Structure for peptidase M12.225: ADAMTS5 peptidase

PDB	Organism	Resolution	Comment
3B8Z_A	Homo sapiens	1.40 Å	high resolution crystal structure of the catalytic domain of adamts-5 (aggrecanase-2)
One monomer of the dimer is shown. The catalytic zinc atom is shown as a light grey CPK sphere. The zinc ligands are shown in ball-and-stick representation: His410, His414 and His 420. The catalytic Glu411 is shown in blue ball-and-stick representation. The structural calcium atoms are shown as yellow CPK spheres. The bound inhibitor is shown in grey ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
complex with inhibitor	2.60 Å	2RJQ	2RJQ	2RJQ	2RJQ	2RJQ	2RJQ	Mosyak et al., 2008
high resolution crystal structure of the catalytic domain of adamts-5 (aggrecanase-2)	1.40 Å	3B8Z	3B8Z	3B8Z	3B8Z	3B8Z	3B8Z	Shieh et al., 2008
mature peptidase	1.69 Å	3HY7	3HY7	3HY7	3HY7	3HY7	3HY7	Tortorella et al., 2009
mature peptidase	2.02 Å	3HY9	3HY9	3HY9	3HY9	3HY9	3HY9	Tortorella et al., 2009
mature peptidase	1.40 Å	3HYG	3HYG	3HYG	3HYG	3HYG	3HYG	Tortorella et al., 2009
mature peptidase	1.60 Å	3LJT	3LJT	3LJT	3LJT	3LJT	3LJT	Shieh et al., 2011