Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase S08.090: tripeptidyl-peptidase II

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, P Specificity, K Knockout, V Review, M Mutation, R Splicing, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Zhao,J., He,C., Fan,X., Wang,L., Zhao,L., Liu,H., Shen,W., Jiang,S., Pei,K., Gao,J., Qi,Y., Liu,Y., Zhao,J., Zhang,R., Lu,C., Tong,J. and Huai,J.
    Tripeptidyl peptidase II coordinates the homeostasis of calcium and lipids in the central nervous system and its depletion causes presenile dementia in female mice through calcium/lipid dyshomeostasis-induced autophagic degradation of CYP19A1
    Theranostics14, 1390-1429. PubMed  Europe PubMed DOI
    2. 2021
  2. Stockdale,C., Rice,L., Carter,C., Berry,I., Poulter,J., O'Riordan,S., Pollard,S., Anwar,R., Tooze,R. and Savic,S.
    Novel Case of Tripeptidyl Peptidase 2 Deficiency Associated with Mild Clinical Phenotype
    J Clin Immunol PubMed  Europe PubMed DOI
    3. 2019
  3. Bialy,L.P., Kuckelkorn,U., Henklein,P., Fayet,J., Wilczynski,G.M., Kaminski,A. and Mlynarczuk-Bialy,I.
    Changes in spatio-temporal localization of tripeptidyl peptidase II (TPPII) in murine colon adenocarcinoma cells during aggresome formation: a microscopy study based on a novel fluorescent proteasome inhibitor
    Histol Histopathol34, 359-372. PubMed  Europe PubMed DOI  I
  4. Tomkinson,B.
    Tripeptidyl-peptidase II: update on an oldie that still counts
    Biochimie166, 27-37. PubMed  Europe PubMed DOI  V
    5. 2018
  5. Bialy,L.P., Fayet,J., Wilczynski,G.M. and Mlynarczuk-Bialy,I.
    Semispecific TPPII inhibitor Ala-Ala-Phe-chloromethylketone (AAF-cmk) displays cytotoxic activity by induction of apoptosis, autophagy and protein aggregation in U937 cells
    Folia Histochem Cytobiol56, 185-194. PubMed  Europe PubMed DOI  I
  6. Reinthaler,E.M., Graf,E., Zrzavy,T., Wieland,T., Hotzy,C., Kopecky,C., Pferschy,S., Schmied,C., Leutmezer,F., Keilani,M., Lill,C.M., Hoffjan,S., Epplen,J.T., Zettl,U.K., Hecker,M., Deutschlander,A., Meuth,S.G., Ahram,M., Mustafa,B., El-Khateeb,M., Vilarino-Guell,C., Sadovnick,A.D., Zimprich,F., Tomkinson,B., Strom,T., Kristoferitsch,W., Lassmann,H. and Zimprich,A.
    TPP2 mutation associated with sterile brain inflammation mimicking MS
    Neurol Genet4, e285-e285. PubMed  Europe PubMed DOI  M
  7. Vigneron,N., Ferrari,V., Van den Eynde,B.J., Cresswell,P. and Leonhardt,R.M.
    Cytosolic processing governs TAP-independent presentation of a critical melanoma antigen
    J Immunol201, 1875-1888. PubMed  Europe PubMed DOI  I
    8. 2017
  8. Fukuda,Y., Beck,F., Plitzko,J.M. and Baumeister,W.
    In situ structural studies of tripeptidyl peptidase II (TPPII) reveal spatial association with proteasomes
    Proc Natl Acad Sci U S A114, 4412-4417. PubMed  Europe PubMed DOI  S
  9. Tan,Q., Ma,S., Hu,J., Chen,X., Yu,Y., Tang,Z. and Zang,G.
    Adenovirus vector harboring the HBcAg and tripeptidyl peptidase II genes induces potent cellular immune responses in vivo
    Cell Physiol Biochem41, 423-438. PubMed  Europe PubMed DOI  U
    10. 2016
  10. Shibata,M., Koike,M., Kusumi,S., Sato,N. and Uchiyama,Y.
    A specific tripeptidyl substrate for tripeptidyl peptidase activity is effectively hydrolyzed by alanyl aminopeptidase/aminopeptidase N/CD13 in the rat kidney
    Arch Histol Cytol76, 1-8. DOI
  11. Tan,Q., Ma,S., Hu,J., Chen,X., Yu,Y., Zang,G. and Tang,Z.
    Role of tripeptidyl peptidase II in MHC class I antigen presentation: biological characteristics, cellular crosstalk and signaling
    Biomed Pharmacother84, 1954-1958. PubMed  Europe PubMed DOI  V
    12. 2015
  12. Stepensky,P., Rensing-Ehl,A., Gather,R., Revel-Vilk,S., Fischer,U., Nabhani,S., Beier,F., Brummendorf,T.H., Fuchs,S., Zenke,S., Firat,E., Pessach,V.M., Borkhardt,A., Rakhmanov,M., Keller,B., Warnatz,K., Eibel,H., Niedermann,G., Elpeleg,O. and Ehl,S.
    Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency
    Blood125, 753-761. PubMed  Europe PubMed DOI  K  M
  13. Wiemhoefer,A., Stargardt,A., van der Linden,W.A., Renner,M.C., van Kesteren,R.E., Stap,J., Raspe,M.A., Tomkinson,B., Kessels,H.W., Ovaa,H., Overkleeft,H.S., Florea,B. and Reits,E.A.
    Tripeptidyl peptidase II mediates levels of nuclear phosphorylated ERK1 and ERK2
    Mol Cell Proteomics14, 2177-2193. PubMed  Europe PubMed DOI  I
    14. 2014
  14. Lu,W., Zhang,Y., McDonald,D.O., Jing,H., Carroll,B., Robertson,N., Zhang,Q., Griffin,H., Sanderson,S., Lakey,J.H., Morgan,N.V., Reynard,L.N., Zheng,L., Murdock,H.M., Turvey,S.E., Hackett,S.J., Prestidge,T., Hall,J.M., Cant,A.J., Matthews,H.F., Koref,M.F., Simon,A.K., Korolchuk,V.I., Lenardo,M.J., Hambleton,S. and Su,H.C.
    Dual proteolytic pathways govern glycolysis and immune competence
    Cell159, 1578-1590. PubMed  Europe PubMed DOI
  15. Nahalkova,J. and Tomkinson,B.
    TPPII, MYBBP1A and CDK2 form a protein-protein interaction network
    Arch Biochem Biophys564, 128-135. PubMed  Europe PubMed DOI
    16. 2012
  16. Eklund,S., Dogan,J., Jemth,P., Kalbacher,H. and Tomkinson,B.
    Characterization of the endopeptidase activity of tripeptidyl-peptidase II
    Biochem Biophys Res Commun424, 503-507. PubMed  Europe PubMed DOI  P
  17. Eklund,S., Lindas,A.C., Hamnevik,E., Widersten,M. and Tomkinson,B.
    Exploring the active site of tripeptidyl-peptidase II through studies of pH dependence of reaction kinetics
    Biochim Biophys Acta1824, 561-570. PubMed  Europe PubMed DOI
  18. Eklund,S. and Tomkinson,B.
    Structure, function and evolution of a giant enzyme, tripeptidyl-peptidase II
    Proteomics Res J3, 213-228.  V
  19. Glaeser,R.M.
    Human tripeptidyl peptidase II: a gentle giant
    Structure20, 565-566. PubMed  Europe PubMed DOI  S
  20. Rockel,B., Kopec,K.O., Lupas,A.N. and Baumeister,W.
    Structure and function of tripeptidyl peptidase II, a giant cytosolic protease
    Biochim Biophys Acta1824, 237-245. PubMed  Europe PubMed DOI  V
  21. Schonegge,A.M., Villa,E., Forster,F., Hegerl,R., Peters,J., Baumeister,W. and Rockel,B.
    The structure of human tripeptidyl peptidase II as determined by a hybrid approach
    Structure20, 593-603. PubMed  Europe PubMed DOI  S
  22. Tomkinson,B. and Eklund,S.
    Tripeptidyl-peptidase II
    [ISSN:978-0-12-407742-3]3, 3325-3331. DOI
    23. 2011
  23. Zhang,J., Wong,J., Gao,G. and Luo,H.
    Tripeptidyl peptidase II serves as an alternative to impaired proteasome to maintain viral growth in the host cells
    FEBS Lett585, 261-265. PubMed  Europe PubMed DOI
    24. 2010
  24. Chuang,C.K., Rockel,B., Seyit,G., Walian,P.J., Schonegge,A.M., Peters,J., Zwart,P.H., Baumeister,W. and Jap,B.K.
    Hybrid molecular structure of the giant protease tripeptidyl peptidase II
    Nat Struct Mol Biol17, 990-996. PubMed  Europe PubMed DOI  S
  25. Duensing,S., Darr,S., Cuevas,R., Melquiot,N., Brickner,A.G., Duensing,A. and Munger,K.
    Tripeptidyl peptidase II is required for c-MYC-induced centriole overduplication and a novel therapeutic target in c-MYC-associated neoplasms
    Genes Cancer1, 883-892. PubMed  Europe PubMed DOI  T
  26. Preta,G., de Klark,R., Gavioli,R. and Glas,R.
    The enigma of tripeptidyl-peptidase II: dual roles in housekeeping and stress
    J Oncol2010, 128478-128478. PubMed  Europe PubMed DOI  V
  27. Preta,G., de Klark,R., Chakraborti,S. and Glas,R.
    MAP kinase-signaling controls nuclear translocation of tripeptidyl-peptidase II in response to DNA damage and oxidative stress
    Biochem Biophys Res Commun399, 324-330. PubMed  Europe PubMed DOI
  28. Villasevil,E.M., Guil,S., Lopez-Ferreras,L., Sanchez,C., Del Val,M. and Anton,L.C.
    Accumulation of polyubiquitylated proteins in response to Ala-Ala-Phe-chloromethylketone is independent of the inhibition of tripeptidyl peptidase II
    Biochim Biophys Acta1803, 1094-1105. PubMed  Europe PubMed DOI  I
    29. 2009
  29. Diekmann,J., Adamopoulou,E., Beck,O., Rauser,G., Lurati,S., Tenzer,S., Einsele,H., Rammensee,H.G., Schild,H. and Topp,M.S.
    Processing of two latent membrane protein 1 MHC class I epitopes requires tripeptidyl peptidase II involvement
    J Immunol183, 1587-1597. PubMed  Europe PubMed DOI
  30. Eriksson,S., Gutierrez,O.A., Bjerling,P. and Tomkinson,B.
    Development, evaluation and application of tripeptidyl-peptidase II sequence signatures
    Arch Biochem Biophys484, 39-45. PubMed  Europe PubMed DOI
  31. Firat,E., Tsurumi,C., Gaedicke,S., Huai,J. and Niedermann,G.
    Tripeptidyl peptidase II plays a role in the radiation response of selected primary cell types but not based on nuclear translocation and p53 stabilization
    Cancer Res69, 3325-3331. PubMed  Europe PubMed DOI
  32. Grauling-Halama,S., Bahr,U., Schenk,S. and Geginat,G.
    Role of tripeptidyl peptidase II in the processing of Listeria monocytogenes-derived MHC class I-presented antigenic peptides
    Microbes Infect11, 795-802. PubMed  Europe PubMed DOI
  33. Kawahara,M., York,I.A., Hearn,A., Farfan,D. and Rock,K.L.
    Analysis of the role of tripeptidyl peptidase II in MHC class I antigen presentation in vivo
    J Immunol183, 6069-6077. PubMed  Europe PubMed DOI  K
  34. Preta,G., de Klark,R. and Glas,R.
    A role for nuclear translocation of tripeptidyl-peptidase II in reactive oxygen species-dependent DNA damage responses
    Biochem Biophys Res Commun389, 575-579. PubMed  Europe PubMed DOI
  35. Schnurr,M., Orban,M., Robson,N.C., Shin,A., Braley,H., Airey,D., Cebon,J., Maraskovsky,E. and Endres,S.
    ISCOMATRIX adjuvant induces efficient cross-presentation of tumor antigen by dendritic cells via rapid cytosolic antigen delivery and processing via tripeptidyl peptidase II
    J Immunol182, 1253-1259. PubMed  Europe PubMed
  36. Tsurumi,C., Firat,E., Gaedicke,S., Huai,J., Mandal,P.K. and Niedermann,G.
    Viability and DNA damage responses of TPPII-deficient Myc- and Ras-transformed fibroblasts
    Biochem Biophys Res Commun386, 563-568. PubMed  Europe PubMed DOI
    37. 2008
  37. Endert,P.
    Role of tripeptidyl peptidase II in MHC class I antigen processing - the end of controversies?
    Eur J Immunol38, 609-613. PubMed  Europe PubMed DOI
  38. Huai,J., Firat,E., Nil,A., Million,D., Gaedicke,S., Kanzler,B., Freudenberg,M., van Endert,P., Kohler,G., Pahl,H.L., Aichele,P., Eichmann,K. and Niedermann,G.
    Activation of cellular death programs associated with immunosenescence-like phenotype in TPPII knockout mice
    Proc Natl Acad Sci U S A105, 5177-5182. PubMed  Europe PubMed DOI  K
  39. Lindas,A.C., Eriksson,S., Jozsa,E. and Tomkinson,B.
    Investigation of a role for Glu-331 and Glu-305 in substrate binding of tripeptidyl-peptidase II
    Biochim Biophys Acta1784, 1899-1907. PubMed  Europe PubMed DOI
  40. Marcilla,M., Villasevil,E.M. and de Castro,J.A.
    Tripeptidyl peptidase II is dispensable for the generation of both proteasome-dependent and proteasome-independent ligands of HLA-B27 and other class I molecules
    Eur J Immunol38, 631-639. PubMed  Europe PubMed DOI  I
  41. Rockel,B. and Baumeister,W.
    A tale of two giant proteases
    Ernst Schering Found Symp Proc2008, 17-40. PubMed  Europe PubMed  V
    42. 2007
  42. Basler,M. and Groettrup,M.
    No essential role for tripeptidyl peptidase II for the processing of LCMV-derived T cell epitopes
    Eur J Immunol37, 896-904. PubMed  Europe PubMed DOI
  43. Firat,E., Huai,J., Saveanu,L., Gaedicke,S., Aichele,P., Eichmann,K., van Endert,P. and Niedermann,G.
    Analysis of direct and cross-presentation of antigens in TPPII knockout mice
    J Immunol179, 8137-8145. PubMed  Europe PubMed  K
  44. McKay,R.M., McKay,J.P., Suh,J.M., Avery,L. and Graff,J.M.
    Tripeptidyl peptidase II promotes fat formation in a conserved fashion
    EMBO Rep8, 1183-1189. PubMed  Europe PubMed DOI  K
  45. Poole,C.B., Jin,J. and McReynolds,L.A.
    Subtilisin-like proteases in nematodes
    Mol Biochem Parasitol155, 1-8. PubMed  Europe PubMed DOI
    46. 2006
  46. Guil,S., Rodriguez-Castro,M., Aguilar,F., Villasevil,E.M., Anton,L.C. and Del Val,M.
    Need for tripeptidyl-peptidase II in major histocompatibility complex class I viral antigen processing when proteasomes are detrimental
    J Biol Chem281, 39925-39934. PubMed  Europe PubMed DOI
  47. [YEAR:1-9-2006]Seyit,G., Rockel,B., Baumeister,W. and Peters,J.
    Size matters for the tripeptidylpeptidase II complex from Drosophila: the 6-MDa spindle form stabilizes the activated state
    J Biol Chem281, 25723-25733. PubMed  Europe PubMed DOI
  48. Stavropoulou,V., Vasquez,V., Cereser,B., Freda,E. and Masucci,M.G.
    TPPII promotes genetic instability by allowing the escape from apoptosis of cells with activated mitotic checkpoints
    Biochem Biophys Res Commun346, 415-425. PubMed  Europe PubMed DOI
  49. [YEAR:1-8-2006]York,I.A., Bhutani,N., Zendzian,S., Goldberg,A.L. and Rock,K.L.
    Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation
    J Immunol177, 1434-1443. PubMed  Europe PubMed
    50. 2005
  50. [YEAR:20-5-2005]Book,A.J., Yang,P., Scalf,M., Smith,L.M. and Vierstra,R.D.
    Tripeptidyl peptidase II. An oligomeric protease complex from Arabidopsis
    Plant Physiol138, 1046-1057. PubMed  Europe PubMed DOI  I
  51. Chand,A., Wyke,S.M. and Tisdale,M.J.
    Effect of cancer cachexia on the activity of tripeptidyl-peptidase II in skeletal muscle
    Cancer Lett218, 215-222. PubMed  Europe PubMed DOI
  52. De Winter,H., Breslin,H., Miskowski,T., Kavash,R. and Somers,M.
    Inhibitor-based validation of a homology model of the active-site of tripeptidyl peptidase II
    J Mol Graph Model23, 409-418. PubMed  Europe PubMed DOI
  53. [YEAR:17-11-2005]Ganellin,C.R., Bishop,P.B., Bambal,R.B., Chan,S.M., Leblond,B., Moore,A.N., Zhao,L., Bourgeat,P., Rose,C., Vargas,F. and Schwartz,J.C.
    Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors
    J Med Chem48, 7333-7342. PubMed  Europe PubMed DOI  I
  54. [YEAR:5-1-2005]Lindas,A.C. and Tomkinson,B.
    Identification and characterization of the promoter for the gene encoding human tripeptidyl-peptidase II
    Gene345, 249-257. PubMed  Europe PubMed DOI
  55. [YEAR:19-7-2005]Rockel,B., Peters,J., Muller,S.A., Seyit,G., Ringler,P., Hegerl,R., Glaeser,R.M. and Baumeister,W.
    Molecular architecture and assembly mechanism of Drosophila tripeptidyl peptidase II
    Proc Natl Acad Sci U S A102, 10135-10140. PubMed  Europe PubMed DOI
  56. [YEAR:15-2-2005]Stavropoulou,V., Xie,J., Henriksson,M., Tomkinson,B., Imreh,S. and Masucci,M.G.
    Mitotic infidelity and centrosome duplication errors in cells overexpressing tripeptidyl-peptidase II
    Cancer Res65, 1361-1368. PubMed  Europe PubMed DOI
  57. Tomkinson,B. and Lindas,A.C.
    Tripeptidyl-peptidase II: a multi-purpose peptidase
    Int J Biochem Cell Biol37, 1933-1937. PubMed  Europe PubMed DOI  V
    58. 2004
  58. Kloetzel,P.M.
    Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII
    Nat Immunol5, 661-669. PubMed  Europe PubMed DOI
  59. Reits,E., Neijssen,J., Herberts,C., Benckhuijsen,W., Janssen,L., Drijfhout,J.W. and Neefjes,J.
    A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation
    Immunity20, 495-506. PubMed  Europe PubMed DOI
  60. Tomkinson,B.
    Tripeptidyl-peptidase II
    [ISSN:0-12-079610-4]2, 1882-1885.  V
    61. 2003
  61. [YEAR:15-12-2003]Breslin,H.J., Miskowski,T.A., Kukla,M.J., De Winter,H.L., Somers,M.V., Roevens,P.W. and Kavash,R.W.
    Tripeptidyl-peptidase II (TPP II) inhibitory activity of (S)-2,3-dihydro-2-(1H-imidazol-2-yl)-1H-indoles, a systematic SAR evaluation. Part 2
    Bioorg Med Chem Lett13, 4467-4471. PubMed  Europe PubMed DOI  I
  62. Hong,X., Lei,L. and Glas,R.
    Tumors acquire inhibitor of apoptosis protein (IAP)-mediated apoptosis resistance through altered specificity of cytosolic proteolysis
    J Exp Med197, 1731-1743. PubMed  Europe PubMed DOI
  63. Seifert,U., Maranon,C., Shmueli,A., Desoutter,J.F., Wesoloski,L., Janek,K., Henklein,P., Diescher,S., Andrieu,M., de la Salle,H., Weinschenk,T., Schild,H., Laderach,D., Galy,A., Haas,G., Kloetzel,P.M., Reiss,Y. and Hosmalin,A.
    An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope
    Nat Immunol4, 375-379. PubMed  Europe PubMed DOI
    64. 2002
  64. [YEAR:21-11-2002]Breslin,H.J., Miskowski,T.A., Kukla,M.J., Leister,W.H., De Winter,H.L., Gauthier,D.A., Somers,M.V., Peeters,D.C. and Roevens,P.W.
    Design, synthesis, and tripeptidyl peptidase II inhibitory activity of a novel series of (S)-2,3-dihydro-2-(4-alkyl-1H-imidazol-2-yl)-1H-indoles
    J Med Chem45, 5303-5310. PubMed  Europe PubMed DOI  I
  65. [YEAR:16-12-2002]Hilbi,H., Jozsa,E. and Tomkinson,B.
    Identification of the catalytic triad in tripeptidyl-peptidase II through site-directed mutagenesis
    Biochim Biophys Acta1601, 149-154. PubMed  Europe PubMed DOI
  66. [YEAR:15-10-2002]Levy,F., Burri,L., Morel,S., Peitrequin,A.L., Levy,N., Bachi,A., Hellman,U., Van den Eynde,B.J. and Servis,C.
    The final N-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases
    J Immunol169, 4161-4171. PubMed  Europe PubMed
  67. [YEAR:15-11-2002]Rockel,B., Peters,J., Kuhlmorgen,B., Glaeser,R.M. and Baumeister,W.
    A giant protease with a twist: the TPP II complex from Drosophila studied by electron microscopy
    EMBO J21, 5979-5984. PubMed  Europe PubMed DOI  S
  68. Tomkinson,B., Ni Laoi,B. and Wellington,K.
    The insert within the catalytic domain of tripeptidyl-peptidase II is important for the formation of the active complex
    Eur J Biochem269, 1438-1443. PubMed  Europe PubMed DOI
  69. [YEAR:9-8-2002]Wray,C.J., Tomkinson,B., Robb,B.W. and Hasselgren,P.O.
    Tripeptidyl-peptidase II expression and activity are increased in skeletal muscle during sepsis
    Biochem Biophys Res Commun296, 41-47. PubMed  Europe PubMed DOI
    70. 2001
  70. Bury,M., Mlynarczuk,I., Pleban,E., Hoser,G., Kawiak,J. and Wojcik,C.
    Effects of an inhibitor of tripeptidyl peptidase II (Ala-Ala-Phe-chloromethylketone) and its combination with an inhibitor of the chymotrypsin-like activity of the proteasome (PSI) on apoptosis, cell cycle and proteasome activity in U937 cells
    Folia Histochem Cytobiol39, 131-132. PubMed  Europe PubMed  I
    71. 2000
  71. [YEAR:24-2-2000]Ganellin,C.R., Bishop,P.B., Bambal,R.B., Chan,S.M., Law,J.K., Marabout,B., Luthra,P.M., Moore,A.N., Peschard,O., Bourgeat,P., Rose,C., Vargas,F. and Schwartz,J.C.
    Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors
    J Med Chem43, 664-674. PubMed  Europe PubMed DOI  I
  72. Hilbi,H., Puro,R.J. and Zychlinsky,A.
    Tripeptidyl peptidase II promotes maturation of caspase-1 in Shigella flexneri-induced macrophage apoptosis
    Infect Immun68, 5502-5508. PubMed  Europe PubMed DOI  I
  73. [YEAR:15-4-2000]Tomkinson,B.
    Association and dissociation of the tripeptidyl-peptidase II complex as a way of regulating the enzyme activity
    Arch Biochem Biophys376, 275-280. PubMed  Europe PubMed DOI
  74. [YEAR:29-8-2000]Wang,E.W., Kessler,B.M., Borodovsky,A., Cravatt,B.F., Bogyo,M., Ploegh,H.L. and Glas,R.
    Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity
    Proc Natl Acad Sci U S A97, 9990-9995. PubMed  Europe PubMed DOI
    75. 1999
  75. Facchinetti,P., Rose,C., Rostaing,P., Triller,A. and Schwartz,J.C.
    Immunolocalization of tripeptidyl peptidase II, a cholecystokinin-inactivating enzyme, in rat brain
    Neuroscience88, 1225-1240. PubMed  Europe PubMed DOI
  76. [YEAR:12-2-1999]Geier,E., Pfeifer,G., Wilm,M., Lucchiari-Hartz,M., Baumeister,W., Eichmann,K. and Niedermann,G.
    A giant protease with potential to substitute for some functions of the proteasome
    Science283, 978-981. PubMed  Europe PubMed DOI
  77. Tomkinson,B.
    Tripeptidyl peptidases: enzymes that count
    Trends Biochem Sci24, 355-359. PubMed  Europe PubMed DOI
  78. Yao,T. and Cohen,R.E.
    Giant proteases: beyond the proteasome
    Curr Biol9, R551-R553. PubMed  Europe PubMed DOI
    79. 1998
  79. [YEAR:24-7-1998]Renn,S.C., Tomkinson,B. and Taghert,P.H.
    Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster
    J Biol Chem273, 19173-19182. PubMed  Europe PubMed DOI
    80. 1997
  80. Tomkinson,B., Hansen,M. and Cheung,W.F.
    Structure-function studies of recombinant murine tripeptidyl-peptidase II: the extra domain which is subject to alternative splicing is involved in complex formation
    FEBS Lett405, 277-280. PubMed  Europe PubMed DOI  R
    81. 1996
  81. Rose,C., Vargas,F., Facchinetti,P., Bourgeat,P., Bambal,R.B., Bishop,P.B., Chan,S.M., Moore,A.N., Ganellin,C.R. and Schwartz,J.C.
    Characterization and inhibition of a cholecystokinin-inactivating serine peptidase
    Nature380, 403-409. PubMed  Europe PubMed DOI  I
    82. 1994
  82. Tomkinson,B.
    Characterization of cDNA for murine tripeptidyl-peptidase II reveals alternative splicing
    Biochem J304, 517-523. PubMed  Europe PubMed
  83. [YEAR:1-11-1994]Tomkinson,B., Grehn,L., Fransson,B. and Zetterqvist,O.
    Use of a dehydroalanine-containing peptide as an efficient inhibitor of tripeptidyl peptidase II
    Arch Biochem Biophys314, 276-279. PubMed  Europe PubMed DOI  I
    84. 1990
  84. Tomkinson,B. and Zetterqvist,O.
    Immunological cross-reactivity between human tripeptidyl peptidase II and fibronectin
    Biochem J267, 149-154. PubMed  Europe PubMed
    85. 1987
  85. [YEAR:15-11-1987]Macpherson,E., Tomkinson,B., Balow,R.M., Hoglund,S. and Zetterqvist,O.
    Supramolecular structure of tripeptidyl peptidase II from human erythrocytes as studied by electron microscopy, and its correlation to enzyme activity
    Biochem J248, 259-263. PubMed  Europe PubMed
  86. Nyberg,F., Balow,R.M., Tomkinson,B. and Zetterqvist,O.
    Degradation of Leu- and Met-enkephalin and their C-terminal extensions by tripeptidyl peptidase II
    193-196.
  87. Tomkinson,B., Wernstedt,C., Hellman,U. and Zetterqvist,O.
    Active site of tripeptidyl peptidase II from human erythrocytes is of the subtilisin type
    Proc Natl Acad Sci U S A84, 7508-7512. PubMed  Europe PubMed
    88. 1986
  88. Balow,R.M., Tomkinson,B., Ragnarsson,U. and Zetterqvist,O.
    Purification, substrate specificity, and classification of tripeptidyl peptidase II
    J Biol Chem261, 2409-2417. PubMed  Europe PubMed
    89. 1983
  89. [YEAR:10-10-1983]Balow,R.M., Ragnarsson,U. and Zetterqvist,O.
    Tripeptidyl aminopeptidase in the extralysosomal fraction of rat liver
    J Biol Chem258, 11622-11628. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use