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Literature for peptidase S09.007: fibroblast activation protein alpha subunit

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Mu,X., Chen,Z., Chow,H.Y., Li,J., Li,J., Zhang,L., Chong,W., Mo,Y., Tam,K.P., Tang,W., Huang,W., Liang,S., Shi,Y., Cui,M., Zhang,X., Tang,G., Li,X. and Fu,W.<br>Structure-guided design and clinical evaluation of (68)Ga-GP01 for FAP-targeted PET imaging in solid tumors<br>J Control Release (2026) 389, 114475-114475. PubMed  Europe PubMed DOI
  2. Xie,C., Wu,J.J., Feng,Y., Ren,T.B., Yuan,L., Huan,S.Y. and Zhang,X.B.<br>FAPalpha-Activated NIR-I Fluorescent Probe with Improved Water Solubility for Tumor Imaging<br>Anal Chem (2026) 98, 4940-4949. PubMed  Europe PubMed DOI
  3. Xu,H.W., Chang,S.J., Wang,S., Liu,X.W. and Wang,S.J.<br>Inhibition of Fibroblast Activation Protein-alpha Ameliorates Intervertebral Disc Degeneration via Reduced Vascular Invasion in Cartilage Endplate<br>Cell Prolif (2026) , e70162-e70162. PubMed  Europe PubMed DOI
  4. Xu,Q., Shi,X., Zhang,X., Song,P. and Chu,C.Q.<br>Targeting Fibrosis in Arthritis Using mRNA Vaccine-Based Approach<br>Methods Mol Biol (2026) 2983, 327-340. PubMed  Europe PubMed DOI
    5. 2025
  5. Adhikari,K., Grintsevich,S., de Groot,A., Verhulst,E., Van Rymenant,Y., Vangestel,C., Lauwerys,L., Miranda,A., De Meester,I., Van der Veken,P. and Elvas,F.<br>Synthesis and Preclinical Evaluation of Druglike (18)F-Labeled Fibroblast Activation Protein (FAP) Inhibitors with Enhanced Tumor Retention<br>Bioconjug Chem (2025) 36, 1887-1906. PubMed  Europe PubMed DOI  I
  6. Baek,A., Pedersen,A.K.N., Billeskov,T.B., Dollerup,O.L., Arlien-Soborg,M.C., Jessen,N., Bjerre,M. and Jorgensen,J.O.L.<br>GH replacement therapy in adults stimulates fibroblast activation protein-alpha activity<br>Eur J Endocrinol (2025) 193, 659-666. PubMed  Europe PubMed DOI
  7. Basak,S., Satapathy,S., Shukla,A., Srivastava,N. and Meher,N.<br>Fibroblast Activation Protein as a Molecular Handle in Cancer Phototheranostics: Recent Advances<br>Mol Pharm (2025) PubMed  Europe PubMed DOI  V
  8. Brzeminski,P., Verhulst,E., Fabisiak,A., Pacifico,R., Willocx,D., Peeters,S., de Groot,A., Corthaut,S., Van Meel,K., Stroobants,S., Augustyns,K., Berg,M., Lambeir,A.M., Rosch,F., De Meester,I., Elvas,F. and Van der Veken,P.<br>Structure-Property Investigation of New "KetoFAPI" Inhibitors of Fibroblast Activation Protein (FAP): Discovery of Highly Potent, Selective Compounds with Prolonged Residence Times and Promising Radiotheranostic Potential<br>J Med Chem (2025) 68, 21739-21765. PubMed  Europe PubMed DOI  I
  9. Butuzova,D.A., Kulebyakina,M.A., Basalova,N.A. and Efimenko,A.Y.<br>Fibroblast Activation Protein Alpha (FAPalpha) as a Promising Target in the Diagnostics and Treatment of Cancer and Fibrotic Diseases: Recent Approaches to Imaging and Assessment of Functional Activity<br>Biochemistry (Mosc) (2025) 90, S135-S135. PubMed  Europe PubMed DOI
  10. Chen,C.C., Wang,L., Wong,A.A.W.L., Lau,W.S., Ng,P., Merkens,H., Benard,F. and Lin,K.S.<br>A Novel (68)Ga-Labeled 2-Azabicyclo[3.1.0]Hexane-3-Carbonitrile-Based Fibroblast Activation Protein-Targeted Tracer for Cancer Imaging With Positron Emission Tomography<br>J Labelled Comp Radiopharm (2025) 68, e4143-e4143. PubMed  Europe PubMed DOI
  11. Chen,P., Lu,Z., Feng,X., Hu,Y., Qin,Y., Lu,Y., Han,F. and Li,T.<br>Monomeric or Homodimer Conjugates of Fibroblast Activation Protein Inhibitor and Cyanine 7 Bearing a Meso-Chloride as Near-Infrared Fluorescence Probes: Design, Synthesis, and Comparative In Vivo Imaging of Distinct Breast Cancer Subtypes<br>J Med Chem (2025) 68, 1417-1432. PubMed  Europe PubMed DOI
  12. Dong,Y., Hu,X., Liu,W., Hao,Y., Zhou,J., Li,X. and Wang,B.<br>Fibroblast activation protein-alpha interacts with CXCL12 to inactivate canonical Wnt signaling and regulate osteoblast differentiation<br>Stem Cells (2025) PubMed  Europe PubMed DOI
  13. Faucher,F.F., Lovell,S., Bertolini,M., Blazkova,K., Cosco,E.D., Bogyo,M. and Barniol-Xicota,M.<br>Macrocyclic phage display for identification of selective protease substrates<br>bioRxiv (2025) PubMed  Europe PubMed DOI  PMC  EPMC
  14. Hemmingsen,J.K., Enemark,M.H., Pedersen,A.K.N., Sorensen,E.F., Lauridsen,K.L., Lohde,J.B., d'Amore,F., Hamilton-Dutoit,S.J., Bjerre,M. and Ludvigsen,M.<br>Reduced Activity of Soluble Fibroblast Activation Protein (sFAP) Represents a Biomarker of Aggressive Disease in Lymphoid Malignancies<br>Int J Mol Sci (2025) 26 PubMed  Europe PubMed DOI  PMC  EPMC
  15. Larrinaga,G., Redrado,M., Loizaga-Iriarte,A., Perez-Fernandez,A., Santos-Martin,A., Angulo,J.C., Fernandez,J.A., Calvo,A. and Lopez,J.I.<br>Spatial expression of fibroblast activation protein-alpha in clear cell renal cell carcinomas revealed by multiplex immunoprofiling analysis of the tumor microenvironment<br>Cancer Immunol Immunother (2025) 74, 53-53. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Ma,H., de Muynck,L.D.A.N., Houvast,R.D., Beekman,S., Piet,A., March,T.L., Hawinkels,L.J.A.C., Mieog,J.S.D., Vahrmeijer,A.L. and Seimbille,Y.<br>Revolutionizing Solid Tumor Surgery with Fibroblast Activation Protein (FAP)-Targeted Imaging Probes for a Fluorescence-Guided Surgery of Pancreatic Cancer<br>Bioconjug Chem (2025) 36, 2145-2157. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Maynard,R.E., Fitzgerald,A.A., Marcisak,E.F., Nasir,A., Eisman,S.E., Glasgow,E., Lee,A.J., Wang,N., Jablonski,S.A., Van der Veken,P., Pearson,G., Mace,E.M., Fertig,E.J., Afifi,M.M. and Weiner,L.M.<br>Fibroblast activation protein promotes natural killer cell invasion and tumor infiltration<br>J Immunol (2025) PubMed  Europe PubMed DOI
  18. Meng,L., Lin,R., Zhang,J., Li,H., Xia,D., Zhao,Z., Zhuang,R., Huang,L., Zhang,X., Fang,J., Miao,W. and Guo,Z.<br>Modification of Asp-Peptide Adapters: Giving the FAP-Targeted Radioligand a "Squirrel Tail"<br>J Med Chem (2025) 68, 6576-6587. PubMed  Europe PubMed DOI
  19. Qu,Y.A., Huang,J.C., Wang,Z.V., Ferguson,A.L., Nguyen,J.M.H., Zhang,M., Osborne,K.A., Boumelhem,B.B., McCaughan,G.W., Liu,K. and Gorrell,M.D.<br>Understanding the Cancer-Associated Fibroblast (CAF) and Its Biomarker Fibroblast Activation Protein (FAP), and Aspects in Human Liver Cancer<br>Front Biosci (Landmark Ed) (2025) 30, 44837-44837. PubMed  Europe PubMed DOI
  20. Wu,X., Wang,Y., Li,Y. and Hu,W.<br>Recent clinical advances in fibroblast activation protein targeted radioligand therapy for solid tumors<br>Front Nucl Med (2025) 5, 1737443-1737443. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Xu,Z., Sinha,A., Pandya,D.N., Schnicker,N.J. and Wadas,T.J.<br>Cryo-electron microscopy reveals a single domain antibody with a unique binding epitope on fibroblast activation protein alpha<br>RSC Chem Biol (2025) PubMed  Europe PubMed DOI  PMC  EPMC
  22. Yuan,H., Li,H., Wu,T., Tang,S., Wang,Y., Yang,Z., Liu,Y., Zheng,W., Liu,N., Chen,Y. and Zhou,Z.<br>Structural Optimization of Fibroblast Activation Protein Inhibitors Through Zwitterionic and PEG Modification Strategy: Impact on Pharmacokinetics and Tumor Imaging<br>Mol Pharm (2025) 22, 4831-4843. PubMed  Europe PubMed DOI
    23. 2024
  23. Bendre,S., Merkens,H., Kuo,H.T., Ng,P., Wong,A.A.W.L., Lau,W.S., Zhang,Z., Kurkowska,S., Chen,C.C., Uribe,C., Benard,F. and Lin,K.S.<br>Development, preclinical evaluation and preliminary dosimetry profiling of SB03178, a first-of-its-kind benzo[h]quinoline-based fibroblast activation protein-alpha-targeted radiotheranostic for cancer imaging and therapy<br>Eur J Med Chem (2024) 268, 116238-116238. PubMed  Europe PubMed DOI
  24. Chen,Y., Du,J., Meng,X., Wu,L.L., Zhang,Q., Han,X., Zhang,L., Wang,Q. and Hu,H.Y.<br>A self-immobilizing near-infrared fluorogenic probe for in vivo imaging of fibroblast activation protein-alpha<br>Talanta (2024) 278, 126475-126475. PubMed  Europe PubMed DOI
  25. Du,X., Gu,B., Wang,X., Wang,X., Ji,M., Zhang,J., He,S., Xu,X., Yang,Z. and Song,S.<br>Preclinical Evaluation and a Pilot Clinical Positron Emission Tomography Imaging Study of [(68)Ga]Ga-FAPI-FUSCC-II<br>Mol Pharm (2024) 21, 904-915. PubMed  Europe PubMed DOI
  26. Gao,J., Wang,Y., Meng,X., Wang,X., Han,F., Xing,H., Lv,G., Zhang,L., Wu,S., Jiang,X., Yao,Z., Fang,X., Zhang,J. and Bu,W.<br>A FAPalpha-activated MRI nanoprobe for precise grading diagnosis of clinical liver fibrosis<br>Nat Commun (2024) 15, 8036-8036. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Hamacher,R., Pabst,K.M., Cheung,P.F., Heilig,C.E., Hullein,J., Liffers,S.T., Borchert,S., Costa,P.F., Schaarschmidt,B.M., Kessler,L., Miera,M.A., Droste,M., Akbulut,M., Falkenhorst,J., Zarrad,F., Kostbade,K., Mavroeidi,I.A., Glimm,H., Umutlu,L., Schuler,M., Hubschmann,D., Bauer,S., Frohling,S., Herrmann,K., Siveke,J.T., Schildhaus,H.U. and Fendler,W.P.<br>Fibroblast Activation Protein alpha-Directed Imaging and Therapy of Solitary Fibrous Tumor<br>J Nucl Med (2024) 65, 252-257. PubMed  Europe PubMed DOI
  28. Hisada,K., Kaneda-Nakashima,K., Shirakami,Y., Kadonaga,Y., Saito,A., Watabe,T., Feng,S., Ooe,K., Yin,X., Haba,H., Murakami,M., Toyoshima,A., Cardinale,J., Giesel,F.L. and Fukase,K.<br>Comparison Length of Linker in Compound for Nuclear Medicine Targeting Fibroblast Activation Protein as Molecular Target<br>Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC  I
  29. Morandeau,L., Ioppolo,J.A., Alvarez de Eulate,E., Mohamed,S., Cullen,D., Asad,A.H., Francis,R.J. and Atkinson,J.<br>An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use<br>J Vis Exp (2024) PubMed  Europe PubMed DOI
  30. Nakayama,M., Hope,T.A. and Salavati,A.<br>Diagnostic and Therapeutic Application of Fibroblast Activation Protein Inhibitors in Oncologic and Nononcologic Diseases<br>Cancer J (2024) 30, 210-217. PubMed  Europe PubMed DOI  V
  31. Poplawski,S.E., Hallett,R.M., Dornan,M.H., Novakowski,K.E., Pan,S., Belanger,A.P., Nguyen,Q.D., Wu,W., Felten,A.E., Liu,Y., Ahn,S.H., Hergott,V.S., Jones,B., Lai,J.H., McCann,J.A.B. and Bachovchin,W.W.<br>Preclinical Development of PNT6555, a Boronic Acid-Based, Fibroblast Activation Protein-alpha (FAP)-Targeted Radiotheranostic for Imaging and Treatment of FAP-Positive Tumors<br>J Nucl Med (2024) 65, 100-108. PubMed  Europe PubMed DOI  I
  32. Thorn,S.L., Spinale,F.G. and Sinusas,A.J.<br>Imaging Fibroblast Activation Protein: Direct Visualization of Matrix Proteolytic Activity in Patients Post Myocardial Infarction<br>J Am Coll Cardiol (2024) PubMed  Europe PubMed DOI
  33. Yu,Z., Jiang,Z., Cheng,X., Yuan,L., Chen,H., Ai,L. and Wu,Z.<br>Development of fibroblast activation protein-alpha radiopharmaceuticals: Recent advances and perspectives<br>Eur J Med Chem (2024) 277, 116787-116787. PubMed  Europe PubMed DOI
  34. Zhang,X.L., Xiao,W., Qian,J.P., Yang,W.J., Xu,H., Xu,X.D. and Zhang,G.W.<br>The role and application of fibroblast activating protein<br>Curr Mol Med (2024) 24, 1097-1110. PubMed  Europe PubMed DOI
    35. 2023
  35. Bendre,S., Kuo,H.T., Merkens,H., Zhang,Z., Wong,A.A.W.L., Benard,F. and Lin,K.S.<br>Synthesis and Preclinical Evaluation of Novel (68)Ga-Labeled (R)-Pyrrolidin-2-yl-boronic Acid-Based PET Tracers for Fibroblast Activation Protein-Targeted Cancer Imaging<br>Pharmaceuticals (Basel) (2023) 16 PubMed  Europe PubMed DOI  PMC  EPMC  I
  36. Castle,A.R., Kang,S.G., Eskandari-Sedighi,G., Wohlgemuth,S., Nguyen,M.A., Drucker,D.J., Mulvihill,E.E. and Westaway,D.<br>Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein<br>Proc Natl Acad Sci U S A (2023) 120, e2209815120-e2209815120. PubMed  Europe PubMed DOI  PMC  EPMC
  37. DiMagno,S.G. and Babich,J.W.<br>Advanced Fibroblast Activation Protein-Ligand Developments: FAP Imaging Agents: A Review of the Structural Requirements<br>PET Clin (2023) 18, 287-294. PubMed  Europe PubMed DOI
  38. Fan,A., Wu,G., Wang,J., Lu,L., Wang,J., Wei,H., Sun,Y., Xu,Y., Mo,C., Zhang,X., Pang,Z., Pan,Z., Wang,Y., Lu,L., Fu,G., Ma,M., Zhu,Q., Cao,D., Qin,J., Yin,F. and Yue,R.<br>Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression<br>Bone Res (2023) 11, 3-3. PubMed  Europe PubMed DOI  PMC  EPMC
  39. Jin,J., Barnett,J.D., Krishnamachary,B., Mironchik,Y., Luo,C.K., Kobayashi,H. and Bhujwalla,Z.M.<br>Evaluating near-infrared photoimmunotherapy for targeting fibroblast activation protein-alpha expressing cells in vitro and in vivo<br>Cancer Sci (2023) 114, 236-246. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Ora,M., Soni,N., Nazar,A.H., Dixit,M., Singh,R., Puri,S., Graham,M.M. and Gambhir,S.<br>Fibroblast Activation Protein Inhibitor-Based Radionuclide Therapies: Current Status and Future Directions<br>J Nucl Med (2023) 64, 1001-1008. PubMed  Europe PubMed DOI  V
  41. Rezaei,S., Gharapapagh,E., Dabiri,S., Heidari,P. and Aghanejad,A.<br>Theranostics in targeting fibroblast activation protein bearing cells: Progress and challenges<br>Life Sci (2023) 329, 121970-121970. PubMed  Europe PubMed DOI  V
  42. Wang,Z., Wang,J., Lan,T., Zhang,L., Yan,Z., Zhang,N., Xu,Y. and Tao,Q.<br>Role and mechanism of fibroblast-activated protein-alpha expression on the surface of fibroblast-like synoviocytes in rheumatoid arthritis<br>Front Immunol (2023) 14, 1135384-1135384. PubMed  Europe PubMed DOI  PMC  EPMC  V
  43. Weiner,L., Fitzgerald,A., Maynard,R., Marcisak,E., Nasir,A., Glasgow,E., Jablonski,S., Van der Veken,P., Pearson,G., Eisman,S., Mace,E. and Fertig,E.<br>Fibroblast activation protein regulates natural killer cell migration, extravasation and tumor infiltration<br>Res Sq (2023) PubMed  Europe PubMed DOI  PMC  EPMC
    44. 2022
  44. An,J., Hou,D., Wang,L., Wang,L., Yang,Y. and Wang,H.<br>Fibroblast activation protein-alpha knockdown suppresses prostate cancer cell invasion and proliferation<br>Histol Histopathol (2022) , 18430-18430. PubMed  Europe PubMed DOI
  45. Boinapally,S., Lisok,A., Lofland,G., Minn,I., Yan,Y., Jiang,Z., Shin,M.J., Merino,V.F., Zheng,L., Brayton,C., Pomper,M.G. and Banerjee,S.R.<br>Hetero-bivalent agents targeting FAP and PSMA<br>Eur J Nucl Med Mol Imaging (2022) 49, 4369-4381. PubMed  Europe PubMed DOI
  46. Cheng,C.S., Yang,P.W., Sun,Y., Song,S.L. and Chen,Z.<br>Fibroblast activation protein-based theranostics in pancreatic cancer<br>Front Oncol (2022) 12, 969731-969731. PubMed  Europe PubMed DOI  PMC  EPMC  V
  47. Huang,R., Pu,Y., Huang,S., Yang,C., Yang,F., Pu,Y., Li,J., Chen,L. and Huang,Y.<br>FAPI-PET/CT in Cancer Imaging: A Potential Novel Molecule of the Century<br>Front Oncol (2022) 12, 854658-854658. PubMed  Europe PubMed DOI  PMC  EPMC  V
  48. Liu,S.Y., Wang,H. and Nie,G.<br>Ultrasensitive Fibroblast Activation Protein-alpha-Activated Fluorogenic Probe Enables Selective Imaging and Killing of Melanoma In Vivo<br>ACS Sens (2022) 7, 1837-1846. PubMed  Europe PubMed DOI
  49. Plescia,J., Hedou,D., Pousse,M.E., Labarre,A., Dufresne,C., Mittermaier,A. and Moitessier,N.<br>Modulating the selectivity of inhibitors for prolyl oligopeptidase inhibitors and fibroblast activation protein-alpha for different indications<br>Eur J Med Chem (2022) 240, 114543-114543. PubMed  Europe PubMed DOI
  50. Tagirasa,R. and Yoo,E.<br>Role of Serine Proteases at the Tumor-Stroma Interface<br>Front Immunol (2022) 13, 832418-832418. PubMed  Europe PubMed DOI  PMC  EPMC  V
  51. Zhang,L., Ying,W., Sheng,Z., Lv,L., Gao,J., Xue,Y. and Liu,L.<br>Bioluminescence imaging of fibroblast activation protein-alpha in vivo and human plasma with highly sensitive probe<br>Anal Biochem (2022) 655, 114859-114859. PubMed  Europe PubMed DOI
  52. Zhao,L., Chen,J., Pang,Y., Fu,K., Shang,Q., Wu,H., Sun,L., Lin,Q. and Chen,H.<br>Fibroblast activation protein-based theranostics in cancer research: A state-of-the-art review<br>Theranostics (2022) 12, 1557-1569. PubMed  Europe PubMed DOI  PMC  EPMC
    53. 2021
  53. Altmann,A., Haberkorn,U.A. and Siveke,J.<br>The latest developments in imaging fibroblast activation protein (FAP)<br>J Nucl Med (2021) 62, 160-167. PubMed  Europe PubMed DOI
  54. Bughda,R., Dimou,P., D'Souza,R.R. and Klampatsa,A.<br>Fibroblast Activation Protein (FAP)-Targeted CAR-T Cells: Launching an Attack on Tumor Stroma<br>Immunotargets Ther (2021) 10, 313-323. PubMed  Europe PubMed DOI  PMC  EPMC  V
  55. Juillerat-Jeanneret,L., Tafelmeyer,P. and Golshayan,D.<br>Regulation of Fibroblast Activation Protein-alpha Expression: Focus on Intracellular Protein Interactions<br>J Med Chem (2021) PubMed  Europe PubMed DOI
  56. Jung,H.J., Nam,E.H., Park,J.Y., Ghosh,P. and Kim,I.S.<br>Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor<br>Bioorg Med Chem Lett (2021) 37, 127846-127846. PubMed  Europe PubMed DOI  I
  57. Kelly,J.M., Jeitner,T.M., Ponnala,S., Williams,C., Jr., Nikolopoulou,A., DiMagno,S.G. and Babich,J.W.<br>A Trifunctional Theranostic Ligand Targeting Fibroblast Activation Protein-alpha (FAPalpha)<br>Mol Imaging Biol (2021) PubMed  Europe PubMed DOI
  58. Lindner,T., Altmann,A., Giesel,F., Kratochwil,C., Kleist,C., Kramer,S., Mier,W., Cardinale,J., Kauczor,H.U., Jager,D., Debus,J. and Haberkorn,U.<br>(18)F-labeled tracers targeting fibroblast activation protein<br>EJNMMI Radiopharm Chem (2021) 6, 26-26. PubMed  Europe PubMed DOI  PMC  EPMC
  59. Moon,E.S., Van Rymenant,Y., Battan,S., De Loose,J., Bracke,A., Van der Veken,P., De Meester,I. and Rosch,F.<br>In Vitro Evaluation of the Squaramide-Conjugated Fibroblast Activation Protein Inhibitor-Based Agents AAZTA(5).SA.FAPi and DOTA.SA.FAPi<br>Molecules (2021) 26 PubMed  Europe PubMed DOI  PMC  EPMC  I
  60. Simkova,A., Ormsby,T., Sidej,N., Slavetinska,L.P., Brynda,J., Beranova,J., Sacha,P., Majer,P. and Konvalinka,J.<br>Structure-activity relationship and biochemical evaluation of novel fibroblast activation protein and prolyl endopeptidase inhibitors with alpha-ketoamide warheads<br>Eur J Med Chem (2021) 224, 113717-113717. PubMed  Europe PubMed DOI  I
  61. Sun,M., Yao,S., Fan,L., Fang,Z., Miao,W., Hu,Z. and Wang,Z.<br>Fibroblast Activation Protein-alpha Responsive Peptide Assembling Prodrug Nanoparticles for Remodeling the Immunosuppressive Microenvironment and Boosting Cancer Immunotherapy<br>Small (2021) , e2106296-e2106296. PubMed  Europe PubMed DOI
  62. Xi,C.R., Di Fazio,A., Nadvi,N.A., Xiang,M.S.W., Zhang,H.E., Deshpande,C., Chen,Y., Tabar,M.S., Wang,X.M., Bailey,C.G., McCaughan,G.W., Church,W.B. and Gorrell,M.D.<br>An improved production and purification protocol for recombinant soluble human fibroblast activation protein alpha<br>Protein Expr Purif (2021) 181, 105833-105833. PubMed  Europe PubMed DOI
  63. Xin,L., Gao,J., Zheng,Z., Chen,Y., Lv,S., Zhao,Z., Yu,C., Yang,X. and Zhang,R.<br>Fibroblast Activation Protein-alpha as a Target in the Bench-to-Bedside Diagnosis and Treatment of Tumors: A Narrative Review<br>Front Oncol (2021) 11, 648187-648187. PubMed  Europe PubMed DOI  PMC  EPMC  V
  64. Yuan,Z., Hu,H., Zhu,Y., Zhang,W., Fang,Q., Qiao,T., Ma,T., Wang,M., Huang,R., Tang,Q., Gao,F., Zou,C., Gao,X., Wang,G. and Wang,X.<br>Colorectal cancer cell intrinsic fibroblast activation protein alpha binds to Enolase1 and activates NF-kappaB pathway to promote metastasis<br>Cell Death Dis (2021) 12, 543-543. PubMed  Europe PubMed DOI  PMC  EPMC  K
  65. Zhang,X., Chen,D., Babich,J.W., Green,S.J.E., Deng,X.H. and Rodeo,S.A.<br>In Vivo Imaging of Fibroblast Activity Using a 68Ga-Labeled Fibroblast Activation Protein Alpha (FAP-alpha) Inhibitor: Study in a Mouse Rotator Cuff Repair Model<br>J Bone Joint Surg Am (2021) 103, e40-e40. PubMed  Europe PubMed DOI
    66. 2020
  66. Cho,J.M., Yang,E.H., Quan,W., Nam,E.H. and Cheon,H.G.<br>Discovery of a novel fibroblast activation protein (FAP) inhibitor, BR103354, with anti-diabetic and anti-steatotic effects<br>Sci Rep (2020) 10, 21280-21280. PubMed  Europe PubMed DOI  PMC  EPMC  I
  67. Fitzgerald,A.A. and Weiner,L.M.<br>The role of fibroblast activation protein in health and malignancy<br>Cancer Metastasis Rev (2020) PubMed  Europe PubMed DOI  V
  68. Li,F., Wu,X., Sun,Z., Cai,P., Wu,L. and Li,D.<br>Fibroblast Activation Protein-alpha Expressing Fibroblasts Promote Lymph Node Metastasis in Esophageal Squamous Cell Carcinoma<br>Onco Targets Ther (2020) 13, 8141-8148. PubMed  Europe PubMed DOI  PMC  EPMC
  69. Simkova,A., Busek,P., Sedo,A. and Konvalinka,J.<br>Molecular recognition of fibroblast activation protein for diagnostic and therapeutic applications<br>Biochim Biophys Acta Proteins Proteom (2020) , 140409-140409. PubMed  Europe PubMed DOI  I
  70. Solano-Iturri,J.D., Beitia,M., Errarte,P., Calvete-Candenas,J., Etxezarraga,M.C., Loizate,A., Echevarria,E., Badiola,I. and Larrinaga,G.<br>Altered expression of fibroblast activation protein-alpha (FAP) in colorectal adenoma-carcinoma sequence and in lymph node and liver metastases<br>Aging (Albany NY) (2020) 12 PubMed  Europe PubMed DOI
  71. Teng,C., Zhang,B., Yuan,Z., Kuang,Z., Chai,Z., Ren,L., Qin,C., Yang,L., Han,X. and Yin,L.<br>Fibroblast activation protein-alpha-adaptive micelles deliver anti-cancer drugs and reprogram stroma fibrosis<br>Nanoscale (2020) 12, 23756-23767. PubMed  Europe PubMed DOI  I
  72. Wei,H., Xu,Y., Wang,Y., Xu,L., Mo,C., Li,L., Shen,B., Sun,Y., Cheng,P., Yang,L., Pang,Y., Qin,A., Cao,Y., Morrison,S.J. and Yue,R.<br>Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target<br>Cell Rep (2020) 33, 108252-108252. PubMed  Europe PubMed DOI
    73. 2019
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