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Literature for peptidase C03.001: poliovirus-type picornain 3C

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Dias-Solange,D., Le,M.T., Gottipati,K. and Choi,K.H.
    Structure of coxsackievirus cloverleaf RNA and 3C(pro) dimer establishes the RNA-binding mechanism of enterovirus protease 3C(pro)
    Sci Adv11, eads6862-eads6862. PubMed  Europe PubMed DOI
    2. 2024
  2. Arita,M.
    An efficient trans complementation system for in vivo replication of defective poliovirus mutants
    J Virole0052324-e0052324. PubMed  Europe PubMed DOI
  3. Azzolino,V.N., Shaqra,A.M., Ali,A., Kurt Yilmaz,N. and Schiffer,C.A.
    Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance
    Viruses16, PubMed  Europe PubMed DOI  I
  4. Jassey,A., Pollack,N., Wagner,M.A., Wu,J., Benton,A. and Jackson,W.T.
    Transcription factor EB (TFEB) interaction with RagC is disrupted during enterovirus D68 infection
    J Virole0055624-e0055624. PubMed  Europe PubMed DOI
  5. Li,X., Guo,H., Yang,J., Liu,X., Li,H., Yang,W., Zhang,L., Li,Y. and Wei,W.
    Enterovirus D68 3C protease antagonizes type I interferon signaling by cleaving signal transducer and activator of transcription 1
    J Virol98, e0199423-e0199423. PubMed  Europe PubMed DOI
  6. Shen,S., Guo,H., Li,Y., Zhang,L., Tang,Y., Li,H., Li,X., Wang,P.H., Yu,X.F. and Wei,W.
    SARS-CoV-2 and oncolytic EV-D68-encoded proteases differentially regulate pyroptosis
    J Virol98, e0190923-e0190923. PubMed  Europe PubMed DOI
  7. Wang,S., Pang,Z., Fan,H. and Tong,Y.
    Advances in anti-EV-A71 drug development research
    J Adv Res56, 137-156. PubMed  Europe PubMed DOI  V
    8. 2023
  8. Andrews,D.D.T., Vlok,M., Akbari Bani,D., Hay,B.N., Mohamud,Y., Foster,L.J., Luo,H., Overall,C.M. and Jan,E.
    Cleavage of 14-3-3epsilon by the enteroviral 3C protease dampens RIG-I-mediated antiviral signaling
    J Virol97, e0060423-e0060423. PubMed  Europe PubMed DOI
  9. Campagnola,G. and Peersen,O.
    Co-folding and RNA activation of poliovirus 3C(pro) polyprotein precursors
    J Biol Chem299, 105258-105258. PubMed  Europe PubMed DOI
    10. 2021
  10. Yi,J., Peng,J., Yang,W., Zhu,G., Ren,J., Li,D. and Zheng,H.
    Picornavirus 3C - a protease ensuring virus replication and subverting host responses
    J Cell Sci134, PubMed  Europe PubMed DOI  V
    11. 2018
  11. Jagdeo,J.M., Dufour,A., Klein,T., Solis,N., Kleifeld,O., Kizhakkedathu,J., Luo,H., Overall,C.M. and Jan,E.
    N-Terminomics TAILS identifies host cell substrates of poliovirus and coxsackievirus B3 3C proteinases that modulate virus infection
    J Virol92, e02211-17-e02211-17. PubMed  Europe PubMed DOI
  12. Uma,M., Hegde,S.R., Rao,P.P., Nagalekshmi,K., Gauthami,S., Kumar,D. and Hegde,N.R.
    A novel point mutation (L70P) inactivates poliovirus 3C protease
    Acta Virol62, 68-77. PubMed  Europe PubMed DOI
    13. 2016
  13. Chan,Y.M., Moustafa,I.M., Arnold,J.J., Cameron,C.E. and Boehr,D.D.
    Long-range communication between different functional sites in the picornaviral 3C protein
    Structure24, 509-517. PubMed  Europe PubMed DOI  S
  14. Laitinen,O.H., Svedin,E., Kapell,S., Nurminen,A., Hytonen,V.P. and Flodstrom-Tullberg,M.
    Enteroviral proteases: structure, host interactions and pathogenicity
    Rev Med Virol26, 251-267. PubMed  Europe PubMed DOI
  15. Sun,D., Chen,S., Cheng,A. and Wang,M.
    Roles of the picornaviral 3C proteinase in the viral life cycle and host cells
    Viruses8, 82-82. PubMed  Europe PubMed DOI  I
    16. 2015
  16. Dougherty,J.D., Tsai,W.C. and Lloyd,R.E.
    Multiple poliovirus proteins repress cytoplasmic RNA granules
    Viruses7, 6127-6140. PubMed  Europe PubMed DOI
    17. 2014
  17. Chase,A.J., Daijogo,S. and Semler,B.L.
    Inhibition of poliovirus-induced cleavage of cellular protein PCBP2 reduces the levels of viral RNA replication
    J Virol88, 3192-3201. PubMed  Europe PubMed DOI
  18. Tam,J.C., Bidgood,S.R., McEwan,W.A. and James,L.C.
    Intracellular sensing of complement C3 activates cell autonomous immunity
    Science345, 1256070-1256070. PubMed  Europe PubMed DOI  I
  19. van der Linden,L., Ulferts,R., Nabuurs,S.B., Kusov,Y., Liu,H., George,S., Lacroix,C., Goris,N., Lefebvre,D., Lanke,K.H., De Clercq,K., Hilgenfeld,R., Neyts,J. and van Kuppeveld,F.J.
    Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases
    Antiviral Res103, 17-24. PubMed  Europe PubMed DOI  I
    20. 2012
  20. Rozovics,J.M., Chase,A.J., Cathcart,A.L., Chou,W., Gershon,P.D., Palusa,S., Wilusz,J. and Semler,B.L.
    Picornavirus modification of a host mRNA decay protein
    MBio3, e00431-e00412. PubMed  Europe PubMed DOI
  21. Skern,T.
    Picornain 3C
    [ISSN:978-0-12-407743-0]3, 2396-2402. DOI
    22. 2011
  22. Gouvea,I.E., Santos,J.A., Burlandy,F.M., Tersariol,I.L., da Silva,E.E., Juliano,M.A., Juliano,L. and Cunha,R.L.
    Poliovirus 3C proteinase inhibition by organotelluranes
    Biol Chem392, 587-591. PubMed  Europe PubMed DOI  I
    23. 2009
  23. Barral,P.M., Sarkar,D., Fisher,P.B. and Racaniello,V.R.
    RIG-I is cleaved during picornavirus infection
    Virology391, 171-176. PubMed  Europe PubMed DOI
    24. 2008
  24. Bonderoff,J.M., Larey,J.L. and Lloyd,R.E.
    Cleavage of poly(A)-binding protein by poliovirus 3C proteinase inhibits viral internal ribosome entry site-mediated translation
    J Virol82, 9389-9399. PubMed  Europe PubMed DOI
  25. de Breyne,S., Bonderoff,J.M., Chumakov,K.M., Lloyd,R.E. and Hellen,C.U.
    Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases
    Virology378, 118-122. PubMed  Europe PubMed DOI
  26. Rivera,C.I. and Lloyd,R.E.
    Modulation of enteroviral proteinase cleavage of poly(A)-binding protein (PABP) by conformation and PABP-associated factors
    Virology375, 59-72. PubMed  Europe PubMed DOI
    27. 2007
  27. Marcotte,L.L., Wass,A.B., Gohara,D.W., Pathak,H.B., Arnold,J.J., Filman,D.J., Cameron,C.E. and Hogle,J.M.
    Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase
    J Virol81, 3583-3596. PubMed  Europe PubMed DOI  S
  28. Schutz,S. and Sarnow,P.
    How viruses avoid stress
    Cell Host Microbe2, 284-285. PubMed  Europe PubMed DOI
  29. White,J.P., Cardenas,A.M., Marissen,W.E. and Lloyd,R.E.
    Inhibition of cytoplasmic mRNA stress granule formation by a viral proteinase
    Cell Host Microbe2, 295-305. PubMed  Europe PubMed DOI
    30. 2006
  30. [YEAR:3-10-2006]Gouvea,I.E., Judice,W.A., Cezari,M.H., Juliano,M.A., Juhasz,T., Szeltner,Z., Polgar,L. and Juliano,L.
    Kosmotropic salt activation and substrate specificity of poliovirus protease 3C
    Biochemistry45, 12083-12089. PubMed  Europe PubMed DOI
    31. 2004
  31. Calandria,C., Irurzun,A., Barco,A. and Carrasco,L.
    Individual expression of poliovirus 2Apro and 3Cpro induces activation of caspase-3 and PARP cleavage in HeLa cells
    Virus Res104, 39-49. PubMed  Europe PubMed DOI
  32. Kuyumcu-Martinez,N.M., Van Eden,M.E., Younan,P. and Lloyd,R.E.
    Cleavage of poly(A)-binding protein by poliovirus 3C protease inhibits host cell translation: a novel mechanism for host translation shutoff
    Mol Cell Biol24, 1779-1790. PubMed  Europe PubMed DOI
  33. Skern,T.
    Picornain 3C
    [ISSN:0-12-079610-4]2, 1353-1357.  V
    34. 2003
  34. [YEAR:21-1-2003]Sarkany,Z. and Polgar,L.
    The unusual catalytic triad of poliovirus protease 3C
    Biochemistry42, 516-522. PubMed  Europe PubMed DOI
    35. 2002
  35. Back,S.H., Kim,Y.K., Kim,W.J., Cho,S., Oh,H.R., Kim,J.E. and Jang,S.K.
    Translation of polioviral mRNA is inhibited by cleavage of polypyrimidine tract-binding proteins executed by polioviral 3C(pro)
    J Virol76, 2529-2542. PubMed  Europe PubMed DOI
  36. Kuyumcu-Martinez,N.M., Joachims,M. and Lloyd,R.E.
    Efficient cleavage of ribosome-associated poly(A)-binding protein by enterovirus 3C protease
    J Virol76, 2062-2074. PubMed  Europe PubMed DOI
  37. Tong,L.
    Viral proteases
    Chem Rev102, 4609-4626. PubMed  Europe PubMed DOI  V
    38. 2000
  38. [YEAR:20-1-2000]Barco,A., Feduchi,E. and Carrasco,L.
    Poliovirus protease 3C(pro) kills cells by apoptosis
    Virology266, 352-360. PubMed  Europe PubMed DOI
  39. Hata,S., Sato,T., Sorimachi,H., Ishiura,S. and Suzuki,K.
    A simple purification and fluorescent assay method of the poliovirus 3C protease searching for specific inhibitors
    J Virol Methods84, 117-126. PubMed  Europe PubMed DOI  A
    40. 1997
  40. [YEAR:14-11-1997]Babe,L.M. and Craik,C.S.
    Viral proteases: evolution of diverse structural motifs to optimize function
    Cell91, 427-430. PubMed  Europe PubMed
  41. [YEAR:14-11-1997]Mosimann,S.C., Cherney,M.M., Sia,S., Plotch,S. and James,M.N.
    Refined x-ray crystallographic structure of the poliovirus 3C gene product
    J Mol Biol273, 1032-1047. PubMed  Europe PubMed DOI
    42. 1996
  42. Blom,N., Hansen,J., Blaas,D. and Brunak,S.
    Cleavage site analysis in picornaviral polyproteins: discovering cellular targets by neural networks
    Protein Sci5, 2203-2216. PubMed  Europe PubMed DOI  P
    43. 1995
  43. Joachims,M., Harris,K.S. and Etchison,D.
    Poliovirus protease 3C mediates cleavage of microtubule-associated protein 4
    Virology211, 451-461. PubMed  Europe PubMed DOI
    44. 1994
  44. Skern,T. and Liebig,H.D.
    Picornains 2A and 3C
    Methods Enzymol244, 583-595. PubMed  Europe PubMed DOI  V  I
    45. 1993
  45. Kean,K.M., Howell,M.T., Grunert,S., Girard,M. and Jackson,R.J.
    Substitution mutations at the putative catalytic triad of the poliovirus 3C protease have differential effects on cleavage at different sites
    Virology194, 360-364. PubMed  Europe PubMed DOI
    46. 1991
  46. Blair,W.S. and Semler,B.L.
    Role for the P4 amino acid residue in substrate utilization by the poliovirus 3CD proteinase
    J Virol65, 6111-6123. PubMed  Europe PubMed  P
  47. Clark,M.E., Hammerle,T., Wimmer,E. and Dasgupta,A.
    Poliovirus proteinase 3C converts an active form of transcription factor IIIC to an inactive form: a mechanism for inhibition of host cell polymerase III transcription by poliovirus
    EMBO J10, 2941-2947. PubMed  Europe PubMed
  48. Sablina,E.P. and Antonov,V.K.
    Recombinant poliovirus 3C protease. The enzyme application to protein specific fragmentation
    FEBS Lett283, 291-294. PubMed  Europe PubMed DOI
    49. 1990
  49. Tesar,M. and Marquardt,O.
    Foot-and-mouth disease virus protease 3C inhibits cellular transcription and mediates cleavage of histone H3
    Virology174, 364-374. PubMed  Europe PubMed DOI
    50. 1989
  50. [YEAR:15-6-1989]Pallai,P.V., Burkhardt,F., Skoog,M., Schreiner,K., Bax,P., Cohen,K.A., Hansen,G., Palladino,D.E., Harris,K.S. and Nicklin,M.J.
    Cleavage of synthetic peptides by purified poliovirus 3C proteinase
    J Biol Chem264, 9738-9741. PubMed  Europe PubMed
    51. 1988
  51. Krausslich,H.G. and Wimmer,E.
    Viral proteinases
    Annu Rev Biochem57, 701-754. PubMed  Europe PubMed DOI
  52. Nicklin,M.J., Harris,K.S., Pallai,P.V. and Wimmer,E.
    Poliovirus proteinase 3C: large-scale expression, purification, and specific cleavage activity on natural and synthetic substrates in vitro
    J Virol62, 4586-4593. PubMed  Europe PubMed  A
  53. [YEAR:25-11-1988]Ypma-Wong,M.F., Filman,D.J., Hogle,J.M. and Semler,B.L.
    Structural domains of the poliovirus polyprotein are major determinants for proteolytic cleavage at Gln-Gly pairs
    J Biol Chem263, 17846-17856. PubMed  Europe PubMed
  54. Ypma-Wong,M.F., Dewalt,P.G., Johnson,V.H., Lamb,J.G. and Semler,B.L.
    Protein 3CD is the major poliovirus proteinase responsible for cleavage of the P1 capsid precursor
    Virology166, 265-270. PubMed  Europe PubMed
    55. 1986
  55. [YEAR:6-1-1986]Gorbalenya,A.E., Blinov,V.M. and Donchenko,A.P.
    Poliovirus-encoded proteinase 3C: a possible evolutionary link between cellular serine and cysteine proteinase families
    FEBS Lett194, 253-257. PubMed  Europe PubMed
  56. Ivanoff,L.A., Towatari,T., Ray,J., Korant,B.D. and Petteway,S.R., Jr.
    Expression and site-specific mutagenesis of the poliovirus 3C protease in Escherichia coli
    Proc Natl Acad Sci U S A83, 5392-5396. PubMed  Europe PubMed
    57. 1983
  57. Cann,A.J., Stanway,G., Hauptmann,R., Minor,P.D., Schild,G.C., Clarke,L.D., Mountford,R.C. and Almond,J.W.
    Poliovirus type 3: molecular cloning of the genome and nucleotide sequence of the region encoding the protease and polymerase proteins
    Nucleic Acids Res11, 1267-1281. PubMed  Europe PubMed

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