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Literature for peptidase M12.225: ADAMTS5 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Dulos,J., Sun,R., Jovanovska,V., Kolb,F. and Stupka,N.
    Adamts5 deletion exacerbates inflammation and fibrosis resulting in compromised skeletal muscle regeneration
    Am J Physiol Cell Physiol (2026) PubMed  Europe PubMed DOI
    2. 2025
  2. Martin,D.R., Sardelli,G., Burkhard,T., Fowkes,M.M., Minns,A.F., Moschini,R., Del Corso,A., de Groot,R., Apte,S.S. and Santamaria,S.
    Characterization of ADAMTS9 proteoglycanase activity: comparison with ADAMTS1, ADAMTS4 and ADAMTS5
    J Biol Chem (2025) , 110301-110301. PubMed  Europe PubMed DOI
    3. 2024
  3. Chen,Z., Du,F., Zhang,R., Wu,Q., Lu,Z., Zhang,R.L. and Wang,Q.
    ADAMTS5 Promotes Permeability of the Blood-Brain Barrier during Treponema pallidum Subspecies pallidum Invading the Central Nervous System
    ACS Infect Dis (2024) 10, 1222-1231. PubMed  Europe PubMed DOI
    4. 2023
  4. Liu,Y., Yao,Y., Zhang,Y., Yan,C., Yang,M., Wang,Z., Li,W., Li,F., Wang,W., Yang,Y., Li,X. and Tang,Z.
    MicroRNA-200c-5p Regulates Migration and Differentiation of Myoblasts via Targeting Adamts5 in Skeletal Muscle Regeneration and Myogenesis
    Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2022
  5. He,S., Li,J., Ma,D., Liu,Z. and Lv,N.
    MicroRNA-148a targets ADAMTS5 to inhibit proliferation of endometriosis cells
    Pak J Pharm Sci (2022) 35, 335-341. PubMed  Europe PubMed
  6. Porto,C., Rogers-DeCotes,A., Schafer,E. and Kern,B.
    The adaptive response of the mandibular condyle to increased load is disrupted by c deficiency
    Connect Tissue Res (2022) , 1-12. PubMed  Europe PubMed DOI
  7. Yu,Y., Liu,M., Choi,V.N.T., Cheung,Y.W. and Tanner,J.A.
    Selection and characterization of DNA aptamers inhibiting a druggable target of osteoarthritis, ADAMTS-5
    Biochimie (2022) 201, 168-176. PubMed  Europe PubMed DOI
    8. 2021
  8. Martin,D.R., Santamaria,S., Koch,C.D., Ahnstrom,J. and Apte,S.S.
    Identification of novel ADAMTS1, ADAMTS4 and ADAMTS5 cleavage sites in versican using a label-free quantitative proteomics approach
    J Proteomics (2021) 249, 104358-104358. PubMed  Europe PubMed DOI
  9. Santamaria,S., Cuffaro,D., Nuti,E., Ciccone,L., Tuccinardi,T., Liva,F., D'Andrea,F., de Groot,R., Rossello,A. and Ahnstrom,J.
    Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide
    Sci Rep (2021) 11, 949-949. PubMed  Europe PubMed DOI  PMC  EPMC  I
    10. 2020
  10. Fowkes,M.M. and Lim,N.H.
    Purification and activity determination of ADAMTS-4 and ADAMTS-5 and their domain deleted mutants
    Methods Mol Biol (2020) 2043, 75-91. PubMed  Europe PubMed DOI  V
  11. Hong,C.C., Tang,A.T., Detter,M.R., Choi,J.P., Wang,R., Yang,X., Guerrero,A.A., Wittig,C.F., Hobson,N., Girard,R., Lightle,R., Moore,T., Shenkar,R., Polster,S.P., Goddard,L.M., Ren,A.A., Leu,N.A., Sterling,S., Yang,J., Li,L., Chen,M., Mericko-Ishizuka,P., Dow,L.E., Watanabe,H., Schwaninger,M., Min,W., Marchuk,D.A., Zheng,X., Awad,I.A. and Kahn,M.L.
    Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican
    J Exp Med (2020) 217 PubMed  Europe PubMed DOI
    12. 2019
  12. Dupuis,L.E., Nelson,E.L., Hozik,B., Porto,S.C., Rogers-DeCotes,A., Fosang,A. and Kern,C.B.
    Adamts5(-/-) mice exhibit altered aggrecan proteolytic profiles that correlate with ascending aortic anomalies
    Arterioscler Thromb Vasc Biol (2019) 39, 2067-2081. PubMed  Europe PubMed DOI  K
  13. Malemud,C.J.
    Inhibition of MMPs and ADAM/ADAMTS
    Biochem Pharmacol (2019) 165, 33-40. PubMed  Europe PubMed DOI  I
  14. Santamaria,S., Yamamoto,K., Teraz-Orosz,A., Koch,C., Apte,S.S., de Groot,R., Lane,D.A. and Ahnstrom,J.
    Exosites in hypervariable loops of ADAMTS spacer domains control substrate recognition and proteolysis
    Sci Rep (2019) 9, 10914-10914. PubMed  Europe PubMed DOI  PMC  EPMC  P
  15. Scavenius,C., Poulsen,E.C., Thogersen,I.B., Roebuck,M., Frostick,S., Bou-Gharios,G., Yamamoto,K., Deleuran,B. and Enghild,J.J.
    Matrix-degrading protease ADAMTS-5 cleaves inter-alpha-inhibitor and releases active heavy chain 2 in synovial fluids from arthritic patients
    J Biol Chem (2019) 294, 15495-15504. PubMed  Europe PubMed DOI
    16. 2018
  16. Fava,M., Barallobre-Barreiro,J., Mayr,U., Lu,R., Didangelos,A., Baig,F., Lynch,M., Catibog,N., Joshi,A., Barwari,T., Yin,X., Jahangiri,M. and Mayr,M.
    Role of ADAMTS-5 in aortic dilatation and extracellular matrix remodeling
    Arterioscler Thromb Vasc Biol (2018) 38, 1537-1548. PubMed  Europe PubMed DOI
    17. 2016
  17. Apte,S.S.
    Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis
    Biochem J (2016) 473, e1-e4. PubMed  Europe PubMed DOI
  18. Biniossek,M.L., Niemer,M., Maksimchuk,K., Mayer,B., Fuchs,J., Huesgen,P.F., McCafferty,D.G., Turk,B., Fritz,G., Mayer,J., Haecker,G., Mach,L. and Schilling,O.
    Identification of protease specificity by combining proteome-derived peptide libraries and quantitative proteomics
    Mol Cell Proteomics (2016) 15, 2515-2524. PubMed  Europe PubMed DOI  P
  19. Kosasih,H.J., Last,K., Rogerson,F.M., Golub,S.B., Gauci,S.J., Russo,V.C., Stanton,H., Wilson,R., Lamande,S.R., Holden,P. and Fosang,A.J.
    A disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5) forms catalytically active oligomers
    J Biol Chem (2016) 291, 3197-3208. PubMed  Europe PubMed DOI
    20. 2014
  20. Demircan,K., Topcu,V., Takigawa,T., Akyol,S., Yonezawa,T., Ozturk,G., Ugurcu,V., Hasgul,R., Yigitoglu,M.R., Akyol,O., McCulloch,D.R. and Hirohata,S.
    ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury
    Biomed Res Int (2014) 2014, 693746-693746. PubMed  Europe PubMed DOI  PMC  EPMC  K
  21. Durham,T.B., Klimkowski,V.J., Rito,C.J., Marimuthu,J., Toth,J.L., Liu,C., Durbin,J.D., Stout,S.L., Adams,L., Swearingen,C., Lin,C., Chambers,M.G., Thirunavukkarasu,K. and Wiley,M.R.
    Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis
    J Med Chem (2014) 57, 10476-10485. PubMed  Europe PubMed DOI  I
  22. Foulcer,S.J., Nelson,C.M., Quintero,M.V., Kuberan,B., Larkin,J., Dours-Zimmermann,M.T., Zimmermann,D.R. and Apte,S.S.
    Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5
    J Biol Chem (2014) 289, 27859-27873. PubMed  Europe PubMed DOI  P
  23. Wang,Z., Luo,J., Iwamoto,S. and Chen,Q.
    Matrilin-2 is proteolytically cleaved by ADAMTS-4 and ADAMTS-5
    Molecules (2014) 19, 8472-8487. PubMed  Europe PubMed DOI
    24. 2013
  24. Miller,R.E., Lu,Y., Tortorella,M.D. and Malfait,A.M.
    Genetically engineered mouse models reveal the importance of proteases as osteoarthritis drug targets
    Curr Rheumatol Rep (2013) 15, 350-350. PubMed  Europe PubMed DOI  K
  25. Stupka,N., Kintakas,C., White,J.D., Fraser,F.W., Hanciu,M., Aramaki-Hattori,N., Martin,S., Coles,C., Collier,F., Ward,A.C., Apte,S.S. and McCulloch,D.R.
    Versican processing by a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats proteinases-5 and -15 facilitates myoblast fusion
    J Biol Chem (2013) 288, 1907-1917. PubMed  Europe PubMed DOI
  26. Yamamoto,K., Troeberg,L., Scilabra,S.D., Pelosi,M., Murphy,C.L., Strickland,D.K. and Nagase,H.
    LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage
    FASEB J (2013) 27, 511-521. PubMed  Europe PubMed DOI
    27. 2012
  27. Bondeson,J., Wainwright,S., Caterson,B. and Hughes,C.
    ADAMTS5
    [ISSN:978-0-12-407744-7] (2012) 3, 1174-1180. DOI
  28. Gao,W., Zhu,J., Westfield,L.A., Tuley,E.A., Anderson,P.J. and Sadler,J.E.
    Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases
    J Biol Chem (2012) 287, 26944-26952. PubMed  Europe PubMed DOI
  29. Troeberg,L. and Nagase,H.
    Proteases involved in cartilage matrix degradation in osteoarthritis
    Biochim Biophys Acta (2012) 1824, 133-145. PubMed  Europe PubMed DOI  V
  30. Troeberg,L., Mulloy,B., Ghosh,P., Lee,M.H., Murphy,G. and Nagase,H.
    Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex
    Biochem J (2012) 443, 307-315. PubMed  Europe PubMed DOI
    31. 2011
  31. De Savi,C., Pape,A., Sawyer,Y., Milne,D., Davies,C., Cumming,J.G., Ting,A., Lamont,S., Smith,P.D., Tart,J., Page,K. and Moore,P.
    Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis
    Bioorg Med Chem Lett (2011) 21, 3301-3306. PubMed  Europe PubMed DOI  I
  32. Hattori,N., Carrino,D.A., Lauer,M.E., Vasanji,A., Wylie,J.D., Nelson,C.M. and Apte,S.S.
    Pericellular versican regulates the fibroblast-myofibroblast transition: a role for ADAMTS5 protease-mediated proteolysis
    J Biol Chem (2011) 286, 34298-34310. PubMed  Europe PubMed DOI  K
  33. Stanton,H., Melrose,J., Little,C.B. and Fosang,A.J.
    Proteoglycan degradation by the ADAMTS family of proteinases
    Biochim Biophys Acta Mol Basis Dis (2011) 1812, 1616-1629. PubMed  Europe PubMed DOI  P
    34. 2010
  34. Fosang,A.J. and Rogerson,F.M.
    Identifying the human aggrecanase
    Osteoarthritis Cartilage (2010) 18, 1109-1116. PubMed  Europe PubMed DOI
  35. Lim,N.H., Kashiwagi,M., Visse,R., Jones,J., Enghild,J.J., Brew,K. and Nagase,H.
    Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications
    Biochem J (2010) 431, 113-122. PubMed  Europe PubMed DOI
  36. Lin,E.A. and Liu,C.J.
    The role of ADAMTSs in arthritis
    Protein Cell (2010) 1, 33-47. PubMed  Europe PubMed DOI
  37. McCulloch,D.R., Wylie,J.D., Longpre,J.M., Leduc,R. and Apte,S.S.
    10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin
    Osteoarthritis Cartilage (2010) 18, 455-463. PubMed  Europe PubMed DOI
    38. 2009
  38. Longpre,J.M., McCulloch,D.R., Koo,B.H., Alexander,J.P., Apte,S.S. and Leduc,R.
    Characterization of proADAMTS5 processing by proprotein convertases
    Int J Biochem Cell Biol (2009) 41, 1116-1126. PubMed  Europe PubMed DOI
  39. McCulloch,D.R., Le Goff,C., Bhatt,S., Dixon,L.J., Sandy,J.D. and Apte,S.S.
    Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues
    Gene Expr Patterns (2009) 9, 314-323. PubMed  Europe PubMed DOI  PMC  EPMC
  40. McCulloch,D.R., Nelson,C.M., Dixon,L.J., Silver,D.L., Wylie,J.D., Lindner,V., Sasaki,T., Cooley,M.A., Argraves,W.S. and Apte,S.S.
    ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression
    Dev Cell (2009) 17, 687-698. PubMed  Europe PubMed DOI  PMC  EPMC
  41. Tortorella,M.D., Malfait,F., Barve,R.A., Shieh,H.S. and Malfait,A.M.
    A review of the ADAMTS family, pharmaceutical targets of the future
    Curr Pharm Des (2009) 15, 2359-2374. PubMed  Europe PubMed DOI  V  T
  42. Tortorella,M.D., Tomasselli,A.G., Mathis,K.J., Schnute,M.E., Woodard,S.S., Munie,G., Williams,J.M., Caspers,N., Wittwer,A.J., Malfait,A.M. and Shieh,H.S.
    Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors
    J Biol Chem (2009) 284, 24185-24191. PubMed  Europe PubMed DOI  PMC  EPMC  I
  43. Troeberg,L., Fushimi,K., Scilabra,S.D., Nakamura,H., Dive,V., Thogersen,I.B., Enghild,J.J. and Nagase,H.
    The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3
    Matrix Biol (2009) 28, 463-469. PubMed  Europe PubMed DOI
    44. 2008
  44. Bondeson,J., Wainwright,S., Hughes,C. and Caterson,B.
    The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review
    Clin Exp Rheumatol (2008) 26, 139-145. PubMed  Europe PubMed
  45. Fosang,A.J., Rogerson,F.M., East,C.J. and Stanton,H.
    ADAMTS-5: the story so far
    Eur Cell Mater (2008) 15, 11-26. PubMed  Europe PubMed  V
  46. Fosang,A.J. and Little,C.B.
    Drug insight: aggrecanases as therapeutic targets for osteoarthritis
    Nat Clin Pract Rheumatol (2008) 4, 420-427. PubMed  Europe PubMed DOI  T
  47. Fushimi,K., Troeberg,L., Nakamura,H., Lim,N.H. and Nagase,H.
    Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity
    J Biol Chem (2008) 283, 6706-6716. PubMed  Europe PubMed DOI
  48. Malfait,A.M., Arner,E.C., Song,R.H., Alston,J.T., Markosyan,S., Staten,N., Yang,Z., Griggs,D.W. and Tortorella,M.D.
    Proprotein convertase activation of aggrecanases in cartilage in situ
    Arch Biochem Biophys (2008) 478, 43-51. PubMed  Europe PubMed DOI  T
  49. Mosyak,L., Georgiadis,K., Shane,T., Svenson,K., Hebert,T., McDonagh,T., Mackie,S., Olland,S., Lin,L., Zhong,X., Kriz,R., Reifenberg,E.L., Collins-Racie,L.A., Corcoran,C., Freeman,B., Zollner,R., Marvell,T., Vera,M., Sum,P.E., LaVallie,E.R., Stahl,M. and Somers,W.
    Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5
    Protein Sci (2008) 17, 16-21. PubMed  Europe PubMed DOI  PMC  EPMC  S
  50. Shieh,H.S., Mathis,K.J., Williams,J.M., Hills,R.L., Wiese,J.F., Benson,T.E., Kiefer,J.R., Marino,M.H., Carroll,J.N., Leone,J.W., Malfait,A.M., Arner,E.C., Tortorella,M.D. and Tomasselli,A.
    High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)
    J Biol Chem (2008) 283, 1501-1507. PubMed  Europe PubMed DOI  S
  51. Troeberg,L., Fushimi,K., Khokha,R., Emonard,H., Ghosh,P. and Nagase,H.
    Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases
    FASEB J (2008) 22, 3515-3524. PubMed  Europe PubMed DOI  PMC  EPMC
    52. 2007
  52. East,C.J., Stanton,H., Golub,S.B., Rogerson,F.M. and Fosang,A.J.
    ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan
    J Biol Chem (2007) 282, 8632-8640. PubMed  Europe PubMed DOI  K
  53. Gendron,C., Kashiwagi,M., Lim,N.H., Enghild,J.J., Thogersen,I.B., Hughes,C., Caterson,B. and Nagase,H.
    Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4
    J Biol Chem (2007) 282, 18294-18306. PubMed  Europe PubMed DOI
  54. Ilic,M.Z., East,C.J., Rogerson,F.M., Fosang,A.J. and Handley,C.J.
    Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice
    J Biol Chem (2007) 282, 37420-37428. PubMed  Europe PubMed DOI  K
  55. Powell,A.J., Little,C.B. and Hughes,C.E.
    Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system
    Arthritis Rheum (2007) 56, 3010-3019. PubMed  Europe PubMed DOI
  56. Song,R.H., Tortorella,M.D., Malfait,A.M., Alston,J.T., Yang,Z., Arner,E.C. and Griggs,D.W.
    Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5
    Arthritis Rheum (2007) 56, 575-585. PubMed  Europe PubMed DOI
  57. Thirunavukkarasu,K., Pei,Y. and Wei,T.
    Characterization of the human ADAMTS-5 (aggrecanase-2) gene promoter
    Mol Biol Rep (2007) 34, 225-231. PubMed  Europe PubMed DOI
    58. 2006
  58. Melching,L.I., Fisher,W.D., Lee,E.R., Mort,J.S. and Roughley,P.J.
    The cleavage of biglycan by aggrecanases
    Osteoarthritis Cartilage (2006) 14, 1147-1154. PubMed  Europe PubMed DOI
    59. 2005
  59. [YEAR:31-3-2005]Glasson,S.S., Askew,R., Sheppard,B., Carito,B., Blanchet,T., Ma,H.L., Flannery,C.R., Peluso,D., Kanki,K., Yang,Z., Majumdar,M.K. and Morris,E.A.
    Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
    Nature (31-3-2005) 434, 644-648. PubMed  Europe PubMed DOI  K
  60. Nakada,M., Miyamori,H., Kita,D., Takahashi,T., Yamashita,J., Sato,H., Miura,R., Yamaguchi,Y. and Okada,Y.
    Human glioblastomas overexpress ADAMTS-5 that degrades brevican
    Acta Neuropathol (2005) 110, 239-246. PubMed  Europe PubMed DOI
  61. [YEAR:19-1-2005]Richards,J.S., Hernandez-Gonzalez,I., Gonzalez-Robayna,I., Teuling,E., Lo,Y., Boerboom,D., Falender,A.E., Doyle,K.H., LeBaron,R.G., Thompson,V. and Sandy,J.D.
    Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation
    Biol Reprod (19-1-2005) 72, 1241-1255. PubMed  Europe PubMed DOI
  62. [YEAR:31-3-2005]Stanton,H., Rogerson,F.M., East,C.J., Golub,S.B., Lawlor,K.E., Meeker,C.T., Little,C.B., Last,K., Farmer,P.J., Campbell,I.K., Fourie,A.M. and Fosang,A.J.
    ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
    Nature (31-3-2005) 434, 648-652. PubMed  Europe PubMed DOI
    63. 2004
  63. Arai,M., Anderson,D., Kurdi,Y., Annis-Freeman,B., Shields,K., Collins-Racie,L.A., Corcoran,C., DiBlasio-Smith,E., Pittman,D.D., Dorner,A.J., Morris,E. and LaVallie,E.R.
    Effect of adenovirus-mediated overexpression of bovine ADAMTS-4 and human ADAMTS-5 in primary bovine articular chondrocyte pellet culture system
    Osteoarthritis Cartilage (2004) 12, 599-613. PubMed  Europe PubMed DOI
  64. Hughes,C.E., Caterson,B., Little,C.B. and Wainwright,S.W.
    Aggrecanases 1 and 2
    [ISSN:0-12-079610-4] (2004) 2, 740-746.  V
  65. [YEAR:7-1-2004]Tortorella,M.D., Arner,E.C., Hills,R., Easton,A., Korte-Sarfaty,J., Fok,K., Wittwer,A.J., Liu,R.Q. and Malfait,A.M.
    Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes
    J Biol Chem (7-1-2004) 279, 17554-17561. PubMed  Europe PubMed DOI
    66. 2003
  66. Makihira,S., Yan,W., Murakami,H., Furukawa,M., Kawai,T., Nikawa,H., Yoshida,E., Hamada,T., Okada,Y. and Kato,Y.
    Thyroid hormone enhances aggrecanase-2/ADAM-TS5 expression and proteoglycan degradation in growth plate cartilage
    Endocrinology (2003) 144, 2480-2488. PubMed  Europe PubMed DOI
  67. [YEAR:15-3-2003]Miller,J.A., Liu,R.Q., Davis,G.L., Pratta,M.A., Trzaskos,J.M. and Copeland,R.A.
    A microplate assay specific for the enzyme aggrecanase
    Anal Biochem (15-3-2003) 314, 260-265. PubMed  Europe PubMed DOI  A
    68. 2002
  68. Arner,E.C.
    Aggrecanase-mediated cartilage degradation
    Curr Opin Pharmacol (2002) 2, 322-329. PubMed  Europe PubMed DOI
  69. [YEAR:21-6-2002]Malfait,A.M., Liu,R.Q., Ijiri,K., Komiya,S. and Tortorella,M.D.
    Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage
    J Biol Chem (21-6-2002) 277, 22201-22208. PubMed  Europe PubMed DOI
  70. Tortorella,M.D., Liu,R.Q., Burn,T., Newton,R.C. and Arner,E.
    Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4)
    Matrix Biol (2002) 21, 499-511. PubMed  Europe PubMed DOI
  71. [YEAR:1-2-2002]Yamanishi,Y., Boyle,D.L., Clark,M., Maki,R.A., Tortorella,M.D., Arner,E.C. and Firestein,G.S.
    Expression and regulation of aggrecanase in arthritis: the role of TGF-beta
    J Immunol (1-2-2002) 168, 1405-1412. PubMed  Europe PubMed
    72. 2001
  72. Tortorella,M.D., Malfait,A.M., Deccico,C. and Arner,E.
    The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation
    Osteoarthritis Cartilage (2001) 9, 539-552. PubMed  Europe PubMed DOI
  73. Vankemmelbeke,M.N., Holen,I., Wilson,A.G., Ilic,M.Z., Handley,C.J., Kelner,G.S., Clark,M., Liu,C., Maki,R.A., Burnett,D. and Buttle,D.J.
    Expression and activity of ADAMTS-5 in synovium
    Eur J Biochem (2001) 268, 1259-1268. PubMed  Europe PubMed DOI
    74. 1999
  74. [YEAR:13-8-1999]Abbaszade,I., Liu,R.Q., Yang,F., Rosenfeld,S.A., Ross,O.H., Link,J.R., Ellis,D.M., Tortorella,M.D., Pratta,M.A., Hollis,J.M., Wynn,R., Duke,J.L., George,H.J., Hillman,M.C., Jr., Murphy,K., Wiswall,B.H., Copeland,R.A., Decicco,C.P., Bruckner,R., Nagase,H., Itoh,Y., Newton,R.C., Magolda,R.L., Trzaskos,J.M. and Burn,T.C.
    Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family
    J Biol Chem (13-8-1999) 274, 23443-23450. PubMed  Europe PubMed DOI
  75. [YEAR:5-7-1999]Flannery,C.R., Little,C.B., Hughes,C.E. and Caterson,B.
    Expression of ADAMTS homologues in articular cartilage
    Biochem Biophys Res Commun (5-7-1999) 260, 318-322. PubMed  Europe PubMed DOI
  76. [YEAR:3-9-1999]Hurskainen,T.L., Hirohata,S., Seldin,M.F. and Apte,S.S.
    ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family
    J Biol Chem (3-9-1999) 274, 25555-25563. PubMed  Europe PubMed DOI

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