Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase S01.306: kallikrein-related peptidase 13

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors Pharma

(Topics flags: A Assay, M Mutation, R Splicing, P Specificity, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Zingkou,E., Bisyris,E., Pampalakis,G. and Sotiropoulou,G.
    Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing
    J Pathol (2026) PubMed  Europe PubMed DOI
    2. 2025
  2. Cao,W., Zheng,N., Cao,H., Chen,R., Chen,J., Deng,X., Zhang,H., Yuan,S. and Zhang,G.
    Nasal mucus-derived KLK13 restricts SARS-CoV-2 infection via proteolytic cleavage of spike
    MBio (2025) , e0205125-e0205125. PubMed  Europe PubMed DOI
    3. 2024
  3. Kim,H., Kang,Y., Kim,S., Park,D., Heo,S.Y., Yoo,J.S., Choi,I., N,M.P.A., Ahn,J.W., Yang,J.S., Bak,N., Kim,K.K., Lee,J.Y. and Choi,Y.K.
    The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation
    Sci Signal (2024) 17, eadn3785-eadn3785. PubMed  Europe PubMed DOI
    4. 2023
  4. Sumiya,R., Yamada,K., Hagiwara,T., Nagasaka,S., Miyazaki,H., Igari,T. and Kawamura,Y.I.
    Kallikrein-related peptidase 13 expression and clinicopathological features in lung squamous cell carcinoma
    Mol Clin Oncol (2023) 19, 64-64. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2020
  5. Milewska,A., Falkowski,K., Kulczycka,M., Bielecka,E., Naskalska,A., Mak,P., Lesner,A., Ochman,M., Urlik,M., Diamandis,E., Prassas,I., Potempa,J., Kantyka,T. and Pyrc,K.
    Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1
    Sci Signal (2020) 13 PubMed  Europe PubMed DOI
    6. 2019
  6. Gruba,N., Bielecka,E., Wysocka,M., Wojtysiak,A., Brzezinska-Bodal,M., Sychowska,K., Kalinska,M., Magoch,M., Pecak,A., Falkowski,K., Wisniewska,M., Sasiadek,L., Plaza,K., Kroll,E., Pejkovska,A., Rehders,M., Brix,K., Dubin,G., Kantyka,T., Potempa,J. and Lesner,A.
    Development of chemical tools to monitor human kallikrein 13 (KLK13) activity
    Int J Mol Sci (2019) 20 PubMed  Europe PubMed DOI  A
    7. 2016
  7. Karakosta,T.D., Soosaipillai,A., Diamandis,E.P., Batruch,I. and Drabovich,A.P.
    Quantification of human kallikrein-related peptidases in biological fluids by multiplatform targeted mass spectrometry assays
    Mol Cell Proteomics (2016) 15, 2863-2876. PubMed  Europe PubMed DOI  A
  8. Plaza,K., Kalinska,M., Bochenska,O., Meyer-Hoffert,U., Wu,Z., Fischer,J., Falkowski,K., Sasiadek,L., Bielecka,E., Potempa,B., Kozik,A., Potempa,J. and Kantyka,T.
    Gingipains of Porphyromonas gingivalis affect the stability and function of serine protease inhibitor of Kazal-type 6 (SPINK6), a tissue inhibitor of human kallikreins
    J Biol Chem (2016) 291, 18753-18764. PubMed  Europe PubMed DOI
    9. 2015
  9. Angelopoulou,K. and Karagiannis,G.S.
    Identification, molecular characterization and alternative splicing of three novel members of the canine kallikrein (Klk)-related peptidase family
    Anticancer Res (2015) 35, 2715-2723. PubMed  Europe PubMed
    10. 2014
  10. Ishige,S., Kasamatsu,A., Ogoshi,K., Saito,Y., Usukura,K., Yokoe,H., Kouzu,Y., Koike,H., Sakamoto,Y., Ogawara,K., Shiiba,M., Tanzawa,H. and Uzawa,K.
    Decreased expression of kallikrein-related peptidase 13: Possible contribution to metastasis of human oral cancer
    Mol Carcinog (2014) 53, 557-565. PubMed  Europe PubMed DOI
    11. 2013
  11. Lose,F., Batra,J., O'Mara,T., Fahey,P., Marquart,L., Eeles,R.A., Easton,D.F., Al Olama,A.A., Kote-Jarai,Z., Guy,M., Muir,K., Lophatananon,A., Rahman,A.A., Neal,D.E., Hamdy,F.C., Donovan,J.L., Chambers,S., Gardiner,R.A., Aitken,J.F., Yaxley,J., Alexander,K., Clements,J.A., Spurdle,A.B. and Kedda,M.A.
    Common variation in kallikrein genes KLK5, KLK6, KLK12, and KLK13 and risk of prostate cancer and tumor aggressiveness
    Urol Oncol (2013) 31, 635-643. PubMed  Europe PubMed DOI  M
  12. Lundwall,A.
    Old genes and new genes: The evolution of the kallikrein locus
    Thromb Haemost (2013) 110, 469-475. PubMed  Europe PubMed DOI  V
    13. 2012
  13. Clements,J.A., Hooper,J.D. and Dong,Y.
    The human tissue kallikrein and kallikrein-related peptidase family
    [ISSN:978-0-12-407742-3] (2012) 3, 2747-2756. DOI
  14. Cretu,D. and Diamandis,E.P.
    Kallikrein-related peptidase 13
    [ISSN:978-0-12-407742-3] (2012) 3, 2805-2808. DOI
    15. 2011
  15. Andrade,D., Assis,D.M., Santos,J.A., Alves,F.M., Hirata,I.Y., Araujo,M.S., Blaber,S.I., Blaber,M., Juliano,M.A. and Juliano,L.
    Substrate specificity of kallikrein-related peptidase 13 activated by salts or glycosaminoglycans and a search for natural substrate candidates
    Biochimie (2011) 93, 1701-1709. PubMed  Europe PubMed DOI  P
    16. 2008
  16. Clements,J.A.
    Reflections on the tissue kallikrein and kallikrein-related peptidase family - from mice to men - what have we learnt in the last two decades?
    Biol Chem (2008) 389, 1447-1454. PubMed  Europe PubMed DOI  V
  17. Planque,C., Blechet,C., Ayadi-Kaddour,A., Heuze-Vourc'h,N., Dumont,P., Guyetant,S., Diamandis,E.P., El Mezni,F. and Courty,Y.
    Quantitative RT-PCR analysis and immunohistochemical localization of the kallikrein-related peptidases 13 and 14 in lung
    Biol Chem (2008) 389, 781-786. PubMed  Europe PubMed DOI
    18. 2007
  18. Borgono,C.A., Gavigan,J.A., Alves,J., Bowles,B., Harris,J.L., Sotiropoulou,G. and Diamandis,E.P.
    Defining the extended substrate specificity of kallikrein 1-related peptidases
    Biol Chem (2007) 388, 1215-1225. PubMed  Europe PubMed DOI  P
  19. Fernando,S.C., Najar,F.Z., Guo,X., Zhou,L., Fu,Y., Geisert,R.D., Roe,B.A. and DeSilva,U.
    Porcine kallikrein gene family: genomic structure, mapping, and differential expression analysis
    Genomics (2007) 89, 429-438. PubMed  Europe PubMed DOI
  20. Yoon,H., Laxmikanthan,G., Lee,J., Blaber,S.I., Rodriguez,A., Kogot,J.M., Scarisbrick,I.A. and Blaber,M.
    Activation profiles and regulatory cascades of the human kallikrein-related peptidases
    J Biol Chem (2007) 282, 31852-31864. PubMed  Europe PubMed DOI  V
    21. 2006
  21. Luo,L.Y. and Jiang,W.
    Inhibition profiles of human tissue kallikreins by serine protease inhibitors
    Biol Chem (2006) 387, 813-816. PubMed  Europe PubMed DOI
    22. 2005
  22. [YEAR:25-5-2005]Kurlender,L., Borgono,C., Michael,I.P., Obiezu,C., Elliott,M.B., Yousef,G.M. and Diamandis,E.P.
    A survey of alternative transcripts of human tissue kallikrein genes
    Biochim Biophys Acta (25-5-2005) 1755, 1-14. PubMed  Europe PubMed DOI  R
    23. 2004
  23. Clements,J.A., Hooper,J.D., Odorico,D.M. and Dong,Y.
    The tissue kallikrein gene cluster
    [ISSN:0-12-079610-4] (2004) 2, 1569-1577.  V
  24. [YEAR:22-10-2004]Kapadia,C., Ghosh,M.C., Grass,L. and Diamandis,E.P.
    Human kallikrein 13 involvement in extracellular matrix degradation
    Biochem Biophys Res Commun (22-10-2004) 323, 1084-1090. PubMed  Europe PubMed DOI
  25. Kapadia,C., Yousef,G.M., Mellati,A.A., Magklara,A., Wasney,G.A. and Diamandis,E.P.
    Complex formation between human kallikrein 13 and serum protease inhibitors
    Clin Chim Acta (2004) 339, 157-167. PubMed  Europe PubMed DOI
  26. [YEAR:15-2-2004]Scorilas,A., Borgono,C.A., Harbeck,N., Dorn,J., Schmalfeldt,B., Schmitt,M. and Diamandis,E.P.
    Human kallikrein 13 protein in ovarian cancer cytosols: a new favorable prognostic marker
    J Clin Oncol (15-2-2004) 22, 678-685. PubMed  Europe PubMed DOI
    27. 2003
  27. Kapadia,C., Chang,A., Sotiropoulou,G., Yousef,G.M., Grass,L., Soosaipillai,A., Xing,X., Howarth,D.H. and Diamandis,E.P.
    Human kallikrein 13: production and purification of recombinant protein and monoclonal and polyclonal antibodies, and development of a sensitive and specific immunofluorometric assay
    Clin Chem (2003) 49, 77-86. PubMed  Europe PubMed DOI  A
  28. Petraki,C.D., Karavana,V.N. and Diamandis,E.P.
    Human kallikrein 13 expression in normal tissues: an immunohistochemical study
    J Histochem Cytochem (2003) 51, 493-501. PubMed  Europe PubMed
    29. 2002
  29. [YEAR:6-5-2002]Chang,A., Yousef,G.M., Scorilas,A., Grass,L., Sismondi,P., Ponzone,R. and Diamandis,E.P.
    Human kallikrein gene 13 (KLK13) expression by quantitative RT-PCR: an independent indicator of favourable prognosis in breast cancer
    Br J Cancer (6-5-2002) 86, 1457-1464. PubMed  Europe PubMed DOI  PMC  EPMC
    30. 2001
  30. Chang,A., Yousef,G.M., Jung,K., Rajpert-De Meyts,E. and Diamandis,E.P.
    Identification and molecular characterization of five novel kallikrein gene 13 (KLK13; KLK-L4) splice variants: Differential expression in the human testis and testicular cancer
    Anticancer Res (2001) 21, 3147-3152. PubMed  Europe PubMed
  31. Clements,J., Hooper,J., Dong,Y. and Harvey,T.
    The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions
    Biol Chem (2001) 382, 5-14. PubMed  Europe PubMed DOI  V
    32. 2000
  32. Diamandis,E.P., Yousef,G.M., Luo,L.Y., Magklara,A. and Obiezu,C.V.
    The new human kallikrein gene family: implications in carcinogenesis
    Trends Endocrinol Metab (2000) 11, 54-60. PubMed  Europe PubMed DOI
  33. [YEAR:21-4-2000]Yousef,G.M., Chang,A. and Diamandis,E.P.
    Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues
    J Biol Chem (21-4-2000) 275, 11891-11898. PubMed  Europe PubMed DOI

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use