Literature for peptidase S01.232: t-plasminogen activator

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Arsanjani,A.A., Faradonbeh,D.R., Malekshahi,Z.V., Mosayyebi,B. and Negahdari,B. Strategies for the Discovery and Design of Tissue Plasminogen Activators: Insights Into Bioengineering Objectives Drug Dev Res (2025) 86, e70072-e70072. PubMed Europe PubMed DOI V
Bahi,A. and Steele,S. Novel Roles for Urokinase- and Tissue-Type Plasminogen Activators in the Pathogenesis of Mood Disorders Int J Mol Sci (2025) 26 PubMed Europe PubMed DOI PMC EPMC
Delaunay-Piednoir,B., Pouettre,E., Etard,O., Goux,D., Baudron,E., Docagne,F., Maubert,E., Vivien,D. and Bardou,I. Tissue-type plasminogen activator expression by endothelial cells and oligodendrocytes is required for proper CNS myelination Acta Neuropathol Commun (2025) 13, 192-192. PubMed Europe PubMed DOI PMC EPMC
Didehvar,K., Haghshenas,M., Yarmohammadi,R., Hajikarimloo,B. and Ghafoury,R. Tissue Plasminogen Activator as an Approved Strategy for Ischemic Stroke: A Review of tPA's Structure, Mechanism of Action and the Novel Targeting Methods J Mol Neurosci (2025) 75, 152-152. PubMed Europe PubMed DOI PMC EPMC

2024

Challa,S.R., Nalamolu,K.R., Fornal,C.A., Baker,I.M., Mohandass,A., Mada,S.R., Wang,B.C., Pinson,D.M., Lahoti,S., Klopfenstein,J.D. and Veeravalli,K.K. The paradox of tPA in ischemic stroke: tPA knockdown following recanalization improves functional and histological outcomes Exp Neurol (2024) 374, 114727-114727. PubMed Europe PubMed DOI PMC EPMC
Yepes,M. Fibrinolytic and Non-fibrinolytic Roles of Tissue-type Plasminogen Activator in the Ischemic Brain Neuroscience (2024) 542, 69-80. PubMed Europe PubMed DOI V

2023

Dai,W., Zhang,H., Lund,H., Zhang,Z., Castleberry,M., Rodriguez,M., Kuriakose,G., Gupta,S., Lewandowska,M., Powers,H.R., Valmiki,S., Zhu,J., Shapiro,A.D., Hussain,M.M., Lopez,J.A., Sorci-Thomas,M.G., Silverstein,R.L., Ginsberg,H.N., Sahoo,D., Tabas,I. and Zheng,Z. Intracellular tPA-PAI-1 interaction determines VLDL assembly in hepatocytes Science (2023) 381, eadh5207-eadh5207. PubMed Europe PubMed DOI PMC EPMC
Forry,J. and Chappell,A. Tenecteplase: A Review of Its Pharmacology and Uses AACN Adv Crit Care (2023) 34, 77-83. PubMed Europe PubMed DOI
Lin,L. and Hu,K. Macrophage Function Modulated by tPA Signaling in Mouse Experimental Kidney Disease Models Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC V
Mennesson,M. and Revest,J.M. Glucocorticoid-Responsive Tissue Plasminogen Activator (tPA) and Its Inhibitor Plasminogen Activator Inhibitor-1 (PAI-1): Relevance in Stress-Related Psychiatric Disorders Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC V
Smart,C., Mitchell,A., McCutcheon,F., Medcalf,R.L. and Thiele,A. Tissue-type plasminogen activator induces conditioned receptive field plasticity in the mouse auditory cortex iScience (2023) 26, 105947-105947. PubMed Europe PubMed DOI PMC EPMC
Tao,Y., Ma,J., Feng,Y., Gao,C., Wu,T., Xia,Y., Cheng,Z., Zhang,Y., Liu,T., Hu,Y. and Tang,L.V. Tissue-type plasminogen activator (tPA) homozygous Tyr471His mutation associates with thromboembolic disease MedComm (2020) (2023) 4, e392-e392. PubMed Europe PubMed DOI PMC EPMC
Yang,J., Cha,L., Wang,Y., Zhang,Q., Tang,X., Shao,J. and Duan,Z. L-Palmitoylcarnitine potentiates plasmin and tPA to inhibit thrombosis Nat Prod Bioprospect (2023) 13, 48-48. PubMed Europe PubMed DOI PMC EPMC

2022

Tomadesso,C., de Lizarrondo,S.M., Ali,C., Landeau,B., Mezenge,F., Perrotin,A., de la Sayette,V., Vivien,D. and Chetelat,G. Plasma Levels of Tissue-Type Plasminogen Activator (tPA) in Normal Aging and Alzheimer's Disease: Links With Cognition, Brain Structure, Brain Function and Amyloid Burden Front Aging Neurosci (2022) 14, 871214-871214. PubMed Europe PubMed DOI PMC EPMC
Zuba,V., Furon,J., Bellemain-Sagnard,M., Martinez de Lizarrondo,S., Lebouvier,L., Rubio,M., Hommet,Y., Gauberti,M., Vivien,D. and Ali,C. The choroid plexus: a door between the blood and the brain for tissue-type plasminogen activator Fluids Barriers CNS (2022) 19, 80-80. PubMed Europe PubMed DOI PMC EPMC

2021

Hedou,E., Douceau,S., Chevilley,A., Varangot,A., Thiebaut,A.M., Triniac,H., Bardou,I., Ali,C., Maillasson,M., Crepaldi,T., Comoglio,P., Lemarchand,E., Agin,V., Roussel,B.D. and Vivien,D. Two-Chains Tissue Plasminogen Activator Unifies Met and NMDA Receptor Signalling to Control Neuronal Survival Int J Mol Sci (2021) 22 PubMed Europe PubMed DOI PMC EPMC
Ismail,A.A., Shaker,B.T. and Bajou,K. The Plasminogen-Activator Plasmin System in Physiological and Pathophysiological Angiogenesis Int J Mol Sci (2021) 23 PubMed Europe PubMed DOI PMC EPMC

2020

Bellien,J., Iacob,M., Richard,V., Wils,J., Le Cam-Duchez,V. and Joannides,R. Evidence for wall shear stress-dependent t-PA release in human conduit arteries: role of endothelial factors and impact of high blood pressure Hypertens Res (2020) PubMed Europe PubMed DOI
Carneiro,T., Dashkoff,J., Leung,L.Y., Nobleza,C.O.S., Marulanda-Londono,E., Hathidara,M., Koch,S., Sur,N., Boske,A., Voetsch,B., Aboul Nour,H., Miller,D.J., Daneshmand,A., Shulman,J., Curiale,G., Greer,D.M., Romero,J.R., Anand,P. and Cervantes-Arslanian,A.M. Intravenous tPA for Acute Ischemic Stroke in Patients with COVID-19 J Stroke Cerebrovasc Dis (2020) 29, 105201-105201. PubMed Europe PubMed DOI PMC EPMC
Chang,Z., Zou,H., Xie,Z., Deng,B., Que,R., Huang,Z., Weng,G., Wu,Z., Pan,Y., Wang,Y., Li,M., Xie,H., Zhu,S., Xiong,L., Ct Mok,V., Jin,K., Yenari,M.A., Wei,X. and Wang,Q. Cystatin C is a potential predictor of unfavorable outcomes for cerebral ischemia with intravenous tissue plasminogen activator treatment: A multicenter prospective nested case-control study Eur J Neurol (2020) PubMed Europe PubMed DOI
Kipshidze,N., Dangas,G., White,C.J., Kipshidze,N., Siddiqui,F., Lattimer,C.R., Carter,C.A. and Fareed,J. Viral Coagulopathy in Patients With COVID-19: Treatment and Care Clin Appl Thromb Hemost (2020) 26, 1076029620936776-1076029620936776. PubMed Europe PubMed DOI
Marceau,F., Rivard,G.E., Gauthier,J.M., Binkley,K.E., Bonnefoy,A., Boccon-Gibod,I., Bouillet,L., Picard,M., Levesque,G., Elfassy,H.L., Bachelard,H., Hebert,J. and Bork,K. Measurement of Bradykinin Formation and Degradation in Blood Plasma: Relevance for Acquired Angioedema Associated With Angiotensin Converting Enzyme Inhibition and for Hereditary Angioedema Due to Factor XII or Plasminogen Gene Variants Front Med (Lausanne) (2020) 7, 358-358. PubMed Europe PubMed DOI PMC EPMC I
Ranucci,M., Sitzia,C., Baryshnikova,E., Di Dedda,U., Cardani,R., Martelli,F. and Corsi Romanelli,M. Covid-19-Associated Coagulopathy: Biomarkers of Thrombin Generation and Fibrinolysis Leading the Outcome J Clin Med (2020) 9 PubMed Europe PubMed DOI
Saggese,C.E., Del Bianco,C., Di Ruzza,M.R., Magarelli,M., Gandini,R. and Plocco,M. COVID-19 and Stroke: Casual or Causal Role? Cerebrovasc Dis (2020) 49, 341-344. PubMed Europe PubMed DOI
Sanda,T., Yoshimura,M., Hyodo,K., Ishii,H. and Yamashita,T. Effects of Long-term Thrombin Inhibition (Dabigatran Etexilate) on Spontaneous Thrombolytic Activity during the Progression of Atherosclerosis in ApoE(-/-)-LDLR(-/-) Double-Knockout Mice Korean Circ J (2020) 50, 804-816. PubMed Europe PubMed DOI I
Suzuki,Y., Sano,H., Mochizuki,L., Honkura,N. and Urano,T. Activated platelet-based inhibition of fibrinolysis via thrombin-activatable fibrinolysis inhibitor activation system Blood Adv (2020) 4, 5501-5511. PubMed Europe PubMed DOI PMC EPMC

2019

Chana-Munoz,A., Jendroszek,A., Sonnichsen,M., Wang,T., Ploug,M., Jensen,J.K., Andreasen,P.A., Bendixen,C. and Panitz,F. Origin and diversification of the plasminogen activation system among chordates BMC Evol Biol (2019) 19, 27-27. PubMed Europe PubMed DOI PMC EPMC
Ghaheh,H.S., Ganjalikhany,M.R., Yaghmaei,P., Pourfarzam,M. and Mir Mohammad Sadeghi,H. Improving the solubility, activity, and stability of reteplase using in silico design of new variants Res Pharm Sci (2019) 14, 359-368. PubMed Europe PubMed DOI PMC EPMC
Li,C.Y., de Veer,S.J., Law,R.H.P., Whisstock,J.C., Craik,D.J. and Swedberg,J.E. Characterising the subsite specificity of urokinase-type plasminogen activator and tissue-type plasminogen activator using a sequence-defined peptide aldehyde library Chembiochem (2019) 20, 46-50. PubMed Europe PubMed DOI P I
Mohammadi,E., Seyedhosseini-Ghaheh,H., Mahnam,K., Jahanian-Najafabadi,A. and Mir Mohammad Sadeghi,H. Reteplase: structure, function, and production Adv Biomed Res (2019) 8, 19-19. PubMed Europe PubMed DOI PMC EPMC
Peng,S., Xue,G., Chen,S., Chen,Z., Yuan,C., Li,J. and Huang,M. tPA Point mutation at autolysis loop enhances resistance to PAI-1 inhibition and catalytic activity Thromb Haemost (2019) 119, 77-86. PubMed Europe PubMed DOI

2018

Ito,Y., Noguchi,K., Morishima,Y. and Yamaguchi,K. Tissue-type plasminogen activator transgenic rats for evaluating inhibitors of the activated form of thrombin-activatable fibrinolysis inhibitor Blood Coagul Fibrinolysis (2018) 29, 314-321. PubMed Europe PubMed DOI K I

2017

Bjerregaard,N., Dupont,D.M. and Andreasen,P.A. A conjugate of two tPA-binding RNA aptamers efficiently inhibits fibrinolysis Nucleic Acid Ther (2017) 27, 95-104. PubMed Europe PubMed DOI I
Simao,F., Ustunkaya,T., Clermont,A.C. and Feener,E.P. Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke Blood (2017) 129, 2280-2290. PubMed Europe PubMed DOI

2016

Abdoli Nasab,M., Jalali Javaran,M., Cusido,R.M. and Palazon,J. Purification of recombinant tissue plasminogen activator (rtPA) protein from transplastomic tobacco plants Plant Physiol Biochem (2016) 108, 139-144. PubMed Europe PubMed DOI E
Carlson,K.S., Nguyen,L., Schwartz,K., Lawrence,D.A. and Schwartz,B.S. Neuroserpin differentiates between forms of tissue type plasminogen activator via pH dependent deacylation Front Cell Neurosci (2016) 10, 154-154. PubMed Europe PubMed DOI PMC EPMC
Gong,L., Liu,M., Zeng,T., Shi,X., Yuan,C., Andreasen,P.A. and Huang,M. Structural basis of specific inhibition of tissue-type plasminogen activator by plasminogen activators inhibitor-1 Data Brief (2016) 6, 550-555. PubMed Europe PubMed DOI PMC EPMC
Hebert,M., Lesept,F., Vivien,D. and Macrez,R. The story of an exceptional serine protease, tissue-type plasminogen activator (tPA) Rev Neurol (Paris) (2016) 172, 186-197. PubMed Europe PubMed DOI V

2015

Gong,L., Liu,M., Zeng,T., Shi,X., Yuan,C., Andreasen,P.A. and Huang,M. Crystal structure of the Michaelis complex between tissue-type plasminogen activator and plasminogen activators inhibitor-1 J Biol Chem (2015) 290, 25795-25804. PubMed Europe PubMed DOI S
Long,X., Gou,Y., Luo,M., Zhang,S., Zhang,H., Bai,L., Wu,S., He,Q., Chen,K., Huang,A., Zhou,J. and Wang,D. Soluble expression, purification, and characterization of active recombinant human tissue plasminogen activator by auto-induction in E. coli BMC Biotechnol (2015) 15, 13- PubMed Europe PubMed DOI PMC EPMC E

2014

Asgari,M., Javaran,M.J., Moieni,A., Masoumiasl,A. and Abdolinasab,M. Production of human tissue plasminogen activator (tPA) in Cucumis sativus Prep Biochem Biotechnol (2014) 44, 182-192. PubMed Europe PubMed DOI E
Freeman,R., Niego,B., Croucher,D.R., Pedersen,L.O. and Medcalf,R.L. t-PA, but not desmoteplase, induces plasmin-dependent opening of a blood-brain barrier model under normoxic and ischaemic conditions Brain Res (2014) 1565, 63-73. PubMed Europe PubMed DOI
Kazemali,M., Majidzadeh-A,K., Sardari,S., Saadatirad,A.H., Khalaj,V., Zarei,N., Barkhordari,F., Adeli,A. and Mahboudi,F. Design of a novel chimeric tissue plasminogen activator with favorable Vampire bat plasminogen activator properties Enzyme Microb Technol (2014) 67, 82-86. PubMed Europe PubMed DOI E
Sonderegger,P. and Matsumoto-Miyai,K. Activity-controlled proteolytic cleavage at the synapse Trends Neurosci (2014) 37, 413-423. PubMed Europe PubMed DOI
Valapala,M., Maji,S., Borejdo,J. and Vishwanatha,J.K. Cell surface translocation of annexin A2 facilitates glutamate-induced extracellular proteolysis J Biol Chem (2014) 289, 15915-15926. PubMed Europe PubMed DOI

2013

Aflakiyan,S., Sadeghi,H.M., Shokrgozar,M., Rabbani,M., Bouzari,S. and Jahanian-Najafabadi,A. Expression of the recombinant plasminogen activator (reteplase) by a non-lytic insect cell expression system Res Pharm Sci (2013) 8, 9-15. PubMed Europe PubMed PMC EPMC E
Gomaraschi,M., Ossoli,A., Vitali,C., Pozzi,S., Vitali Serdoz,L., Pitzorno,C., Sinagra,G., Franceschini,G. and Calabresi,L. Off-target effects of thrombolytic drugs: apolipoprotein A-I proteolysis by alteplase and tenecteplase Biochem Pharmacol (2013) 85, 525-530. PubMed Europe PubMed DOI

2012

Bahi,A. and Dreyer,J.L. Involvement of tissue plasminogen activator "tPA" in ethanol-induced locomotor sensitization and conditioned-place preference Behav Brain Res (2012) 226, 250-258. PubMed Europe PubMed DOI
Lijnen,H.R. and Rijken,D.C. t-Plasminogen activator [ISSN:978-0-12-407742-3] (2012) 3, 2946-2952. DOI
Ng,K.S., Leung,H.W., Wong,P.T. and Low,C.M. Cleavage of the NR2B subunit amino terminus of N-methyl-D-aspartate (NMDA) receptor by tissue plasminogen activator: identification of the cleavage site and characterization of ifenprodil and glycine affinities on truncated NMDA receptor J Biol Chem (2012) 287, 25520-25529. PubMed Europe PubMed DOI P

2011

Liang,Y.G., Liu,P., Gao,H.Z., Li,H.Y., Hao,G.T., Wang,X.F., Zhang,X.G., Meng,Q.Y. and Liu,Z.Y. Pharmacokinetics and safety of a new bioengineered thrombolytic agent, human tissue urokinase type plasminogen activator in Chinese healthy volunteers Eur J Drug Metab Pharmacokinet (2011) 35, 97-102. PubMed Europe PubMed DOI
Luo,X.G., Tian,W.J., Ni,M., Jing,X.L., Lv,L.H., Wang,N., Jiang,Y. and Zhang,T.C. Soluble expression of active recombinant human tissue plasminogen activator derivative (K2S) in Escherichia coli Pharm Biol (2011) 49, 653-657. PubMed Europe PubMed DOI E
Nazari,R. and Davoudi,N. Cloning and expression of truncated form of tissue plasminogen activator in Leishmania tarentolae Biotechnol Lett (2011) 33, 503-508. PubMed Europe PubMed DOI E

2010

Jiang,H., Wu,S.L., Karger,B.L. and Hancock,W.S. Characterization of the glycosylation occupancy and the active site in the follow-on protein therapeutic: TNK-tissue plasminogen activator Anal Chem (2010) 82, 6154-6162. PubMed Europe PubMed DOI PMC EPMC U
Majidzadeh,A., Khalaj,V., Fatemeh,D., Mahdi,H., Farzaneh,B., Ahmad,A. and Mahboudi,F. Cloning and expression of functional full-length human tissue plasminogen activator in Pichia pastoris Appl Biochem Biotechnol (2010) 162, 2037-2048. PubMed Europe PubMed DOI E
Mandi,N., Sundaram,K.R., Tandra,S.K., Bandyopadhyay,S. and Padmanabhan,S. Asn12 and Asn278: critical residues for in vitro biological activity of reteplase Adv Hematol (2010) 2010, 172484-172484. PubMed Europe PubMed DOI PMC EPMC E
Wu,S.L., Jiang,H., Hancock,W.S. and Karger,B.L. Identification of the unpaired cysteine status and complete mapping of the 17 disulfides of recombinant tissue plasminogen activator using LC-MS with electron transfer dissociation/collision induced dissociation Anal Chem (2010) 82, 5296-5303. PubMed Europe PubMed DOI PMC EPMC

2009

Hou,S.J., Yen,F.C. and Tsai,S.J. Is dysfunction of the tissue plasminogen activator (tPA)-plasmin pathway a link between major depression and cardiovascular disease? Med Hypotheses (2009) 72, 166-168. PubMed Europe PubMed DOI
Zivin,J.A. Acute stroke therapy with tissue plasminogen activator (tPA) since it was approved by the U.S. Food and Drug Administration (FDA) Ann Neurol (2009) 66, 6-10. PubMed Europe PubMed DOI U

2008

Maas,C., Schiks,B., Strangi,R.D., Hackeng,T.M., Bouma,B.N., Gebbink,M.F. and Bouma,B. Identification of fibronectin type I domains as amyloid-binding modules on tissue-type plasminogen activator and three homologs Amyloid (2008) 15, 166-180. PubMed Europe PubMed DOI
Park,L., Gallo,E.F., Anrather,J., Wang,G., Norris,E.H., Paul,J., Strickland,S. and Iadecola,C. Key role of tissue plasminogen activator in neurovascular coupling Proc Natl Acad Sci U S A (2008) 105, 1073-1078. PubMed Europe PubMed DOI PMC EPMC
Skrzypiec,A.E., Buczko,W. and Pawlak,R. Tissue plasminogen activator in the amygdala: a new role for an old protease J Physiol Pharmacol (2008) 59 Suppl 8, 135-146. PubMed Europe PubMed K

2007

Kumaresan,P.R., Natarajan,A., Song,A., Wang,X., Liu,R., DeNardo,G., DeNardo,S. and Lam,K.S. Development of tissue plasminogen activator specific "on demand cleavable" (odc) linkers for radioimmunotherapy by screening one-bead-one-compound combinatorial peptide libraries Bioconjug Chem (2007) 18, 175-182. PubMed Europe PubMed DOI
Lee,H.Y., Hwang,I.Y., Im,H., Koh,J.Y. and Kim,Y.H. Non-proteolytic neurotrophic effects of tissue plasminogen activator on cultured mouse cerebrocortical neurons J Neurochem (2007) 101, 1236-1247. PubMed Europe PubMed DOI
Ortiz-Zapater,E., Peiro,S., Roda,O., Corominas,J.M., Aguilar,S., Ampurdanes,C., Real,F.X. and Navarro,P. Tissue plasminogen activator induces pancreatic cancer cell proliferation by a non-catalytic mechanism that requires extracellular signal-regulated kinase 1/2 activation through epidermal growth factor receptor and annexin A2 Am J Pathol (2007) 170, 1573-1584. PubMed Europe PubMed DOI PMC EPMC
Simpson,D., Siddiqui,M.A., Scott,L.J. and Hilleman,D.E. Spotlight on reteplase in thrombotic occlusive disorders BioDrugs (2007) 21, 65-68. PubMed Europe PubMed DOI

2006

[YEAR:22-11-2006]Hu,K., Yang,J., Tanaka,S., Gonias,S.L., Mars,W.M. and Liu,Y. Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression J Biol Chem (22-11-2006) 281, 2120-2127. PubMed Europe PubMed DOI
[YEAR:27-6-2006]Liot,G., Roussel,B.D., Lebeurrier,N., Benchenane,K., Lopez-Atalaya,J.P., Vivien,D. and Ali,C. Tissue-type plasminogen activator rescues neurones from serum deprivation-induced apoptosis through a mechanism independent of its proteolytic activity J Neurochem (27-6-2006) 98, 1458-1464. PubMed Europe PubMed DOI

2005

[YEAR:3-2-2005]Carroll,V.A., Nikitenko,L.L., Bicknell,R. and Harris,A.L. Antiangiogenic activity of a domain deletion mutant of tissue plasminogen activator containing kringle 2 Arterioscler Thromb Vasc Biol (3-2-2005) 25, 736-741. PubMed Europe PubMed DOI
Grobholz,K., Burggraf,D., Martens,K.H., Wunderlich,N., Pichler,M. and Hamann,F.G. Recombinant tissue plasminogen activator attenuates basal lamina antigen loss after experimental focal cerebral ischemia Neurol Res (2005) 27, 212-217. PubMed Europe PubMed DOI
Haley,E.C., Jr., Lyden,P.D., Johnston,K.C. and Hemmen,T.M. A pilot dose-escalation safety study of Tenecteplase in acute ischemic stroke Stroke (2005) 36, 607-612. PubMed Europe PubMed DOI

2004

[YEAR:29-9-2004]Fredriksson,L., Li,H., Fieber,C., Li,X. and Eriksson,U. Tissue plasminogen activator is a potent activator of PDGF-CC EMBO J (29-9-2004) 23, 3793-3802. PubMed Europe PubMed DOI PMC EPMC
Kruithof,E.K. and Schleuning,W.D. A comparative study of amyloid-beta (1-42) as a cofactor for plasminogen activation by vampire bat plasminogen activator and recombinant human tissue-type plasminogen activator Thromb Haemost (2004) 92, 559-567. PubMed Europe PubMed DOI
Lijnen,H.R. and Collen,D. t-Plasminogen activator [ISSN:0-12-079610-4] (2004) 2, 1684-1689. V
Yepes,M. and Lawrence,D.A. Tissue-type plasminogen activator and neuroserpin: a well-balanced act in the nervous system? Trends Cardiovasc Med (2004) 14, 173-180. PubMed Europe PubMed DOI
Yepes,M. and Lawrence,D.A. New functions for an old enzyme: nonhemostatic roles for tissue-type plasminogen activator in the central nervous system Exp Biol Med (Maywood) (2004) 229, 1097-1104. PubMed Europe PubMed
Yi,J.S., Kim,Y.H. and Koh,J.Y. Infarct reduction in rats following intraventricular administration of either tissue plasminogen activator (tPA) or its non-protease mutant S478A-tPA Exp Neurol (2004) 189, 354-360. PubMed Europe PubMed DOI

2003

Daci,E., Everts,V., Torrekens,S., Van Herck,E., Tigchelaar-Gutterr,W., Bouillon,R. and Carmeliet,G. Increased bone formation in mice lacking plasminogen activators J Bone Miner Res (2003) 18, 1167-1176. PubMed Europe PubMed DOI K
[YEAR:5-6-2003]Hermans,J.M., Haines,D.S., James,P.S. and Jones,R. Kinetics of inhibition of sperm beta-acrosin activity by suramin FEBS Lett (5-6-2003) 544, 119-122. PubMed Europe PubMed DOI
Ladenvall,P., Nilsson,S., Jood,K., Rosengren,A., Blomstrand,C. and Jern,C. Genetic variation at the human tissue-type plasminogen activator (tPA) locus: haplotypes and analysis of association to plasma levels of tPA Eur J Hum Genet (2003) 11, 603-610. PubMed Europe PubMed DOI M

2002

[YEAR:6-12-2002]Barker-Carlson,K., Lawrence,D.A. and Schwartz,B.S. Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro J Biol Chem (6-12-2002) 277, 46852-46857. PubMed Europe PubMed DOI
Manosroi,J., Tayapiwatana,C., Manosroi,A., Beer,J., Bergemann,K. and Werner,R.G. Lekteplase - a secreted tissue plasminogen activator derivative from Escherichia coli Arzneimittelforschung (2002) 52, 60-66. PubMed Europe PubMed DOI E
Yang,J., Shultz,R.W., Mars,W.M., Wegner,R.E., Li,Y., Dai,C., Nejak,K. and Liu,Y. Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy J Clin Invest (2002) 110, 1525-1538. PubMed Europe PubMed DOI PMC EPMC

2001

[YEAR:11-9-2001]Hudson,M.P., Granger,C.B., Topol,E.J., Pieper,K.S., Armstrong,P.W., Barbash,G.I., Guerci,A.D., Vahanian,A., Califf,R.M. and Ohman,E.M. Early reinfarction after fibrinolysis: experience from the Global Utilization of Streptokinase and Tissue plasminogen activator (alteplase) for occluded coronary arteries (GUSTO I) and Global Use of Strategies to Open occluded coronary arteries (GUSTO III) trials Circulation (11-9-2001) 104, 1229-1235. PubMed Europe PubMed
Manosroi,J., Tayapiwatana,C., Gotz,F., Werner,R.G. and Manosroi,A. Secretion of active recombinant human tissue plasminogen activator derivatives in Escherichia coli Appl Environ Microbiol (2001) 67, 2657-2664. PubMed Europe PubMed DOI PMC EPMC E
Shortell,C.K., Queiroz,R., Johansson,M., Waldman,D., Illig,K.A., Ouriel,K. and Green,R.M. Safety and efficacy of limited-dose tissue plasminogen activator in acute vascular occlusion J Vasc Surg (2001) 34, 854-859. PubMed Europe PubMed DOI
Werner,R.G. Improving natural principles with genetic engineering: TNK-tissue plasminogen activator Arzneimittelforschung (2001) 51, 516-520. PubMed Europe PubMed DOI
Wiebe,M.G., Karandikar,A., Robson,G.D., Trinci,A.P., Candia,J.L., Trappe,S., Wallis,G., Rinas,U., Derkx,P.M., Madrid,S.M., Sisniega,H., Faus,I., Montijn,R., van den Hondel,C.A. and Punt,P.J. Production of tissue plasminogen activator (t-PA) in Aspergillus niger Biotechnol Bioeng (2001) 76, 164-174. PubMed Europe PubMed DOI E

2000

[YEAR:5-7-2000]Harris,J.L., Backes,B.J., Leonetti,F., Mahrus,S., Ellman,J.A. and Craik,C.S. Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries Proc Natl Acad Sci U S A (5-7-2000) 97, 7754-7759. PubMed Europe PubMed DOI PMC EPMC P
Ladenvall,P., Wall,U., Jern,S. and Jern,C. Identification of eight novel single-nucleotide polymorphisms at human tissue-type plasminogen activator (t-PA) locus: association with vascular t-PA release in vivo Thromb Haemost (2000) 84, 150-155. PubMed Europe PubMed M
Vindigni,A., Winfield,M., Ayala,Y.M. and Di Cera,E. Role of residue Y99 in tissue plasminogen activator Protein Sci (2000) 9, 619-622. PubMed Europe PubMed DOI PMC EPMC

1999

Dekker,R.J., Eichinger,A., Stoop,A.A., Bode,W., Pannekoek,H. and Horrevoets,A.J. The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop J Mol Biol (1999) 293, 613-627. PubMed Europe PubMed DOI S
[YEAR:23-11-1999]Seeds,N.W., Basham,M.E. and Haffke,S.P. Neuronal migration is retarded in mice lacking the tissue plasminogen activator gene Proc Natl Acad Sci U S A (23-11-1999) 96, 14118-14123. PubMed Europe PubMed DOI PMC EPMC

1998

Stubbs,M.T., Renatus,M. and Bode,W. An active zymogen: Unravelling the mystery of tissue-type plasminogen activator Biol Chem (1998) 379, 95-103. PubMed Europe PubMed

1997

Alberts,M.J. Hyperacute stroke therapy with tissue plasminogen activator Am J Cardiol (1997) 80, 29D-34D. PubMed Europe PubMed DOI
Bode,W. and Renatus,M. Tissue-type plasminogen activator: variants and crystal/solution structures demarcate structural determinants of function Curr Opin Struct Biol (1997) 7, 865-872. PubMed Europe PubMed DOI
Butenas,S., Kalafatis,M. and Mann,K.G. Analysis of tissue plasminogen activator specificity using peptidyl fluorogenic substrates Biochemistry (1997) 36, 2123-2131. PubMed Europe PubMed DOI
Emeis,J.J., Eijnden-Schrauwen,Y., van den Hoogen,C.M., de Priester,W., Westmuckett,A. and Lupu,F. An endothelial storage granule for tissue-type plasminogen activator J Cell Biol (1997) 139, 245-256. PubMed Europe PubMed DOI PMC EPMC
[YEAR:26-12-1997]Hastings,G.A., Coleman,T.A., Haudenschild,C.C., Stefansson,S., Smith,E.P., Barthlow,R., Cherry,S., Sandkvist,M. and Lawrence,D.A. Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. Implications for the regulation of motor learning and neuronal survival J Biol Chem (26-12-1997) 272, 33062-33067. PubMed Europe PubMed DOI
Ke,S.H., Coombs,G.S., Tachias,K., Navre,M., Corey,D.R. and Madison,E.L. Distinguishing the specificities of closely related proteases: role of p3 in substrate and inhibitor discrimination between tissue type plasminogen activator and urokinase Fibrinolysis Proteolysis (1997) 11 Suppl. 3, 51-51. P
Ke,S.H., Tachias,K., Lamba,D., Bode,W. and Madison,E.L. Identification of a hydrophobic exosite on tissue type plasminogen activator that modulates specificity for plasminogen J Biol Chem (1997) 272, 1811-1816. PubMed Europe PubMed DOI
Ke,S.H., Coombs,G.S., Tachias,K., Navre,M., Corey,D.R. and Madison,E.L. Distinguishing the specificities of closely related proteases. Role of P3 in substrate and inhibitor discrimination between tissue-type plasminogen activator and urokinase J Biol Chem (1997) 272, 16603-16609. PubMed Europe PubMed DOI P
Renatus,M., Bode,W., Huber,R., Sturzebecher,J., Prasa,D., Fischer,S., Kohnert,U. and Stubbs,M.T. Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors J Biol Chem (1997) 272, 21713-21719. PubMed Europe PubMed DOI S
[YEAR:15-8-1997]Renatus,M., Engh,R.A., Stubbs,M.T., Huber,R., Fischer,S., Kohnert,U. and Bode,W. Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA EMBO J (15-8-1997) 16, 4797-4805. PubMed Europe PubMed DOI PMC EPMC S

1996

Coombs,G.S., Dang,A.T., Madison,E.L. and Corey,D.R. Distinct mechanisms contribute to stringent substrate specificity of tissue-type plasminogen activator J Biol Chem (1996) 271, 4461-4467. PubMed Europe PubMed DOI
Gils,A., Knockaert,I. and Declerck,P.J. Substrate behavior of plasminogen activator inhibitor-1 is not associated with a lack of insertion of the reactive site loop Biochemistry (1996) 35, 7474-7481. PubMed Europe PubMed DOI
Lamba,D., Bauer,M., Huber,R., Fischer,S., Rudolph,R., Kohnert,U. and Bode,W. The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator J Mol Biol (1996) 258, 117-135. PubMed Europe PubMed DOI S

1995

Madison,E.L., Coombs,G.S. and Corey,D.R. Substrate specificity of tissue type plasminogen activator. Characterization of the fibrin independent specificity of t-PA for plasminogen J Biol Chem (1995) 270, 7558-7562. PubMed Europe PubMed DOI P

1994

Bjorquist,P., Brohlin,M., Ehnebom,J., Ericsson,M., Kristiansen,C., Pohl,G. and Deinum,J. Plasminogen activator inhibitor type-1 interacts exclusively with the proteinase domain of tissue plasminogen activator Biochim Biophys Acta (1994) 1209, 191-202. PubMed Europe PubMed
Carmeliet,P., Schoonjans,L., Kieckens,L., Ream,B., Degen,J., Bronson,R., De Vos,R., van den Oord,J.J., Collen,D. and Mulligan,R.C. Physiological consequences of loss of plasminogen activator gene function in mice Nature (1994) 368, 419-424. PubMed Europe PubMed DOI K
Cesarman,G.M., Guevara,C.A. and Hajjar,K.A. An endothelial cell receptor for plasminogen/tissue plasminogen activator (t-PA). II. Annexin II-mediated enhancement of t-PA-dependent plasminogen activation J Biol Chem (1994) 269, 21198-21203. PubMed Europe PubMed
De Serrano,V.S. and Castellino,F.J. Involvement of tyrosine-76 of the kringle 2 domain of tissue-type plasminogen activator in its thermal stability and its omega-amino acid ligand binding site Biochemistry (1994) 33, 3509-3514. PubMed Europe PubMed

1993

Madison,E.L., Kobe,A., Gething,M.J., Sambrook,J.F. and Goldsmith,E.J. Converting tissue plasminogen activator to a zymogen: a regulatory triad of Asp-His-Ser Science (1993) 262, 419-421. PubMed Europe PubMed
[YEAR:4-6-1993]Margossian,S.S., Slayter,H.S., Kaczmarek,E. and McDonagh,J. Physical characterization of recombinant tissue plasminogen activator Biochim Biophys Acta (4-6-1993) 1163, 250-256. PubMed Europe PubMed DOI

1992

[YEAR:5-6-1992]Downing,A.K., Driscoll,P.C., Harvey,T.S., Dudgeon,T.J., Smith,B.O., Baron,M. and Campbell,I.D. Solution structure of the fibrin binding finger domain of tissue-type plasminogen activator determined by 1H nuclear magnetic resonance J Mol Biol (5-6-1992) 225, 821-833. PubMed Europe PubMed DOI
Ludwig,M., Wohn,K.D., Schleuning,W.D. and Olek,K. Allelic dimorphism in the human tissue-type plasminogen activator (TPA) gene as a result of an Alu insertion/deletion event Hum Genet (1992) 88, 388-392. PubMed Europe PubMed M
[YEAR:21-4-1992]Nienaber,V.L., Young,S.L., Birktoft,J.J., Higgins,D.L. and Berliner,L.J. Conformational similarities between one-chain and two-chain tissue plasminogen activator (t-PA): implications to the activation mechanism on one-chain t-PA Biochemistry (21-4-1992) 31, 3852-3861. PubMed Europe PubMed DOI
Schnyder,J., Marti,R., Cooper,P.H. and Payne,T.G. Spectrophotometric method to quantify and discriminate urokinase and tissue-type plasminogen activators Anal Biochem (1992) 200, 156-162. PubMed Europe PubMed A

1991

Andreasen,P.A., Petersen,L.C. and Dano,K. Diversity in catalytic properties of single chain and two chain tissue-type plasminogen activator Fibrinolysis (1991) 5, 207-215. DOI
Berg,D.T. and Grinnell,B.W. Signal and propeptide processing of human tissue plasminogen activator: Activity of a pro-tPA derivative Biochem Biophys Res Commun (1991) 179, 1289-1296. PubMed Europe PubMed
Harris,R.J., Leonard,C.K., Guzzetta,A.W. and Spellman,M.W. Tissue plasminogen activator has an O-linked fucose attached to threonine-61 in the epidermal growth factor domain Biochemistry (1991) 30, 2311-2314. PubMed Europe PubMed

1990

[YEAR:5-2-1990]Feng,P., Ohlsson,M. and Ny,T. The structure of the TATA-less rat tissue-type plasminogen activator gene. Species-specific sequence divergences in the promoter predict differences in regulation of gene expression J Biol Chem (5-2-1990) 265, 2022-2027. PubMed Europe PubMed

1988

Petersen,L.C., Johannessen,M., Foster,D., Kumar,A. and Mulvihill,E. The effect of polymerised fibrin on the catalytic activities of one-chain tissue-type plasminogen activator as revealed by an analogue resistant to plasmin cleavage Biochim Biophys Acta (1988) 952, 245-254. PubMed Europe PubMed
Rijken,D.C. Relationships between structure and function of tissue-type plasminogen activator Klin Wochenschr (1988) 66 Suppl 12, 33-39. PubMed Europe PubMed V
Saksela,O. and Rifkin,D.B. Cell-associated plasminogen activation: regulation and physiological functions Annu Rev Cell Biol (1988) 4, 93-126. PubMed Europe PubMed DOI

1987

[YEAR:18-12-1987]Gaffney,P.J. and Curtis,A.D. A collaborative study to establish the 2nd international standard for tissue plasminogen activator (t-PA) Thromb Haemost (18-12-1987) 58, 1085-1087. PubMed Europe PubMed
Tate,K.M., Higgins,D.L., Holmes,W.E., Winkler,M.E., Heyneker,H.L. and Vehar,G.A. Functional role of proteolytic cleavage at arginine-275 of human tissue plasminogen activator as assessed by site-directed mutagenesis Biochemistry (1987) 26, 338-343. PubMed Europe PubMed

1985

Kasai,S., Arimura,H., Nishida,M. and Suyama,T. Proteolytic cleavage of single-chain pro-urokinase induces conformational change which follows activation of the zymogen and reduction of its high affinity for fibrin J Biol Chem (1985) 260, 12377-12381. PubMed Europe PubMed

1984

Collen,D., Stassen,J.M., Marafino,B.J.J., Builder,S., De Cock,F., Ogez,J., Tajiri,D., Pennica,D., Bennett,W.F. and Salwa,J. Biological properties of human tissue-type plasminogen activator obtained by expression of recombinant DNA in mammalian cells J Pharmacol Exp Ther (1984) 231, 146-152. PubMed Europe PubMed
[YEAR:1-6-1984]Lijnen,H.R., Uytterhoeven,M. and Collen,D. Inhibition of trypsin-like serine proteinases by tripeptide arginyl and lysyl chloromethylketones Thromb Res (1-6-1984) 34, 431-437. PubMed Europe PubMed I

1983

Pennica,D., Holmes,W.E., Kohr,W.J., Harkins,R.N., Vehar,G.A., Ward,C.A., Bennett,W.F., Yelverton,E., Seeburg,P.H., Heyneker,H.L., Goeddel,D.V. and Collen,D. Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli Nature (1983) 301, 214-221. PubMed Europe PubMed

1982

[YEAR:15-9-1982]Ranby,M., Norrman,B. and Wallen,P. A sensitive assay for tissue plasminogen activator Thromb Res (15-9-1982) 27, 743-749. PubMed Europe PubMed
Ranby,M. Studies on the kinetics of plasminogen activation by tissue plasminogen activator Biochim Biophys Acta (1982) 704, 461-469. PubMed Europe PubMed
[YEAR:27-12-1982]Verheijen,J.H., Mullaart,E., Chang,G.T., Kluft,C. and Wijngaards,G. A simple, sensitive spectrophotometric assay for extrinsic (tissue-type) plasminogen activator applicable to measurements in plasma Thromb Haemost (27-12-1982) 48, 266-269. PubMed Europe PubMed

1981

[YEAR:30-6-1981]Matsuo,O., Rijken,D.C. and Collen,D. Comparison of the relative fibrinogenolytic, fibrinolytic and thrombolytic properties of tissue plasminogen activator and urokinase in vitro Thromb Haemost (30-6-1981) 45, 225-229. PubMed Europe PubMed
[YEAR:7-11-1981]Weimar,W., Stibbe,J., van Seyen,A.J., Billiau,A., De Somer,P. and Collen,D. Specific lysis of an iliofemoral thrombus by administration of extrinsic (tissue-type) plasminogen activator Lancet (7-11-1981) 2, 1018-1020. PubMed Europe PubMed

1974

Thorsen,S. and Astrup,T. Substrate composition and the effect of úomegaú-aminocaproic acid on tissue plasminogen activator and urokinase-induced fibrinolysis Thromb Diath Haemorrh (1974) 32, 306-324. PubMed Europe PubMed I

1970

Astrup,T. and Kok,P. Assay and preparation of a tissue plasminogen activator Methods Enzymol (1970) 19, 821-834.

1969

Kok,P. and Astrup,T. Isolation and purification of a tissue plasminogen activator and its comparison with urokinase Biochemistry (1969) 8, 79-86. PubMed Europe PubMed

1966

Astrup,T. Tissue activators of plasminogen Fed Proc (1966) 25, 42-51. PubMed Europe PubMed

1965

Astrup,T. and Rasmussen,J. Preparation and purification of a plasminogen activator from porcine tissue Thromb Diath Haemorrh (1965) 13, 418-427.

1947

Astrup,T. and Permin,P.M. Fibrinolysis in the animal organism Nature (1947) 159, 681-682. PubMed Europe PubMed