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Literature for peptidase S08.090: tripeptidyl-peptidase II

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, P Specificity, K Knockout, V Review, M Mutation, R Splicing, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Zhao,J., He,C., Fan,X., Wang,L., Zhao,L., Liu,H., Shen,W., Jiang,S., Pei,K., Gao,J., Qi,Y., Liu,Y., Zhao,J., Zhang,R., Lu,C., Tong,J. and Huai,J.<br>Tripeptidyl peptidase II coordinates the homeostasis of calcium and lipids in the central nervous system and its depletion causes presenile dementia in female mice through calcium/lipid dyshomeostasis-induced autophagic degradation of CYP19A1<br>Theranostics (2024) 14, 1390-1429. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2021
  2. Stockdale,C., Rice,L., Carter,C., Berry,I., Poulter,J., O'Riordan,S., Pollard,S., Anwar,R., Tooze,R. and Savic,S.<br>Novel Case of Tripeptidyl Peptidase 2 Deficiency Associated with Mild Clinical Phenotype<br>J Clin Immunol (2021) PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2019
  3. Bialy,L.P., Kuckelkorn,U., Henklein,P., Fayet,J., Wilczynski,G.M., Kaminski,A. and Mlynarczuk-Bialy,I.<br>Changes in spatio-temporal localization of tripeptidyl peptidase II (TPPII) in murine colon adenocarcinoma cells during aggresome formation: a microscopy study based on a novel fluorescent proteasome inhibitor<br>Histol Histopathol (2019) 34, 359-372. PubMed  Europe PubMed DOI  I
  4. Tomkinson,B.<br>Tripeptidyl-peptidase II: update on an oldie that still counts<br>Biochimie (2019) 166, 27-37. PubMed  Europe PubMed DOI  V
    5. 2018
  5. Bialy,L.P., Fayet,J., Wilczynski,G.M. and Mlynarczuk-Bialy,I.<br>Semispecific TPPII inhibitor Ala-Ala-Phe-chloromethylketone (AAF-cmk) displays cytotoxic activity by induction of apoptosis, autophagy and protein aggregation in U937 cells<br>Folia Histochem Cytobiol (2018) 56, 185-194. PubMed  Europe PubMed DOI  I
  6. Reinthaler,E.M., Graf,E., Zrzavy,T., Wieland,T., Hotzy,C., Kopecky,C., Pferschy,S., Schmied,C., Leutmezer,F., Keilani,M., Lill,C.M., Hoffjan,S., Epplen,J.T., Zettl,U.K., Hecker,M., Deutschlander,A., Meuth,S.G., Ahram,M., Mustafa,B., El-Khateeb,M., Vilarino-Guell,C., Sadovnick,A.D., Zimprich,F., Tomkinson,B., Strom,T., Kristoferitsch,W., Lassmann,H. and Zimprich,A.<br>TPP2 mutation associated with sterile brain inflammation mimicking MS<br>Neurol Genet (2018) 4, e285-e285. PubMed  Europe PubMed DOI  PMC  EPMC  M
  7. Vigneron,N., Ferrari,V., Van den Eynde,B.J., Cresswell,P. and Leonhardt,R.M.<br>Cytosolic processing governs TAP-independent presentation of a critical melanoma antigen<br>J Immunol (2018) 201, 1875-1888. PubMed  Europe PubMed DOI  I
    8. 2017
  8. Fukuda,Y., Beck,F., Plitzko,J.M. and Baumeister,W.<br>In situ structural studies of tripeptidyl peptidase II (TPPII) reveal spatial association with proteasomes<br>Proc Natl Acad Sci U S A (2017) 114, 4412-4417. PubMed  Europe PubMed DOI  S
  9. Tan,Q., Ma,S., Hu,J., Chen,X., Yu,Y., Tang,Z. and Zang,G.<br>Adenovirus vector harboring the HBcAg and tripeptidyl peptidase II genes induces potent cellular immune responses in vivo<br>Cell Physiol Biochem (2017) 41, 423-438. PubMed  Europe PubMed DOI  U
    10. 2016
  10. Shibata,M., Koike,M., Kusumi,S., Sato,N. and Uchiyama,Y.<br>A specific tripeptidyl substrate for tripeptidyl peptidase activity is effectively hydrolyzed by alanyl aminopeptidase/aminopeptidase N/CD13 in the rat kidney<br>Arch Histol Cytol (2016) 76, 1-8. DOI
  11. Tan,Q., Ma,S., Hu,J., Chen,X., Yu,Y., Zang,G. and Tang,Z.<br>Role of tripeptidyl peptidase II in MHC class I antigen presentation: biological characteristics, cellular crosstalk and signaling<br>Biomed Pharmacother (2016) 84, 1954-1958. PubMed  Europe PubMed DOI  V
    12. 2015
  12. Stepensky,P., Rensing-Ehl,A., Gather,R., Revel-Vilk,S., Fischer,U., Nabhani,S., Beier,F., Brummendorf,T.H., Fuchs,S., Zenke,S., Firat,E., Pessach,V.M., Borkhardt,A., Rakhmanov,M., Keller,B., Warnatz,K., Eibel,H., Niedermann,G., Elpeleg,O. and Ehl,S.<br>Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency<br>Blood (2015) 125, 753-761. PubMed  Europe PubMed DOI  K  M
  13. Wiemhoefer,A., Stargardt,A., van der Linden,W.A., Renner,M.C., van Kesteren,R.E., Stap,J., Raspe,M.A., Tomkinson,B., Kessels,H.W., Ovaa,H., Overkleeft,H.S., Florea,B. and Reits,E.A.<br>Tripeptidyl peptidase II mediates levels of nuclear phosphorylated ERK1 and ERK2<br>Mol Cell Proteomics (2015) 14, 2177-2193. PubMed  Europe PubMed DOI  I
    14. 2014
  14. Lu,W., Zhang,Y., McDonald,D.O., Jing,H., Carroll,B., Robertson,N., Zhang,Q., Griffin,H., Sanderson,S., Lakey,J.H., Morgan,N.V., Reynard,L.N., Zheng,L., Murdock,H.M., Turvey,S.E., Hackett,S.J., Prestidge,T., Hall,J.M., Cant,A.J., Matthews,H.F., Koref,M.F., Simon,A.K., Korolchuk,V.I., Lenardo,M.J., Hambleton,S. and Su,H.C.<br>Dual proteolytic pathways govern glycolysis and immune competence<br>Cell (2014) 159, 1578-1590. PubMed  Europe PubMed DOI
  15. Nahalkova,J. and Tomkinson,B.<br>TPPII, MYBBP1A and CDK2 form a protein-protein interaction network<br>Arch Biochem Biophys (2014) 564, 128-135. PubMed  Europe PubMed DOI
    16. 2012
  16. Eklund,S., Dogan,J., Jemth,P., Kalbacher,H. and Tomkinson,B.<br>Characterization of the endopeptidase activity of tripeptidyl-peptidase II<br>Biochem Biophys Res Commun (2012) 424, 503-507. PubMed  Europe PubMed DOI  P
  17. Eklund,S., Lindas,A.C., Hamnevik,E., Widersten,M. and Tomkinson,B.<br>Exploring the active site of tripeptidyl-peptidase II through studies of pH dependence of reaction kinetics<br>Biochim Biophys Acta (2012) 1824, 561-570. PubMed  Europe PubMed DOI
  18. Eklund,S. and Tomkinson,B.<br>Structure, function and evolution of a giant enzyme, tripeptidyl-peptidase II<br>Proteomics Res J (2012) 3, 213-228.  V
  19. Glaeser,R.M.<br>Human tripeptidyl peptidase II: a gentle giant<br>Structure (2012) 20, 565-566. PubMed  Europe PubMed DOI  S
  20. Rockel,B., Kopec,K.O., Lupas,A.N. and Baumeister,W.<br>Structure and function of tripeptidyl peptidase II, a giant cytosolic protease<br>Biochim Biophys Acta (2012) 1824, 237-245. PubMed  Europe PubMed DOI  V
  21. Schonegge,A.M., Villa,E., Forster,F., Hegerl,R., Peters,J., Baumeister,W. and Rockel,B.<br>The structure of human tripeptidyl peptidase II as determined by a hybrid approach<br>Structure (2012) 20, 593-603. PubMed  Europe PubMed DOI  S
  22. Tomkinson,B. and Eklund,S.<br>Tripeptidyl-peptidase II<br>[ISSN:978-0-12-407742-3] (2012) 3, 3325-3331. DOI
    23. 2011
  23. Zhang,J., Wong,J., Gao,G. and Luo,H.<br>Tripeptidyl peptidase II serves as an alternative to impaired proteasome to maintain viral growth in the host cells<br>FEBS Lett (2011) 585, 261-265. PubMed  Europe PubMed DOI
    24. 2010
  24. Chuang,C.K., Rockel,B., Seyit,G., Walian,P.J., Schonegge,A.M., Peters,J., Zwart,P.H., Baumeister,W. and Jap,B.K.<br>Hybrid molecular structure of the giant protease tripeptidyl peptidase II<br>Nat Struct Mol Biol (2010) 17, 990-996. PubMed  Europe PubMed DOI  S
  25. Duensing,S., Darr,S., Cuevas,R., Melquiot,N., Brickner,A.G., Duensing,A. and Munger,K.<br>Tripeptidyl peptidase II is required for c-MYC-induced centriole overduplication and a novel therapeutic target in c-MYC-associated neoplasms<br>Genes Cancer (2010) 1, 883-892. PubMed  Europe PubMed DOI  T
  26. Preta,G., de Klark,R., Chakraborti,S. and Glas,R.<br>MAP kinase-signaling controls nuclear translocation of tripeptidyl-peptidase II in response to DNA damage and oxidative stress<br>Biochem Biophys Res Commun (2010) 399, 324-330. PubMed  Europe PubMed DOI
  27. Preta,G., de Klark,R., Gavioli,R. and Glas,R.<br>The enigma of tripeptidyl-peptidase II: dual roles in housekeeping and stress<br>J Oncol (2010) 2010, 128478-128478. PubMed  Europe PubMed DOI  PMC  EPMC  V
  28. Villasevil,E.M., Guil,S., Lopez-Ferreras,L., Sanchez,C., Del Val,M. and Anton,L.C.<br>Accumulation of polyubiquitylated proteins in response to Ala-Ala-Phe-chloromethylketone is independent of the inhibition of tripeptidyl peptidase II<br>Biochim Biophys Acta (2010) 1803, 1094-1105. PubMed  Europe PubMed DOI  I
    29. 2009
  29. Diekmann,J., Adamopoulou,E., Beck,O., Rauser,G., Lurati,S., Tenzer,S., Einsele,H., Rammensee,H.G., Schild,H. and Topp,M.S.<br>Processing of two latent membrane protein 1 MHC class I epitopes requires tripeptidyl peptidase II involvement<br>J Immunol (2009) 183, 1587-1597. PubMed  Europe PubMed DOI
  30. Eriksson,S., Gutierrez,O.A., Bjerling,P. and Tomkinson,B.<br>Development, evaluation and application of tripeptidyl-peptidase II sequence signatures<br>Arch Biochem Biophys (2009) 484, 39-45. PubMed  Europe PubMed DOI
  31. Firat,E., Tsurumi,C., Gaedicke,S., Huai,J. and Niedermann,G.<br>Tripeptidyl peptidase II plays a role in the radiation response of selected primary cell types but not based on nuclear translocation and p53 stabilization<br>Cancer Res (2009) 69, 3325-3331. PubMed  Europe PubMed DOI
  32. Grauling-Halama,S., Bahr,U., Schenk,S. and Geginat,G.<br>Role of tripeptidyl peptidase II in the processing of Listeria monocytogenes-derived MHC class I-presented antigenic peptides<br>Microbes Infect (2009) 11, 795-802. PubMed  Europe PubMed DOI
  33. Kawahara,M., York,I.A., Hearn,A., Farfan,D. and Rock,K.L.<br>Analysis of the role of tripeptidyl peptidase II in MHC class I antigen presentation in vivo<br>J Immunol (2009) 183, 6069-6077. PubMed  Europe PubMed DOI  K
  34. Preta,G., de Klark,R. and Glas,R.<br>A role for nuclear translocation of tripeptidyl-peptidase II in reactive oxygen species-dependent DNA damage responses<br>Biochem Biophys Res Commun (2009) 389, 575-579. PubMed  Europe PubMed DOI
  35. Schnurr,M., Orban,M., Robson,N.C., Shin,A., Braley,H., Airey,D., Cebon,J., Maraskovsky,E. and Endres,S.<br>ISCOMATRIX adjuvant induces efficient cross-presentation of tumor antigen by dendritic cells via rapid cytosolic antigen delivery and processing via tripeptidyl peptidase II<br>J Immunol (2009) 182, 1253-1259. PubMed  Europe PubMed
  36. Tsurumi,C., Firat,E., Gaedicke,S., Huai,J., Mandal,P.K. and Niedermann,G.<br>Viability and DNA damage responses of TPPII-deficient Myc- and Ras-transformed fibroblasts<br>Biochem Biophys Res Commun (2009) 386, 563-568. PubMed  Europe PubMed DOI
    37. 2008
  37. Endert,P.<br>Role of tripeptidyl peptidase II in MHC class I antigen processing - the end of controversies?<br>Eur J Immunol (2008) 38, 609-613. PubMed  Europe PubMed DOI
  38. Huai,J., Firat,E., Nil,A., Million,D., Gaedicke,S., Kanzler,B., Freudenberg,M., van Endert,P., Kohler,G., Pahl,H.L., Aichele,P., Eichmann,K. and Niedermann,G.<br>Activation of cellular death programs associated with immunosenescence-like phenotype in TPPII knockout mice<br>Proc Natl Acad Sci U S A (2008) 105, 5177-5182. PubMed  Europe PubMed DOI  PMC  EPMC  K
  39. Lindas,A.C., Eriksson,S., Jozsa,E. and Tomkinson,B.<br>Investigation of a role for Glu-331 and Glu-305 in substrate binding of tripeptidyl-peptidase II<br>Biochim Biophys Acta (2008) 1784, 1899-1907. PubMed  Europe PubMed DOI
  40. Marcilla,M., Villasevil,E.M. and de Castro,J.A.<br>Tripeptidyl peptidase II is dispensable for the generation of both proteasome-dependent and proteasome-independent ligands of HLA-B27 and other class I molecules<br>Eur J Immunol (2008) 38, 631-639. PubMed  Europe PubMed DOI  I
  41. Rockel,B. and Baumeister,W.<br>A tale of two giant proteases<br>Ernst Schering Found Symp Proc (2008) 2008, 17-40. PubMed  Europe PubMed  V
    42. 2007
  42. Basler,M. and Groettrup,M.<br>No essential role for tripeptidyl peptidase II for the processing of LCMV-derived T cell epitopes<br>Eur J Immunol (2007) 37, 896-904. PubMed  Europe PubMed DOI
  43. Firat,E., Huai,J., Saveanu,L., Gaedicke,S., Aichele,P., Eichmann,K., van Endert,P. and Niedermann,G.<br>Analysis of direct and cross-presentation of antigens in TPPII knockout mice<br>J Immunol (2007) 179, 8137-8145. PubMed  Europe PubMed  K
  44. McKay,R.M., McKay,J.P., Suh,J.M., Avery,L. and Graff,J.M.<br>Tripeptidyl peptidase II promotes fat formation in a conserved fashion<br>EMBO Rep (2007) 8, 1183-1189. PubMed  Europe PubMed DOI  PMC  EPMC  K
  45. Poole,C.B., Jin,J. and McReynolds,L.A.<br>Subtilisin-like proteases in nematodes<br>Mol Biochem Parasitol (2007) 155, 1-8. PubMed  Europe PubMed DOI
    46. 2006
  46. Guil,S., Rodriguez-Castro,M., Aguilar,F., Villasevil,E.M., Anton,L.C. and Del Val,M.<br>Need for tripeptidyl-peptidase II in major histocompatibility complex class I viral antigen processing when proteasomes are detrimental<br>J Biol Chem (2006) 281, 39925-39934. PubMed  Europe PubMed DOI
  47. [YEAR:1-9-2006]Seyit,G., Rockel,B., Baumeister,W. and Peters,J.<br>Size matters for the tripeptidylpeptidase II complex from Drosophila: the 6-MDa spindle form stabilizes the activated state<br>J Biol Chem (1-9-2006) 281, 25723-25733. PubMed  Europe PubMed DOI
  48. Stavropoulou,V., Vasquez,V., Cereser,B., Freda,E. and Masucci,M.G.<br>TPPII promotes genetic instability by allowing the escape from apoptosis of cells with activated mitotic checkpoints<br>Biochem Biophys Res Commun (2006) 346, 415-425. PubMed  Europe PubMed DOI
  49. [YEAR:1-8-2006]York,I.A., Bhutani,N., Zendzian,S., Goldberg,A.L. and Rock,K.L.<br>Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation<br>J Immunol (1-8-2006) 177, 1434-1443. PubMed  Europe PubMed
    50. 2005
  50. [YEAR:20-5-2005]Book,A.J., Yang,P., Scalf,M., Smith,L.M. and Vierstra,R.D.<br>Tripeptidyl peptidase II. An oligomeric protease complex from Arabidopsis<br>Plant Physiol (20-5-2005) 138, 1046-1057. PubMed  Europe PubMed DOI  PMC  EPMC  I
  51. Chand,A., Wyke,S.M. and Tisdale,M.J.<br>Effect of cancer cachexia on the activity of tripeptidyl-peptidase II in skeletal muscle<br>Cancer Lett (2005) 218, 215-222. PubMed  Europe PubMed DOI
  52. De Winter,H., Breslin,H., Miskowski,T., Kavash,R. and Somers,M.<br>Inhibitor-based validation of a homology model of the active-site of tripeptidyl peptidase II<br>J Mol Graph Model (2005) 23, 409-418. PubMed  Europe PubMed DOI
  53. [YEAR:17-11-2005]Ganellin,C.R., Bishop,P.B., Bambal,R.B., Chan,S.M., Leblond,B., Moore,A.N., Zhao,L., Bourgeat,P., Rose,C., Vargas,F. and Schwartz,J.C.<br>Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors<br>J Med Chem (17-11-2005) 48, 7333-7342. PubMed  Europe PubMed DOI  I
  54. [YEAR:5-1-2005]Lindas,A.C. and Tomkinson,B.<br>Identification and characterization of the promoter for the gene encoding human tripeptidyl-peptidase II<br>Gene (5-1-2005) 345, 249-257. PubMed  Europe PubMed DOI
  55. [YEAR:19-7-2005]Rockel,B., Peters,J., Muller,S.A., Seyit,G., Ringler,P., Hegerl,R., Glaeser,R.M. and Baumeister,W.<br>Molecular architecture and assembly mechanism of Drosophila tripeptidyl peptidase II<br>Proc Natl Acad Sci U S A (19-7-2005) 102, 10135-10140. PubMed  Europe PubMed DOI  PMC  EPMC
  56. [YEAR:15-2-2005]Stavropoulou,V., Xie,J., Henriksson,M., Tomkinson,B., Imreh,S. and Masucci,M.G.<br>Mitotic infidelity and centrosome duplication errors in cells overexpressing tripeptidyl-peptidase II<br>Cancer Res (15-2-2005) 65, 1361-1368. PubMed  Europe PubMed DOI
  57. Tomkinson,B. and Lindas,A.C.<br>Tripeptidyl-peptidase II: a multi-purpose peptidase<br>Int J Biochem Cell Biol (2005) 37, 1933-1937. PubMed  Europe PubMed DOI  V
    58. 2004
  58. Kloetzel,P.M.<br>Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII<br>Nat Immunol (2004) 5, 661-669. PubMed  Europe PubMed DOI
  59. Reits,E., Neijssen,J., Herberts,C., Benckhuijsen,W., Janssen,L., Drijfhout,J.W. and Neefjes,J.<br>A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation<br>Immunity (2004) 20, 495-506. PubMed  Europe PubMed DOI
  60. Tomkinson,B.<br>Tripeptidyl-peptidase II<br>[ISSN:0-12-079610-4] (2004) 2, 1882-1885.  V
    61. 2003
  61. [YEAR:15-12-2003]Breslin,H.J., Miskowski,T.A., Kukla,M.J., De Winter,H.L., Somers,M.V., Roevens,P.W. and Kavash,R.W.<br>Tripeptidyl-peptidase II (TPP II) inhibitory activity of (S)-2,3-dihydro-2-(1H-imidazol-2-yl)-1H-indoles, a systematic SAR evaluation. Part 2<br>Bioorg Med Chem Lett (15-12-2003) 13, 4467-4471. PubMed  Europe PubMed DOI  I
  62. Hong,X., Lei,L. and Glas,R.<br>Tumors acquire inhibitor of apoptosis protein (IAP)-mediated apoptosis resistance through altered specificity of cytosolic proteolysis<br>J Exp Med (2003) 197, 1731-1743. PubMed  Europe PubMed DOI  PMC  EPMC
  63. Seifert,U., Maranon,C., Shmueli,A., Desoutter,J.F., Wesoloski,L., Janek,K., Henklein,P., Diescher,S., Andrieu,M., de la Salle,H., Weinschenk,T., Schild,H., Laderach,D., Galy,A., Haas,G., Kloetzel,P.M., Reiss,Y. and Hosmalin,A.<br>An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope<br>Nat Immunol (2003) 4, 375-379. PubMed  Europe PubMed DOI
    64. 2002
  64. [YEAR:21-11-2002]Breslin,H.J., Miskowski,T.A., Kukla,M.J., Leister,W.H., De Winter,H.L., Gauthier,D.A., Somers,M.V., Peeters,D.C. and Roevens,P.W.<br>Design, synthesis, and tripeptidyl peptidase II inhibitory activity of a novel series of (S)-2,3-dihydro-2-(4-alkyl-1H-imidazol-2-yl)-1H-indoles<br>J Med Chem (21-11-2002) 45, 5303-5310. PubMed  Europe PubMed DOI  I
  65. [YEAR:16-12-2002]Hilbi,H., Jozsa,E. and Tomkinson,B.<br>Identification of the catalytic triad in tripeptidyl-peptidase II through site-directed mutagenesis<br>Biochim Biophys Acta (16-12-2002) 1601, 149-154. PubMed  Europe PubMed DOI
  66. [YEAR:15-10-2002]Levy,F., Burri,L., Morel,S., Peitrequin,A.L., Levy,N., Bachi,A., Hellman,U., Van den Eynde,B.J. and Servis,C.<br>The final N-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases<br>J Immunol (15-10-2002) 169, 4161-4171. PubMed  Europe PubMed
  67. [YEAR:15-11-2002]Rockel,B., Peters,J., Kuhlmorgen,B., Glaeser,R.M. and Baumeister,W.<br>A giant protease with a twist: the TPP II complex from Drosophila studied by electron microscopy<br>EMBO J (15-11-2002) 21, 5979-5984. PubMed  Europe PubMed DOI  PMC  EPMC  S
  68. Tomkinson,B., Ni Laoi,B. and Wellington,K.<br>The insert within the catalytic domain of tripeptidyl-peptidase II is important for the formation of the active complex<br>Eur J Biochem (2002) 269, 1438-1443. PubMed  Europe PubMed DOI
  69. [YEAR:9-8-2002]Wray,C.J., Tomkinson,B., Robb,B.W. and Hasselgren,P.O.<br>Tripeptidyl-peptidase II expression and activity are increased in skeletal muscle during sepsis<br>Biochem Biophys Res Commun (9-8-2002) 296, 41-47. PubMed  Europe PubMed DOI
    70. 2001
  70. Bury,M., Mlynarczuk,I., Pleban,E., Hoser,G., Kawiak,J. and Wojcik,C.<br>Effects of an inhibitor of tripeptidyl peptidase II (Ala-Ala-Phe-chloromethylketone) and its combination with an inhibitor of the chymotrypsin-like activity of the proteasome (PSI) on apoptosis, cell cycle and proteasome activity in U937 cells<br>Folia Histochem Cytobiol (2001) 39, 131-132. PubMed  Europe PubMed  I
    71. 2000
  71. [YEAR:24-2-2000]Ganellin,C.R., Bishop,P.B., Bambal,R.B., Chan,S.M., Law,J.K., Marabout,B., Luthra,P.M., Moore,A.N., Peschard,O., Bourgeat,P., Rose,C., Vargas,F. and Schwartz,J.C.<br>Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors<br>J Med Chem (24-2-2000) 43, 664-674. PubMed  Europe PubMed DOI  I
  72. Hilbi,H., Puro,R.J. and Zychlinsky,A.<br>Tripeptidyl peptidase II promotes maturation of caspase-1 in Shigella flexneri-induced macrophage apoptosis<br>Infect Immun (2000) 68, 5502-5508. PubMed  Europe PubMed DOI  PMC  EPMC  I
  73. [YEAR:15-4-2000]Tomkinson,B.<br>Association and dissociation of the tripeptidyl-peptidase II complex as a way of regulating the enzyme activity<br>Arch Biochem Biophys (15-4-2000) 376, 275-280. PubMed  Europe PubMed DOI
  74. [YEAR:29-8-2000]Wang,E.W., Kessler,B.M., Borodovsky,A., Cravatt,B.F., Bogyo,M., Ploegh,H.L. and Glas,R.<br>Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity<br>Proc Natl Acad Sci U S A (29-8-2000) 97, 9990-9995. PubMed  Europe PubMed DOI  PMC  EPMC
    75. 1999
  75. Facchinetti,P., Rose,C., Rostaing,P., Triller,A. and Schwartz,J.C.<br>Immunolocalization of tripeptidyl peptidase II, a cholecystokinin-inactivating enzyme, in rat brain<br>Neuroscience (1999) 88, 1225-1240. PubMed  Europe PubMed DOI
  76. [YEAR:12-2-1999]Geier,E., Pfeifer,G., Wilm,M., Lucchiari-Hartz,M., Baumeister,W., Eichmann,K. and Niedermann,G.<br>A giant protease with potential to substitute for some functions of the proteasome<br>Science (12-2-1999) 283, 978-981. PubMed  Europe PubMed DOI
  77. Tomkinson,B.<br>Tripeptidyl peptidases: enzymes that count<br>Trends Biochem Sci (1999) 24, 355-359. PubMed  Europe PubMed DOI
  78. Yao,T. and Cohen,R.E.<br>Giant proteases: beyond the proteasome<br>Curr Biol (1999) 9, R551-R553. PubMed  Europe PubMed DOI
    79. 1998
  79. [YEAR:24-7-1998]Renn,S.C., Tomkinson,B. and Taghert,P.H.<br>Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster<br>J Biol Chem (24-7-1998) 273, 19173-19182. PubMed  Europe PubMed DOI
    80. 1997
  80. Tomkinson,B., Hansen,M. and Cheung,W.F.<br>Structure-function studies of recombinant murine tripeptidyl-peptidase II: the extra domain which is subject to alternative splicing is involved in complex formation<br>FEBS Lett (1997) 405, 277-280. PubMed  Europe PubMed DOI  R
    81. 1996
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