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Literature for peptidase S28.001: lysosomal Pro-Xaa carboxypeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2022
  1. Baharin,A., Ting,T.Y. and Goh,H.H.
    Post-Proline Cleaving Enzymes (PPCEs): Classification, Structure, Molecular Properties, and Applications
    Plants (Basel)11, PubMed  Europe PubMed DOI  V
    2. 2020
  2. Dunaevsky,Y.E., Tereshchenkova,V.F., Oppert,B., Belozersky,M.A., Filippova,I.Y. and Elpidina,E.N.
    Human proline specific peptidases: a comprehensive analysis
    Biochim Biophys Acta Gen Subj1864, 129636-129636. PubMed  Europe PubMed DOI  V
  3. Hao,P., Liu,Y., Guo,H., Zhang,Z., Chen,Q., Hao,G., Zhang,C. and Zhang,Y.
    Prolylcarboxypeptidase Mitigates Myocardial Ischemia/Reperfusion Injury by Stabilizing Mitophagy
    Front Cell Dev Biol8, 584933-584933. PubMed  Europe PubMed DOI  K
  4. Wu,Y., Pan,X. and Jin,X.
    Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of China
    J Renin Angiotensin Aldosterone Syst21, 1470320320981316-1470320320981316. PubMed  Europe PubMed DOI  M
  5. Wu,Y., Yang,H. and Xiao,C.
    Genetic association study of prolylcarboxypeptidase polymorphisms with susceptibility to essential hypertension in the Yi minority of China: A case-control study based on an isolated population
    J Renin Angiotensin Aldosterone Syst21, 1470320320919586-1470320320919586. PubMed  Europe PubMed DOI  M
    6. 2018
  6. Bruschetta,G., Jin,S., Kim,J.D. and Diano,S.
    Prolyl carboxypeptidase in Agouti-related peptide neurons modulates food intake and body weight
    Mol Metab10, 28-38. PubMed  Europe PubMed DOI  K
    7. 2017
  7. Graham,T.H.
    Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review
    Expert Opin Ther Pat27, 1077-1088. PubMed  Europe PubMed DOI  I
  8. Luft,F.C.
    The renin-angiotensin system and prolylcarboxypeptidase
    J Mol Med (Berl)95, 461-463. PubMed  Europe PubMed DOI
  9. Maier,C., Schadock,I., Haber,P.K., Wysocki,J., Ye,M., Kanwar,Y., Flask,C.A., Yu,X., Hoit,B.D., Adams,G.N., Schmaier,A.H., Bader,M. and Batlle,D.
    Prolylcarboxypeptidase deficiency is associated with increased blood pressure, glomerular lesions, and cardiac dysfunction independent of altered circulating and cardiac angiotensin II
    J Mol Med (Berl)95, 473-486. PubMed  Europe PubMed DOI  M
    10. 2016
  10. Gittleman,H.R., Merkulova,A., Alhalabi,O., Stavrou,E.X., Veigl,M.L., Barnholtz-Sloan,J.S. and Schmaier,A.H.
    A cross-sectional study of KLKB1 and PRCP polymorphisms in patient samples with cardiovascular disease
    Front Med (Lausanne)3, 17-17. PubMed  Europe PubMed DOI  M
  11. Kehoe,K., Van Elzen,R., Verkerk,R., Sim,Y., Van der Veken,P., Lambeir,A.M. and De Meester,I.
    Prolyl carboxypeptidase purified from human placenta: Its characterization and identification as an apelin-cleaving enzyme
    Biochim Biophys Acta1864, 1481-1488. PubMed  Europe PubMed DOI
    12. 2015
  12. Waumans,Y., Baerts,L., Kehoe,K., Lambeir,A.M. and De Meester,I.
    The dipeptidyl peptidase family, prolyl oligopeptidase, and prolyl carboxypeptidase in the immune system and inflammatory disease, including atherosclerosis
    Front Immunol6, 387-387. PubMed  Europe PubMed DOI
    13. 2014
  13. Graham,T.H., Shu,M., Verras,A., Chen,Q., Garcia-Calvo,M., Li,X., Lisnock,J., Tong,X., Tung,E.C., Wiltsie,J., Hale,J.J., Pinto,S. and Shen,D.M.
    Pyrazoles as non-classical bioisosteres in prolylcarboxypeptidase (PrCP) inhibitors
    Bioorg Med Chem Lett24, 1657-1660. PubMed  Europe PubMed DOI  I
  14. Marangoni,R.A., Santos,R.A. and Piccolo,C.
    Deficient prolylcarboxypeptidase gene and protein expression in left ventricles of spontaneously hypertensive rats (SHR)
    Peptides61, 69-74. PubMed  Europe PubMed DOI
  15. Wang,J., Matafonov,A., Madkhali,H., Mahdi,F., Watson,D., Schmaier,A.H., Gailani,D. and Shariat-Madar,Z.
    Prolylcarboxypeptidase independently activates plasma prekallikrein (Fletcher factor)
    Curr Mol Med14, 1173-1185. PubMed  Europe PubMed
    16. 2013
  16. Adams,G.N., Stavrou,E.X., Fang,C., Merkulova,A., Alaiti,M.A., Nakajima,K., Morooka,T., Merkulov,S., LaRusch,G.A., Simon,D.I., Jain,M.K. and Schmaier,A.H.
    Prolylcarboxypeptidase promotes angiogenesis and vascular repair
    Blood122, 1522-1531. PubMed  Europe PubMed DOI  K
  17. Debenham,J.S., Graham,T.H., Verras,A., Zhang,Y., Clements,M.J., Kuethe,J.T., Madsen-Duggan,C., Liu,W., Bhatt,U.R., Chen,D., Chen,Q., Garcia-Calvo,M., Geissler,W.M., He,H., Li,X., Lisnock,J., Shen,Z., Tong,X., Tung,E.C., Wiltsie,J., Xu,S., Hale,J.J., Pinto,S. and Shen,D.M.
    Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors
    Bioorg Med Chem Lett23, 6228-6233. PubMed  Europe PubMed DOI  I
  18. Goptar,I.A., Shagin,D.A., Shagina,I.A., Mudrik,E.S., Smirnova,Y.A., Zhuzhikov,D.P., Belozersky,M.A., Dunaevsky,Y.E., Oppert,B., Filippova,I.Y. and Elpidina,E.N.
    A digestive prolyl carboxypeptidase in Tenebrio molitor larvae
    Insect Biochem Mol Biol43, 501-509. PubMed  Europe PubMed DOI
  19. Grobe,N., Weir,N.M., Leiva,O., Ong,F.S., Bernstein,K.E., Schmaier,A.H., Morris,M. and Elased,K.M.
    Identification of prolyl carboxypeptidase as an alternative enzyme for processing of renal angiotensin II using mass spectrometry
    Am J Physiol Cell Physiol304, C945-C953. PubMed  Europe PubMed DOI
  20. Jeong,J.K. and Diano,S.
    Prolyl carboxypeptidase and its inhibitors in metabolism
    Trends Endocrinol Metab24, 61-67. PubMed  Europe PubMed DOI  I
  21. Kehoe,K., Verkerk,R., Sim,Y., Waumans,Y., Van der Veken,P., Lambeir,A.M. and De Meester,I.
    Validation of a specific prolylcarboxypeptidase activity assay and its suitability for plasma and serum measurements
    Anal Biochem443, 232-239. PubMed  Europe PubMed DOI  A
  22. Wu,Y., Yang,H., Yang,B., Yang,K. and Xiao,C.
    Association of polymorphisms in prolylcarboxypeptidase and chymase genes with essential hypertension in the Chinese Han population
    J Renin Angiotensin Aldosterone Syst14, 263-270. PubMed  Europe PubMed DOI  M
    23. 2012
  23. Graham,T.H., Shen,H.C., Liu,W., Xiong,Y., Verras,A., Bleasby,K., Bhatt,U.R., Chabin,R.M., Chen,D., Chen,Q., Garcia-Calvo,M., Geissler,W.M., He,H., Lassman,M.E., Shen,Z., Tong,X., Tung,E.C., Xie,D., Xu,S., Colletti,S.L., Tata,J.R., Hale,J.J., Pinto,S. and Shen,D.M.
    The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors
    Bioorg Med Chem Lett22, 658-665. PubMed  Europe PubMed DOI  I
  24. Graham,T.H., Liu,W., Verras,A., Sebhat,I.K., Xiong,Y., Bleasby,K., Bhatt,U.R., Chen,Q., Garcia-Calvo,M., Geissler,W.M., Gorski,J.N., He,H., Lassman,M.E., Lisnock,J., Li,X., Shen,Z., Tong,X., Tung,E.C., Wiltsie,J., Xiao,J., Xie,D., Xu,S., Hale,J.J., Pinto,S. and Shen,D.M.
    A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation
    Bioorg Med Chem Lett22, 2811-2817. PubMed  Europe PubMed DOI  I
  25. Graham,T.H., Liu,W., Verras,A., Reibarkh,M., Bleasby,K., Bhatt,U.R., Chen,Q., Garcia-Calvo,M., Geissler,W.M., Gorski,J.N., He,H., Lassman,M.E., Lisnock,J., Li,X., Shen,Z., Tong,X., Tung,E.C., Wiltsie,J., Xie,D., Xu,S., Xiao,J., Hale,J.J., Pinto,S. and Shen,D.M.
    A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes
    Bioorg Med Chem Lett22, 2818-2822. PubMed  Europe PubMed DOI  I
  26. Jeong,J.K., Szabo,G., Raso,G.M., Meli,R. and Diano,S.
    Deletion of prolyl carboxypeptidase attenuates the metabolic effects of diet-induced obesity
    Am J Physiol Endocrinol Metab302, E1502-E1510. PubMed  Europe PubMed DOI  K
  27. Tan,F., Skidgel,R.A. and Erdos,E.G.
    Lysosomal Pro-Xaa carboxypeptidase
    [ISSN:978-0-12-407742-3]3, 3425-3432. DOI
  28. Wu,Z., Yang,C., Xiong,Y., Feng,Z., Lombardo,M., Verras,A., Chabin,R.M., Xu,S., Tong,X., Xie,D., Lassman,M.E., Bhatt,U.R., Garcia-Calvo,M.M., Geissler,W., Shen,Z., Chen,Q., SinhaRoy,R., Hale,J.J., Tata,J.R., Pinto,S., Shen,D.M. and Colletti,S.L.
    Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine
    Bioorg Med Chem Lett22, 1774-1778. PubMed  Europe PubMed DOI  I
  29. Wu,Z., Yang,C., Graham,T.H., Verras,A., Chabin,R.M., Xu,S., Tong,X., Xie,D., Lassman,M.E., Bhatt,U.R., Garcia-Calvo,M.M., Shen,Z., Chen,Q., Bleasby,K., SinhaRoy,R., Hale,J.J., Tata,J.R., Pinto,S., Colletti,S.L. and Shen,D.M.
    Discovery of aminoheterocycles as potent and brain penetrant prolylcarboxypeptidase inhibitors
    Bioorg Med Chem Lett22, 1727-1730. PubMed  Europe PubMed DOI  I
    30. 2011
  30. Adams,G.N., LaRusch,G.A., Stavrou,E., Zhou,Y., Nieman,M.T., Jacobs,G.H., Cui,Y., Lu,Y., Jain,M.K., Mahdi,F., Shariat-Madar,Z., Okada,Y., D'Alecy,L.G. and Schmaier,A.H.
    Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis
    Blood117, 3929-3937. PubMed  Europe PubMed DOI  K
  31. Chajkowski,S.M., Mallela,J., Watson,D.E., Wang,J., McCurdy,C.R., Rimoldi,J.M. and Shariat-Madar,Z.
    Highly selective hydrolysis of kinins by recombinant prolylcarboxypeptidase
    Biochem Biophys Res Commun405, 338-343. PubMed  Europe PubMed DOI  E  P
  32. Diano,S.
    New aspects of melanocortin signaling: a role for PRCP in alpha-MSH degradation
    Front Neuroendocrinol32, 70-83. PubMed  Europe PubMed DOI
  33. Duan,L., Motchoulski,N., Danzer,B., Davidovich,I., Shariat-Madar,Z. and Levenson,V.V.
    Prolylcarboxypeptidase regulates proliferation, autophagy, and resistance to 4-hydroxytamoxifen-induced cytotoxicity in estrogen receptor-positive breast cancer cells
    J Biol Chem286, 2864-2876. PubMed  Europe PubMed DOI
  34. Shen,H.C., Ding,F.X., Zhou,C., Xiong,Y., Verras,A., Chabin,R.M., Xu,S., Tong,X., Xie,D., Lassman,M.E., Bhatt,U.R., Garcia-Calvo,M.M., Geissler,W., Shen,Z., Chen,D., SinhaRoy,R., Hale,J.J., Tata,J.R., Pinto,S., Shen,D.M. and Colletti,S.L.
    Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors
    Bioorg Med Chem Lett21, 1299-1305. PubMed  Europe PubMed DOI  I
    35. 2010
  35. Abeywickrema,P.D., Patel,S.B., Byrne,N.J., Diehl,R.E., Hall,D.L., Ford,R.E., Rickert,K.W., Reid,J.C., Shipman,J.M., Geissler,W.M., Pryor,K.D., SinhaRoy,R., Soisson,S.M., Lumb,K.J. and Sharma,S.
    Expression, purification and crystallization of human prolylcarboxypeptidase
    Acta Crystallogr Sect F Struct Biol Cryst Commun66, 702-705. PubMed  Europe PubMed DOI  E
  36. Soisson,S.M., Patel,S.B., Abeywickrema,P.D., Bryne,N.J., Diehl,R.E., Hall,D.L., Ford,R.E., Reid,J.C., Rickert,K.W., Shipman,J.M., Sharma,S. and Lumb,K.J.
    Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase
    BMC Struct Biol10, 16-16. PubMed  Europe PubMed DOI  S
  37. Zhao,X., Southwick,K., Cardasis,H.L., Du,Y., Lassman,M.E., Xie,D., El-Sherbeini,M., Geissler,W.M., Pryor,K.D., Verras,A., Garcia-Calvo,M., Shen,D.M., Yates,N.A., Pinto,S. and Hendrickon,R.C.
    Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase
    Proteomics10, 2882-2886. PubMed  Europe PubMed DOI  P
  38. Zhou,C., Garcia-Calvo,M., Pinto,S., Lombardo,M., Feng,Z., Bender,K., Pryor,K.D., Bhatt,U.R., Chabin,R.M., Geissler,W.M., Shen,Z., Tong,X., Zhang,Z., Wong,K.K., Roy,R.S., Chapman,K.T., Yang,L. and Xiong,Y.
    Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity
    J Med Chem53, 7251-7263. PubMed  Europe PubMed DOI  T  I
  39. Zhu,L., Carretero,O.A., Liao,T.D., Harding,P., Li,H., Sumners,C. and Yang,X.P.
    Role of prolylcarboxypeptidase in angiotensin II type 2 receptor-mediated bradykinin release in mouse coronary artery endothelial cells
    Hypertension56, 384-390. PubMed  Europe PubMed DOI
    40. 2009
  40. Ngo,M.L., Mahdi,F., Kolte,D. and Shariat-Madar,Z.
    Upregulation of prolylcarboxypeptidase (PRCP) in lipopolysaccharide (LPS) treated endothelium promotes inflammation
    J Inflamm (Lond)6, 3-3. PubMed  Europe PubMed DOI
  41. Palmiter,R.D.
    Reduced levels of neurotransmitter-degrading enzyme PRCP promote a lean phenotype
    J Clin Invest119, 2130-2133. PubMed  Europe PubMed DOI
  42. Wallingford,N., Perroud,B., Gao,Q., Coppola,A., Gyengesi,E., Liu,Z.W., Gao,X.B., Diament,A., Haus,K.A., Shariat-Madar,Z., Mahdi,F., Wardlaw,S.L., Schmaier,A.H., Warden,C.H. and Diano,S.
    Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents
    J Clin Invest119, 2291-2303. PubMed  Europe PubMed DOI
  43. Zhang,Y., Hong,X.M., Xing,H.X., Li,J.P., Huo,Y. and Xu,X.P.
    E112D polymorphism in the prolylcarboxypeptidase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients
    Chin Med J (Engl)122, 2461-2465. PubMed  Europe PubMed DOI  M
    44. 2006
  44. Wang,L., Feng,Y., Zhang,Y., Zhou,H., Jiang,S., Niu,T., Wei,L.J., Xu,X., Xu,X. and Wang,X.
    Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia
    Am J Obstet Gynecol195, 162-171. PubMed  Europe PubMed DOI
    45. 2005
  45. Shariat-Madar,Z., Rahimy,E., Mahdi,F. and Schmaier,A.H.
    Overexpression of prolylcarboxypeptidase enhances plasma prekallikrein activation on Chinese hamster ovary cells
    Am J Physiol Heart Circ Physiol289, H2697-H2703. PubMed  Europe PubMed DOI
    46. 2004
  46. [YEAR:12-2-2004]Maryanoff,B.E.
    Inhibitors of serine proteases as potential therapeutic agents: the road from thrombin to tryptase to cathepsin G
    J Med Chem47, 769-787. PubMed  Europe PubMed DOI  I
  47. [YEAR:2-3-2004]Shariat-Madar,Z., Mahdi,F. and Schmaier,A.H.
    Recombinant prolylcarboxypeptidase activates plasma prekallikrein
    Blood103, 4554-4561. PubMed  Europe PubMed DOI  I
  48. Tan,F. and Erdos,E.G.
    Lysosomal Pro-X carboxypeptidase
    [ISSN:0-12-079610-4]2, 1936-1938.  V
    49. 2002
  49. [YEAR:17-7-2002]Moreira,C.R., Schmaier,A.H., Mahdi,F., da Motta,G., Nader,H.B. and Shariat-Madar,Z.
    Identification of prolylcarboxypeptidase as the cell matrix-associated prekallikrein activator
    FEBS Lett523, 167-170. PubMed  Europe PubMed DOI
  50. Shariat-Madar,Z., Mahdi,F. and Schmaier,A.H.
    Assembly and activation of the plasma kallikrein/kinin system: a new interpretation
    Int Immunopharmacol2, 1841-1849. PubMed  Europe PubMed DOI
  51. [YEAR:17-5-2002]Shariat-Madar,Z., Mahdi,F. and Schmaier,A.H.
    Identification and characterization of prolylcarboxypeptidase as an endothelial cell prekallikrein activator
    J Biol Chem277, 17962-17969. PubMed  Europe PubMed DOI
    52. 1998
  52. Skidgel,R.A. and Erdos,E.G.
    Cellular carboxypeptidases
    Immunol Rev161, 129-141. PubMed  Europe PubMed DOI
    53. 1997
  53. [YEAR:15-9-1997]Watson,B., Jr., Nowak,N.J., Myracle,A.D., Shows,T.B. and Warnock,D.G.
    The human angiotensinase C gene (HUMPCP) maps to 11q14 within 700 kb of D11S901: a candidate gene for essential hypertension
    Genomics44, 365-367. PubMed  Europe PubMed DOI
    54. 1995
  54. Suzawa,Y., Hiraoka,B.Y., Harada,M. and Deguchi,T.
    High-performance liquid chromatographic determination of prolylcarboxypeptidase activity in monkey kidney
    J Chromatogr B Biomed Appl670, 152-156. PubMed  Europe PubMed DOI
    55. 1993
  55. [YEAR:5-8-1993]Tan,F., Morris,P.W., Skidgel,R.A. and Erdos,E.G.
    Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families
    J Biol Chem268, 16631-16638. PubMed  Europe PubMed
    56. 1981
  56. Kumamoto,K., Stewart,T.A., Johnson,A.R. and Erdos,E.G.
    Prolylcarboxypeptidase (angiotensinase C) in human lung and cultured cells
    J Clin Invest67, 210-215. PubMed  Europe PubMed DOI
  57. Odya,C.E. and Erdos,E.G.
    Human prolylcarboxypeptidase
    Methods Enzymol80, 460-466. PubMed  Europe PubMed DOI  V
  58. [YEAR:15-11-1981]Skidgel,R.A., Wickstrom,E., Kumamoto,K. and Erdos,E.G.
    Rapid radioassay for prolylcarboxypeptidase (angiotensinase C)
    Anal Biochem118, 113-119. PubMed  Europe PubMed
    59. 1978
  59. Odya,C.E., Marinkovic,D.V., Hammon,K.J., Stewart,T.A. and Erdos,E.G.
    Purification and properties of prolylcarboxypeptidase (angiotensinase C) from human kidney
    J Biol Chem253, 5927-5931. PubMed  Europe PubMed
    60. 1973
  60. [YEAR:15-3-1973]Kakimoto,T., Oshima,G., Yeh,H.S. and Erdos,E.G.
    Purification of lysosomal prolycarboxypeptidase angiotensinase C
    Biochim Biophys Acta302, 178-182. PubMed  Europe PubMed
    61. 1971
  61. Matsunaga,M.
    Nature of lysosomal angiotensinase activity
    Jpn Circ J35, 333-338. PubMed  Europe PubMed
    62. 1969
  62. Matsunaga,M., Saito,N., Kira,J., Ogino,K. and Takayasu,M.
    Acid angiotensinase as a lysosomal enzyme
    Jpn Circ J33, 545-551. PubMed  Europe PubMed
    63. 1968
  63. [YEAR:26-6-1968]Johnson,D.C. and Ryan,J.W.
    Degradation of angiotensin II by a carboxypeptidase of rabbit liver
    Biochim Biophys Acta160, 196-203. PubMed  Europe PubMed
  64. Yang,H.Y., Erdos,E.G. and Chiang,T.S.
    New enzymatic route for the inactivation of angiotensin
    Nature218, 1224-1226. PubMed  Europe PubMed DOI

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