Literature for peptidase M12.225: ADAMTS5 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Dulos,J., Sun,R., Jovanovska,V., Kolb,F. and Stupka,N. Adamts5 deletion exacerbates inflammation and fibrosis resulting in compromised skeletal muscle regeneration Am J Physiol Cell Physiol (2026) PubMed Europe PubMed DOI

2025

Martin,D.R., Sardelli,G., Burkhard,T., Fowkes,M.M., Minns,A.F., Moschini,R., Del Corso,A., de Groot,R., Apte,S.S. and Santamaria,S. Characterization of ADAMTS9 proteoglycanase activity: comparison with ADAMTS1, ADAMTS4 and ADAMTS5 J Biol Chem (2025) , 110301-110301. PubMed Europe PubMed DOI

2024

Chen,Z., Du,F., Zhang,R., Wu,Q., Lu,Z., Zhang,R.L. and Wang,Q. ADAMTS5 Promotes Permeability of the Blood-Brain Barrier during Treponema pallidum Subspecies pallidum Invading the Central Nervous System ACS Infect Dis (2024) 10, 1222-1231. PubMed Europe PubMed DOI

2023

Liu,Y., Yao,Y., Zhang,Y., Yan,C., Yang,M., Wang,Z., Li,W., Li,F., Wang,W., Yang,Y., Li,X. and Tang,Z. MicroRNA-200c-5p Regulates Migration and Differentiation of Myoblasts via Targeting Adamts5 in Skeletal Muscle Regeneration and Myogenesis Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC

2022

He,S., Li,J., Ma,D., Liu,Z. and Lv,N. MicroRNA-148a targets ADAMTS5 to inhibit proliferation of endometriosis cells Pak J Pharm Sci (2022) 35, 335-341. PubMed Europe PubMed
Porto,C., Rogers-DeCotes,A., Schafer,E. and Kern,B. The adaptive response of the mandibular condyle to increased load is disrupted by c deficiency Connect Tissue Res (2022) , 1-12. PubMed Europe PubMed DOI
Yu,Y., Liu,M., Choi,V.N.T., Cheung,Y.W. and Tanner,J.A. Selection and characterization of DNA aptamers inhibiting a druggable target of osteoarthritis, ADAMTS-5 Biochimie (2022) 201, 168-176. PubMed Europe PubMed DOI

2021

Martin,D.R., Santamaria,S., Koch,C.D., Ahnstrom,J. and Apte,S.S. Identification of novel ADAMTS1, ADAMTS4 and ADAMTS5 cleavage sites in versican using a label-free quantitative proteomics approach J Proteomics (2021) 249, 104358-104358. PubMed Europe PubMed DOI
Santamaria,S., Cuffaro,D., Nuti,E., Ciccone,L., Tuccinardi,T., Liva,F., D'Andrea,F., de Groot,R., Rossello,A. and Ahnstrom,J. Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide Sci Rep (2021) 11, 949-949. PubMed Europe PubMed DOI PMC EPMC I

2020

Fowkes,M.M. and Lim,N.H. Purification and activity determination of ADAMTS-4 and ADAMTS-5 and their domain deleted mutants Methods Mol Biol (2020) 2043, 75-91. PubMed Europe PubMed DOI V
Hong,C.C., Tang,A.T., Detter,M.R., Choi,J.P., Wang,R., Yang,X., Guerrero,A.A., Wittig,C.F., Hobson,N., Girard,R., Lightle,R., Moore,T., Shenkar,R., Polster,S.P., Goddard,L.M., Ren,A.A., Leu,N.A., Sterling,S., Yang,J., Li,L., Chen,M., Mericko-Ishizuka,P., Dow,L.E., Watanabe,H., Schwaninger,M., Min,W., Marchuk,D.A., Zheng,X., Awad,I.A. and Kahn,M.L. Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican J Exp Med (2020) 217 PubMed Europe PubMed DOI

2019

Dupuis,L.E., Nelson,E.L., Hozik,B., Porto,S.C., Rogers-DeCotes,A., Fosang,A. and Kern,C.B. Adamts5(-/-) mice exhibit altered aggrecan proteolytic profiles that correlate with ascending aortic anomalies Arterioscler Thromb Vasc Biol (2019) 39, 2067-2081. PubMed Europe PubMed DOI K
Malemud,C.J. Inhibition of MMPs and ADAM/ADAMTS Biochem Pharmacol (2019) 165, 33-40. PubMed Europe PubMed DOI I
Santamaria,S., Yamamoto,K., Teraz-Orosz,A., Koch,C., Apte,S.S., de Groot,R., Lane,D.A. and Ahnstrom,J. Exosites in hypervariable loops of ADAMTS spacer domains control substrate recognition and proteolysis Sci Rep (2019) 9, 10914-10914. PubMed Europe PubMed DOI PMC EPMC P
Scavenius,C., Poulsen,E.C., Thogersen,I.B., Roebuck,M., Frostick,S., Bou-Gharios,G., Yamamoto,K., Deleuran,B. and Enghild,J.J. Matrix-degrading protease ADAMTS-5 cleaves inter-alpha-inhibitor and releases active heavy chain 2 in synovial fluids from arthritic patients J Biol Chem (2019) 294, 15495-15504. PubMed Europe PubMed DOI

2018

Fava,M., Barallobre-Barreiro,J., Mayr,U., Lu,R., Didangelos,A., Baig,F., Lynch,M., Catibog,N., Joshi,A., Barwari,T., Yin,X., Jahangiri,M. and Mayr,M. Role of ADAMTS-5 in aortic dilatation and extracellular matrix remodeling Arterioscler Thromb Vasc Biol (2018) 38, 1537-1548. PubMed Europe PubMed DOI

2016

Apte,S.S. Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis Biochem J (2016) 473, e1-e4. PubMed Europe PubMed DOI
Biniossek,M.L., Niemer,M., Maksimchuk,K., Mayer,B., Fuchs,J., Huesgen,P.F., McCafferty,D.G., Turk,B., Fritz,G., Mayer,J., Haecker,G., Mach,L. and Schilling,O. Identification of protease specificity by combining proteome-derived peptide libraries and quantitative proteomics Mol Cell Proteomics (2016) 15, 2515-2524. PubMed Europe PubMed DOI P
Kosasih,H.J., Last,K., Rogerson,F.M., Golub,S.B., Gauci,S.J., Russo,V.C., Stanton,H., Wilson,R., Lamande,S.R., Holden,P. and Fosang,A.J. A disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5) forms catalytically active oligomers J Biol Chem (2016) 291, 3197-3208. PubMed Europe PubMed DOI

2014

Demircan,K., Topcu,V., Takigawa,T., Akyol,S., Yonezawa,T., Ozturk,G., Ugurcu,V., Hasgul,R., Yigitoglu,M.R., Akyol,O., McCulloch,D.R. and Hirohata,S. ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury Biomed Res Int (2014) 2014, 693746-693746. PubMed Europe PubMed DOI PMC EPMC K
Durham,T.B., Klimkowski,V.J., Rito,C.J., Marimuthu,J., Toth,J.L., Liu,C., Durbin,J.D., Stout,S.L., Adams,L., Swearingen,C., Lin,C., Chambers,M.G., Thirunavukkarasu,K. and Wiley,M.R. Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis J Med Chem (2014) 57, 10476-10485. PubMed Europe PubMed DOI I
Foulcer,S.J., Nelson,C.M., Quintero,M.V., Kuberan,B., Larkin,J., Dours-Zimmermann,M.T., Zimmermann,D.R. and Apte,S.S. Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5 J Biol Chem (2014) 289, 27859-27873. PubMed Europe PubMed DOI P
Wang,Z., Luo,J., Iwamoto,S. and Chen,Q. Matrilin-2 is proteolytically cleaved by ADAMTS-4 and ADAMTS-5 Molecules (2014) 19, 8472-8487. PubMed Europe PubMed DOI

2013

Miller,R.E., Lu,Y., Tortorella,M.D. and Malfait,A.M. Genetically engineered mouse models reveal the importance of proteases as osteoarthritis drug targets Curr Rheumatol Rep (2013) 15, 350-350. PubMed Europe PubMed DOI K
Stupka,N., Kintakas,C., White,J.D., Fraser,F.W., Hanciu,M., Aramaki-Hattori,N., Martin,S., Coles,C., Collier,F., Ward,A.C., Apte,S.S. and McCulloch,D.R. Versican processing by a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats proteinases-5 and -15 facilitates myoblast fusion J Biol Chem (2013) 288, 1907-1917. PubMed Europe PubMed DOI
Yamamoto,K., Troeberg,L., Scilabra,S.D., Pelosi,M., Murphy,C.L., Strickland,D.K. and Nagase,H. LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage FASEB J (2013) 27, 511-521. PubMed Europe PubMed DOI

2012

Bondeson,J., Wainwright,S., Caterson,B. and Hughes,C. ADAMTS5 [ISSN:978-0-12-407744-7] (2012) 3, 1174-1180. DOI
Gao,W., Zhu,J., Westfield,L.A., Tuley,E.A., Anderson,P.J. and Sadler,J.E. Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases J Biol Chem (2012) 287, 26944-26952. PubMed Europe PubMed DOI
Troeberg,L. and Nagase,H. Proteases involved in cartilage matrix degradation in osteoarthritis Biochim Biophys Acta (2012) 1824, 133-145. PubMed Europe PubMed DOI V
Troeberg,L., Mulloy,B., Ghosh,P., Lee,M.H., Murphy,G. and Nagase,H. Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex Biochem J (2012) 443, 307-315. PubMed Europe PubMed DOI

2011

De Savi,C., Pape,A., Sawyer,Y., Milne,D., Davies,C., Cumming,J.G., Ting,A., Lamont,S., Smith,P.D., Tart,J., Page,K. and Moore,P. Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis Bioorg Med Chem Lett (2011) 21, 3301-3306. PubMed Europe PubMed DOI I
Hattori,N., Carrino,D.A., Lauer,M.E., Vasanji,A., Wylie,J.D., Nelson,C.M. and Apte,S.S. Pericellular versican regulates the fibroblast-myofibroblast transition: a role for ADAMTS5 protease-mediated proteolysis J Biol Chem (2011) 286, 34298-34310. PubMed Europe PubMed DOI K
Stanton,H., Melrose,J., Little,C.B. and Fosang,A.J. Proteoglycan degradation by the ADAMTS family of proteinases Biochim Biophys Acta Mol Basis Dis (2011) 1812, 1616-1629. PubMed Europe PubMed DOI P

2010

Fosang,A.J. and Rogerson,F.M. Identifying the human aggrecanase Osteoarthritis Cartilage (2010) 18, 1109-1116. PubMed Europe PubMed DOI
Lim,N.H., Kashiwagi,M., Visse,R., Jones,J., Enghild,J.J., Brew,K. and Nagase,H. Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications Biochem J (2010) 431, 113-122. PubMed Europe PubMed DOI
Lin,E.A. and Liu,C.J. The role of ADAMTSs in arthritis Protein Cell (2010) 1, 33-47. PubMed Europe PubMed DOI
McCulloch,D.R., Wylie,J.D., Longpre,J.M., Leduc,R. and Apte,S.S. 10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin Osteoarthritis Cartilage (2010) 18, 455-463. PubMed Europe PubMed DOI

2009

Longpre,J.M., McCulloch,D.R., Koo,B.H., Alexander,J.P., Apte,S.S. and Leduc,R. Characterization of proADAMTS5 processing by proprotein convertases Int J Biochem Cell Biol (2009) 41, 1116-1126. PubMed Europe PubMed DOI
McCulloch,D.R., Le Goff,C., Bhatt,S., Dixon,L.J., Sandy,J.D. and Apte,S.S. Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues Gene Expr Patterns (2009) 9, 314-323. PubMed Europe PubMed DOI PMC EPMC
McCulloch,D.R., Nelson,C.M., Dixon,L.J., Silver,D.L., Wylie,J.D., Lindner,V., Sasaki,T., Cooley,M.A., Argraves,W.S. and Apte,S.S. ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression Dev Cell (2009) 17, 687-698. PubMed Europe PubMed DOI PMC EPMC
Tortorella,M.D., Malfait,F., Barve,R.A., Shieh,H.S. and Malfait,A.M. A review of the ADAMTS family, pharmaceutical targets of the future Curr Pharm Des (2009) 15, 2359-2374. PubMed Europe PubMed DOI V T
Tortorella,M.D., Tomasselli,A.G., Mathis,K.J., Schnute,M.E., Woodard,S.S., Munie,G., Williams,J.M., Caspers,N., Wittwer,A.J., Malfait,A.M. and Shieh,H.S. Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors J Biol Chem (2009) 284, 24185-24191. PubMed Europe PubMed DOI PMC EPMC I
Troeberg,L., Fushimi,K., Scilabra,S.D., Nakamura,H., Dive,V., Thogersen,I.B., Enghild,J.J. and Nagase,H. The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3 Matrix Biol (2009) 28, 463-469. PubMed Europe PubMed DOI

2008

Bondeson,J., Wainwright,S., Hughes,C. and Caterson,B. The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review Clin Exp Rheumatol (2008) 26, 139-145. PubMed Europe PubMed
Fosang,A.J., Rogerson,F.M., East,C.J. and Stanton,H. ADAMTS-5: the story so far Eur Cell Mater (2008) 15, 11-26. PubMed Europe PubMed V
Fosang,A.J. and Little,C.B. Drug insight: aggrecanases as therapeutic targets for osteoarthritis Nat Clin Pract Rheumatol (2008) 4, 420-427. PubMed Europe PubMed DOI T
Fushimi,K., Troeberg,L., Nakamura,H., Lim,N.H. and Nagase,H. Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity J Biol Chem (2008) 283, 6706-6716. PubMed Europe PubMed DOI
Malfait,A.M., Arner,E.C., Song,R.H., Alston,J.T., Markosyan,S., Staten,N., Yang,Z., Griggs,D.W. and Tortorella,M.D. Proprotein convertase activation of aggrecanases in cartilage in situ Arch Biochem Biophys (2008) 478, 43-51. PubMed Europe PubMed DOI T
Mosyak,L., Georgiadis,K., Shane,T., Svenson,K., Hebert,T., McDonagh,T., Mackie,S., Olland,S., Lin,L., Zhong,X., Kriz,R., Reifenberg,E.L., Collins-Racie,L.A., Corcoran,C., Freeman,B., Zollner,R., Marvell,T., Vera,M., Sum,P.E., LaVallie,E.R., Stahl,M. and Somers,W. Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5 Protein Sci (2008) 17, 16-21. PubMed Europe PubMed DOI PMC EPMC S
Shieh,H.S., Mathis,K.J., Williams,J.M., Hills,R.L., Wiese,J.F., Benson,T.E., Kiefer,J.R., Marino,M.H., Carroll,J.N., Leone,J.W., Malfait,A.M., Arner,E.C., Tortorella,M.D. and Tomasselli,A. High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2) J Biol Chem (2008) 283, 1501-1507. PubMed Europe PubMed DOI S
Troeberg,L., Fushimi,K., Khokha,R., Emonard,H., Ghosh,P. and Nagase,H. Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases FASEB J (2008) 22, 3515-3524. PubMed Europe PubMed DOI PMC EPMC

2007

East,C.J., Stanton,H., Golub,S.B., Rogerson,F.M. and Fosang,A.J. ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan J Biol Chem (2007) 282, 8632-8640. PubMed Europe PubMed DOI K
Gendron,C., Kashiwagi,M., Lim,N.H., Enghild,J.J., Thogersen,I.B., Hughes,C., Caterson,B. and Nagase,H. Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4 J Biol Chem (2007) 282, 18294-18306. PubMed Europe PubMed DOI
Ilic,M.Z., East,C.J., Rogerson,F.M., Fosang,A.J. and Handley,C.J. Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice J Biol Chem (2007) 282, 37420-37428. PubMed Europe PubMed DOI K
Powell,A.J., Little,C.B. and Hughes,C.E. Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system Arthritis Rheum (2007) 56, 3010-3019. PubMed Europe PubMed DOI
Song,R.H., Tortorella,M.D., Malfait,A.M., Alston,J.T., Yang,Z., Arner,E.C. and Griggs,D.W. Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5 Arthritis Rheum (2007) 56, 575-585. PubMed Europe PubMed DOI
Thirunavukkarasu,K., Pei,Y. and Wei,T. Characterization of the human ADAMTS-5 (aggrecanase-2) gene promoter Mol Biol Rep (2007) 34, 225-231. PubMed Europe PubMed DOI

2006

Melching,L.I., Fisher,W.D., Lee,E.R., Mort,J.S. and Roughley,P.J. The cleavage of biglycan by aggrecanases Osteoarthritis Cartilage (2006) 14, 1147-1154. PubMed Europe PubMed DOI

2005

[YEAR:31-3-2005]Glasson,S.S., Askew,R., Sheppard,B., Carito,B., Blanchet,T., Ma,H.L., Flannery,C.R., Peluso,D., Kanki,K., Yang,Z., Majumdar,M.K. and Morris,E.A. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis Nature (31-3-2005) 434, 644-648. PubMed Europe PubMed DOI K
Nakada,M., Miyamori,H., Kita,D., Takahashi,T., Yamashita,J., Sato,H., Miura,R., Yamaguchi,Y. and Okada,Y. Human glioblastomas overexpress ADAMTS-5 that degrades brevican Acta Neuropathol (2005) 110, 239-246. PubMed Europe PubMed DOI
[YEAR:19-1-2005]Richards,J.S., Hernandez-Gonzalez,I., Gonzalez-Robayna,I., Teuling,E., Lo,Y., Boerboom,D., Falender,A.E., Doyle,K.H., LeBaron,R.G., Thompson,V. and Sandy,J.D. Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation Biol Reprod (19-1-2005) 72, 1241-1255. PubMed Europe PubMed DOI
[YEAR:31-3-2005]Stanton,H., Rogerson,F.M., East,C.J., Golub,S.B., Lawlor,K.E., Meeker,C.T., Little,C.B., Last,K., Farmer,P.J., Campbell,I.K., Fourie,A.M. and Fosang,A.J. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro Nature (31-3-2005) 434, 648-652. PubMed Europe PubMed DOI

2004

Arai,M., Anderson,D., Kurdi,Y., Annis-Freeman,B., Shields,K., Collins-Racie,L.A., Corcoran,C., DiBlasio-Smith,E., Pittman,D.D., Dorner,A.J., Morris,E. and LaVallie,E.R. Effect of adenovirus-mediated overexpression of bovine ADAMTS-4 and human ADAMTS-5 in primary bovine articular chondrocyte pellet culture system Osteoarthritis Cartilage (2004) 12, 599-613. PubMed Europe PubMed DOI
Hughes,C.E., Caterson,B., Little,C.B. and Wainwright,S.W. Aggrecanases 1 and 2 [ISSN:0-12-079610-4] (2004) 2, 740-746. V
[YEAR:7-1-2004]Tortorella,M.D., Arner,E.C., Hills,R., Easton,A., Korte-Sarfaty,J., Fok,K., Wittwer,A.J., Liu,R.Q. and Malfait,A.M. Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes J Biol Chem (7-1-2004) 279, 17554-17561. PubMed Europe PubMed DOI

2003

Makihira,S., Yan,W., Murakami,H., Furukawa,M., Kawai,T., Nikawa,H., Yoshida,E., Hamada,T., Okada,Y. and Kato,Y. Thyroid hormone enhances aggrecanase-2/ADAM-TS5 expression and proteoglycan degradation in growth plate cartilage Endocrinology (2003) 144, 2480-2488. PubMed Europe PubMed DOI
[YEAR:15-3-2003]Miller,J.A., Liu,R.Q., Davis,G.L., Pratta,M.A., Trzaskos,J.M. and Copeland,R.A. A microplate assay specific for the enzyme aggrecanase Anal Biochem (15-3-2003) 314, 260-265. PubMed Europe PubMed DOI A

2002

Arner,E.C. Aggrecanase-mediated cartilage degradation Curr Opin Pharmacol (2002) 2, 322-329. PubMed Europe PubMed DOI
[YEAR:21-6-2002]Malfait,A.M., Liu,R.Q., Ijiri,K., Komiya,S. and Tortorella,M.D. Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage J Biol Chem (21-6-2002) 277, 22201-22208. PubMed Europe PubMed DOI
Tortorella,M.D., Liu,R.Q., Burn,T., Newton,R.C. and Arner,E. Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4) Matrix Biol (2002) 21, 499-511. PubMed Europe PubMed DOI
[YEAR:1-2-2002]Yamanishi,Y., Boyle,D.L., Clark,M., Maki,R.A., Tortorella,M.D., Arner,E.C. and Firestein,G.S. Expression and regulation of aggrecanase in arthritis: the role of TGF-beta J Immunol (1-2-2002) 168, 1405-1412. PubMed Europe PubMed

2001

Tortorella,M.D., Malfait,A.M., Deccico,C. and Arner,E. The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation Osteoarthritis Cartilage (2001) 9, 539-552. PubMed Europe PubMed DOI
Vankemmelbeke,M.N., Holen,I., Wilson,A.G., Ilic,M.Z., Handley,C.J., Kelner,G.S., Clark,M., Liu,C., Maki,R.A., Burnett,D. and Buttle,D.J. Expression and activity of ADAMTS-5 in synovium Eur J Biochem (2001) 268, 1259-1268. PubMed Europe PubMed DOI

1999

[YEAR:13-8-1999]Abbaszade,I., Liu,R.Q., Yang,F., Rosenfeld,S.A., Ross,O.H., Link,J.R., Ellis,D.M., Tortorella,M.D., Pratta,M.A., Hollis,J.M., Wynn,R., Duke,J.L., George,H.J., Hillman,M.C., Jr., Murphy,K., Wiswall,B.H., Copeland,R.A., Decicco,C.P., Bruckner,R., Nagase,H., Itoh,Y., Newton,R.C., Magolda,R.L., Trzaskos,J.M. and Burn,T.C. Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family J Biol Chem (13-8-1999) 274, 23443-23450. PubMed Europe PubMed DOI
[YEAR:5-7-1999]Flannery,C.R., Little,C.B., Hughes,C.E. and Caterson,B. Expression of ADAMTS homologues in articular cartilage Biochem Biophys Res Commun (5-7-1999) 260, 318-322. PubMed Europe PubMed DOI
[YEAR:3-9-1999]Hurskainen,T.L., Hirohata,S., Seldin,M.F. and Apte,S.S. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family J Biol Chem (3-9-1999) 274, 25555-25563. PubMed Europe PubMed DOI