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Literature for peptidase C14.006: caspase-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Amason,M.E., Li,L., Harvest,C.K., Lacey,C.A. and Miao,E.A.
    Validation of the Intermolecular Disulfide Bond in Caspase-2
    Biology (Basel)13, PubMed  Europe PubMed DOI
  2. Dawar,S., Benitez,M.C., Lim,Y., Dite,T.A., Yousef,J.M., Thio,N., Garciaz,S., Jackson,T.D., Milne,J.V., Dagley,L.F., Phillips,W.A., Kumar,S. and Clemons,N.J.
    Caspase-2 protects against ferroptotic cell death
    Cell Death Dis15, 182-182. PubMed  Europe PubMed DOI
  3. Ge,Y., Zhou,L., Fu,Y., He,L., Chen,Y., Li,D., Xie,Y., Yang,J., Wu,H., Dai,H., Peng,Z., Zhang,Y., Yi,S., Wu,B., Zhang,X., Zhang,Y., Ying,W., Cui,C.P., Liu,C.H. and Zhang,L.
    Caspase-2 is a condensate-mediated deubiquitinase in protein quality control
    Nat Cell Biol26, 1943-1957. PubMed  Europe PubMed DOI
  4. Rizzotto,D., Vigorito,V., Rieder,P., Gallob,F., Moretta,G.M., Soratroi,C., Riley,J.S., Bellutti,F., Veli,S.L., Mattivi,A., Lohmuller,M., Herzog,S., Bornhauser,B.C., Jacotot,E.D., Villunger,A. and Fava,L.L.
    Caspase-2 kills cells with extra centrosomes
    Sci Adv10, eado6607-eado6607. PubMed  Europe PubMed DOI
  5. Shah,R.B., Li,Y., Yu,H., Kini,E. and Sidi,S.
    Stepwise phosphorylation and SUMOylation of PIDD1 drive PIDDosome assembly in response to DNA repair failure
    Nat Commun15, 9195-9195. PubMed  Europe PubMed DOI
  6. Uctepe,E., Vona,B., Esen,F.N., Sonmez,F.M., Smol,T., Tumer,S., Mancilar,H., Geylan Durgun,D.E., Boute,O., Moghbeli,M., Ghayoor Karimiani,E., Hashemi,N., Bakhshoodeh,B., Kim,H.G., Maroofian,R. and Yesilyurt,A.
    Bi-allelic truncating variants in CASP2 underlie a neurodevelopmental disorder with lissencephaly
    Eur J Hum Genet32, 52-60. PubMed  Europe PubMed DOI
  7. Zeng,M., Wang,K., Wu,Q., Ding,J., Xie,D., Qi,X. and Shao,F.
    Dissecting caspase-2-mediated cell death: from intrinsic PIDDosome activation to chemical modulation
    Protein Cell PubMed  Europe PubMed DOI
    8. 2023
  8. Cuellar,M.E., Yang,M., Karavadhi,S., Zhang,Y.Q., Zhu,H., Sun,H., Shen,M., Hall,M.D., Patnaik,S., Ashe,K.H., Walters,M.A. and Pockes,S.
    An electrophilic fragment screening for the development of small molecules targeting caspase-2
    Eur J Med Chem259, 115632-115632. PubMed  Europe PubMed DOI
  9. Pockes,S., Walters,M.A. and Ashe,K.H.
    Targeting caspase-2 interactions with tau in Alzheimer's disease and related dementias
    Transl Res254, 34-40. PubMed  Europe PubMed DOI  V
    10. 2022
  10. Bosc,E., Anastasie,J., Soualmia,F., Coric,P., Kim,J.Y., Wang,L.Q., Lacin,G., Zhao,K., Patel,R., Duplus,E., Tixador,P., Sproul,A.A., Brugg,B., Reboud-Ravaux,M., Troy,C.M., Shelanski,M.L., Bouaziz,S., Karin,M., El Amri,C. and Jacotot,E.D.
    Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics
    Cell Death Dis13, 959-959. PubMed  Europe PubMed DOI  I
  11. Bresinsky,M., Strasser,J.M., Hubmann,A., Vallaster,B., McCue,W.M., Fuller,J., Singh,G., Nelson,K.M., Cuellar,M.E., Finzel,B.C., Ashe,K.H., Walters,M.A. and Pockes,S.
    Characterization of caspase-2 inhibitors based on specific sites of caspase-2-mediated proteolysis
    Arch Pharm (Weinheim)355, e2200095-e2200095. PubMed  Europe PubMed DOI
  12. Bresinsky,M., Strasser,J.M., Vallaster,B., Liu,P., McCue,W.M., Fuller,J., Hubmann,A., Singh,G., Nelson,K.M., Cuellar,M.E., Wilmot,C.M., Finzel,B.C., Ashe,K.H., Walters,M.A. and Pockes,S.
    Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314
    ACS Pharmacol Transl Sci5, 20-40. PubMed  Europe PubMed DOI  I
  13. Geng,S., Gu,L., Zhong,L., Xu,T. and Sun,Y.
    Genomic organization, evolution and functional characterization of caspase-2 and caspase-8 in miiuy croaker (Miichthys miiuy)
    Dev Comp Immunol127, 104308-104308. PubMed  Europe PubMed DOI
  14. Jiang,L. and Li,J.
    lncRNA GMDSAS1 upregulates IL6, TNFalpha and IL1beta, and induces apoptosis in human monocytic THP1 cells via miR965p/caspase 2 signaling
    Mol Med Rep25, PubMed  Europe PubMed DOI  K
  15. Lingg,N., Kross,C., Engele,P., Ohlknecht,C., Koppl,C., Fischer,A., Lier,B., Loibl,J., Sprenger,B., Liu,J., Scheidl,P., Berkemeyer,M., Buchinger,W., Brocard,C., Striedner,G., Oostenbrink,C., Schneider,R., Jungbauer,A. and Cserjan-Puschmann,M.
    CASPON platform technology: Ultrafast circularly permuted caspase-2 cleaves tagged fusion proteins before all 20 natural amino acids at the N-terminus
    N Biotechnol71, 37-46. PubMed  Europe PubMed DOI
  16. Luo,H., Ye,G., Liu,Y., Huang,D., Luo,Q., Chen,W. and Qi,Z.
    miR-150-3p enhances neuroprotective effects of neural stem cell exosomes after hypoxic-ischemic brain injury by targeting CASP2
    Neurosci Lett779, 136635-136635. PubMed  Europe PubMed DOI
  17. Steuer,E.L., Kemper,L.J., Hlynialuk,C.J.W., Leinonen-Wright,K., Montonye,M.L., Lapcinski,I.P., Forster,C.L., Ashe,K.H. and Liu,P.
    Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia
    J Neurosci42, 4737-4754. PubMed  Europe PubMed DOI
  18. Zhao,Y., Dhani,S. and Zhivotovsky,B.
    Unveiling caspase-2 regulation by non-coding RNAs
    Cell Death Dis13, 834-834. PubMed  Europe PubMed DOI  V
    19. 2021
  19. Kopeina,G.S. and Zhivotovsky,B.
    Caspase-2 as a Master Regulator of Genomic Stability
    Trends Cell Biol PubMed  Europe PubMed DOI
  20. Lim,Y., Dorstyn,L. and Kumar,S.
    The p53-caspase-2 axis in the cell cycle and DNA damage response
    Exp Mol Med53, 517-527. PubMed  Europe PubMed DOI  V
  21. Liu,P. and Ashe,K.H.
    The molecular implications of a caspase-2-mediated site-specific tau cleavage in tauopathies
    Neural Regen Res16, 1774-1775. PubMed  Europe PubMed DOI
  22. Ochiai,A., Sawaguchi,S., Memezawa,S., Seki,Y., Morimoto,T., Oizumi,H., Ohbuchi,K., Yamamoto,M., Mizoguchi,K., Miyamoto,Y. and Yamauchi,J.
    Knockdown of Golgi Stress-Responsive Caspase-2 Ameliorates HLD17-Associated AIMP2 Mutant-Mediated Inhibition of Oligodendroglial Cell Morphological Differentiation
    Neurochem Res PubMed  Europe PubMed DOI  K
  23. Ozdemir,A., Ibisoglu,B., Simay Demir,Y.D., Benhur,E., Valipour,F. and Ark,M.
    A novel proteolytic cleavage of ROCK 1 in cell death: Not only by caspases 3 and 7 but also by caspase 2
    Biochem Biophys Res Commun547, 118-124. PubMed  Europe PubMed DOI
    24. 2020
  24. Brown-Suedel,A.N. and Bouchier-Hayes,L.
    Caspase-2 Substrates: To Apoptosis, Cell Cycle Control, and Beyond
    Front Cell Dev Biol8, 610022-610022. PubMed  Europe PubMed DOI  V
  25. Cserjan-Puschmann,M., Lingg,N., Engele,P., Kross,C., Loibl,J., Fischer,A., Bacher,F., Frank,A.C., Ohlknecht,C., Brocard,C., Oostenbrink,C., Berkemeyer,M., Schneider,R., Striedner,G. and Jungbauer,A.
    Production of Circularly Permuted Caspase-2 for Affinity Fusion-Tag Removal: Cloning, Expression in Escherichia coli, Purification, and Characterization
    Biomolecules10, PubMed  Europe PubMed DOI
  26. Fu,S., Ding,M., Wang,J., Yin,X., Zhou,E., Kong,L., Tu,X., Guo,Z., Wang,A., Huang,Y. and Ye,J.
    Identification and functional characterization of three caspases in Takifugu obscurus in response to bacterial infection
    Fish Shellfish Immunol PubMed  Europe PubMed DOI  I
  27. Hong,W., Gu,Y., Guan,R., Xie,D., Zhou,H. and Yu,M.
    Pan-cancer analysis of the CASP gene family in relation to survival, tumor-infiltrating immune cells and therapeutic targets
    Genomics PubMed  Europe PubMed DOI
  28. Huang,J., Huang,Y., Feng,Z., Guo,W., Wang,X. and Liao,Z.
    MiR-1247-3p protects rat cardiomyocytes against hypoxia/reoxygenation-induced injury via targeting BCL2L11 and caspase-2
    J Recept Signal Transduct Res1-9. PubMed  Europe PubMed DOI  K
  29. Ohlknecht,C., Petrov,D., Engele,P., Kross,C., Sprenger,B., Fischer,A., Lingg,N., Schneider,R. and Oostenbrink,C.
    Enhancing the promiscuity of a member of the caspase protease family by rational design
    Proteins PubMed  Europe PubMed DOI
  30. Vigneswara,V. and Ahmed,Z.
    The role of caspase-2 in regulating cell fate
    Cells9, PubMed  Europe PubMed DOI  V
  31. Zamaraev,A.V., Volik,P.I., Nilov,D.K., Turkina,M.V., Egorshina,A.Y., Gorbunova,A.S., Iarovenko,S.I., Zhivotovsky,B. and Kopeina,G.S.
    Requirement for Serine-384 in Caspase-2 processing and activity
    Cell Death Dis11, 825-825. PubMed  Europe PubMed DOI
    32. 2019
  32. Poreba,M., Rut,W., Groborz,K., Snipas,S.J., Salvesen,G.S. and Drag,M.
    Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells
    Cell Death Differ26, 2695-2709. PubMed  Europe PubMed DOI  P  I
    33. 2018
  33. Egorshina,A.Y., Zamaraev,A.V., Lavrik,I.N., Zhivotovsky,B.D. and Kopeina,G.S.
    [Caspase-2 as an oncosupressor and metabolism regulator: what life will bring over the long run?]
    Mol Biol (Mosk)52, 750-763. PubMed  Europe PubMed DOI  V
  34. Forsberg,J., Li,X., Akpinar,B., Salvatori,R., Ott,M., Zhivotovsky,B. and Olsson,M.
    A caspase-2-RFXANK interaction and its implication for MHC class II expression
    Cell Death Dis9, 80-80. PubMed  Europe PubMed DOI
  35. Zamaraev,A.V., Kopeina,G.S., Buchbinder,J.H., Zhivotovsky,B. and Lavrik,I.N.
    Caspase-2 is a negative regulator of necroptosis
    Int J Biochem Cell Biol102, 101-108. PubMed  Europe PubMed DOI  I
    36. 2017
  36. Dawar,S., Lim,Y., Puccini,J., White,M., Thomas,P., Bouchier-Hayes,L., Green,D.R., Dorstyn,L. and Kumar,S.
    Caspase-2-mediated cell death is required for deleting aneuploid cells
    Oncogene36, 2704-2714. PubMed  Europe PubMed DOI
  37. Forsberg,J., Zhivotovsky,B. and Olsson,M.
    Caspase-2: an orphan enzyme out of the shadows
    Oncogene36, 5441-5444. PubMed  Europe PubMed DOI
  38. Imre,G., Berthelet,J., Heering,J., Kehrloesser,S., Melzer,I.M., Lee,B.I., Thiede,B., Dotsch,V. and Rajalingam,K.
    Apoptosis inhibitor 5 is an endogenous inhibitor of caspase-2
    EMBO Rep18, 733-744. PubMed  Europe PubMed DOI
  39. Miles,M.A., Kitevska-Ilioski,T. and Hawkins,C.J.
    Old and novel functions of caspase-2
    Int Rev Cell Mol Biol332, 155-212. PubMed  Europe PubMed DOI
  40. O'Byrne,K.J. and Richard,D.J.
    Nucleolar caspase-2: protecting us from DNA damage
    J Cell Biol216, 1521-1523. PubMed  Europe PubMed DOI
  41. Wilson,C.H., Nikolic,A., Kentish,S.J., Keller,M., Hatzinikolas,G., Dorstyn,L., Page,A.J. and Kumar,S.
    Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity
    Cell Death Dis8, e3136-e3136. PubMed  Europe PubMed DOI  K
  42. Yan,Q., Zhu,H., Lan,L., Yi,J. and Yang,J.
    Cleavage of Ku80 by caspase-2 promotes non-homologous end joining-mediated DNA repair
    DNA Repair (Amst)60, 18-28. PubMed  Europe PubMed DOI
    43. 2016
  43. Julien,O., Zhuang,M., Wiita,A.P., O'Donoghue,A.J., Knudsen,G.M., Craik,C.S. and Wells,J.A.
    Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles
    Proc Natl Acad Sci U S A113, E2001-E2010. PubMed  Europe PubMed DOI  P
  44. Lopez-Cruzan,M., Sharma,R., Tiwari,M., Karbach,S., Holstein,D., Martin,C.R., Lechleiter,J.D. and Herman,B.
    Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment
    Cell Death Discov2, PubMed  Europe PubMed DOI
  45. Troy,C.M. and Shelanski,M.L.
    Caspase-2 and tau - a toxic partnership?
    Nat Med22, 1207-1208. PubMed  Europe PubMed DOI
  46. Vigneswara,V. and Ahmed,Z.
    Long-term neuroprotection of retinal ganglion cells by inhibiting caspase-2
    Cell Death Discov2, 16044-16044. PubMed  Europe PubMed DOI
  47. Ye,S., Gao,Y., Wang,S., Li,Q., Li,R. and Li,H.
    Characterization and expression analysis of a caspase-2 in an invertebrate echinoderm sea cumber Apostichopus japonicus
    Fish Shellfish Immunol48, 266-272. PubMed  Europe PubMed DOI
  48. Zhao,X., Kotilinek,L.A., Smith,B., Hlynialuk,C., Zahs,K., Ramsden,M., Cleary,J. and Ashe,K.H.
    Caspase-2 cleavage of tau reversibly impairs memory
    Nat Med22, 1268-1276. PubMed  Europe PubMed DOI  P
    49. 2015
  49. Olsson,M., Forsberg,J. and Zhivotovsky,B.
    Caspase-2: the reinvented enzyme
    Oncogene34, 1877-1882. PubMed  Europe PubMed DOI
  50. Parsons,M.J. and Bouchier-Hayes,L.
    Measuring initiator caspase activation by bimolecular fluorescence complementation
    Cold Spring Harb Protoc2015, pdb.prot082552-pdb.prot082552. PubMed  Europe PubMed DOI  L
  51. Shalini,S. and Kumar,S.
    Caspase-2 and the oxidative stress response
    Mol Cell Oncol2, e1004956-e1004956. PubMed  Europe PubMed DOI
    52. 2014
  52. Dorstyn,L. and Kumar,S.
    Caspase-2 protocols
    Methods Mol Biol1133, 71-87. PubMed  Europe PubMed DOI
  53. Kitevska,T., Roberts,S.J., Pantaki-Eimany,D., Boyd,S.E., Scott,F.L. and Hawkins,C.J.
    Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate
    Biosci Rep34, e00100- PubMed  Europe PubMed DOI  A  P
  54. Solano,E.C., Kornbrust,D.J., Beaudry,A., Foy,J.W., Schneider,D.J. and Thompson,J.D.
    Toxicological and pharmacokinetic properties of QPI-1007, a chemically modified synthetic siRNA targeting caspase 2 mRNA, following intravitreal injection
    Nucleic Acid Ther24, 258-266. PubMed  Europe PubMed DOI  K
  55. Tiwari,M., Sharma,L.K., Vanegas,D., Callaway,D.A., Bai,Y., Lechleiter,J.D. and Herman,B.
    A nonapoptotic role for CASP2/caspase 2: modulation of autophagy
    Autophagy10, 1054-1070. PubMed  Europe PubMed DOI
    56. 2013
  56. Aksenova,V.I., Bylino,O.V., Zhivotovsky,B.D. and Lavrik,I.N.
    Caspase-2: What do we know today?
    Mol Biol47, 165-180. DOI
  57. Bronner,D.N., O'Riordan,M.X. and He,Y.
    Caspase-2 mediates a Brucella abortus RB51-induced hybrid cell death having features of apoptosis and pyroptosis
    Front Cell Infect Microbiol3, 83-83. PubMed  Europe PubMed DOI
  58. Delgado,M.E., Olsson,M., Lincoln,F.A., Zhivotovsky,B. and Rehm,M.
    Determining the contributions of caspase-2, caspase-8 and effector caspases to intracellular VDVADase activities during apoptosis initiation and execution
    Biochim Biophys Acta1833, 2279-2292. PubMed  Europe PubMed DOI  A
  59. Puccini,J., Dorstyn,L. and Kumar,S.
    Caspase-2 as a tumour suppressor
    Cell Death Differ20, 1133-1139. PubMed  Europe PubMed DOI
  60. Tinnikov,A.A. and Samuels,H.H.
    A novel cell lysis approach reveals that caspase-2 rapidly translocates from the nucleus to the cytoplasm in response to apoptotic stimuli
    PLoS ONE8, e61085-e61085. PubMed  Europe PubMed DOI
    61. 2012
  61. Bouchier-Hayes,L. and Green,D.R.
    Caspase-2: the orphan caspase
    Cell Death Differ19, 51-57. PubMed  Europe PubMed DOI
  62. Fava,L.L., Bock,F.J., Geley,S. and Villunger,A.
    Caspase-2 at a glance
    J Cell Sci125, 5911-5915. PubMed  Europe PubMed DOI  V
  63. Imre,G., Heering,J., Takeda,A.N., Husmann,M., Thiede,B., Zu Heringdorf,D.M., Green,D.R., van der Goot,F.G., Sinha,B., Dotsch,V. and Rajalingam,K.
    Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis
    EMBO J31, 2615-2628. PubMed  Europe PubMed DOI
  64. Kim,S.H. and Dass,C.R.
    Induction of caspase-2 activation by a DNA enzyme evokes tumor cell apoptosis
    DNA Cell Biol31, 1-7. PubMed  Europe PubMed DOI
  65. Ren,K., Lu,J., Porollo,A. and Du,C.
    Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice
    J Biol Chem287, 14792-14802. PubMed  Europe PubMed DOI
  66. Roschitzki-Voser,H., Schroeder,T., Lenherr,E.D., Frolich,F., Schweizer,A., Donepudi,M., Ganesan,R., Mittl,P.R., Baici,A. and Grutter,M.G.
    Human caspases in vitro: expression, purification and kinetic characterization
    Protein Expr Purif84, 236-246. PubMed  Europe PubMed DOI  E
  67. Troy,C.M. and Jean,Y.Y.
    Caspase-2
    [ISSN:978-0-12-407743-0]3, 2243-2247. DOI
  68. Wejda,M., Impens,F., Takahashi,N., Van Damme,P., Gevaert,K. and Vandenabeele,P.
    Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike
    J Biol Chem287, 33983-33995. PubMed  Europe PubMed DOI  P
    69. 2011
  69. Ahmed,Z., Kalinski,H., Berry,M., Almasieh,M., Ashush,H., Slager,N., Brafman,A., Spivak,I., Prasad,N., Mett,I., Shalom,E., Alpert,E., Di Polo,A., Feinstein,E. and Logan,A.
    Ocular neuroprotection by siRNA targeting caspase-2
    Cell Death Dis2, e173-e173. PubMed  Europe PubMed DOI  K
  70. Carroll,J.B., Southwell,A.L., Graham,R.K., Lerch,J.P., Ehrnhoefer,D.E., Cao,L.P., Zhang,W.N., Deng,Y., Bissada,N., Henkelman,R.M. and Hayden,M.R.
    Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington Disease
    Mol Neurodegener6, 59-59. PubMed  Europe PubMed DOI  K
  71. Coe,L.M., Lippner,D., Perez,G.I. and McCabe,L.R.
    Caspase-2 deficiency protects mice from diabetes-induced marrow adiposity
    J Cell Biochem112, 2403-2411. PubMed  Europe PubMed DOI  K
  72. Kim,M.S., Chung,N.G., Yoo,N.J. and Lee,S.H.
    Somatic mutation of proapoptotic caspase-2 gene is rare in acute leukemias and common solid cancers
    Eur J Haematol86, 449-450. PubMed  Europe PubMed DOI  M
  73. Maillard,M.C., Brookfield,F.A., Courtney,S.M., Eustache,F.M., Gemkow,M.J., Handel,R.K., Johnson,L.C., Johnson,P.D., Kerry,M.A., Krieger,F., Meniconi,M., Munoz-Sanjuan,I., Palfrey,J.J., Park,H., Schaertl,S., Taylor,M.G., Weddell,D. and Dominguez,C.
    Exploiting differences in caspase-2 and -3 S2 subsites for selectivity: structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors
    Bioorg Med Chem19, 5833-5851. PubMed  Europe PubMed DOI  I
  74. Tang,Y., Wells,J.A. and Arkin,M.R.
    Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis
    J Biol Chem286, 34147-34154. PubMed  Europe PubMed DOI  S
  75. Tiwari,M., Lopez-Cruzan,M., Morgan,W.W. and Herman,B.
    Loss of caspase-2-dependent apoptosis induces autophagy after mitochondrial oxidative stress in primary cultures of young adult cortical neurons
    J Biol Chem286, 8493-8506. PubMed  Europe PubMed DOI
    76. 2010
  76. Ark,M., Ozdemir,A. and Polat,B.
    Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2
    Apoptosis15, 1494-1506. PubMed  Europe PubMed DOI  P  I
  77. Bouchier-Hayes,L.
    The role of caspase-2 in stress-induced apoptosis
    J Cell Mol Med14, 1212-1224. PubMed  Europe PubMed DOI
  78. Dass,C.R., Galloway,S.J. and Choong,P.F.
    Dz13, a c-jun DNAzyme, is a potent inducer of caspase-2 activation
    Oligonucleotides20, 137-146. PubMed  Europe PubMed DOI
  79. Vakifahmetoglu-Norberg,H. and Zhivotovsky,B.
    The unpredictable caspase-2: what can it do?
    Trends Cell Biol20, 150-159. PubMed  Europe PubMed DOI  V
    80. 2009
  80. Andersen,J.L. and Kornbluth,S.
    A cut above the other caspases
    Mol Cell35, 733-734. PubMed  Europe PubMed DOI  L
  81. Benkova,B., Lozanov,V., Ivanov,I.P. and Mitev,V.
    Evaluation of recombinant caspase specificity by competitive substrates
    Anal Biochem394, 68-74. PubMed  Europe PubMed DOI  A  P
  82. Bouchier-Hayes,L., Oberst,A., McStay,G.P., Connell,S., Tait,S.W., Dillon,C.P., Flanagan,J.M., Beere,H.M. and Green,D.R.
    Characterization of cytoplasmic caspase-2 activation by induced proximity
    Mol Cell35, 830-840. PubMed  Europe PubMed DOI  L
  83. Kitevska,T., Spencer,D.M. and Hawkins,C.J.
    Caspase-2: controversial killer or checkpoint controller?
    Apoptosis14, 829-848. PubMed  Europe PubMed DOI  V
  84. Krumschnabel,G., Manzl,C. and Villunger,A.
    Caspase-2: killer, savior and safeguard - emerging versatile roles for an ill-defined caspase
    Oncogene28, 3093-3096. PubMed  Europe PubMed DOI  V
  85. Krumschnabel,G., Sohm,B., Bock,F., Manzl,C. and Villunger,A.
    The enigma of caspase-2: the laymen's view
    Cell Death Differ16, 195-207. PubMed  Europe PubMed DOI  V
  86. Kumar,S.
    Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?
    Nat Rev Cancer9, 897-903. PubMed  Europe PubMed DOI
  87. Manzl,C., Krumschnabel,G., Bock,F., Sohm,B., Labi,V., Baumgartner,F., Logette,E., Tschopp,J. and Villunger,A.
    Caspase-2 activation in the absence of PIDDosome formation
    J Cell Biol185, 291-303. PubMed  Europe PubMed DOI
  88. Olsson,M., Vakifahmetoglu,H., Abruzzo,P.M., Hogstrand,K., Grandien,A. and Zhivotovsky,B.
    DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis
    Oncogene28, 1949-1959. PubMed  Europe PubMed DOI
    89. 2008
  89. Ho,L.H., Read,S.H., Dorstyn,L., Lambrusco,L. and Kumar,S.
    Caspase-2 is required for cell death induced by cytoskeletal disruption
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