Substrates for peptidase S01.192: complement component activated C1r

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ac-Arg-Ome			Ac-Arg+Ome	S	-	-	Ac	Arg	OME	-	-	-	Arlaud & Thielens, 1993
Ac-Gly-Lys-OMe			Ac-Gly-Lys+OMe	S	-	Ac	Gly	Lys	OMe	-	-	-	Arlaud & Thielens, 1993
complement C1r subcomponent	P00736	18-705	peptide-Arg463+Ile-peptide	P	Gln	Arg	Gln	Arg	Ile	Ile	Gly	Gly	Lacroix et al., 1997	3617
complement C1r subcomponent	P00736	18-705	peptide-Arg296+Gly-peptide	P	Gly	Asp	Ser	Arg	Gly	Trp	Lys	Leu	Lacroix et al., 1997	3616
complement component C1s precursor	P09871	16-688	peptide-Arg437+Ile-peptide	P	Glu	Lys	Gln	Arg	Ile	Ile	Gly	Gly	Luo et al., 1992	3615
Plasma protease C1 inhibitor	P05155	23-500	peptide-Arg466+Thr-peptide	P	Ser	Val	Ala	Arg	Thr	Leu	Leu	Val	Duncan et al., 2008	20318
Z-Gly-Arg-SBzl			Z-Gly-Arg+SBzl	S	-	Z	Gly	Arg	SBz	-	-	-	Arlaud & Thielens, 1993