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Literature for peptidase S01.232: t-plasminogen activator

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Arsanjani,A.A., Faradonbeh,D.R., Malekshahi,Z.V., Mosayyebi,B. and Negahdari,B.
    Strategies for the Discovery and Design of Tissue Plasminogen Activators: Insights Into Bioengineering Objectives
    Drug Dev Res86, e70072-e70072. PubMed  Europe PubMed DOI  V
    2. 2024
  2. Challa,S.R., Nalamolu,K.R., Fornal,C.A., Baker,I.M., Mohandass,A., Mada,S.R., Wang,B.C., Pinson,D.M., Lahoti,S., Klopfenstein,J.D. and Veeravalli,K.K.
    The paradox of tPA in ischemic stroke: tPA knockdown following recanalization improves functional and histological outcomes
    Exp Neurol374, 114727-114727. PubMed  Europe PubMed DOI
  3. Yepes,M.
    Fibrinolytic and Non-fibrinolytic Roles of Tissue-type Plasminogen Activator in the Ischemic Brain
    Neuroscience542, 69-80. PubMed  Europe PubMed DOI  V
    4. 2023
  4. Dai,W., Zhang,H., Lund,H., Zhang,Z., Castleberry,M., Rodriguez,M., Kuriakose,G., Gupta,S., Lewandowska,M., Powers,H.R., Valmiki,S., Zhu,J., Shapiro,A.D., Hussain,M.M., Lopez,J.A., Sorci-Thomas,M.G., Silverstein,R.L., Ginsberg,H.N., Sahoo,D., Tabas,I. and Zheng,Z.
    Intracellular tPA-PAI-1 interaction determines VLDL assembly in hepatocytes
    Science381, eadh5207-eadh5207. PubMed  Europe PubMed DOI
  5. Forry,J. and Chappell,A.
    Tenecteplase: A Review of Its Pharmacology and Uses
    AACN Adv Crit Care34, 77-83. PubMed  Europe PubMed DOI
  6. Lin,L. and Hu,K.
    Macrophage Function Modulated by tPA Signaling in Mouse Experimental Kidney Disease Models
    Int J Mol Sci24, PubMed  Europe PubMed DOI  V
  7. Mennesson,M. and Revest,J.M.
    Glucocorticoid-Responsive Tissue Plasminogen Activator (tPA) and Its Inhibitor Plasminogen Activator Inhibitor-1 (PAI-1): Relevance in Stress-Related Psychiatric Disorders
    Int J Mol Sci24, PubMed  Europe PubMed DOI  V
  8. Smart,C., Mitchell,A., McCutcheon,F., Medcalf,R.L. and Thiele,A.
    Tissue-type plasminogen activator induces conditioned receptive field plasticity in the mouse auditory cortex
    iScience26, 105947-105947. PubMed  Europe PubMed DOI
  9. Tao,Y., Ma,J., Feng,Y., Gao,C., Wu,T., Xia,Y., Cheng,Z., Zhang,Y., Liu,T., Hu,Y. and Tang,L.V.
    Tissue-type plasminogen activator (tPA) homozygous Tyr471His mutation associates with thromboembolic disease
    MedComm (2020)4, e392-e392. PubMed  Europe PubMed DOI
  10. Yang,J., Cha,L., Wang,Y., Zhang,Q., Tang,X., Shao,J. and Duan,Z.
    L-Palmitoylcarnitine potentiates plasmin and tPA to inhibit thrombosis
    Nat Prod Bioprospect13, 48-48. PubMed  Europe PubMed DOI
    11. 2022
  11. Tomadesso,C., de Lizarrondo,S.M., Ali,C., Landeau,B., Mezenge,F., Perrotin,A., de la Sayette,V., Vivien,D. and Chetelat,G.
    Plasma Levels of Tissue-Type Plasminogen Activator (tPA) in Normal Aging and Alzheimer's Disease: Links With Cognition, Brain Structure, Brain Function and Amyloid Burden
    Front Aging Neurosci14, 871214-871214. PubMed  Europe PubMed DOI
  12. Zuba,V., Furon,J., Bellemain-Sagnard,M., Martinez de Lizarrondo,S., Lebouvier,L., Rubio,M., Hommet,Y., Gauberti,M., Vivien,D. and Ali,C.
    The choroid plexus: a door between the blood and the brain for tissue-type plasminogen activator
    Fluids Barriers CNS19, 80-80. PubMed  Europe PubMed DOI
    13. 2021
  13. Hedou,E., Douceau,S., Chevilley,A., Varangot,A., Thiebaut,A.M., Triniac,H., Bardou,I., Ali,C., Maillasson,M., Crepaldi,T., Comoglio,P., Lemarchand,E., Agin,V., Roussel,B.D. and Vivien,D.
    Two-Chains Tissue Plasminogen Activator Unifies Met and NMDA Receptor Signalling to Control Neuronal Survival
    Int J Mol Sci22, PubMed  Europe PubMed DOI
  14. Ismail,A.A., Shaker,B.T. and Bajou,K.
    The Plasminogen-Activator Plasmin System in Physiological and Pathophysiological Angiogenesis
    Int J Mol Sci23, PubMed  Europe PubMed DOI
    15. 2020
  15. Bellien,J., Iacob,M., Richard,V., Wils,J., Le Cam-Duchez,V. and Joannides,R.
    Evidence for wall shear stress-dependent t-PA release in human conduit arteries: role of endothelial factors and impact of high blood pressure
    Hypertens Res PubMed  Europe PubMed DOI
  16. Carneiro,T., Dashkoff,J., Leung,L.Y., Nobleza,C.O.S., Marulanda-Londono,E., Hathidara,M., Koch,S., Sur,N., Boske,A., Voetsch,B., Aboul Nour,H., Miller,D.J., Daneshmand,A., Shulman,J., Curiale,G., Greer,D.M., Romero,J.R., Anand,P. and Cervantes-Arslanian,A.M.
    Intravenous tPA for Acute Ischemic Stroke in Patients with COVID-19
    J Stroke Cerebrovasc Dis29, 105201-105201. PubMed  Europe PubMed DOI
  17. Chang,Z., Zou,H., Xie,Z., Deng,B., Que,R., Huang,Z., Weng,G., Wu,Z., Pan,Y., Wang,Y., Li,M., Xie,H., Zhu,S., Xiong,L., Ct Mok,V., Jin,K., Yenari,M.A., Wei,X. and Wang,Q.
    Cystatin C is a potential predictor of unfavorable outcomes for cerebral ischemia with intravenous tissue plasminogen activator treatment: A multicenter prospective nested case-control study
    Eur J Neurol PubMed  Europe PubMed DOI
  18. Kipshidze,N., Dangas,G., White,C.J., Kipshidze,N., Siddiqui,F., Lattimer,C.R., Carter,C.A. and Fareed,J.
    Viral Coagulopathy in Patients With COVID-19: Treatment and Care
    Clin Appl Thromb Hemost26, 1076029620936776-1076029620936776. PubMed  Europe PubMed DOI
  19. Marceau,F., Rivard,G.E., Gauthier,J.M., Binkley,K.E., Bonnefoy,A., Boccon-Gibod,I., Bouillet,L., Picard,M., Levesque,G., Elfassy,H.L., Bachelard,H., Hebert,J. and Bork,K.
    Measurement of Bradykinin Formation and Degradation in Blood Plasma: Relevance for Acquired Angioedema Associated With Angiotensin Converting Enzyme Inhibition and for Hereditary Angioedema Due to Factor XII or Plasminogen Gene Variants
    Front Med (Lausanne)7, 358-358. PubMed  Europe PubMed DOI  I
  20. Ranucci,M., Sitzia,C., Baryshnikova,E., Di Dedda,U., Cardani,R., Martelli,F. and Corsi Romanelli,M.
    Covid-19-Associated Coagulopathy: Biomarkers of Thrombin Generation and Fibrinolysis Leading the Outcome
    J Clin Med9, PubMed  Europe PubMed DOI
  21. Saggese,C.E., Del Bianco,C., Di Ruzza,M.R., Magarelli,M., Gandini,R. and Plocco,M.
    COVID-19 and Stroke: Casual or Causal Role?
    Cerebrovasc Dis49, 341-344. PubMed  Europe PubMed DOI
  22. Sanda,T., Yoshimura,M., Hyodo,K., Ishii,H. and Yamashita,T.
    Effects of Long-term Thrombin Inhibition (Dabigatran Etexilate) on Spontaneous Thrombolytic Activity during the Progression of Atherosclerosis in ApoE(-/-)-LDLR(-/-) Double-Knockout Mice
    Korean Circ J50, 804-816. PubMed  Europe PubMed DOI  I
  23. Suzuki,Y., Sano,H., Mochizuki,L., Honkura,N. and Urano,T.
    Activated platelet-based inhibition of fibrinolysis via thrombin-activatable fibrinolysis inhibitor activation system
    Blood Adv4, 5501-5511. PubMed  Europe PubMed DOI
    24. 2019
  24. Chana-Munoz,A., Jendroszek,A., Sonnichsen,M., Wang,T., Ploug,M., Jensen,J.K., Andreasen,P.A., Bendixen,C. and Panitz,F.
    Origin and diversification of the plasminogen activation system among chordates
    BMC Evol Biol19, 27-27. PubMed  Europe PubMed DOI
  25. Ghaheh,H.S., Ganjalikhany,M.R., Yaghmaei,P., Pourfarzam,M. and Mir Mohammad Sadeghi,H.
    Improving the solubility, activity, and stability of reteplase using in silico design of new variants
    Res Pharm Sci14, 359-368. PubMed  Europe PubMed DOI
  26. Li,C.Y., de Veer,S.J., Law,R.H.P., Whisstock,J.C., Craik,D.J. and Swedberg,J.E.
    Characterising the subsite specificity of urokinase-type plasminogen activator and tissue-type plasminogen activator using a sequence-defined peptide aldehyde library
    Chembiochem20, 46-50. PubMed  Europe PubMed DOI  P  I
  27. Mohammadi,E., Seyedhosseini-Ghaheh,H., Mahnam,K., Jahanian-Najafabadi,A. and Mir Mohammad Sadeghi,H.
    Reteplase: structure, function, and production
    Adv Biomed Res8, 19-19. PubMed  Europe PubMed DOI
  28. Peng,S., Xue,G., Chen,S., Chen,Z., Yuan,C., Li,J. and Huang,M.
    tPA Point mutation at autolysis loop enhances resistance to PAI-1 inhibition and catalytic activity
    Thromb Haemost119, 77-86. PubMed  Europe PubMed DOI
    29. 2018
  29. Ito,Y., Noguchi,K., Morishima,Y. and Yamaguchi,K.
    Tissue-type plasminogen activator transgenic rats for evaluating inhibitors of the activated form of thrombin-activatable fibrinolysis inhibitor
    Blood Coagul Fibrinolysis29, 314-321. PubMed  Europe PubMed DOI  K  I
    30. 2017
  30. Bjerregaard,N., Dupont,D.M. and Andreasen,P.A.
    A conjugate of two tPA-binding RNA aptamers efficiently inhibits fibrinolysis
    Nucleic Acid Ther27, 95-104. PubMed  Europe PubMed DOI  I
  31. Simao,F., Ustunkaya,T., Clermont,A.C. and Feener,E.P.
    Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke
    Blood129, 2280-2290. PubMed  Europe PubMed DOI
    32. 2016
  32. Abdoli Nasab,M., Jalali Javaran,M., Cusido,R.M. and Palazon,J.
    Purification of recombinant tissue plasminogen activator (rtPA) protein from transplastomic tobacco plants
    Plant Physiol Biochem108, 139-144. PubMed  Europe PubMed DOI  E
  33. Carlson,K.S., Nguyen,L., Schwartz,K., Lawrence,D.A. and Schwartz,B.S.
    Neuroserpin differentiates between forms of tissue type plasminogen activator via pH dependent deacylation
    Front Cell Neurosci10, 154-154. PubMed  Europe PubMed DOI
  34. Gong,L., Liu,M., Zeng,T., Shi,X., Yuan,C., Andreasen,P.A. and Huang,M.
    Structural basis of specific inhibition of tissue-type plasminogen activator by plasminogen activators inhibitor-1
    Data Brief6, 550-555. PubMed  Europe PubMed DOI
  35. Hebert,M., Lesept,F., Vivien,D. and Macrez,R.
    The story of an exceptional serine protease, tissue-type plasminogen activator (tPA)
    Rev Neurol (Paris)172, 186-197. PubMed  Europe PubMed DOI  V
    36. 2015
  36. Gong,L., Liu,M., Zeng,T., Shi,X., Yuan,C., Andreasen,P.A. and Huang,M.
    Crystal structure of the Michaelis complex between tissue-type plasminogen activator and plasminogen activators inhibitor-1
    J Biol Chem290, 25795-25804. PubMed  Europe PubMed DOI  S
  37. Long,X., Gou,Y., Luo,M., Zhang,S., Zhang,H., Bai,L., Wu,S., He,Q., Chen,K., Huang,A., Zhou,J. and Wang,D.
    Soluble expression, purification, and characterization of active recombinant human tissue plasminogen activator by auto-induction in E. coli
    BMC Biotechnol15, 13- PubMed  Europe PubMed DOI  E
    38. 2014
  38. Asgari,M., Javaran,M.J., Moieni,A., Masoumiasl,A. and Abdolinasab,M.
    Production of human tissue plasminogen activator (tPA) in Cucumis sativus
    Prep Biochem Biotechnol44, 182-192. PubMed  Europe PubMed DOI  E
  39. Freeman,R., Niego,B., Croucher,D.R., Pedersen,L.O. and Medcalf,R.L.
    t-PA, but not desmoteplase, induces plasmin-dependent opening of a blood-brain barrier model under normoxic and ischaemic conditions
    Brain Res1565, 63-73. PubMed  Europe PubMed DOI
  40. Kazemali,M., Majidzadeh-A,K., Sardari,S., Saadatirad,A.H., Khalaj,V., Zarei,N., Barkhordari,F., Adeli,A. and Mahboudi,F.
    Design of a novel chimeric tissue plasminogen activator with favorable Vampire bat plasminogen activator properties
    Enzyme Microb Technol67, 82-86. PubMed  Europe PubMed DOI  E
  41. Sonderegger,P. and Matsumoto-Miyai,K.
    Activity-controlled proteolytic cleavage at the synapse
    Trends Neurosci37, 413-423. PubMed  Europe PubMed DOI
  42. Valapala,M., Maji,S., Borejdo,J. and Vishwanatha,J.K.
    Cell surface translocation of annexin A2 facilitates glutamate-induced extracellular proteolysis
    J Biol Chem289, 15915-15926. PubMed  Europe PubMed DOI
    43. 2013
  43. Aflakiyan,S., Sadeghi,H.M., Shokrgozar,M., Rabbani,M., Bouzari,S. and Jahanian-Najafabadi,A.
    Expression of the recombinant plasminogen activator (reteplase) by a non-lytic insect cell expression system
    Res Pharm Sci8, 9-15. PubMed  Europe PubMed  E
  44. Gomaraschi,M., Ossoli,A., Vitali,C., Pozzi,S., Vitali Serdoz,L., Pitzorno,C., Sinagra,G., Franceschini,G. and Calabresi,L.
    Off-target effects of thrombolytic drugs: apolipoprotein A-I proteolysis by alteplase and tenecteplase
    Biochem Pharmacol85, 525-530. PubMed  Europe PubMed DOI
    45. 2012
  45. Bahi,A. and Dreyer,J.L.
    Involvement of tissue plasminogen activator "tPA" in ethanol-induced locomotor sensitization and conditioned-place preference
    Behav Brain Res226, 250-258. PubMed  Europe PubMed DOI
  46. Lijnen,H.R. and Rijken,D.C.
    t-Plasminogen activator
    [ISSN:978-0-12-407742-3]3, 2946-2952. DOI
  47. Ng,K.S., Leung,H.W., Wong,P.T. and Low,C.M.
    Cleavage of the NR2B subunit amino terminus of N-methyl-D-aspartate (NMDA) receptor by tissue plasminogen activator: identification of the cleavage site and characterization of ifenprodil and glycine affinities on truncated NMDA receptor
    J Biol Chem287, 25520-25529. PubMed  Europe PubMed DOI  P
    48. 2011
  48. Liang,Y.G., Liu,P., Gao,H.Z., Li,H.Y., Hao,G.T., Wang,X.F., Zhang,X.G., Meng,Q.Y. and Liu,Z.Y.
    Pharmacokinetics and safety of a new bioengineered thrombolytic agent, human tissue urokinase type plasminogen activator in Chinese healthy volunteers
    Eur J Drug Metab Pharmacokinet35, 97-102. PubMed  Europe PubMed DOI
  49. Luo,X.G., Tian,W.J., Ni,M., Jing,X.L., Lv,L.H., Wang,N., Jiang,Y. and Zhang,T.C.
    Soluble expression of active recombinant human tissue plasminogen activator derivative (K2S) in Escherichia coli
    Pharm Biol49, 653-657. PubMed  Europe PubMed DOI  E
  50. Nazari,R. and Davoudi,N.
    Cloning and expression of truncated form of tissue plasminogen activator in Leishmania tarentolae
    Biotechnol Lett33, 503-508. PubMed  Europe PubMed DOI  E
    51. 2010
  51. Jiang,H., Wu,S.L., Karger,B.L. and Hancock,W.S.
    Characterization of the glycosylation occupancy and the active site in the follow-on protein therapeutic: TNK-tissue plasminogen activator
    Anal Chem82, 6154-6162. PubMed  Europe PubMed DOI  U
  52. Majidzadeh,A., Khalaj,V., Fatemeh,D., Mahdi,H., Farzaneh,B., Ahmad,A. and Mahboudi,F.
    Cloning and expression of functional full-length human tissue plasminogen activator in Pichia pastoris
    Appl Biochem Biotechnol162, 2037-2048. PubMed  Europe PubMed DOI  E
  53. Mandi,N., Sundaram,K.R., Tandra,S.K., Bandyopadhyay,S. and Padmanabhan,S.
    Asn12 and Asn278: critical residues for in vitro biological activity of reteplase
    Adv Hematol2010, 172484-172484. PubMed  Europe PubMed DOI  E
  54. Wu,S.L., Jiang,H., Hancock,W.S. and Karger,B.L.
    Identification of the unpaired cysteine status and complete mapping of the 17 disulfides of recombinant tissue plasminogen activator using LC-MS with electron transfer dissociation/collision induced dissociation
    Anal Chem82, 5296-5303. PubMed  Europe PubMed DOI
    55. 2009
  55. Hou,S.J., Yen,F.C. and Tsai,S.J.
    Is dysfunction of the tissue plasminogen activator (tPA)-plasmin pathway a link between major depression and cardiovascular disease?
    Med Hypotheses72, 166-168. PubMed  Europe PubMed DOI
  56. Zivin,J.A.
    Acute stroke therapy with tissue plasminogen activator (tPA) since it was approved by the U.S. Food and Drug Administration (FDA)
    Ann Neurol66, 6-10. PubMed  Europe PubMed DOI  U
    57. 2008
  57. Maas,C., Schiks,B., Strangi,R.D., Hackeng,T.M., Bouma,B.N., Gebbink,M.F. and Bouma,B.
    Identification of fibronectin type I domains as amyloid-binding modules on tissue-type plasminogen activator and three homologs
    Amyloid15, 166-180. PubMed  Europe PubMed DOI
  58. Park,L., Gallo,E.F., Anrather,J., Wang,G., Norris,E.H., Paul,J., Strickland,S. and Iadecola,C.
    Key role of tissue plasminogen activator in neurovascular coupling
    Proc Natl Acad Sci U S A105, 1073-1078. PubMed  Europe PubMed DOI
  59. Skrzypiec,A.E., Buczko,W. and Pawlak,R.
    Tissue plasminogen activator in the amygdala: a new role for an old protease
    J Physiol Pharmacol59 Suppl 8, 135-146. PubMed  Europe PubMed  K
    60. 2007
  60. Kumaresan,P.R., Natarajan,A., Song,A., Wang,X., Liu,R., DeNardo,G., DeNardo,S. and Lam,K.S.
    Development of tissue plasminogen activator specific "on demand cleavable" (odc) linkers for radioimmunotherapy by screening one-bead-one-compound combinatorial peptide libraries
    Bioconjug Chem18, 175-182. PubMed  Europe PubMed DOI
  61. Lee,H.Y., Hwang,I.Y., Im,H., Koh,J.Y. and Kim,Y.H.
    Non-proteolytic neurotrophic effects of tissue plasminogen activator on cultured mouse cerebrocortical neurons
    J Neurochem101, 1236-1247. PubMed  Europe PubMed DOI
  62. Ortiz-Zapater,E., Peiro,S., Roda,O., Corominas,J.M., Aguilar,S., Ampurdanes,C., Real,F.X. and Navarro,P.
    Tissue plasminogen activator induces pancreatic cancer cell proliferation by a non-catalytic mechanism that requires extracellular signal-regulated kinase 1/2 activation through epidermal growth factor receptor and annexin A2
    Am J Pathol170, 1573-1584. PubMed  Europe PubMed DOI
  63. Simpson,D., Siddiqui,M.A., Scott,L.J. and Hilleman,D.E.
    Spotlight on reteplase in thrombotic occlusive disorders
    BioDrugs21, 65-68. PubMed  Europe PubMed DOI
    64. 2006
  64. [YEAR:22-11-2006]Hu,K., Yang,J., Tanaka,S., Gonias,S.L., Mars,W.M. and Liu,Y.
    Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression
    J Biol Chem281, 2120-2127. PubMed  Europe PubMed DOI
  65. [YEAR:27-6-2006]Liot,G., Roussel,B.D., Lebeurrier,N., Benchenane,K., Lopez-Atalaya,J.P., Vivien,D. and Ali,C.
    Tissue-type plasminogen activator rescues neurones from serum deprivation-induced apoptosis through a mechanism independent of its proteolytic activity
    J Neurochem98, 1458-1464. PubMed  Europe PubMed DOI
    66. 2005
  66. [YEAR:3-2-2005]Carroll,V.A., Nikitenko,L.L., Bicknell,R. and Harris,A.L.
    Antiangiogenic activity of a domain deletion mutant of tissue plasminogen activator containing kringle 2
    Arterioscler Thromb Vasc Biol25, 736-741. PubMed  Europe PubMed DOI
  67. Grobholz,K., Burggraf,D., Martens,K.H., Wunderlich,N., Pichler,M. and Hamann,F.G.
    Recombinant tissue plasminogen activator attenuates basal lamina antigen loss after experimental focal cerebral ischemia
    Neurol Res27, 212-217. PubMed  Europe PubMed DOI
  68. Haley,E.C., Jr., Lyden,P.D., Johnston,K.C. and Hemmen,T.M.
    A pilot dose-escalation safety study of Tenecteplase in acute ischemic stroke
    Stroke36, 607-612. PubMed  Europe PubMed DOI
    69. 2004
  69. [YEAR:29-9-2004]Fredriksson,L., Li,H., Fieber,C., Li,X. and Eriksson,U.
    Tissue plasminogen activator is a potent activator of PDGF-CC
    EMBO J23, 3793-3802. PubMed  Europe PubMed DOI
  70. Kruithof,E.K. and Schleuning,W.D.
    A comparative study of amyloid-beta (1-42) as a cofactor for plasminogen activation by vampire bat plasminogen activator and recombinant human tissue-type plasminogen activator
    Thromb Haemost92, 559-567. PubMed  Europe PubMed DOI
  71. Lijnen,H.R. and Collen,D.
    t-Plasminogen activator
    [ISSN:0-12-079610-4]2, 1684-1689.  V
  72. Yepes,M. and Lawrence,D.A.
    Tissue-type plasminogen activator and neuroserpin: a well-balanced act in the nervous system?
    Trends Cardiovasc Med14, 173-180. PubMed  Europe PubMed DOI
  73. Yepes,M. and Lawrence,D.A.
    New functions for an old enzyme: nonhemostatic roles for tissue-type plasminogen activator in the central nervous system
    Exp Biol Med (Maywood)229, 1097-1104. PubMed  Europe PubMed
  74. Yi,J.S., Kim,Y.H. and Koh,J.Y.
    Infarct reduction in rats following intraventricular administration of either tissue plasminogen activator (tPA) or its non-protease mutant S478A-tPA
    Exp Neurol189, 354-360. PubMed  Europe PubMed DOI
    75. 2003
  75. Daci,E., Everts,V., Torrekens,S., Van Herck,E., Tigchelaar-Gutterr,W., Bouillon,R. and Carmeliet,G.
    Increased bone formation in mice lacking plasminogen activators
    J Bone Miner Res18, 1167-1176. PubMed  Europe PubMed DOI  K
  76. [YEAR:5-6-2003]Hermans,J.M., Haines,D.S., James,P.S. and Jones,R.
    Kinetics of inhibition of sperm beta-acrosin activity by suramin
    FEBS Lett544, 119-122. PubMed  Europe PubMed DOI
  77. Ladenvall,P., Nilsson,S., Jood,K., Rosengren,A., Blomstrand,C. and Jern,C.
    Genetic variation at the human tissue-type plasminogen activator (tPA) locus: haplotypes and analysis of association to plasma levels of tPA
    Eur J Hum Genet11, 603-610. PubMed  Europe PubMed DOI  M
    78. 2002
  78. [YEAR:6-12-2002]Barker-Carlson,K., Lawrence,D.A. and Schwartz,B.S.
    Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro
    J Biol Chem277, 46852-46857. PubMed  Europe PubMed DOI
  79. Manosroi,J., Tayapiwatana,C., Manosroi,A., Beer,J., Bergemann,K. and Werner,R.G.
    Lekteplase - a secreted tissue plasminogen activator derivative from Escherichia coli
    Arzneimittelforschung52, 60-66. PubMed  Europe PubMed DOI  E
  80. Yang,J., Shultz,R.W., Mars,W.M., Wegner,R.E., Li,Y., Dai,C., Nejak,K. and Liu,Y.
    Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy
    J Clin Invest110, 1525-1538. PubMed  Europe PubMed DOI
    81. 2001
  81. [YEAR:11-9-2001]Hudson,M.P., Granger,C.B., Topol,E.J., Pieper,K.S., Armstrong,P.W., Barbash,G.I., Guerci,A.D., Vahanian,A., Califf,R.M. and Ohman,E.M.
    Early reinfarction after fibrinolysis: experience from the Global Utilization of Streptokinase and Tissue plasminogen activator (alteplase) for occluded coronary arteries (GUSTO I) and Global Use of Strategies to Open occluded coronary arteries (GUSTO III) trials
    Circulation104, 1229-1235. PubMed  Europe PubMed
  82. Manosroi,J., Tayapiwatana,C., Gotz,F., Werner,R.G. and Manosroi,A.
    Secretion of active recombinant human tissue plasminogen activator derivatives in Escherichia coli
    Appl Environ Microbiol67, 2657-2664. PubMed  Europe PubMed DOI  E
  83. Shortell,C.K., Queiroz,R., Johansson,M., Waldman,D., Illig,K.A., Ouriel,K. and Green,R.M.
    Safety and efficacy of limited-dose tissue plasminogen activator in acute vascular occlusion
    J Vasc Surg34, 854-859. PubMed  Europe PubMed DOI
  84. Werner,R.G.
    Improving natural principles with genetic engineering: TNK-tissue plasminogen activator
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