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Literature for peptidase S01.306: kallikrein-related peptidase 13

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

(Topics flags: A Assay, M Mutation, R Splicing, P Specificity, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Zingkou,E., Bisyris,E., Pampalakis,G. and Sotiropoulou,G.<br>Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing<br>J Pathol (2026) PubMed  Europe PubMed DOI
    2. 2025
  2. Cao,W., Zheng,N., Cao,H., Chen,R., Chen,J., Deng,X., Zhang,H., Yuan,S. and Zhang,G.<br>Nasal mucus-derived KLK13 restricts SARS-CoV-2 infection via proteolytic cleavage of spike<br>MBio (2025) , e0205125-e0205125. PubMed  Europe PubMed DOI
    3. 2024
  3. Kim,H., Kang,Y., Kim,S., Park,D., Heo,S.Y., Yoo,J.S., Choi,I., N,M.P.A., Ahn,J.W., Yang,J.S., Bak,N., Kim,K.K., Lee,J.Y. and Choi,Y.K.<br>The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation<br>Sci Signal (2024) 17, eadn3785-eadn3785. PubMed  Europe PubMed DOI
    4. 2023
  4. Sumiya,R., Yamada,K., Hagiwara,T., Nagasaka,S., Miyazaki,H., Igari,T. and Kawamura,Y.I.<br>Kallikrein-related peptidase 13 expression and clinicopathological features in lung squamous cell carcinoma<br>Mol Clin Oncol (2023) 19, 64-64. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2020
  5. Milewska,A., Falkowski,K., Kulczycka,M., Bielecka,E., Naskalska,A., Mak,P., Lesner,A., Ochman,M., Urlik,M., Diamandis,E., Prassas,I., Potempa,J., Kantyka,T. and Pyrc,K.<br>Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1<br>Sci Signal (2020) 13 PubMed  Europe PubMed DOI
    6. 2019
  6. Gruba,N., Bielecka,E., Wysocka,M., Wojtysiak,A., Brzezinska-Bodal,M., Sychowska,K., Kalinska,M., Magoch,M., Pecak,A., Falkowski,K., Wisniewska,M., Sasiadek,L., Plaza,K., Kroll,E., Pejkovska,A., Rehders,M., Brix,K., Dubin,G., Kantyka,T., Potempa,J. and Lesner,A.<br>Development of chemical tools to monitor human kallikrein 13 (KLK13) activity<br>Int J Mol Sci (2019) 20 PubMed  Europe PubMed DOI  A
    7. 2016
  7. Karakosta,T.D., Soosaipillai,A., Diamandis,E.P., Batruch,I. and Drabovich,A.P.<br>Quantification of human kallikrein-related peptidases in biological fluids by multiplatform targeted mass spectrometry assays<br>Mol Cell Proteomics (2016) 15, 2863-2876. PubMed  Europe PubMed DOI  A
  8. Plaza,K., Kalinska,M., Bochenska,O., Meyer-Hoffert,U., Wu,Z., Fischer,J., Falkowski,K., Sasiadek,L., Bielecka,E., Potempa,B., Kozik,A., Potempa,J. and Kantyka,T.<br>Gingipains of Porphyromonas gingivalis affect the stability and function of serine protease inhibitor of Kazal-type 6 (SPINK6), a tissue inhibitor of human kallikreins<br>J Biol Chem (2016) 291, 18753-18764. PubMed  Europe PubMed DOI
    9. 2015
  9. Angelopoulou,K. and Karagiannis,G.S.<br>Identification, molecular characterization and alternative splicing of three novel members of the canine kallikrein (Klk)-related peptidase family<br>Anticancer Res (2015) 35, 2715-2723. PubMed  Europe PubMed
    10. 2014
  10. Ishige,S., Kasamatsu,A., Ogoshi,K., Saito,Y., Usukura,K., Yokoe,H., Kouzu,Y., Koike,H., Sakamoto,Y., Ogawara,K., Shiiba,M., Tanzawa,H. and Uzawa,K.<br>Decreased expression of kallikrein-related peptidase 13: Possible contribution to metastasis of human oral cancer<br>Mol Carcinog (2014) 53, 557-565. PubMed  Europe PubMed DOI
    11. 2013
  11. Lose,F., Batra,J., O'Mara,T., Fahey,P., Marquart,L., Eeles,R.A., Easton,D.F., Al Olama,A.A., Kote-Jarai,Z., Guy,M., Muir,K., Lophatananon,A., Rahman,A.A., Neal,D.E., Hamdy,F.C., Donovan,J.L., Chambers,S., Gardiner,R.A., Aitken,J.F., Yaxley,J., Alexander,K., Clements,J.A., Spurdle,A.B. and Kedda,M.A.<br>Common variation in kallikrein genes KLK5, KLK6, KLK12, and KLK13 and risk of prostate cancer and tumor aggressiveness<br>Urol Oncol (2013) 31, 635-643. PubMed  Europe PubMed DOI  M
  12. Lundwall,A.<br>Old genes and new genes: The evolution of the kallikrein locus<br>Thromb Haemost (2013) 110, 469-475. PubMed  Europe PubMed DOI  V
    13. 2012
  13. Clements,J.A., Hooper,J.D. and Dong,Y.<br>The human tissue kallikrein and kallikrein-related peptidase family<br>[ISSN:978-0-12-407742-3] (2012) 3, 2747-2756. DOI
  14. Cretu,D. and Diamandis,E.P.<br>Kallikrein-related peptidase 13<br>[ISSN:978-0-12-407742-3] (2012) 3, 2805-2808. DOI
    15. 2011
  15. Andrade,D., Assis,D.M., Santos,J.A., Alves,F.M., Hirata,I.Y., Araujo,M.S., Blaber,S.I., Blaber,M., Juliano,M.A. and Juliano,L.<br>Substrate specificity of kallikrein-related peptidase 13 activated by salts or glycosaminoglycans and a search for natural substrate candidates<br>Biochimie (2011) 93, 1701-1709. PubMed  Europe PubMed DOI  P
    16. 2008
  16. Clements,J.A.<br>Reflections on the tissue kallikrein and kallikrein-related peptidase family - from mice to men - what have we learnt in the last two decades?<br>Biol Chem (2008) 389, 1447-1454. PubMed  Europe PubMed DOI  V
  17. Planque,C., Blechet,C., Ayadi-Kaddour,A., Heuze-Vourc'h,N., Dumont,P., Guyetant,S., Diamandis,E.P., El Mezni,F. and Courty,Y.<br>Quantitative RT-PCR analysis and immunohistochemical localization of the kallikrein-related peptidases 13 and 14 in lung<br>Biol Chem (2008) 389, 781-786. PubMed  Europe PubMed DOI
    18. 2007
  18. Borgono,C.A., Gavigan,J.A., Alves,J., Bowles,B., Harris,J.L., Sotiropoulou,G. and Diamandis,E.P.<br>Defining the extended substrate specificity of kallikrein 1-related peptidases<br>Biol Chem (2007) 388, 1215-1225. PubMed  Europe PubMed DOI  P
  19. Fernando,S.C., Najar,F.Z., Guo,X., Zhou,L., Fu,Y., Geisert,R.D., Roe,B.A. and DeSilva,U.<br>Porcine kallikrein gene family: genomic structure, mapping, and differential expression analysis<br>Genomics (2007) 89, 429-438. PubMed  Europe PubMed DOI
  20. Yoon,H., Laxmikanthan,G., Lee,J., Blaber,S.I., Rodriguez,A., Kogot,J.M., Scarisbrick,I.A. and Blaber,M.<br>Activation profiles and regulatory cascades of the human kallikrein-related peptidases<br>J Biol Chem (2007) 282, 31852-31864. PubMed  Europe PubMed DOI  V
    21. 2006
  21. Luo,L.Y. and Jiang,W.<br>Inhibition profiles of human tissue kallikreins by serine protease inhibitors<br>Biol Chem (2006) 387, 813-816. PubMed  Europe PubMed DOI
    22. 2005
  22. [YEAR:25-5-2005]Kurlender,L., Borgono,C., Michael,I.P., Obiezu,C., Elliott,M.B., Yousef,G.M. and Diamandis,E.P.<br>A survey of alternative transcripts of human tissue kallikrein genes<br>Biochim Biophys Acta (25-5-2005) 1755, 1-14. PubMed  Europe PubMed DOI  R
    23. 2004
  23. Clements,J.A., Hooper,J.D., Odorico,D.M. and Dong,Y.<br>The tissue kallikrein gene cluster<br>[ISSN:0-12-079610-4] (2004) 2, 1569-1577.  V
  24. [YEAR:22-10-2004]Kapadia,C., Ghosh,M.C., Grass,L. and Diamandis,E.P.<br>Human kallikrein 13 involvement in extracellular matrix degradation<br>Biochem Biophys Res Commun (22-10-2004) 323, 1084-1090. PubMed  Europe PubMed DOI
  25. Kapadia,C., Yousef,G.M., Mellati,A.A., Magklara,A., Wasney,G.A. and Diamandis,E.P.<br>Complex formation between human kallikrein 13 and serum protease inhibitors<br>Clin Chim Acta (2004) 339, 157-167. PubMed  Europe PubMed DOI
  26. [YEAR:15-2-2004]Scorilas,A., Borgono,C.A., Harbeck,N., Dorn,J., Schmalfeldt,B., Schmitt,M. and Diamandis,E.P.<br>Human kallikrein 13 protein in ovarian cancer cytosols: a new favorable prognostic marker<br>J Clin Oncol (15-2-2004) 22, 678-685. PubMed  Europe PubMed DOI
    27. 2003
  27. Kapadia,C., Chang,A., Sotiropoulou,G., Yousef,G.M., Grass,L., Soosaipillai,A., Xing,X., Howarth,D.H. and Diamandis,E.P.<br>Human kallikrein 13: production and purification of recombinant protein and monoclonal and polyclonal antibodies, and development of a sensitive and specific immunofluorometric assay<br>Clin Chem (2003) 49, 77-86. PubMed  Europe PubMed DOI  A
  28. Petraki,C.D., Karavana,V.N. and Diamandis,E.P.<br>Human kallikrein 13 expression in normal tissues: an immunohistochemical study<br>J Histochem Cytochem (2003) 51, 493-501. PubMed  Europe PubMed
    29. 2002
  29. [YEAR:6-5-2002]Chang,A., Yousef,G.M., Scorilas,A., Grass,L., Sismondi,P., Ponzone,R. and Diamandis,E.P.<br>Human kallikrein gene 13 (KLK13) expression by quantitative RT-PCR: an independent indicator of favourable prognosis in breast cancer<br>Br J Cancer (6-5-2002) 86, 1457-1464. PubMed  Europe PubMed DOI  PMC  EPMC
    30. 2001
  30. Chang,A., Yousef,G.M., Jung,K., Rajpert-De Meyts,E. and Diamandis,E.P.<br>Identification and molecular characterization of five novel kallikrein gene 13 (KLK13; KLK-L4) splice variants: Differential expression in the human testis and testicular cancer<br>Anticancer Res (2001) 21, 3147-3152. PubMed  Europe PubMed
  31. Clements,J., Hooper,J., Dong,Y. and Harvey,T.<br>The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions<br>Biol Chem (2001) 382, 5-14. PubMed  Europe PubMed DOI  V
    32. 2000
  32. Diamandis,E.P., Yousef,G.M., Luo,L.Y., Magklara,A. and Obiezu,C.V.<br>The new human kallikrein gene family: implications in carcinogenesis<br>Trends Endocrinol Metab (2000) 11, 54-60. PubMed  Europe PubMed DOI
  33. [YEAR:21-4-2000]Yousef,G.M., Chang,A. and Diamandis,E.P.<br>Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues<br>J Biol Chem (21-4-2000) 275, 11891-11898. PubMed  Europe PubMed DOI

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