Literature for peptidase C03.001: poliovirus-type picornain 3C

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Bakhache,W., Symonds-Orr,W. and Dolan,P.T. Genotype-by-Inhibitor Interactions to Dissect Enterovirus Replication Res Sq (2025) PubMed Europe PubMed DOI PMC EPMC
Dias-Solange,D., Le,M.T., Gottipati,K. and Choi,K.H. Structure of coxsackievirus cloverleaf RNA and 3C(pro) dimer establishes the RNA-binding mechanism of enterovirus protease 3C(pro) Sci Adv (2025) 11, eads6862-eads6862. PubMed Europe PubMed DOI PMC EPMC
Yang,X., Li,W., Yang,S., Wang,Z., Yin,J., Zhang,W., Tao,H., Li,S., Guo,X., Dai,Q., Zhu,W., Li,Y., Yan,X., Luo,C., Li,J., Ren,S., Wang,P., Shao,Y., Luo,Y., Li,Z., Yang,J., Chang,Z., Cao,R., Li,S. and Zhong,W. Gene Therapy with Enterovirus 3 C Protease: A Promising Strategy for Various Solid Tumors Nat Commun (2025) 16, 4298-4298. PubMed Europe PubMed DOI PMC EPMC
Yu,J., Winston,D.S. and Boehr,D.D. Molecular determinants of picornavirus 3C protease binding to phosphoinositide-enriched lipid membranes J Biol Chem (2025) , 110543-110543. PubMed Europe PubMed DOI

2024

Arita,M. An efficient trans complementation system for in vivo replication of defective poliovirus mutants J Virol (2024) , e0052324-e0052324. PubMed Europe PubMed DOI
Azzolino,V.N., Shaqra,A.M., Ali,A., Kurt Yilmaz,N. and Schiffer,C.A. Elucidating the Substrate Envelope of Enterovirus 68-3C Protease: Structural Basis of Specificity and Potential Resistance Viruses (2024) 16 PubMed Europe PubMed DOI PMC EPMC I
Jassey,A., Pollack,N., Wagner,M.A., Wu,J., Benton,A. and Jackson,W.T. Transcription factor EB (TFEB) interaction with RagC is disrupted during enterovirus D68 infection J Virol (2024) , e0055624-e0055624. PubMed Europe PubMed DOI
Li,X., Guo,H., Yang,J., Liu,X., Li,H., Yang,W., Zhang,L., Li,Y. and Wei,W. Enterovirus D68 3C protease antagonizes type I interferon signaling by cleaving signal transducer and activator of transcription 1 J Virol (2024) 98, e0199423-e0199423. PubMed Europe PubMed DOI PMC EPMC
Shen,S., Guo,H., Li,Y., Zhang,L., Tang,Y., Li,H., Li,X., Wang,P.H., Yu,X.F. and Wei,W. SARS-CoV-2 and oncolytic EV-D68-encoded proteases differentially regulate pyroptosis J Virol (2024) 98, e0190923-e0190923. PubMed Europe PubMed DOI PMC EPMC
Wang,S., Pang,Z., Fan,H. and Tong,Y. Advances in anti-EV-A71 drug development research J Adv Res (2024) 56, 137-156. PubMed Europe PubMed DOI V

2023

Andrews,D.D.T., Vlok,M., Akbari Bani,D., Hay,B.N., Mohamud,Y., Foster,L.J., Luo,H., Overall,C.M. and Jan,E. Cleavage of 14-3-3epsilon by the enteroviral 3C protease dampens RIG-I-mediated antiviral signaling J Virol (2023) 97, e0060423-e0060423. PubMed Europe PubMed DOI PMC EPMC
Campagnola,G. and Peersen,O. Co-folding and RNA activation of poliovirus 3C(pro) polyprotein precursors J Biol Chem (2023) 299, 105258-105258. PubMed Europe PubMed DOI PMC EPMC

2021

Yi,J., Peng,J., Yang,W., Zhu,G., Ren,J., Li,D. and Zheng,H. Picornavirus 3C - a protease ensuring virus replication and subverting host responses J Cell Sci (2021) 134 PubMed Europe PubMed DOI V

2018

Jagdeo,J.M., Dufour,A., Klein,T., Solis,N., Kleifeld,O., Kizhakkedathu,J., Luo,H., Overall,C.M. and Jan,E. N-Terminomics TAILS identifies host cell substrates of poliovirus and coxsackievirus B3 3C proteinases that modulate virus infection J Virol (2018) 92, e02211-17-e02211-17. PubMed Europe PubMed DOI
Uma,M., Hegde,S.R., Rao,P.P., Nagalekshmi,K., Gauthami,S., Kumar,D. and Hegde,N.R. A novel point mutation (L70P) inactivates poliovirus 3C protease Acta Virol (2018) 62, 68-77. PubMed Europe PubMed DOI

2016

Chan,Y.M., Moustafa,I.M., Arnold,J.J., Cameron,C.E. and Boehr,D.D. Long-range communication between different functional sites in the picornaviral 3C protein Structure (2016) 24, 509-517. PubMed Europe PubMed DOI PMC EPMC S
Laitinen,O.H., Svedin,E., Kapell,S., Nurminen,A., Hytonen,V.P. and Flodstrom-Tullberg,M. Enteroviral proteases: structure, host interactions and pathogenicity Rev Med Virol (2016) 26, 251-267. PubMed Europe PubMed DOI
Sun,D., Chen,S., Cheng,A. and Wang,M. Roles of the picornaviral 3C proteinase in the viral life cycle and host cells Viruses (2016) 8, 82-82. PubMed Europe PubMed DOI I

2015

Dougherty,J.D., Tsai,W.C. and Lloyd,R.E. Multiple poliovirus proteins repress cytoplasmic RNA granules Viruses (2015) 7, 6127-6140. PubMed Europe PubMed DOI

2014

Chase,A.J., Daijogo,S. and Semler,B.L. Inhibition of poliovirus-induced cleavage of cellular protein PCBP2 reduces the levels of viral RNA replication J Virol (2014) 88, 3192-3201. PubMed Europe PubMed DOI
Tam,J.C., Bidgood,S.R., McEwan,W.A. and James,L.C. Intracellular sensing of complement C3 activates cell autonomous immunity Science (2014) 345, 1256070-1256070. PubMed Europe PubMed DOI I
van der Linden,L., Ulferts,R., Nabuurs,S.B., Kusov,Y., Liu,H., George,S., Lacroix,C., Goris,N., Lefebvre,D., Lanke,K.H., De Clercq,K., Hilgenfeld,R., Neyts,J. and van Kuppeveld,F.J. Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases Antiviral Res (2014) 103, 17-24. PubMed Europe PubMed DOI I

2012

Rozovics,J.M., Chase,A.J., Cathcart,A.L., Chou,W., Gershon,P.D., Palusa,S., Wilusz,J. and Semler,B.L. Picornavirus modification of a host mRNA decay protein MBio (2012) 3, e00431-e00412. PubMed Europe PubMed DOI PMC EPMC
Skern,T. Picornain 3C [ISSN:978-0-12-407743-0] (2012) 3, 2396-2402. DOI

2011

Gouvea,I.E., Santos,J.A., Burlandy,F.M., Tersariol,I.L., da Silva,E.E., Juliano,M.A., Juliano,L. and Cunha,R.L. Poliovirus 3C proteinase inhibition by organotelluranes Biol Chem (2011) 392, 587-591. PubMed Europe PubMed DOI I

2009

Barral,P.M., Sarkar,D., Fisher,P.B. and Racaniello,V.R. RIG-I is cleaved during picornavirus infection Virology (2009) 391, 171-176. PubMed Europe PubMed DOI PMC EPMC

2008

Bonderoff,J.M., Larey,J.L. and Lloyd,R.E. Cleavage of poly(A)-binding protein by poliovirus 3C proteinase inhibits viral internal ribosome entry site-mediated translation J Virol (2008) 82, 9389-9399. PubMed Europe PubMed DOI PMC EPMC
de Breyne,S., Bonderoff,J.M., Chumakov,K.M., Lloyd,R.E. and Hellen,C.U. Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases Virology (2008) 378, 118-122. PubMed Europe PubMed DOI PMC EPMC
Rivera,C.I. and Lloyd,R.E. Modulation of enteroviral proteinase cleavage of poly(A)-binding protein (PABP) by conformation and PABP-associated factors Virology (2008) 375, 59-72. PubMed Europe PubMed DOI PMC EPMC

2007

Marcotte,L.L., Wass,A.B., Gohara,D.W., Pathak,H.B., Arnold,J.J., Filman,D.J., Cameron,C.E. and Hogle,J.M. Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase J Virol (2007) 81, 3583-3596. PubMed Europe PubMed DOI PMC EPMC S
Schutz,S. and Sarnow,P. How viruses avoid stress Cell Host Microbe (2007) 2, 284-285. PubMed Europe PubMed DOI
White,J.P., Cardenas,A.M., Marissen,W.E. and Lloyd,R.E. Inhibition of cytoplasmic mRNA stress granule formation by a viral proteinase Cell Host Microbe (2007) 2, 295-305. PubMed Europe PubMed DOI

2006

[YEAR:3-10-2006]Gouvea,I.E., Judice,W.A., Cezari,M.H., Juliano,M.A., Juhasz,T., Szeltner,Z., Polgar,L. and Juliano,L. Kosmotropic salt activation and substrate specificity of poliovirus protease 3C Biochemistry (3-10-2006) 45, 12083-12089. PubMed Europe PubMed DOI

2004

Calandria,C., Irurzun,A., Barco,A. and Carrasco,L. Individual expression of poliovirus 2Apro and 3Cpro induces activation of caspase-3 and PARP cleavage in HeLa cells Virus Res (2004) 104, 39-49. PubMed Europe PubMed DOI
Kuyumcu-Martinez,N.M., Van Eden,M.E., Younan,P. and Lloyd,R.E. Cleavage of poly(A)-binding protein by poliovirus 3C protease inhibits host cell translation: a novel mechanism for host translation shutoff Mol Cell Biol (2004) 24, 1779-1790. PubMed Europe PubMed DOI PMC EPMC
Skern,T. Picornain 3C [ISSN:0-12-079610-4] (2004) 2, 1353-1357. V

2003

[YEAR:21-1-2003]Sarkany,Z. and Polgar,L. The unusual catalytic triad of poliovirus protease 3C Biochemistry (21-1-2003) 42, 516-522. PubMed Europe PubMed DOI

2002

Back,S.H., Kim,Y.K., Kim,W.J., Cho,S., Oh,H.R., Kim,J.E. and Jang,S.K. Translation of polioviral mRNA is inhibited by cleavage of polypyrimidine tract-binding proteins executed by polioviral 3C(pro) J Virol (2002) 76, 2529-2542. PubMed Europe PubMed DOI PMC EPMC
Kuyumcu-Martinez,N.M., Joachims,M. and Lloyd,R.E. Efficient cleavage of ribosome-associated poly(A)-binding protein by enterovirus 3C protease J Virol (2002) 76, 2062-2074. PubMed Europe PubMed DOI PMC EPMC
Tong,L. Viral proteases Chem Rev (2002) 102, 4609-4626. PubMed Europe PubMed DOI V

2000

[YEAR:20-1-2000]Barco,A., Feduchi,E. and Carrasco,L. Poliovirus protease 3C(pro) kills cells by apoptosis Virology (20-1-2000) 266, 352-360. PubMed Europe PubMed DOI
Hata,S., Sato,T., Sorimachi,H., Ishiura,S. and Suzuki,K. A simple purification and fluorescent assay method of the poliovirus 3C protease searching for specific inhibitors J Virol Methods (2000) 84, 117-126. PubMed Europe PubMed DOI A

1997

[YEAR:14-11-1997]Babe,L.M. and Craik,C.S. Viral proteases: evolution of diverse structural motifs to optimize function Cell (14-11-1997) 91, 427-430. PubMed Europe PubMed
[YEAR:14-11-1997]Mosimann,S.C., Cherney,M.M., Sia,S., Plotch,S. and James,M.N. Refined x-ray crystallographic structure of the poliovirus 3C gene product J Mol Biol (14-11-1997) 273, 1032-1047. PubMed Europe PubMed DOI

1996

Blom,N., Hansen,J., Blaas,D. and Brunak,S. Cleavage site analysis in picornaviral polyproteins: discovering cellular targets by neural networks Protein Sci (1996) 5, 2203-2216. PubMed Europe PubMed DOI PMC EPMC P

1995

Joachims,M., Harris,K.S. and Etchison,D. Poliovirus protease 3C mediates cleavage of microtubule-associated protein 4 Virology (1995) 211, 451-461. PubMed Europe PubMed DOI

1994

Skern,T. and Liebig,H.D. Picornains 2A and 3C Methods Enzymol (1994) 244, 583-595. PubMed Europe PubMed DOI V I

1993

Kean,K.M., Howell,M.T., Grunert,S., Girard,M. and Jackson,R.J. Substitution mutations at the putative catalytic triad of the poliovirus 3C protease have differential effects on cleavage at different sites Virology (1993) 194, 360-364. PubMed Europe PubMed DOI

1991

Blair,W.S. and Semler,B.L. Role for the P4 amino acid residue in substrate utilization by the poliovirus 3CD proteinase J Virol (1991) 65, 6111-6123. PubMed Europe PubMed PMC EPMC P
Clark,M.E., Hammerle,T., Wimmer,E. and Dasgupta,A. Poliovirus proteinase 3C converts an active form of transcription factor IIIC to an inactive form: a mechanism for inhibition of host cell polymerase III transcription by poliovirus EMBO J (1991) 10, 2941-2947. PubMed Europe PubMed PMC EPMC
Sablina,E.P. and Antonov,V.K. Recombinant poliovirus 3C protease. The enzyme application to protein specific fragmentation FEBS Lett (1991) 283, 291-294. PubMed Europe PubMed DOI

1990

Tesar,M. and Marquardt,O. Foot-and-mouth disease virus protease 3C inhibits cellular transcription and mediates cleavage of histone H3 Virology (1990) 174, 364-374. PubMed Europe PubMed DOI

1989

[YEAR:15-6-1989]Pallai,P.V., Burkhardt,F., Skoog,M., Schreiner,K., Bax,P., Cohen,K.A., Hansen,G., Palladino,D.E., Harris,K.S. and Nicklin,M.J. Cleavage of synthetic peptides by purified poliovirus 3C proteinase J Biol Chem (15-6-1989) 264, 9738-9741. PubMed Europe PubMed

1988

Krausslich,H.G. and Wimmer,E. Viral proteinases Annu Rev Biochem (1988) 57, 701-754. PubMed Europe PubMed DOI
Nicklin,M.J., Harris,K.S., Pallai,P.V. and Wimmer,E. Poliovirus proteinase 3C: large-scale expression, purification, and specific cleavage activity on natural and synthetic substrates in vitro J Virol (1988) 62, 4586-4593. PubMed Europe PubMed PMC EPMC A
Ypma-Wong,M.F., Dewalt,P.G., Johnson,V.H., Lamb,J.G. and Semler,B.L. Protein 3CD is the major poliovirus proteinase responsible for cleavage of the P1 capsid precursor Virology (1988) 166, 265-270. PubMed Europe PubMed
[YEAR:25-11-1988]Ypma-Wong,M.F., Filman,D.J., Hogle,J.M. and Semler,B.L. Structural domains of the poliovirus polyprotein are major determinants for proteolytic cleavage at Gln-Gly pairs J Biol Chem (25-11-1988) 263, 17846-17856. PubMed Europe PubMed

1986

[YEAR:6-1-1986]Gorbalenya,A.E., Blinov,V.M. and Donchenko,A.P. Poliovirus-encoded proteinase 3C: a possible evolutionary link between cellular serine and cysteine proteinase families FEBS Lett (6-1-1986) 194, 253-257. PubMed Europe PubMed
Ivanoff,L.A., Towatari,T., Ray,J., Korant,B.D. and Petteway,S.R., Jr. Expression and site-specific mutagenesis of the poliovirus 3C protease in Escherichia coli Proc Natl Acad Sci U S A (1986) 83, 5392-5396. PubMed Europe PubMed PMC EPMC

1983

Cann,A.J., Stanway,G., Hauptmann,R., Minor,P.D., Schild,G.C., Clarke,L.D., Mountford,R.C. and Almond,J.W. Poliovirus type 3: molecular cloning of the genome and nucleotide sequence of the region encoding the protease and polymerase proteins Nucleic Acids Res (1983) 11, 1267-1281. PubMed Europe PubMed PMC EPMC