$VAR1 = undef;

Summary for peptidase C03.001: poliovirus-type picornain 3C

Names
MEROPS Name	poliovirus-type picornain 3C
Other names	picornavirus endopeptidase 3C, picornavirus peptidase 3C (poliovirus), picornain 3C (poliovirus), protein 3CD

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(C) >> Family C3 >> Subfamily A >> C03.001
Holotype	poliovirus-type picornain 3C (human poliovirus 1), Uniprot accession P03299 (peptidase unit: 1564-1745), MERNUM MER0000748
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Cysteine
Peplist	Included in the Peplist with identifier PL00081
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.28
Enzymology	BRENDA database
Proteolytic events	CutDB database (13 cleavages)
Physiology	Viral polyprotein processing in replication. Cleaves some host transcription factors and microtubule-associated protein 4.
Pharmaceutical relevance	A potential target for antiviral drugs.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	av/-/-/QG/-/-/- (based on 14 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	1	0	0	13	0	2	0
Pro	1	0	1	0	0	3	3	2
Ala	7	0	3	0	0	2	0	0
Val	2	0	2	0	0	1	1	2
Leu	1	3	2	0	0	2	1	0
Ile	1	2	0	0	0	2	1	0
Met	0	1	0	0	0	0	0	0
Phe	0	0	1	0	0	0	0	1
Tyr	0	0	0	0	0	0	1	0
Trp	1	0	0	0	0	0	0	1
Ser	0	0	1	0	0	0	1	1
Thr	1	1	0	0	1	0	1	1
Cys	0	1	0	0	0	0	0	0
Asn	0	0	1	0	0	0	1	1
Gln	0	2	0	14	0	2	0	3
Asp	0	0	0	0	0	1	0	0
Glu	0	0	1	0	0	1	1	0
Lys	0	1	1	0	0	0	0	0
Arg	0	1	0	0	0	0	1	2
His	0	1	1	0	0	0	0	0