Literature for peptidase C14.006: caspase-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Dorstyn,L., Lim,Y., Scanlan,J., McLennan,E., De Bellis,D., Katschner,M., Finnie,J., Emery-Corbin,S., Yousef,J., Dagley,L.F., Kok,C.H., Shah,S.S., Takahashi,C., Febbraio,M.A. and Kumar,S. Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice Sci Adv (2026) 12, eaeb2571-eaeb2571. PubMed Europe PubMed DOI PMC EPMC

2025

Zamaraev,A.V., Volik,P.I., Nilov,D.K., Turkina,M.V., Egorshina,A.Y., Gorbunova,A.S., Iarovenko,S.I., Zhivotovsky,B. and Kopeina,G.S. Correction: Requirement for Serine-384 in Caspase-2 processing and activity Cell Death Dis (2025) 16, 911-911. PubMed Europe PubMed DOI PMC EPMC

2024

Amason,M.E., Li,L., Harvest,C.K., Lacey,C.A. and Miao,E.A. Validation of the Intermolecular Disulfide Bond in Caspase-2 Biology (Basel) (2024) 13 PubMed Europe PubMed DOI PMC EPMC
Dawar,S., Benitez,M.C., Lim,Y., Dite,T.A., Yousef,J.M., Thio,N., Garciaz,S., Jackson,T.D., Milne,J.V., Dagley,L.F., Phillips,W.A., Kumar,S. and Clemons,N.J. Caspase-2 protects against ferroptotic cell death Cell Death Dis (2024) 15, 182-182. PubMed Europe PubMed DOI PMC EPMC
Ge,Y., Zhou,L., Fu,Y., He,L., Chen,Y., Li,D., Xie,Y., Yang,J., Wu,H., Dai,H., Peng,Z., Zhang,Y., Yi,S., Wu,B., Zhang,X., Zhang,Y., Ying,W., Cui,C.P., Liu,C.H. and Zhang,L. Caspase-2 is a condensate-mediated deubiquitinase in protein quality control Nat Cell Biol (2024) 26, 1943-1957. PubMed Europe PubMed DOI
Rizzotto,D., Vigorito,V., Rieder,P., Gallob,F., Moretta,G.M., Soratroi,C., Riley,J.S., Bellutti,F., Veli,S.L., Mattivi,A., Lohmuller,M., Herzog,S., Bornhauser,B.C., Jacotot,E.D., Villunger,A. and Fava,L.L. Caspase-2 kills cells with extra centrosomes Sci Adv (2024) 10, eado6607-eado6607. PubMed Europe PubMed DOI PMC EPMC
Shah,R.B., Li,Y., Yu,H., Kini,E. and Sidi,S. Stepwise phosphorylation and SUMOylation of PIDD1 drive PIDDosome assembly in response to DNA repair failure Nat Commun (2024) 15, 9195-9195. PubMed Europe PubMed DOI PMC EPMC
Uctepe,E., Vona,B., Esen,F.N., Sonmez,F.M., Smol,T., Tumer,S., Mancilar,H., Geylan Durgun,D.E., Boute,O., Moghbeli,M., Ghayoor Karimiani,E., Hashemi,N., Bakhshoodeh,B., Kim,H.G., Maroofian,R. and Yesilyurt,A. Bi-allelic truncating variants in CASP2 underlie a neurodevelopmental disorder with lissencephaly Eur J Hum Genet (2024) 32, 52-60. PubMed Europe PubMed DOI PMC EPMC
Volik,P.I., Zamaraev,A.V., Egorshina,A.Y., Pervushin,N.V., Kapusta,A.A., Tyurin-Kuzmin,P.A., Lipatova,A.V., Kaehne,T., Lavrik,I.N., Zhivotovsky,B. and Kopeina,G.S. Ally or traitor: the dual role of p62 in caspase-2 regulation Cell Death Dis (2024) 15, 827-827. PubMed Europe PubMed DOI PMC EPMC
Zeng,M., Wang,K., Wu,Q., Ding,J., Xie,D., Qi,X. and Shao,F. Dissecting caspase-2-mediated cell death: from intrinsic PIDDosome activation to chemical modulation Protein Cell (2024) PubMed Europe PubMed DOI

2023

Cuellar,M.E., Yang,M., Karavadhi,S., Zhang,Y.Q., Zhu,H., Sun,H., Shen,M., Hall,M.D., Patnaik,S., Ashe,K.H., Walters,M.A. and Pockes,S. An electrophilic fragment screening for the development of small molecules targeting caspase-2 Eur J Med Chem (2023) 259, 115632-115632. PubMed Europe PubMed DOI PMC EPMC
Pockes,S., Walters,M.A. and Ashe,K.H. Targeting caspase-2 interactions with tau in Alzheimer's disease and related dementias Transl Res (2023) 254, 34-40. PubMed Europe PubMed DOI PMC EPMC V

2022

Bosc,E., Anastasie,J., Soualmia,F., Coric,P., Kim,J.Y., Wang,L.Q., Lacin,G., Zhao,K., Patel,R., Duplus,E., Tixador,P., Sproul,A.A., Brugg,B., Reboud-Ravaux,M., Troy,C.M., Shelanski,M.L., Bouaziz,S., Karin,M., El Amri,C. and Jacotot,E.D. Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics Cell Death Dis (2022) 13, 959-959. PubMed Europe PubMed DOI PMC EPMC I
Bresinsky,M., Strasser,J.M., Vallaster,B., Liu,P., McCue,W.M., Fuller,J., Hubmann,A., Singh,G., Nelson,K.M., Cuellar,M.E., Wilmot,C.M., Finzel,B.C., Ashe,K.H., Walters,M.A. and Pockes,S. Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314 ACS Pharmacol Transl Sci (2022) 5, 20-40. PubMed Europe PubMed DOI PMC EPMC I
Bresinsky,M., Strasser,J.M., Hubmann,A., Vallaster,B., McCue,W.M., Fuller,J., Singh,G., Nelson,K.M., Cuellar,M.E., Finzel,B.C., Ashe,K.H., Walters,M.A. and Pockes,S. Characterization of caspase-2 inhibitors based on specific sites of caspase-2-mediated proteolysis Arch Pharm (Weinheim) (2022) 355, e2200095-e2200095. PubMed Europe PubMed DOI
Geng,S., Gu,L., Zhong,L., Xu,T. and Sun,Y. Genomic organization, evolution and functional characterization of caspase-2 and caspase-8 in miiuy croaker (Miichthys miiuy) Dev Comp Immunol (2022) 127, 104308-104308. PubMed Europe PubMed DOI
Jiang,L. and Li,J. lncRNA GMDSAS1 upregulates IL6, TNFalpha and IL1beta, and induces apoptosis in human monocytic THP1 cells via miR965p/caspase 2 signaling Mol Med Rep (2022) 25 PubMed Europe PubMed DOI PMC EPMC K
Lingg,N., Kross,C., Engele,P., Ohlknecht,C., Koppl,C., Fischer,A., Lier,B., Loibl,J., Sprenger,B., Liu,J., Scheidl,P., Berkemeyer,M., Buchinger,W., Brocard,C., Striedner,G., Oostenbrink,C., Schneider,R., Jungbauer,A. and Cserjan-Puschmann,M. CASPON platform technology: Ultrafast circularly permuted caspase-2 cleaves tagged fusion proteins before all 20 natural amino acids at the N-terminus N Biotechnol (2022) 71, 37-46. PubMed Europe PubMed DOI
Luo,H., Ye,G., Liu,Y., Huang,D., Luo,Q., Chen,W. and Qi,Z. miR-150-3p enhances neuroprotective effects of neural stem cell exosomes after hypoxic-ischemic brain injury by targeting CASP2 Neurosci Lett (2022) 779, 136635-136635. PubMed Europe PubMed DOI
Steuer,E.L., Kemper,L.J., Hlynialuk,C.J.W., Leinonen-Wright,K., Montonye,M.L., Lapcinski,I.P., Forster,C.L., Ashe,K.H. and Liu,P. Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia J Neurosci (2022) 42, 4737-4754. PubMed Europe PubMed DOI PMC EPMC
Weiler,E.S., Szabo,T.G., Garcia-Carpio,I. and Villunger,A. PIDD1 in cell cycle control, sterile inflammation and cell death Biochem Soc Trans (2022) 50, 813-824. PubMed Europe PubMed DOI V
Zhao,Y., Dhani,S. and Zhivotovsky,B. Unveiling caspase-2 regulation by non-coding RNAs Cell Death Dis (2022) 13, 834-834. PubMed Europe PubMed DOI PMC EPMC V

2021

Kopeina,G.S. and Zhivotovsky,B. Caspase-2 as a Master Regulator of Genomic Stability Trends Cell Biol (2021) PubMed Europe PubMed DOI
Lim,Y., Dorstyn,L. and Kumar,S. The p53-caspase-2 axis in the cell cycle and DNA damage response Exp Mol Med (2021) 53, 517-527. PubMed Europe PubMed DOI V
Liu,P. and Ashe,K.H. The molecular implications of a caspase-2-mediated site-specific tau cleavage in tauopathies Neural Regen Res (2021) 16, 1774-1775. PubMed Europe PubMed DOI
Ochiai,A., Sawaguchi,S., Memezawa,S., Seki,Y., Morimoto,T., Oizumi,H., Ohbuchi,K., Yamamoto,M., Mizoguchi,K., Miyamoto,Y. and Yamauchi,J. Knockdown of Golgi Stress-Responsive Caspase-2 Ameliorates HLD17-Associated AIMP2 Mutant-Mediated Inhibition of Oligodendroglial Cell Morphological Differentiation Neurochem Res (2021) PubMed Europe PubMed DOI K
Ozdemir,A., Ibisoglu,B., Simay Demir,Y.D., Benhur,E., Valipour,F. and Ark,M. A novel proteolytic cleavage of ROCK 1 in cell death: Not only by caspases 3 and 7 but also by caspase 2 Biochem Biophys Res Commun (2021) 547, 118-124. PubMed Europe PubMed DOI

2020

Brown-Suedel,A.N. and Bouchier-Hayes,L. Caspase-2 Substrates: To Apoptosis, Cell Cycle Control, and Beyond Front Cell Dev Biol (2020) 8, 610022-610022. PubMed Europe PubMed DOI PMC EPMC V
Cserjan-Puschmann,M., Lingg,N., Engele,P., Kross,C., Loibl,J., Fischer,A., Bacher,F., Frank,A.C., Ohlknecht,C., Brocard,C., Oostenbrink,C., Berkemeyer,M., Schneider,R., Striedner,G. and Jungbauer,A. Production of Circularly Permuted Caspase-2 for Affinity Fusion-Tag Removal: Cloning, Expression in Escherichia coli, Purification, and Characterization Biomolecules (2020) 10 PubMed Europe PubMed DOI
Fu,S., Ding,M., Wang,J., Yin,X., Zhou,E., Kong,L., Tu,X., Guo,Z., Wang,A., Huang,Y. and Ye,J. Identification and functional characterization of three caspases in Takifugu obscurus in response to bacterial infection Fish Shellfish Immunol (2020) PubMed Europe PubMed DOI I
Hong,W., Gu,Y., Guan,R., Xie,D., Zhou,H. and Yu,M. Pan-cancer analysis of the CASP gene family in relation to survival, tumor-infiltrating immune cells and therapeutic targets Genomics (2020) PubMed Europe PubMed DOI
Huang,J., Huang,Y., Feng,Z., Guo,W., Wang,X. and Liao,Z. MiR-1247-3p protects rat cardiomyocytes against hypoxia/reoxygenation-induced injury via targeting BCL2L11 and caspase-2 J Recept Signal Transduct Res (2020) , 1-9. PubMed Europe PubMed DOI K
Ohlknecht,C., Petrov,D., Engele,P., Kross,C., Sprenger,B., Fischer,A., Lingg,N., Schneider,R. and Oostenbrink,C. Enhancing the promiscuity of a member of the caspase protease family by rational design Proteins (2020) PubMed Europe PubMed DOI
Vigneswara,V. and Ahmed,Z. The role of caspase-2 in regulating cell fate Cells (2020) 9 PubMed Europe PubMed DOI V
Zamaraev,A.V., Volik,P.I., Nilov,D.K., Turkina,M.V., Egorshina,A.Y., Gorbunova,A.S., Iarovenko,S.I., Zhivotovsky,B. and Kopeina,G.S. Requirement for Serine-384 in Caspase-2 processing and activity Cell Death Dis (2020) 11, 825-825. PubMed Europe PubMed DOI PMC EPMC

2019

Poreba,M., Rut,W., Groborz,K., Snipas,S.J., Salvesen,G.S. and Drag,M. Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells Cell Death Differ (2019) 26, 2695-2709. PubMed Europe PubMed DOI P I

2018

Egorshina,A.Y., Zamaraev,A.V., Lavrik,I.N., Zhivotovsky,B.D. and Kopeina,G.S. [Caspase-2 as an oncosupressor and metabolism regulator: what life will bring over the long run?] Mol Biol (Mosk) (2018) 52, 750-763. PubMed Europe PubMed DOI V
Forsberg,J., Li,X., Akpinar,B., Salvatori,R., Ott,M., Zhivotovsky,B. and Olsson,M. A caspase-2-RFXANK interaction and its implication for MHC class II expression Cell Death Dis (2018) 9, 80-80. PubMed Europe PubMed DOI
Zamaraev,A.V., Kopeina,G.S., Buchbinder,J.H., Zhivotovsky,B. and Lavrik,I.N. Caspase-2 is a negative regulator of necroptosis Int J Biochem Cell Biol (2018) 102, 101-108. PubMed Europe PubMed DOI I

2017

Dawar,S., Lim,Y., Puccini,J., White,M., Thomas,P., Bouchier-Hayes,L., Green,D.R., Dorstyn,L. and Kumar,S. Caspase-2-mediated cell death is required for deleting aneuploid cells Oncogene (2017) 36, 2704-2714. PubMed Europe PubMed DOI
Forsberg,J., Zhivotovsky,B. and Olsson,M. Caspase-2: an orphan enzyme out of the shadows Oncogene (2017) 36, 5441-5444. PubMed Europe PubMed DOI
Imre,G., Berthelet,J., Heering,J., Kehrloesser,S., Melzer,I.M., Lee,B.I., Thiede,B., Dotsch,V. and Rajalingam,K. Apoptosis inhibitor 5 is an endogenous inhibitor of caspase-2 EMBO Rep (2017) 18, 733-744. PubMed Europe PubMed DOI
Miles,M.A., Kitevska-Ilioski,T. and Hawkins,C.J. Old and novel functions of caspase-2 Int Rev Cell Mol Biol (2017) 332, 155-212. PubMed Europe PubMed DOI
O'Byrne,K.J. and Richard,D.J. Nucleolar caspase-2: protecting us from DNA damage J Cell Biol (2017) 216, 1521-1523. PubMed Europe PubMed DOI
Wilson,C.H., Nikolic,A., Kentish,S.J., Keller,M., Hatzinikolas,G., Dorstyn,L., Page,A.J. and Kumar,S. Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity Cell Death Dis (2017) 8, e3136-e3136. PubMed Europe PubMed DOI K
Yan,Q., Zhu,H., Lan,L., Yi,J. and Yang,J. Cleavage of Ku80 by caspase-2 promotes non-homologous end joining-mediated DNA repair DNA Repair (Amst) (2017) 60, 18-28. PubMed Europe PubMed DOI

2016

Julien,O., Zhuang,M., Wiita,A.P., O'Donoghue,A.J., Knudsen,G.M., Craik,C.S. and Wells,J.A. Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles Proc Natl Acad Sci U S A (2016) 113, E2001-E2010. PubMed Europe PubMed DOI P
Lopez-Cruzan,M., Sharma,R., Tiwari,M., Karbach,S., Holstein,D., Martin,C.R., Lechleiter,J.D. and Herman,B. Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment Cell Death Discov (2016) 2 PubMed Europe PubMed DOI PMC EPMC
Troy,C.M. and Shelanski,M.L. Caspase-2 and tau - a toxic partnership? Nat Med (2016) 22, 1207-1208. PubMed Europe PubMed DOI
Vigneswara,V. and Ahmed,Z. Long-term neuroprotection of retinal ganglion cells by inhibiting caspase-2 Cell Death Discov (2016) 2, 16044-16044. PubMed Europe PubMed DOI PMC EPMC
Ye,S., Gao,Y., Wang,S., Li,Q., Li,R. and Li,H. Characterization and expression analysis of a caspase-2 in an invertebrate echinoderm sea cumber Apostichopus japonicus Fish Shellfish Immunol (2016) 48, 266-272. PubMed Europe PubMed DOI
Zhao,X., Kotilinek,L.A., Smith,B., Hlynialuk,C., Zahs,K., Ramsden,M., Cleary,J. and Ashe,K.H. Caspase-2 cleavage of tau reversibly impairs memory Nat Med (2016) 22, 1268-1276. PubMed Europe PubMed DOI P

2015

Olsson,M., Forsberg,J. and Zhivotovsky,B. Caspase-2: the reinvented enzyme Oncogene (2015) 34, 1877-1882. PubMed Europe PubMed DOI
Parsons,M.J. and Bouchier-Hayes,L. Measuring initiator caspase activation by bimolecular fluorescence complementation Cold Spring Harb Protoc (2015) 2015, pdb.prot082552-pdb.prot082552. PubMed Europe PubMed DOI L
Shalini,S. and Kumar,S. Caspase-2 and the oxidative stress response Mol Cell Oncol (2015) 2, e1004956-e1004956. PubMed Europe PubMed DOI PMC EPMC

2014

Dorstyn,L. and Kumar,S. Caspase-2 protocols Methods Mol Biol (2014) 1133, 71-87. PubMed Europe PubMed DOI
Kitevska,T., Roberts,S.J., Pantaki-Eimany,D., Boyd,S.E., Scott,F.L. and Hawkins,C.J. Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate Biosci Rep (2014) 34, e00100- PubMed Europe PubMed DOI A P
Solano,E.C., Kornbrust,D.J., Beaudry,A., Foy,J.W., Schneider,D.J. and Thompson,J.D. Toxicological and pharmacokinetic properties of QPI-1007, a chemically modified synthetic siRNA targeting caspase 2 mRNA, following intravitreal injection Nucleic Acid Ther (2014) 24, 258-266. PubMed Europe PubMed DOI K
Tiwari,M., Sharma,L.K., Vanegas,D., Callaway,D.A., Bai,Y., Lechleiter,J.D. and Herman,B. A nonapoptotic role for CASP2/caspase 2: modulation of autophagy Autophagy (2014) 10, 1054-1070. PubMed Europe PubMed DOI

2013

Aksenova,V.I., Bylino,O.V., Zhivotovsky,B.D. and Lavrik,I.N. Caspase-2: What do we know today? Mol Biol (2013) 47, 165-180. DOI
Bronner,D.N., O'Riordan,M.X. and He,Y. Caspase-2 mediates a Brucella abortus RB51-induced hybrid cell death having features of apoptosis and pyroptosis Front Cell Infect Microbiol (2013) 3, 83-83. PubMed Europe PubMed DOI PMC EPMC
Delgado,M.E., Olsson,M., Lincoln,F.A., Zhivotovsky,B. and Rehm,M. Determining the contributions of caspase-2, caspase-8 and effector caspases to intracellular VDVADase activities during apoptosis initiation and execution Biochim Biophys Acta (2013) 1833, 2279-2292. PubMed Europe PubMed DOI A
Puccini,J., Dorstyn,L. and Kumar,S. Caspase-2 as a tumour suppressor Cell Death Differ (2013) 20, 1133-1139. PubMed Europe PubMed DOI
Tinnikov,A.A. and Samuels,H.H. A novel cell lysis approach reveals that caspase-2 rapidly translocates from the nucleus to the cytoplasm in response to apoptotic stimuli PLoS ONE (2013) 8, e61085-e61085. PubMed Europe PubMed DOI PMC EPMC

2012

Bouchier-Hayes,L. and Green,D.R. Caspase-2: the orphan caspase Cell Death Differ (2012) 19, 51-57. PubMed Europe PubMed DOI
Fava,L.L., Bock,F.J., Geley,S. and Villunger,A. Caspase-2 at a glance J Cell Sci (2012) 125, 5911-5915. PubMed Europe PubMed DOI V
Imre,G., Heering,J., Takeda,A.N., Husmann,M., Thiede,B., Zu Heringdorf,D.M., Green,D.R., van der Goot,F.G., Sinha,B., Dotsch,V. and Rajalingam,K. Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis EMBO J (2012) 31, 2615-2628. PubMed Europe PubMed DOI
Kim,S.H. and Dass,C.R. Induction of caspase-2 activation by a DNA enzyme evokes tumor cell apoptosis DNA Cell Biol (2012) 31, 1-7. PubMed Europe PubMed DOI
Ren,K., Lu,J., Porollo,A. and Du,C. Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice J Biol Chem (2012) 287, 14792-14802. PubMed Europe PubMed DOI
Roschitzki-Voser,H., Schroeder,T., Lenherr,E.D., Frolich,F., Schweizer,A., Donepudi,M., Ganesan,R., Mittl,P.R., Baici,A. and Grutter,M.G. Human caspases in vitro: expression, purification and kinetic characterization Protein Expr Purif (2012) 84, 236-246. PubMed Europe PubMed DOI E
Troy,C.M. and Jean,Y.Y. Caspase-2 [ISSN:978-0-12-407743-0] (2012) 3, 2243-2247. DOI
Wejda,M., Impens,F., Takahashi,N., Van Damme,P., Gevaert,K. and Vandenabeele,P. Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike J Biol Chem (2012) 287, 33983-33995. PubMed Europe PubMed DOI P

2011

Ahmed,Z., Kalinski,H., Berry,M., Almasieh,M., Ashush,H., Slager,N., Brafman,A., Spivak,I., Prasad,N., Mett,I., Shalom,E., Alpert,E., Di Polo,A., Feinstein,E. and Logan,A. Ocular neuroprotection by siRNA targeting caspase-2 Cell Death Dis (2011) 2, e173-e173. PubMed Europe PubMed DOI K
Carroll,J.B., Southwell,A.L., Graham,R.K., Lerch,J.P., Ehrnhoefer,D.E., Cao,L.P., Zhang,W.N., Deng,Y., Bissada,N., Henkelman,R.M. and Hayden,M.R. Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington Disease Mol Neurodegener (2011) 6, 59-59. PubMed Europe PubMed DOI K
Coe,L.M., Lippner,D., Perez,G.I. and McCabe,L.R. Caspase-2 deficiency protects mice from diabetes-induced marrow adiposity J Cell Biochem (2011) 112, 2403-2411. PubMed Europe PubMed DOI K
Kim,M.S., Chung,N.G., Yoo,N.J. and Lee,S.H. Somatic mutation of proapoptotic caspase-2 gene is rare in acute leukemias and common solid cancers Eur J Haematol (2011) 86, 449-450. PubMed Europe PubMed DOI M
Maillard,M.C., Brookfield,F.A., Courtney,S.M., Eustache,F.M., Gemkow,M.J., Handel,R.K., Johnson,L.C., Johnson,P.D., Kerry,M.A., Krieger,F., Meniconi,M., Munoz-Sanjuan,I., Palfrey,J.J., Park,H., Schaertl,S., Taylor,M.G., Weddell,D. and Dominguez,C. Exploiting differences in caspase-2 and -3 S2 subsites for selectivity: structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors Bioorg Med Chem (2011) 19, 5833-5851. PubMed Europe PubMed DOI I
Tang,Y., Wells,J.A. and Arkin,M.R. Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis J Biol Chem (2011) 286, 34147-34154. PubMed Europe PubMed DOI S
Tiwari,M., Lopez-Cruzan,M., Morgan,W.W. and Herman,B. Loss of caspase-2-dependent apoptosis induces autophagy after mitochondrial oxidative stress in primary cultures of young adult cortical neurons J Biol Chem (2011) 286, 8493-8506. PubMed Europe PubMed DOI

2010

Ark,M., Ozdemir,A. and Polat,B. Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2 Apoptosis (2010) 15, 1494-1506. PubMed Europe PubMed DOI P I
Bouchier-Hayes,L. The role of caspase-2 in stress-induced apoptosis J Cell Mol Med (2010) 14, 1212-1224. PubMed Europe PubMed DOI
Dass,C.R., Galloway,S.J. and Choong,P.F. Dz13, a c-jun DNAzyme, is a potent inducer of caspase-2 activation Oligonucleotides (2010) 20, 137-146. PubMed Europe PubMed DOI
Vakifahmetoglu-Norberg,H. and Zhivotovsky,B. The unpredictable caspase-2: what can it do? Trends Cell Biol (2010) 20, 150-159. PubMed Europe PubMed DOI V

2009

Andersen,J.L. and Kornbluth,S. A cut above the other caspases Mol Cell (2009) 35, 733-734. PubMed Europe PubMed DOI L
Benkova,B., Lozanov,V., Ivanov,I.P. and Mitev,V. Evaluation of recombinant caspase specificity by competitive substrates Anal Biochem (2009) 394, 68-74. PubMed Europe PubMed DOI A P
Bouchier-Hayes,L., Oberst,A., McStay,G.P., Connell,S., Tait,S.W., Dillon,C.P., Flanagan,J.M., Beere,H.M. and Green,D.R. Characterization of cytoplasmic caspase-2 activation by induced proximity Mol Cell (2009) 35, 830-840. PubMed Europe PubMed DOI PMC EPMC L
Kitevska,T., Spencer,D.M. and Hawkins,C.J. Caspase-2: controversial killer or checkpoint controller? Apoptosis (2009) 14, 829-848. PubMed Europe PubMed DOI V
Krumschnabel,G., Sohm,B., Bock,F., Manzl,C. and Villunger,A. The enigma of caspase-2: the laymen's view Cell Death Differ (2009) 16, 195-207. PubMed Europe PubMed DOI V
Krumschnabel,G., Manzl,C. and Villunger,A. Caspase-2: killer, savior and safeguard - emerging versatile roles for an ill-defined caspase Oncogene (2009) 28, 3093-3096. PubMed Europe PubMed DOI V
Kumar,S. Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more? Nat Rev Cancer (2009) 9, 897-903. PubMed Europe PubMed DOI
Manzl,C., Krumschnabel,G., Bock,F., Sohm,B., Labi,V., Baumgartner,F., Logette,E., Tschopp,J. and Villunger,A. Caspase-2 activation in the absence of PIDDosome formation J Cell Biol (2009) 185, 291-303. PubMed Europe PubMed DOI PMC EPMC
Olsson,M., Vakifahmetoglu,H., Abruzzo,P.M., Hogstrand,K., Grandien,A. and Zhivotovsky,B. DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis Oncogene (2009) 28, 1949-1959. PubMed Europe PubMed DOI

2008

Ho,L.H., Read,S.H., Dorstyn,L., Lambrusco,L. and Kumar,S. Caspase-2 is required for cell death induced by cytoskeletal disruption Oncogene (2008) 27, 3393-3404. PubMed Europe PubMed DOI
Karki,P., Dahal,G.R., Shin,S.Y., Lee,J.S., Cho,B. and Park,I.S. Efficient cleavage of bid and procaspase-7 by caspase-2 at lower pH Protein Pept Lett (2008) 15, 1044-1049. PubMed Europe PubMed DOI
McStay,G.P., Salvesen,G.S. and Green,D.R. Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways Cell Death Differ (2008) 15, 322-331. PubMed Europe PubMed DOI P
Nijhuis,E.H., Le Gac,S., Poot,A.A., Feijen,J. and Vermes,I. Bax-mediated mitochondrial membrane permeabilization after heat treatment is caspase-2 dependent Int J Hyperthermia (2008) 24, 357-365. PubMed Europe PubMed DOI
Pereira,N.A. and Song,Z. Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity Biochem Biophys Res Commun (2008) 377, 873-877. PubMed Europe PubMed DOI P I
Troy,C.M. and Ribe,E.M. Caspase-2: vestigial remnant or master regulator? Sci Signal (2008) 1, e42-e42. PubMed Europe PubMed DOI

2007

Dahal,G.R., Karki,P., Thapa,A., Shahnawaz,M., Shin,S.Y., Lee,J.S., Cho,B. and Park,I.S. Caspase-2 cleaves DNA fragmentation factor (DFF45)/Inhibitor of caspase-activated DNase (ICAD) Arch Biochem Biophys (2007) 468, 134-139. PubMed Europe PubMed DOI
Schweizer,A., Roschitzki-Voser,H., Amstutz,P., Briand,C., Gulotti-Georgieva,M., Prenosil,E., Binz,H.K., Capitani,G., Baici,A., Pluckthun,A. and Grutter,M.G. Inhibition of caspase-2 by a designed ankyrin repeat protein: specificity, structure, and inhibition mechanism Structure (2007) 15, 625-636. PubMed Europe PubMed DOI
Tanaka,M., Liao,M., Zhou,J., Nishikawa,Y., Xuan,X. and Fujisaki,K. Molecular cloning of two caspase-like genes from the hard tick Haemaphysalis longicornis J Vet Med Sci (2007) 69, 85-90. PubMed Europe PubMed DOI

2006

Bonzon,C., Bouchier-Hayes,L., Pagliari,L.J., Green,D.R. and Newmeyer,D.D. Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death Mol Biol Cell (2006) 17, 2150-2157. PubMed Europe PubMed DOI PMC EPMC
[YEAR:21-9-2006]Ekici,O.D., Li,Z.Z., Campbell,A.J., James,K.E., Asgian,J.L., Mikolajczyk,J., Salvesen,G.S., Ganesan,R., Jelakovic,S., Grutter,M.G. and Powers,J.C. Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10 J Med Chem (21-9-2006) 49, 5728-5749. PubMed Europe PubMed DOI I
[YEAR:23-3-2006]Lavrik,I.N., Golks,A., Baumann,S. and Krammer,P.H. Caspase-2 is activated at the CD95 Death-Inducing Signaling complex in the course of CD95-induced apoptosis Blood (23-3-2006) 108, 559-565. PubMed Europe PubMed DOI
Tu,S., McStay,G.P., Boucher,L.M., Mak,T., Beere,H.M. and Green,D.R. In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis Nat Cell Biol (2006) 8, 72-77. PubMed Europe PubMed DOI
Wang,Q., Maniati,M., Jabado,O., Pavlaki,M., Troy,C.M., Greene,L.A. and Stefanis,L. RAIDD is required for apoptosis of PC12 cells and sympathetic neurons induced by trophic factor withdrawal Cell Death Differ (2006) 13, 75-83. PubMed Europe PubMed DOI

2005

Guicciardi,M.E., Bronk,S.F., Werneburg,N.W., Yin,X.M. and Gores,G.J. Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis Gastroenterology (2005) 129, 269-284. PubMed Europe PubMed DOI
Ho,P.K., Jabbour,A.M., Ekert,P.G. and Hawkins,C.J. Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7 FEBS J (2005) 272, 1401-1414. PubMed Europe PubMed DOI
Iwanaga,N., Kamachi,M., Aratake,K., Izumi,Y., Ida,H., Tanaka,F., Tamai,M., Arima,K., Nakamura,H., Origuchi,T., Kawakami,A. and Eguchi,K. Regulation of alternative splicing of caspase-2 through an intracellular signaling pathway in response to pro-apoptotic stimuli J Lab Clin Med (2005) 145, 105-110. PubMed Europe PubMed DOI R
Lamkanfi,M., D'Hondt,K., Vande Walle,L., van Gurp,M., Denecker,G., Demeulemeester,J., Kalai,M., Declercq,W., Saelens,X. and Vandenabeele,P. A novel caspase-2 complex containing TRAF2 and RIP1 J Biol Chem (2005) 280, 6923-6932. PubMed Europe PubMed DOI
Logette,E., Le Jossic-Corcos,C., Masson,D., Solier,S., Sequeira-Legrand,A., Dugail,I., Lemaire-Ewing,S., Desoche,L., Solary,E. and Corcos,L. Caspase-2, a novel lipid sensor under the control of sterol regulatory element binding protein 2 Mol Cell Biol (2005) 25, 9621-9631. PubMed Europe PubMed DOI PMC EPMC

2004

[YEAR:6-8-2004]Baliga,B.C., Read,S.H. and Kumar,S. The biochemical mechanism of caspase-2 activation Cell Death Differ (6-8-2004) 11, 1234-1241. PubMed Europe PubMed DOI
Chen,H., Chung,S. and Sukumar,S. HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8 Mol Cell Biol (2004) 24, 924-935. PubMed Europe PubMed DOI PMC EPMC
[YEAR:8-10-2004]Enoksson,M., Robertson,J.D., Gogvadze,V., Bu,P., Kropotov,A., Zhivotovsky,B. and Orrenius,S. Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids J Biol Chem (8-10-2004) 279, 49575-49578. PubMed Europe PubMed DOI
Paroni,G., Mizzau,M., Henderson,C., del Sal,G., Schneider,C. and Brancolini,C. Caspase-dependent regulation of histone deacetylase 4 nuclear-cytoplasmic shuttling promotes apoptosis Mol Biol Cell (2004) 15, 2804-2818. PubMed Europe PubMed DOI PMC EPMC P
[YEAR:1-6-2004]Robertson,J.D., Gogvadze,V., Kropotov,A., Vakifahmetoglu,H., Zhivotovsky,B. and Orrenius,S. Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity EMBO Rep (1-6-2004) 5, 643-648. PubMed Europe PubMed DOI PMC EPMC
Rotter,B., Kroviarski,Y., Nicolas,G., Dhermy,D. and Lecomte,M.C. AlphaII-spectrin is an in vitro target for caspase-2, and its cleavage is regulated by calmodulin binding Biochem J (2004) 378, 161-168. PubMed Europe PubMed DOI PMC EPMC
Tinel,A. and Tschopp,J. The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress Science (2004) 304, 843-846. PubMed Europe PubMed DOI
Wagner,K.W., Engels,I.H. and Deveraux,Q.L. Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway J Biol Chem (2004) 279, 35047-35052. PubMed Europe PubMed DOI

2003

[YEAR:14-2-2003]Baliga,B.C., Colussi,P.A., Read,S.H., Dias,M.M., Jans,D.A. and Kumar,S. Role of prodomain in importin-mediated nuclear localization and activation of caspase-2 J Biol Chem (14-2-2003) 278, 4899-4905. PubMed Europe PubMed DOI
[YEAR:13-2-2003]Logette,E., Wotawa,A., Solier,S., Desoche,L., Solary,E. and Corcos,L. The human caspase-2 gene: alternative promoters, pre-mRNA splicing and AUG usage direct isoform-specific expression Oncogene (13-2-2003) 22, 935-946. PubMed Europe PubMed DOI
[YEAR:24-10-2003]Schweizer,A., Briand,C. and Grutter,M.G. Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway J Biol Chem (24-10-2003) 278, 42441-42447. PubMed Europe PubMed DOI S I
Troy,C.M. and Shelanski,M.L. Caspase-2 redux Cell Death Differ (2003) 10, 101-107. PubMed Europe PubMed DOI

2002

Guo,Y., Srinivasula,S.M., Druilhe,A., Fernandes-Alnemri,T. and Alnemri,E.S. Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria J Biol Chem (2002) 277, 13430-13437. PubMed Europe PubMed DOI
Jin,K., Nagayama,T., Mao,X., Kawaguchi,K., Hickey,R.W., Greenberg,D.A., Simon,R.P. and Graham,S.H. Two caspase-2 transcripts are expressed in rat hippocampus after global cerebral ischemia J Neurochem (2002) 81, 25-35. PubMed Europe PubMed DOI I
[YEAR:23-8-2002]Lassus,P., Opitz-Araya,X. and Lazebnik,Y. Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization Science (23-8-2002) 297, 1352-1354. PubMed Europe PubMed DOI
Read,S.H., Baliga,B.C., Ekert,P.G., Vaux,D.L. and Kumar,S. A novel Apaf-1-independent putative caspase-2 activation complex J Cell Biol (2002) 159, 739-745. PubMed Europe PubMed DOI PMC EPMC
[YEAR:16-8-2002]Robertson,J.D., Enoksson,M., Suomela,M., Zhivotovsky,B. and Orrenius,S. Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis J Biol Chem (16-8-2002) 277, 29803-29809. PubMed Europe PubMed DOI I

2001

[YEAR:16-3-2001]Cote,J., Dupuis,S. and Wu,J.Y. Polypyrimidine track-binding protein binding downstream of caspase-2 alternative exon 9 represses its inclusion J Biol Chem (16-3-2001) 276, 8535-8543. PubMed Europe PubMed DOI PMC EPMC
[YEAR:30-1-2001]Cote,J., Dupuis,S., Jiang,Z.H. and Wu,J.Y. Caspase-2 pre-mRNA alternative splicing: identification of an intronic element containing a decoy 3' acceptor site Proc Natl Acad Sci U S A (30-1-2001) 98, 938-943. PubMed Europe PubMed DOI PMC EPMC R
[YEAR:20-4-2001]Shearwin-Whyatt,L., Baliga,B., Doumanis,J. and Kumar,S. Chimeric caspase molecules with potent cell killing activity in apoptosis-resistant cells Biochem Biophys Res Commun (20-4-2001) 282, 1114-1119. PubMed Europe PubMed DOI

2000

[YEAR:15-12-2000]Droin,N., Beauchemin,M., Solary,E. and Bertrand,R. Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade Cancer Res (15-12-2000) 60, 7039-7047. PubMed Europe PubMed R
[YEAR:1-5-2000]Mancini,M., Machamer,C.E., Roy,S., Nicholson,D.W., Thornberry,N.A., Casciola-Rosen,L.A. and Rosen,A. Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis J Cell Biol (1-5-2000) 149, 603-612. PubMed Europe PubMed DOI PMC EPMC
Troy,C.M., Rabacchi,S.A., Friedman,W.J., Frappier,T.F., Brown,K. and Shelanski,M.L. Caspase-2 mediates neuronal cell death induced by beta-amyloid J Neurosci (2000) 20, 1386-1392. PubMed Europe PubMed

1999

Garcia-Calvo,M., Peterson,E.P., Rasper,D.M., Vaillancourt,J.P., Zamboni,R., Nicholson,D.W. and Thornberry,N.A. Purification and catalytic properties of human caspase family members Cell Death Differ (1999) 6, 362-369. PubMed Europe PubMed DOI

1998

Bergeron,L., Perez,G.I., Macdonald,G., Shi,L., Sun,Y., Jurisicova,A., Varmuza,S., Latham,K.E., Flaws,J.A., Salter,J.C., Hara,H., Moskowitz,M.A., Li,E., Greenberg,A., Tilly,J.L. and Yuan,J. Defects in regulation of apoptosis in caspase-2-deficient mice Genes Dev (1998) 12, 1304-1314. PubMed Europe PubMed PMC EPMC K

1997

Khar,A., Pardhasardhi,B.V., Varalakshmi,C., Ali,A.M. and Kumari,A.L. Caspase-2/NEDD-2 protease mediates execution of apoptosis in AK-5 tumor cells Apoptosis (1997) 2, 494-500. PubMed Europe PubMed
[YEAR:20-11-1997]Sato,N., Milligan,C.E., Uchiyama,Y. and Oppenheim,R.W. Cloning and expression of the cDNA encoding rat caspase-2 Gene (20-11-1997) 202, 127-132. PubMed Europe PubMed DOI
[YEAR:11-4-1997]Talanian,R.V., Quinlan,C., Trautz,S., Hackett,M.C., Mankovich,J.A., Banach,D., Ghayur,T., Brady,K.D. and Wong,W.W. Substrate specificities of caspase family proteases J Biol Chem (11-4-1997) 272, 9677-9682. PubMed Europe PubMed DOI P
[YEAR:18-7-1997]Thornberry,N.A., Rano,T.A., Peterson,E.P., Rasper,D.M., Timkey,T., Garcia-Calvo,M., Houtzager,V.M., Nordstrom,P.A., Roy,S., Vaillancourt,J.P., Chapman,K.T. and Nicholson,D.W. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis J Biol Chem (18-7-1997) 272, 17907-17911. PubMed Europe PubMed DOI P
Troy,C.M., Stefanis,L., Greene,L.A. and Shelanski,M.L. Nedd2 is required for apoptosis after trophic factor withdrawal, but not superoxide dismutase (SOD1) downregulation, in sympathetic neurons and PC12 cells J Neurosci (1997) 17, 1911-1918. PubMed Europe PubMed
Van de Craen,M., Vandenabeele,P., Declercq,W., van den Brande,I., Van Loo,G., Molemans,F., Schotte,P., van Criekinge,W., Beyaert,R. and Fiers,W. Characterization of seven murine caspase family members FEBS Lett (1997) 403, 61-69. PubMed Europe PubMed DOI

1994

[YEAR:9-9-1994]Wang,L., Miura,M., Bergeron,L., Zhu,H. and Yuan,J. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death Cell (9-9-1994) 78, 739-750. PubMed Europe PubMed DOI R