$VAR1 = undef;

Summary for peptidase S10.002: serine carboxypeptidase A

Names
MEROPS Name	serine carboxypeptidase A
Other names	carboxypeptidase-L, carboxypeptidase Y-like kininase, cathepsin A, cathepsin I (obs.), CTSA g.p. (Homo sapiens), deamidase, HlSCP1 (Haemaphysalis longicornis), lysosomal carboxypeptidase A, lysosomal protective protein, protective protein, urinary kininase

Domain architecture

MEROPS Classification
Classification	Clan SC >> Subclan (none) >> Family S10 >> Subfamily (none) >> S10.002
Holotype	serine carboxypeptidase A (Homo sapiens), Uniprot accession P10619 (peptidase unit: 39-480), MERNUM MER0000430
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00373
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.16 (Serine-type carboxypeptidases) >> Peptidase 3.4.16.5
Enzymology	BRENDA database
Proteolytic events	CutDB database (2 cleavages)
Activity status	human: active (Pshezhetsky, 2004) mouse: active (by similarity to human) (Zhou et al., 1995)
Physiology	Reported to regulate the degradation of lysosome-associated membrane protein type-2a (lamp2a), a crucial receptor for chaperone-mediated autophagy (Cuervo et al., 2003).
Knockout	Mutations in the gene encoding lysosomal carboxypeptidase A are the cause of the lysosomal disorder galactosialidosis. Human lysosomal beta-galactosidase and neuraminidase exist as a high molecular weight enzyme complex, in which there is also glycoprotein termed "lysosomal protective protein" that is identical with lysosomal carboxypeptidase A. The protective function of lysosomal carboxypeptidase A is distinct from its catalytic activity, however. Knockout mice show a phenotype similar to human galactosialidosis (Zhou et al., 1995).
Pathways	KEGG	Lysosome
	KEGG	Renin-angiotensin system
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Cathepsin_A
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/Flf/-/-/- (based on 10 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	0	0	0	0
Pro	0	1	0	0	0	0	1	0
Ala	0	0	0	0	1	0	0	0
Val	0	0	0	1	0	1	0	0
Leu	0	0	0	0	4	0	0	0
Ile	0	0	0	0	0	0	0	1
Met	0	0	0	0	0	0	0	0
Phe	0	0	1	6	2	0	0	0
Tyr	0	0	0	1	1	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	0	0	0	0	0	0	0	0
Thr	0	0	0	0	0	0	0	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	2	0	0	0	0	0
Gln	0	0	0	0	0	0	0	0
Asp	2	2	0	0	0	0	0	0
Glu	0	0	0	1	0	0	0	0
Lys	0	0	0	0	0	0	0	0
Arg	0	0	0	0	0	0	0	0
His	1	0	0	1	0	0	0	0