Sequence features for peptidase M12.225: ADAMTS5 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

MERNUM	Species	Sequence length	Peptidase unit	Active site residues	Metal ligands	Source
MER0689878	Acanthisitta chloris	597	1-141	E76	H75, H79, H85	GENBANK:XP_009071760
MER0268362	Ailuropoda melanoleuca	938	384-429	E419	H418, H422, H428	GENBANK:XP_002920116
MER0292980	Alligator mississippiensis	868	207-415	E350	H349, H353, H359	GENBANK:XP_006278955
MER0308587	Alligator sinensis	656	137-345	E280	H279, H283, H289	GENBANK:XP_006021454
MER0332900	Anas platyrhynchos	638	1-183	E118	H117, H121, H127	GENBANK:XP_005011504
MER0226085	Anolis carolinensis	850	188-340	E330	H329, H333, H339	UNIPROT:G1KPY2
MER0226085	Anolis carolinensis	850	188-340	E330	H329, H333, H339	UNIPROT:G1KPY2
MER0688092	Apaloderma vittatum	623	59-167	E102	H101, H105, H111	GENBANK:XP_009873943
MER0687105	Aptenodytes forsteri	679	23-223	E158	H157, H161, H167	GENBANK:XP_009281338
MER0686589	Aquila chrysaetos	677	12-220	E155	H154, H158, H164	GENBANK:XP_011592124
MER0555057	Astatotilapia burtoni	960	261-468	E403	H402, H406, H412	GENBANK:XP_005920057
MER0380299	Astyanax mexicanus	894	212-419	E354	H353, H357, H363	GENBANK:XP_007237821
MER0384612	Balaenoptera acutorostrata	963	301-509	E444	H443, H447, H453	GENBANK:XP_007164332
MER0679285	Balearica regulorum	285	1-198	E133	H132, H136, H142	GENBANK:XP_010305133
MER0679399	Bison bison	934	272-480	E415	H414, H418, H424	GENBANK:XP_010836749
MER0015240	Bos taurus	934	266-480	E415	H414, H418, H424	UNIPROT:Q9TT92
MER0015240	Bos taurus	934	266-480	E415	H414, H418, H424	UNIPROT:Q9TT92
MER0015240	Bos taurus	934	266-480	E415	H414, H418, H424	UNIPROT:Q9TT92
MER0581182	Bubalus bubalis	934	272-480	E415	H414, H418, H424	GENBANK:XP_006075705
MER0678847	Buceros rhinoceros	660	1-204	E139	H138, H142, H148	GENBANK:XP_010141158
MER0357850	Callithrix jacchus	929	268-420	E410	H409, H413, H419	UNIPROT:F6VXD6
MER0357850	Callithrix jacchus	929	268-420	E410	H409, H413, H419	UNIPROT:F6VXD6
MER0582250	Calypte anna	683	15-224	E159	H158, H162, H168	GENBANK:XP_008494937
MER0675444	Camelus dromedarius	795	144-341	E276	H275, H279, H285	GENBANK:XP_010975689
MER0522708	Camelus ferus	781	119-327	E262	H261, H265, H271	GENBANK:XP_006186247
MER0829452	Camelus ferus	866	201-362	E344	H343, H347, H353	UNIPROT:S9XY18
MER0829452	Camelus ferus	866	201-362	E344	H343, H347, H353	UNIPROT:S9XY18
MER0174937	Canis lupus familiaris	800	132-346	E281	H280, H284, H290	GENBANK:XP_851118
MER0555973	Capra hircus	726	58-272	E207	H206, H210, H216	GENBANK:XP_005674810
MER0675693	Cariama cristata	568	1-108	E43	H42, H46, H52	GENBANK:XP_009696171
MER0829099	Cathartes aura	651	3-147	E131	H130, H134, H140	UNIPROT:A0A091L4I2
MER0829099	Cathartes aura	651	3-147	E131	H130, H134, H140	UNIPROT:A0A091L4I2
MER0270777	Cavia porcellus	931	267-477	E412	H411, H415, H421	GENBANK:XP_003467232
MER0525038	Ceratotherium simum	930	268-476	E411	H410, H414, H420	GENBANK:XP_004429584
MER0585605	Cercopithecus sabaeus	796	268-476	E411	H410, H414, H420	GENBANK:XP_007964078
MER0585609	Cercopithecus sabaeus	930	268-476	E411	H410, H414, H420	GENBANK:XP_007964073
MER0672879	Chaetura pelagica	620	33-163	E98	H97, H101, H107	GENBANK:XP_009993291
MER0671742	Charadrius vociferus	674	17-218	E153	H152, H156, H162	GENBANK:XP_009893233
MER0829576	Chelonia mydas	1365	101-243	E227, E815	H814, H226, H818, H230, H236, H824	UNIPROT:M7ARI9
MER0829576	Chelonia mydas	1365	101-243	E227, E815	H814, H226, H818, H230, H236, H824	UNIPROT:M7ARI9
MER0582970	Chinchilla lanigera	925	263-471	E406	H405, H409, H415	GENBANK:XP_005375660
MER0577425	Chrysemys picta	524	6-69	missing	missing, H7, H13	GENBANK:XP_005289361
MER0577428	Chrysemys picta	420	247-395	E390	H389, Y393, missing	GENBANK:XP_005289362
MER0575672	Chrysochloris asiatica	930	268-476	E411	H410, H414, H420	GENBANK:XP_006872540
MER0668772	Colius striatus	659	1-202	E137	H136, H140, H146	GENBANK:XP_010203032
MER0670269	Colobus angolensis	930	268-476	E411	H410, H414, H420	GENBANK:XP_011781873
MER0348312	Columba livia	658	102-147	E137	H136, H140, H146	GENBANK:EMC90428
MER0573680	Condylura cristata	931	269-477	E412	H411, H415, H421	GENBANK:XP_004675377
MER0572721	Corvus brachyrhynchos	596	11-141	E76	H75, H79, H85	GENBANK:XP_008631469
MER0667490	Corvus cornix	578	16-123	E58	H57, H61, H67	GENBANK:XP_010389676
MER0357884	Cricetulus griseus	936	268-420	E410	H409, H413, H419	UNIPROT:G3I3J4
MER0357884	Cricetulus griseus	936	268-420	E410	H409, H413, H419	UNIPROT:G3I3J4
MER0665691	Cuculus canorus	756	105-319	E254	H253, H257, H263	GENBANK:XP_009565472
MER0568180	Cynoglossus semilaevis	974	263-470	E405	H404, H408, H414	GENBANK:XP_008323453
MER0357666	Danio rerio	874	215-369	E359	H358, H362, H368	GENBANK:XP_693454
MER0357668	Danio rerio	937	201-355	E345	H344, H348, H354	UNIPROT:G3G3J8
MER0357668	Danio rerio	937	201-355	E345	H344, H348, H354	UNIPROT:G3G3J8
MER0599570	Echinops telfairi	920	258-466	E401	H400, H404, H410	GENBANK:XP_004713149
MER0664738	Egretta garzetta	682	19-226	E161	H160, H164, H170	GENBANK:XP_009639183
MER0565706	Elephantulus edwardii	934	272-480	E415	H414, H418, H424	GENBANK:XP_006896088
MER0563851	Eptesicus fuscus	932	270-478	E413	H412, H416, H422	GENBANK:XP_008143851
MER0037355	Equus caballus	272	1-107	E42	H41, H45, H51	UNIPROT:A8HDR0
MER0037355	Equus caballus	272	1-107	E42	H41, H45, H51	UNIPROT:A8HDR0
MER0357829	Equus caballus	922	261-413	E403	H402, H406, H412	GENBANK:XP_003364266
MER0562862	Equus przewalskii	539	21-85	missing	missing, H23, H29	GENBANK:XP_008505492
MER0661594	Esox lucius	930	234-448	E383	H382, H386, H392	GENBANK:XP_010902695
MER0650434	Eurypyga helias	566	1-108	E43	H42, H46, H52	GENBANK:XP_010157851
MER0560547	Falco cherrug	688	89-232	E167	H166, H170, H176	GENBANK:XP_005438989
MER0545740	Falco peregrinus	746	86-290	E225	H224, H228, H234	GENBANK:XP_005240670
MER0347700	Felis catus	902	241-393	E383	H382, H386, H392	GENBANK:XP_003991564
MER0568549	Ficedula albicollis	659	2-209	E144	H143, H147, H153	GENBANK:XP_005038968
MER0656940	Fukomys damarensis	978	316-524	E459	H458, H462, H468	GENBANK:XP_010606997
MER0654581	Fulmarus glacialis	335	1-128	E63	H62, H66, H72	GENBANK:XP_009572678
MER0558229	Galeopterus variegatus	930	268-476	E411	H410, H414, H420	GENBANK:XP_008581522
MER0179539	Gallus gallus	750	81-295	E230	H229, H233, H239	GENBANK:XP_425541
MER0653625	Gavia stellata	635	59-179	E114	H113, H117, H123	GENBANK:XP_009817152
MER0521441	Geospiza fortis	667	39-213	E148	H147, H151, H157	GENBANK:XP_005430501
MER0347905	Gorilla gorilla	930	269-421	E411	H410, H414, H420	UNIPROT:G3QVR6
MER0347905	Gorilla gorilla	930	269-421	E411	H410, H414, H420	UNIPROT:G3QVR6
MER0652585	Haliaeetus albicilla	609	32-152	E87	H86, H90, H96	GENBANK:XP_009928919
MER0651255	Haliaeetus leucocephalus	1013	348-556	E491	H490, H494, H500	GENBANK:XP_010583635
MER0357820	Heterocephalus glaber	932	271-423	E413	H412, H416, H422	GENBANK:EHB17278
MER0005548	Homo sapiens	930	262-476	E411	H410, H414, H420	UNIPROT:Q9UNA0
MER0548195	Jaculus jaculus	942	280-488	E423	H422, H426, H432	GENBANK:XP_004654446
MER0650234	Larimichthys crocea	949	237-451	E386	H385, H389, H395	GENBANK:XP_010752625
MER0611692	Latimeria chalumnae	927	265-472	E407	H406, H410, H416	GENBANK:XP_005996894
MER0554495	Lepisosteus oculatus	902	240-446	E381	H380, H384, H390	GENBANK:XP_006638110
MER0521415	Leptonychotes weddellii	506	1-78	E43	H42, N46, Y67	GENBANK:XP_006752035
MER0829873	Leptosomus discolor	566	2-60	E44,	H43, H47, H53,	UNIPROT:A0A091PNB5
MER0829873	Leptosomus discolor	566	2-60	E44,	H43, H47, H53,	UNIPROT:A0A091PNB5
MER0549833	Lipotes vexillifer	931	269-477	E412	H411, H415, H421	GENBANK:XP_007466564
MER0259090	Loxodonta africana	929	267-419	E409	H408, H412, H418	GENBANK:XP_003410370
MER0357822	Macaca fascicularis	930	269-421	E411	H410, H414, H420	UNIPROT:G8F2G2
MER0357822	Macaca fascicularis	930	269-421	E411	H410, H414, H420	UNIPROT:G8F2G2
MER0170024	Macaca mulatta	974	309-461	E451	H450, H454, H460	UNIPROT:G7MNA8
MER0170024	Macaca mulatta	974	309-461	E451	H450, H454, H460	UNIPROT:G7MNA8
MER0647600	Manacus vitellinus	576	19-126	E61	H60, H64, H70	GENBANK:XP_008923160
MER0646118	Mandrillus leucophaeus	728	66-274	E209	H208, H212, H218	GENBANK:XP_011853706
MER0542497	Maylandia zebra	960	261-468	E403	H402, H406, H412	GENBANK:XP_004552685
MER0829105	Meleagris gallopavo	601	1-95	E79	H78, H82, H88	UNIPROT:G1NNU2
MER0541129	Melopsittacus undulatus	975	311-517	E452	H451, H455, H461	GENBANK:XP_005151837
MER0639421	Merops nubicus	344	1-196	E131	H130, H134, H140	GENBANK:XP_008941910
MER0642863	Mesitornis unicolor	521	1-63	missing	missing, H1, H7	GENBANK:XP_010186545
MER0544127	Mesocricetus auratus	929	267-475	E410	H409, H413, H419	GENBANK:XP_005073915
MER0539110	Microtus ochrogaster	928	266-474	E409	H408, H412, H418	GENBANK:XP_005345357
MER0166741	Monodelphis domestica	944	276-490	E425	H424, H428, H434	UNIPROT:F6RJX5
MER0166741	Monodelphis domestica	944	276-490	E425	H424, H428, H434	UNIPROT:F6RJX5
MER0006269	Mus musculus	930	262-476	E411	H410, H414, H420	UNIPROT:Q9R001
MER0006269	Mus musculus	930	262-476	E411	H410, H414, H420	UNIPROT:Q9R001
MER0006269	Mus musculus	930	262-476	E411	H410, H414, H420	UNIPROT:Q9R001
MER0571302	Myotis brandtii	662	1-208	E143	H142, H146, H152	GENBANK:XP_005880711
MER0348289	Myotis davidii	652	16-143	E133	H132, H136, H142	UNIPROT:L5M5W3
MER0348289	Myotis davidii	652	16-143	E133	H132, H136, H142	UNIPROT:L5M5W3
MER0638946	Nannospalax galili	928	266-474	E409	H408, H412, H418	GENBANK:XP_008854306
MER0534711	Neolamprologus brichardi	957	261-468	E403	H402, H406, H412	GENBANK:XP_006805057
MER0828883	Neovison vison	678	16-175	E159	H158, H162, H168	UNIPROT:U6DQD8
MER0828883	Neovison vison	678	16-175	E159	H158, H162, H168	UNIPROT:U6DQD8
MER0638874	Nestor notabilis	658	1-203	E138	H137, H141, H147	GENBANK:XP_010013382
MER0634376	Nipponia nippon	700	40-244	E179	H178, H182, H188	GENBANK:XP_009471818
MER0635347	Notothenia coriiceps	946	238-452	E387	H386, H390, H396	GENBANK:XP_010780108
MER0534251	Ochotona princeps	927	266-473	E408	H407, H411, H417	GENBANK:XP_004588648
MER0533412	Octodon degus	925	263-471	E406	H405, H409, H415	GENBANK:XP_004627763
MER0531239	Odobenus rosmarus	930	268-476	E411	H410, H414, H420	GENBANK:XP_004413725
MER0829186	Oncorhynchus mykiss	985	260-415	E400	H399, H403, H409	UNIPROT:A0A060X7T5
MER0829186	Oncorhynchus mykiss	985	260-415	E400	H399, H403, H409	UNIPROT:A0A060X7T5
MER0829351	Oncorhynchus mykiss	1349	675-831	E816	H815, H819, H825	UNIPROT:A0A060X938
MER0829351	Oncorhynchus mykiss	1349	675-831	E816	H815, H819, H825	UNIPROT:A0A060X938
MER0633776	Opisthocomus hoazin	634	45-178	E113	H112, H116, H122	GENBANK:XP_009931671
MER0529065	Orcinus orca	931	269-477	E412	H411, H415, H421	GENBANK:XP_004264535
MER0357664	Oreochromis niloticus	940	263-416	E406	H405, H409, H415	GENBANK:XP_003440995
MER0528080	Orycteropus afer	930	268-476	E411	H410, H414, H420	GENBANK:XP_007941695
MER0015239	Oryctolagus cuniculus	269	1-99	E34	H33, H37, H43	UNIPROT:Q9GL54
MER0015239	Oryctolagus cuniculus	269	1-99	E34	H33, H37, H43	UNIPROT:Q9GL54
MER0357803	Oryctolagus cuniculus	931	270-422	E412	H411, H415, H421	UNIPROT:G1SIH2
MER0357803	Oryctolagus cuniculus	931	270-422	E412	H411, H415, H421	UNIPROT:G1SIH2
MER0110805	Oryzias latipes	906	234-387	E377	H376, H380, H386	GENBANK:XP_004066759
MER0357800	Otolemur garnettii	930	269-421	E411	H410, H414, H420	UNIPROT:H0X883
MER0357800	Otolemur garnettii	930	269-421	E411	H410, H414, H420	UNIPROT:H0X883
MER0348179	Ovis aries	934	271-425	E415	H414, H418, H424	GENBANK:XP_004002845
MER0398380	Pan paniscus	930	269-421	E411	H410, H414, H420	GENBANK:XP_003816720
MER0347918	Pan troglodytes	931	270-422	E412	H411, H415, H421	UNIPROT:K7C8I8
MER0347918	Pan troglodytes	931	270-422	E412	H411, H415, H421	UNIPROT:K7C8I8
MER0519000	Panthera tigris	744	76-290	E225	H224, H228, H234	GENBANK:XP_007075121
MER0517478	Pantholops hodgsonii	671	3-217	E152	H151, H155, H161	GENBANK:XP_005974054
MER0347680	Papio anubis	925	269-421	E411	H410, H414, H420	GENBANK:XP_003895628
MER0524848	Pelodiscus sinensis	912	244-457	E392	H391, H395, H401	UNIPROT:K7FPH2
MER0524848	Pelodiscus sinensis	912	244-457	E392	H391, H395, H401	UNIPROT:K7FPH2
MER0829017	Petromyzon marinus	790	164-324	E309	H308, H312, H318	UNIPROT:S4RRL3
MER0829683	Petromyzon marinus	793	183-343	E328	H327, H331, H337	UNIPROT:S4RRL5
MER0632181	Phaethon lepturus	660	1-204	E139	H138, H142, H148	GENBANK:XP_010291691
MER0630774	Phalacrocorax carbo	564	1-108	E43	H42, H46, H52	GENBANK:XP_009502361
MER0520144	Physeter catodon	929	267-475	E410	H409, H413, H419	GENBANK:XP_007124216
MER0627893	Picoides pubescens	674	4-218	E153	H152, H156, H162	GENBANK:XP_009903995
MER0829499	Podiceps cristatus	565	2-60	E44	H43, H47, H53	UNIPROT:A0A094LEF4
MER0829499	Podiceps cristatus	565	2-60	E44	H43, H47, H53	UNIPROT:A0A094LEF4
MER0522228	Poecilia formosa	955	251-465	E400	H399, H403, H409	GENBANK:XP_007565337
MER0514872	Poecilia reticulata	955	251-465	E400	H399, H403, H409	GENBANK:XP_008425879
MER0357824	Pongo abelii	930	269-421	E411	H410, H414, H420	UNIPROT:H2P2U4
MER0357824	Pongo abelii	930	269-421	E411	H410, H414, H420	UNIPROT:H2P2U4
MER0581119	Pterocles gutturalis	564	1-108	E43	H42, H46, H52	GENBANK:XP_010083667
MER0348320	Pteropus alecto	652	16-143	E133	H132, H136, H142	UNIPROT:L5KY63
MER0348320	Pteropus alecto	652	16-143	E133	H132, H136, H142	UNIPROT:L5KY63
MER0263771	Pteropus vampyrus	932	270-478	E413	H412, H416, H422	GENBANK:XP_011356508
MER0829589	Pygoscelis adeliae	655	6-150	E134	H133, H137, H143	UNIPROT:A0A093PC27
MER0829589	Pygoscelis adeliae	655	6-150	E134	H133, H137, H143	UNIPROT:A0A093PC27
MER0438999	Python bivittatus	927	264-472	E407	H406, H410, H416	GENBANK:XP_007430226
MER0026922	Rattus norvegicus	928	262-474	E409	H408, H412, H418	UNIPROT:Q6TY19
MER0026922	Rattus norvegicus	928	262-474	E409	H408, H412, H418	UNIPROT:Q6TY19
MER0569563	Rhinopithecus roxellana	930	268-476	E411	H410, H414, H420	GENBANK:XP_010381749
MER0347912	Saimiri boliviensis	930	269-421	E411	H410, H414, H420	GENBANK:XP_003934396
MER0357808	Sarcophilus harrisii	942	279-433	E423	H422, H426, H432	UNIPROT:G3WI56
MER0357808	Sarcophilus harrisii	942	279-433	E423	H422, H426, H432	UNIPROT:G3WI56
MER0512162	Serinus canaria	701	42-248	E183	H182, H186, H192	GENBANK:XP_009090995
MER0476895	Stegastes partitus	966	259-473	E408	H407, H411, H417	GENBANK:XP_008280108
MER0503749	Struthio camelus	640	2-185	E120	H119, H123, H129	GENBANK:XP_009665955
MER0357817	Sus scrofa	955	268-420	E410	H409, H413, H419	GENBANK:XP_003132795
MER0829746	Sus scrofa	923	267-426	E410	H409, H413, H419	GENBANK:-
MER0347958	Taeniopygia guttata	764	102-254	E244	H243, H247, H253	GENBANK:XP_004176316
MER0375895	Tauraco erythrolophus	652	1-196	E131	H130, H134, H140	GENBANK:XP_009986586
MER0091114	Tetraodon nigroviridis	981	246-449	E391	H390, H394, H400	UNIPROT:Q4RY30
MER0091114	Tetraodon nigroviridis	981	246-449	E391	H390, H394, H400	UNIPROT:Q4RY30
MER0828900	Tetraodon nigroviridis	863	208-364	E349	H348, H352, H358	GENBANK:-
MER0468364	Tinamus guttatus	806	150-351	E286	H285, H289, H295	GENBANK:XP_010213811
MER0485632	Trichechus manatus	930	268-476	E411	H410, H414, H420	GENBANK:XP_004371420
MER0347591	Tupaia chinensis	937	269-421	E411	H410, H414, H420	UNIPROT:L9JEC4
MER0347591	Tupaia chinensis	937	269-421	E411	H410, H414, H420	UNIPROT:L9JEC4
MER0453614	Tyto alba	609	44-152	E87	H86, H90, H96	GENBANK:XP_009975129
MER0250292	Ursus maritimus	791	129-337	E272	H271, H275, H281	GENBANK:XP_008700157
MER0347379	Xenopus tropicalis	913	252-406	E396	H395, H399, H405	GENBANK:XP_002935740
MER0453305	Xiphophorus maculatus	910	251-465	E400	H399, H403, H409	GENBANK:XP_005805063
MER0448138	Zonotrichia albicollis	844	185-391	E326	H325, H329, H335	GENBANK:XP_005491081