$VAR1 = undef;
Summary for peptidase S01.194: complement component C2a
| Names | |
|---|---|
| MEROPS Name | complement component C2a |
| Other names | complement component 2 (activated), component 2 of classical-complement-pathway C3/C5 convertase |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.194 |
| Holotype | complement component C2a (Homo sapiens), Uniprot accession P06681 (peptidase unit: 453-707), MERNUM MER0000231 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Serine | ||
| NC-IUBMB | Not yet included in IUBMB recommendations. | ||
| Proteolytic events | CutDB database (5 cleavages) | ||
| Activity status | human: active (Kerr, 2004) mouse: active | ||
| Physiology | Acts in classical pathway of complement activation as component of C3/C5 convertase. | ||
| Pathways | KEGG | Complement and coagulation cascades | |
| KEGG | Pertussis | ||
| KEGG | Staphylococcus aureus infection | ||
| KEGG | Systemic lupus erythematosus | ||
| Other databases | WIKIPEDIA | http://en.wikipedia.org/wiki/Complement_component_2 | |
| Human genetics | ||||||
|---|---|---|---|---|---|---|
| Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
| C2 | 6p21.3 | ENSG00000180165 | 717 | C2 | 217000 | |
| Mouse genetics | ||||||
| Gene symbol | Position | Megabases | Ensembl | Entrez gene | MGI | |
| C2 | 17:B1 | ENSMUSG00000024372 | 12263 | MGI:88226 | ||
