immunol (2020) PubMed  Europe PubMed DOI  I
  31. Hong,W., Gu,Y., Guan,R., Xie,D., Zhou,H. and Yu,M.
    Pan-cancer analysis of the CASP gene family in relation to survival, tumor-infiltrating immune cells and therapeutic targets
    Genomics (2020) PubMed  Europe PubMed DOI
  32. Huang,J., Huang,Y., Feng,Z., Guo,W., Wang,X. and Liao,Z.
    MiR-1247-3p protects rat cardiomyocytes against hypoxia/reoxygenation-induced injury via targeting BCL2L11 and caspase-2
    J Recept Signal Transduct Res (2020) , 1-9. PubMed  Europe PubMed DOI  K
  33. Ohlknecht,C., Petrov,D., Engele,P., Kross,C., Sprenger,B., Fischer,A., Lingg,N., Schneider,R. and Oostenbrink,C.
    Enhancing the promiscuity of a member of the caspase protease family by rational design
    Proteins (2020) PubMed  Europe PubMed DOI
  34. Vigneswara,V. and Ahmed,Z.
    The role of caspase-2 in regulating cell fate
    Cells (2020) 9 PubMed  Europe PubMed DOI  V
  35. Zamaraev,A.V., Volik,P.I., Nilov,D.K., Turkina,M.V., Egorshina,A.Y., Gorbunova,A.S., Iarovenko,S.I., Zhivotovsky,B. and Kopeina,G.S.
    Requirement for Serine-384 in Caspase-2 processing and activity
    Cell Death Dis (2020) 11, 825-825. PubMed  Europe PubMed DOI  PMC  EPMC
    36. 2019
  36. Poreba,M., Rut,W., Groborz,K., Snipas,S.J., Salvesen,G.S. and Drag,M.
    Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells
    Cell Death Differ (2019) 26, 2695-2709. PubMed  Europe PubMed DOI  P  I
    37. 2018
  37. Egorshina,A.Y., Zamaraev,A.V., Lavrik,I.N., Zhivotovsky,B.D. and Kopeina,G.S.
    [Caspase-2 as an oncosupressor and metabolism regulator: what life will bring over the long run?]
    Mol Biol (Mosk) (2018) 52, 750-763. PubMed  Europe PubMed DOI  V
  38. Forsberg,J., Li,X., Akpinar,B., Salvatori,R., Ott,M., Zhivotovsky,B. and Olsson,M.
    A caspase-2-RFXANK interaction and its implication for MHC class II expression
    Cell Death Dis (2018) 9, 80-80. PubMed  Europe PubMed DOI
  39. Zamaraev,A.V., Kopeina,G.S., Buchbinder,J.H., Zhivotovsky,B. and Lavrik,I.N.
    Caspase-2 is a negative regulator of necroptosis
    Int J Biochem Cell Biol (2018) 102, 101-108. PubMed  Europe PubMed DOI  I
    40. 2017
  40. Dawar,S., Lim,Y., Puccini,J., White,M., Thomas,P., Bouchier-Hayes,L., Green,D.R., Dorstyn,L. and Kumar,S.
    Caspase-2-mediated cell death is required for deleting aneuploid cells
    Oncogene (2017) 36, 2704-2714. PubMed  Europe PubMed DOI
  41. Forsberg,J., Zhivotovsky,B. and Olsson,M.
    Caspase-2: an orphan enzyme out of the shadows
    Oncogene (2017) 36, 5441-5444. PubMed  Europe PubMed DOI
  42. Imre,G., Berthelet,J., Heering,J., Kehrloesser,S., Melzer,I.M., Lee,B.I., Thiede,B., Dotsch,V. and Rajalingam,K.
    Apoptosis inhibitor 5 is an endogenous inhibitor of caspase-2
    EMBO Rep (2017) 18, 733-744. PubMed  Europe PubMed DOI
  43. Miles,M.A., Kitevska-Ilioski,T. and Hawkins,C.J.
    Old and novel functions of caspase-2
    Int Rev Cell Mol Biol (2017) 332, 155-212. PubMed  Europe PubMed DOI
  44. O'Byrne,K.J. and Richard,D.J.
    Nucleolar caspase-2: protecting us from DNA damage
    J Cell Biol (2017) 216, 1521-1523. PubMed  Europe PubMed DOI
  45. Wilson,C.H., Nikolic,A., Kentish,S.J., Keller,M., Hatzinikolas,G., Dorstyn,L., Page,A.J. and Kumar,S.
    Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity
    Cell Death Dis (2017) 8, e3136-e3136. PubMed  Europe PubMed DOI  K
  46. Yan,Q., Zhu,H., Lan,L., Yi,J. and Yang,J.
    Cleavage of Ku80 by caspase-2 promotes non-homologous end joining-mediated DNA repair
    DNA Repair (Amst) (2017) 60, 18-28. PubMed  Europe PubMed DOI
    47. 2016
  47. Julien,O., Zhuang,M., Wiita,A.P., O'Donoghue,A.J., Knudsen,G.M., Craik,C.S. and Wells,J.A.
    Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles
    Proc Natl Acad Sci U S A (2016) 113, E2001-E2010. PubMed  Europe PubMed DOI  P
  48. Lopez-Cruzan,M., Sharma,R., Tiwari,M., Karbach,S., Holstein,D., Martin,C.R., Lechleiter,J.D. and Herman,B.
    Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment
    Cell Death Discov (2016) 2 PubMed  Europe PubMed DOI  PMC  EPMC
  49. Troy,C.M. and Shelanski,M.L.
    Caspase-2 and tau - a toxic partnership?
    Nat Med (2016) 22, 1207-1208. PubMed  Europe PubMed DOI
  50. Vigneswara,V. and Ahmed,Z.
    Long-term neuroprotection of retinal ganglion cells by inhibiting caspase-2
    Cell Death Discov (2016) 2, 16044-16044. PubMed  Europe PubMed DOI  PMC  EPMC
  51. Ye,S., Gao,Y., Wang,S., Li,Q., Li,R. and Li,H.
    Characterization and expression analysis of a caspase-2 in an invertebrate echinoderm sea cumber Apostichopus japonicus
    Fish Shellfish Immunol (2016) 48, 266-272. PubMed  Europe PubMed DOI
  52. Zhao,X., Kotilinek,L.A., Smith,B., Hlynialuk,C., Zahs,K., Ramsden,M., Cleary,J. and Ashe,K.H.
    Caspase-2 cleavage of tau reversibly impairs memory
    Nat Med (2016) 22, 1268-1276. PubMed  Europe PubMed DOI  P
    53. 2015
  53. Olsson,M., Forsberg,J. and Zhivotovsky,B.
    Caspase-2: the reinvented enzyme
    Oncogene (2015) 34, 1877-1882. PubMed  Europe PubMed DOI
  54. Parsons,M.J. and Bouchier-Hayes,L.
    Measuring initiator caspase activation by bimolecular fluorescence complementation
    Cold Spring Harb Protoc (2015) 2015, pdb.prot082552-pdb.prot082552. PubMed  Europe PubMed DOI  L
  55. Shalini,S. and Kumar,S.
    Caspase-2 and the oxidative stress response
    Mol Cell Oncol (2015) 2, e1004956-e1004956. PubMed  Europe PubMed DOI  PMC  EPMC
    56. 2014
  56. Dorstyn,L. and Kumar,S.
    Caspase-2 protocols
    Methods Mol Biol (2014) 1133, 71-87. PubMed  Europe PubMed DOI
  57. Kitevska,T., Roberts,S.J., Pantaki-Eimany,D., Boyd,S.E., Scott,F.L. and Hawkins,C.J.
    Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate
    Biosci Rep (2014) 34, e00100- PubMed  Europe PubMed DOI  A  P
  58. Solano,E.C., Kornbrust,D.J., Beaudry,A., Foy,J.W., Schneider,D.J. and Thompson,J.D.
    Toxicological and pharmacokinetic properties of QPI-1007, a chemically modified synthetic siRNA targeting caspase 2 mRNA, following intravitreal injection
    Nucleic Acid Ther (2014) 24, 258-266. PubMed  Europe PubMed DOI  K
  59. Tiwari,M., Sharma,L.K., Vanegas,D., Callaway,D.A., Bai,Y., Lechleiter,J.D. and Herman,B.
    A nonapoptotic role for CASP2/caspase 2: modulation of autophagy
    Autophagy (2014) 10, 1054-1070. PubMed  Europe PubMed DOI
    60. 2013
  60. Aksenova,V.I., Bylino,O.V., Zhivotovsky,B.D. and Lavrik,I.N.
    Caspase-2: What do we know today?
    Mol Biol (2013) 47, 165-180. DOI
  61. Bronner,D.N., O'Riordan,M.X. and He,Y.
    Caspase-2 mediates a Brucella abortus RB51-induced hybrid cell death having features of apoptosis and pyroptosis
    Front Cell Infect Microbiol (2013) 3, 83-83. PubMed  Europe PubMed DOI  PMC  EPMC
  62. Delgado,M.E., Olsson,M., Lincoln,F.A., Zhivotovsky,B. and Rehm,M.
    Determining the contributions of caspase-2, caspase-8 and effector caspases to intracellular VDVADase activities during apoptosis initiation and execution
    Biochim Biophys Acta (2013) 1833, 2279-2292. PubMed  Europe PubMed DOI  A
  63. Puccini,J., Dorstyn,L. and Kumar,S.
    Caspase-2 as a tumour suppressor
    Cell Death Differ (2013) 20, 1133-1139. PubMed  Europe PubMed DOI
  64. Tinnikov,A.A. and Samuels,H.H.
    A novel cell lysis approach reveals that caspase-2 rapidly translocates from the nucleus to the cytoplasm in response to apoptotic stimuli
    PLoS ONE (2013) 8, e61085-e61085. PubMed  Europe PubMed DOI  PMC  EPMC
    65. 2012
  65. Bouchier-Hayes,L. and Green,D.R.
    Caspase-2: the orphan caspase
    Cell Death Differ (2012) 19, 51-57. PubMed  Europe PubMed DOI
  66. Fava,L.L., Bock,F.J., Geley,S. and Villunger,A.
    Caspase-2 at a glance
    J Cell Sci (2012) 125, 5911-5915. PubMed  Europe PubMed DOI  V
  67. Imre,G., Heering,J., Takeda,A.N., Husmann,M., Thiede,B., Zu Heringdorf,D.M., Green,D.R., van der Goot,F.G., Sinha,B., Dotsch,V. and Rajalingam,K.
    Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis
    EMBO J (2012) 31, 2615-2628. PubMed  Europe PubMed DOI
  68. Kim,S.H. and Dass,C.R.
    Induction of caspase-2 activation by a DNA enzyme evokes tumor cell apoptosis
    DNA Cell Biol (2012) 31, 1-7. PubMed  Europe PubMed DOI
  69. Ren,K., Lu,J., Porollo,A. and Du,C.
    Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice
    J Biol Chem (2012) 287, 14792-14802. PubMed  Europe PubMed DOI
  70. Roschitzki-Voser,H., Schroeder,T., Lenherr,E.D., Frolich,F., Schweizer,A., Donepudi,M., Ganesan,R., Mittl,P.R., Baici,A. and Grutter,M.G.
    Human caspases in vitro: expression, purification and kinetic characterization
    Protein Expr Purif (2012) 84, 236-246. PubMed  Europe PubMed DOI  E
  71. Troy,C.M. and Jean,Y.Y.
    Caspase-2
    [ISSN:978-0-12-407743-0] (2012) 3, 2243-2247. DOI
  72. Wejda,M., Impens,F., Takahashi,N., Van Damme,P., Gevaert,K. and Vandenabeele,P.
    Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike
    J Biol Chem (2012) 287, 33983-33995. PubMed  Europe PubMed DOI  P
    73. 2011
  73. Ahmed,Z., Kalinski,H., Berry,M., Almasieh,M., Ashush,H., Slager,N., Brafman,A., Spivak,I., Prasad,N., Mett,I., Shalom,E., Alpert,E., Di Polo,A., Feinstein,E. and Logan,A.
    Ocular neuroprotection by siRNA targeting caspase-2
    Cell Death Dis (2011) 2, e173-e173. PubMed  Europe PubMed DOI  K
  74. Carroll,J.B., Southwell,A.L., Graham,R.K., Lerch,J.P., Ehrnhoefer,D.E., Cao,L.P., Zhang,W.N., Deng,Y., Bissada,N., Henkelman,R.M. and Hayden,M.R.
    Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington Disease
    Mol Neurodegener (2011) 6, 59-59. PubMed  Europe PubMed DOI  K
  75. Coe,L.M., Lippner,D., Perez,G.I. and McCabe,L.R.
    Caspase-2 deficiency protects mice from diabetes-induced marrow adiposity
    J Cell Biochem (2011) 112, 2403-2411. PubMed  Europe PubMed DOI  K
  76. Kim,M.S., Chung,N.G., Yoo,N.J. and Lee,S.H.
    Somatic mutation of proapoptotic caspase-2 gene is rare in acute leukemias and common solid cancers
    Eur J Haematol (2011) 86, 449-450. PubMed  Europe PubMed DOI  M
  77. Maillard,M.C., Brookfield,F.A., Courtney,S.M., Eustache,F.M., Gemkow,M.J., Handel,R.K., Johnson,L.C., Johnson,P.D., Kerry,M.A., Krieger,F., Meniconi,M., Munoz-Sanjuan,I., Palfrey,J.J., Park,H., Schaertl,S., Taylor,M.G., Weddell,D. and Dominguez,C.
    Exploiting differences in caspase-2 and -3 S2 subsites for selectivity: structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors
    Bioorg Med Chem (2011) 19, 5833-5851. PubMed  Europe PubMed DOI  I
  78. Tang,Y., Wells,J.A. and Arkin,M.R.
    Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis
    J Biol Chem (2011) 286, 34147-34154. PubMed  Europe PubMed DOI  S
  79. Tiwari,M., Lopez-Cruzan,M., Morgan,W.W. and Herman,B.
    Loss of caspase-2-dependent apoptosis induces autophagy after mitochondrial oxidative stress in primary cultures of young adult cortical neurons
    J Biol Chem (2011) 286, 8493-8506. PubMed  Europe PubMed DOI
    80. 2010
  80. Ark,M., Ozdemir,A. and Polat,B.
    Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2
    Apoptosis (2010) 15, 1494-1506. PubMed  Europe PubMed DOI  P  I
  81. Bouchier-Hayes,L.
    The role of caspase-2 in stress-induced apoptosis
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