| Activity |
|---|
| Catalytic type | Threonine |
| Peplist | Included in the Peplist with identifier PL00419 |
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.25 (Threonine-type endopeptidases) >> Peptidase 3.4.25.1
|
| Enzymology | BRENDA database |
| Activity status | human: active (Seemuller et al., 2004)
mouse: active (by similarity to other mammals)
|
| Physiology | One of the peptidase units of the 20 S proteasome, and thus contributing to the major role of the proteasome in intracellular protein degradation. |
| Pharmaceutical relevance | Proteasome inhibitors exhibit anti-inflammatory and antiproliferative effects, and it is threrefore considered that inhibitors have the potential to be drugs for conditions such as cancer, rheumatoid arthritis and psoriasis that are characterised by these processes (Delcros et al., 2003; Elliott et al., 2003). |
| Pathways |
KEGG | Proteasome |
|
Other databases
| TREEFAM | http://www.treefam.org/family/TF106222 |
| Cleavage site specificity |
Explanations of how to interpret the
following cleavage site sequence logo and specificity matrix can be found here. |
|---|
| Cleavage pattern | -/-/-/R -/v/-/- (based on 32 cleavages) |
