Substrates for peptidase T01.011: proteasome subunit beta2c

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Boc-Leu-Arg-Arg-NHMec			Boc-Leu-Arg-Arg+NHMec	S		Boc	Leu	Arg	Arg	AMC	-	-	-	Seemuller et al., 2004
Boc-Leu-Ser-Thr-Arg-NHMec			Boc-Leu-Ser-Thr-Arg+NHMec	S		Leu	Ser	Thr	Arg	AMC	-	-	-	Seemuller et al., 2004
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Arg30+Arg-peptide	N	MS	Glu	Gln	Leu	Arg	Arg	Asp	Cys	Asp	Berko et al., 2012
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Arg47+Trp-peptide	N	MS	Ala	Arg	Glu	Arg	Trp	Asn	Phe	Asp	Berko et al., 2012
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Arg66+Val-peptide	N	MS	Val	Trp	Glu	Arg	Val	Arg	Ser	Leu	Berko et al., 2012
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Arg68+Ser-peptide	N	MS	Glu	Arg	Val	Arg	Ser	Leu	Gly	Leu	Berko et al., 2012
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Arg82+Ser-peptide	N	MS	Pro	Gly	Ser	Arg	Ser	Arg	Asp	Asp	Berko et al., 2012
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Arg84+Asp-peptide	N	MS	Ser	Arg	Ser	Arg	Asp	Asp	Leu	Gly	Berko et al., 2012
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Arg92+Pro-peptide	N	MS	Gly	Asp	Lys	Arg	Pro	Ser	Thr	Ser	Berko et al., 2012
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Arg137+Arg-peptide	N	MS	Gly	Arg	Lys	Arg	Arg	Gln	Thr	Ser	Berko et al., 2012
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Arg138+Gln-peptide	N	MS	Arg	Lys	Arg	Arg	Gln	Thr	Ser	Leu	Berko et al., 2012
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Arg151+Leu-peptide	N	MS	Ser	Lys	Arg	Arg	Leu	Val	Phe	Cys	Berko et al., 2012
cyclin-dependent kinase inhibitor 1	P39689	1-159	peptide-Lys156+Arg-Lys-Pro	N	MS	Val	Phe	Cys	Lys	Arg	Lys	Pro	'-'	Berko et al., 2012
immediate-early protein 1	P11210	162-186	peptide-Lys181+Arg-peptide	N		Pro	Ser	Glu	Lys	Arg	Val	Trp	Met	Dick et al., 1998
Immediate-early protein 1	P11210	162-186	Peptide-Met172+Pro-Peptide	P	MS	Pro	His	Phe	Met	Pro	Thr	Asn	Leu	Dick et al., 1998
Immediate-early protein 1	P11210	162-186	Peptide-Lys181+Arg-Peptide	P	MS	Pro	Ser	Glu	Lys	Arg	Val	Trp	Met	Dick et al., 1998
nucleoprotein	P03466	140-163	peptide-Arg150+Thr-peptide	N		Thr	Tyr	Gln	Arg	Thr	Arg	Ala	Leu	Dick et al., 1998
nucleoprotein	P03466	140-163	peptide-Arg152+Ala-peptide	N		Gln	Arg	Thr	Arg	Ala	Leu	Val	Arg	Dick et al., 1998
nucleoprotein	P03466	140-163	peptide-Ala153+Leu-peptide	N		Arg	Thr	Arg	Ala	Leu	Val	Arg	Thr	Dick et al., 1998
nucleoprotein	P03466	140-163	peptide-Arg156+Thr-peptide	N		Ala	Leu	Val	Arg	Thr	Gly	Met	Asp	Dick et al., 1998
Nucleoprotein	P03466	140-163	Peptide-Arg150+Thr-Peptide	N	MS	Thr	Tyr	Gln	Arg	Thr	Arg	Ala	Leu	Dick et al., 1998
Nucleoprotein	P03466	140-163	Peptide-Arg152+Ala-Peptide	N	MS	Gln	Arg	Thr	Arg	Ala	Leu	Val	Arg	Dick et al., 1998
Nucleoprotein	P03466	140-163	Peptide-Ala153+Leu-Peptide	N	MS	Arg	Thr	Arg	Ala	Leu	Val	Arg	Thr	Dick et al., 1998
Nucleoprotein	P03466	140-163	Peptide-Leu154+Val-Peptide	N	MS	Thr	Arg	Ala	Leu	Val	Arg	Thr	Gly	Dick et al., 1998
Nucleoprotein	P03466	140-163	Peptide-Arg156+Thr-Peptide	N	MS	Ala	Leu	Val	Arg	Thr	Gly	Met	Asp	Dick et al., 1998
ovalbumin	P01012	52-386	peptide-Arg127+Gly-peptide	N		Glu	Leu	Tyr	Arg	Gly	Gly	Leu	Glu	Berko et al., 2012
ovalbumin	P01012	52-386	peptide-Arg277+Lys-peptide	N		Met	Glu	Glu	Arg	Lys	Ile	Lys	Val	Berko et al., 2012
ovalbumin	P01012	52-386	peptide-Arg340+Glu-peptide	N		Glu	Ala	Gly	Arg	Glu	Val	Val	Gly	Berko et al., 2012
tyrosine-protein kinase JAK1	P23458	360-380	peptide-His374+Ile-peptide	N		Glu	Ile	Thr	His	Ile	Val	Ile	Lys	Dick et al., 1998
Tyrosine-protein kinase JAK1	P52332	359-380	Peptide-His374+Ile+Peptide	P	MS	Glu	Ile	Thr	His	Ile	Val	Ile	Lys	Dick et al., 1998
Z-Ala-Arg-Arg-NHMec			Z-Ala-Arg-Arg+NHMec	S		Z	Ala	Arg	Arg	AMC	-	-	-	Dick et al., 1998
Z-Gly-Gly-Arg-NHMec			Z-Gly-Gly-Arg+NHMec	S		Z	Gly	Gly	Arg	AMC	-	-	-	Seemuller et al., 2004