$VAR1 = undef;

Summary for peptidase S09.007: fibroblast activation protein alpha subunit

Names
MEROPS Name	fibroblast activation protein alpha subunit
Other names	antiplasmin-cleaving enzyme, APCE, FAP alpha, seprase

Domain architecture

MEROPS Classification
Classification	Clan SC >> Subclan (none) >> Family S9 >> Subfamily B >> S09.007
Holotype	fibroblast activation protein alpha subunit (Homo sapiens), Uniprot accession Q12884 (peptidase unit: 498-758), MERNUM MER0000399
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00370
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass () >> Peptidase 3.4.21.B28
Enzymology	BRENDA database
Activity status	human: active (Park & Rettig, 2004) mouse: active (Niedermeyer et al., 1998)
Pharmaceutical relevance	Endopeptidase activity is suggested to contribute to degradation of extracellular matrix proteins in malignant invasion.
Other databases	TREEFAM	http://www.treefam.org/family/TF313309
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	pt/hs/G/Pngs/fqg/ger/Q (based on 10 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	7	0	2	1	4	0
Pro	4	0	0	10	0	0	0	0
Ala	1	0	1	0	0	0	0	0
Val	0	0	0	0	0	0	0	0
Leu	0	0	0	0	1	0	0	0
Ile	0	0	0	0	0	0	0	0
Met	0	1	0	0	0	0	0	0
Phe	0	0	0	0	0	4	0	0
Tyr	0	0	0	0	0	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	0	2	0	0	2	0	0	0
Thr	2	0	0	0	0	0	0	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	3	0	0	0
Gln	0	0	0	0	0	3	0	8
Asp	0	0	0	0	0	0	0	0
Glu	0	0	1	0	0	0	3	0
Lys	0	0	0	0	0	0	0	0
Arg	0	0	0	0	0	0	1	0
His	0	4	0	0	0	0	0	0