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Literature for peptidase S01.192: complement component activated C1r

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, M Mutation, I Inhibitor, P Specificity, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Thomas,S., Schulz,A.M., Leong,J.M., Zeczycki,T.N. and Garcia,B.L.
    The molecular determinants of classical pathway complement inhibition by OspEF-related proteins of Borrelia burgdorferi
    J Biol Chem107236-107236. PubMed  Europe PubMed DOI
    2. 2023
  2. Wu,S., Chen,J., Teo,B.H.D., Wee,S.Y.K., Wong,M.H.M., Cui,J., Chen,J., Leong,K.P. and Lu,J.
    The axis of complement C1 and nucleolus in antinuclear autoimmunity
    Front Immunol14, 1196544-1196544. PubMed  Europe PubMed DOI
    3. 2021
  3. Garrigues,R.J., Powell-Pierce,A.D., Hammel,M., Skare,J.T. and Garcia,B.L.
    A Structural Basis for Inhibition of the Complement Initiator Protease C1r by Lyme Disease Spirochetes
    J Immunol207, 2856-2867. PubMed  Europe PubMed DOI
    4. 2020
  4. Holt,B.A. and Kwong,G.A.
    Protease circuits for processing biological information
    Nat Commun11, 5021-5021. PubMed  Europe PubMed DOI
  5. Rushing,B.R., Rohlik,D.L., Roy,S., Skaff,D.A. and Garcia,B.L.
    Targeting the Initiator Protease of the Classical Pathway of Complement Using Fragment-Based Drug Discovery
    Molecules25, PubMed  Europe PubMed DOI
    6. 2019
  6. Xavier,S., Sahu,R.K., Bontha,S.V., Mass,V., Taylor,R.P., Megyesi,J., Thielens,N.M. and Portilla,D.
    Complement C1r serine protease contributes to kidney fibrosis
    Am J Physiol Renal Physiol317, F1293-F1293. PubMed  Europe PubMed DOI  K
    7. 2018
  7. Almitairi,J.O.M., Venkatraman Girija,U., Furze,C.M., Simpson-Gray,X., Badakshi,F., Marshall,J.E., Schwaeble,W.J., Mitchell,D.A., Moody,P.C.E. and Wallis,R.
    Structure of the C1r-C1s interaction of the C1 complex of complement activation
    Proc Natl Acad Sci U S A115, 768-773. PubMed  Europe PubMed DOI  S
  8. Habib,A., Sawmiller,D., Hou,H., Kanithi,M., Tian,J., Zeng,J., Zi,D., He,Z.X., Sanberg,P.R. and Tan,J.
    Human cord blood serum-derived APP alpha-secretase cleavage activity is mediated by C1 complement
    Cell Transplant27, 666-676. PubMed  Europe PubMed DOI
    9. 2017
  9. Lu,J. and Kishore,U.
    C1 complex: an adaptable proteolytic module for complement and non-complement functions
    Front Immunol8, 592-592. PubMed  Europe PubMed DOI
  10. Nilojan,J., Bathige,S.D.N.K., Kugapreethan,R., Yang,H., Kim,M.J., Nam,B.H. and Lee,J.
    Molecular features and the transcriptional and functional delineation of complement system activators C1r and C1s from Sebastes schlegelii
    Dev Comp Immunol81, 279-290. PubMed  Europe PubMed DOI
    11. 2013
  11. Wijeyewickrema,L.C., Yongqing,T., Tran,T.P., Thompson,P.E., Viljoen,J.E., Coetzer,T.H., Duncan,R.C., Kass,I., Buckle,A.M. and Pike,R.N.
    Molecular determinants of the substrate specificity of the complement-initiating protease, C1r
    J Biol Chem288, 15571-15580. PubMed  Europe PubMed DOI  P
    12. 2012
  12. Forneris,F., Wu,J. and Gros,P.
    The modular serine proteases of the complement cascade
    Curr Opin Struct Biol22, 333-341. PubMed  Europe PubMed DOI  V
  13. Gaboriaud,C., Thielens,N.M. and Arlaud,G.
    Complement component C1r
    [ISSN:978-0-12-407742-3]3, 2849-2852. DOI
    14. 2010
  14. Brier,S., Pflieger,D., Le Mignon,M., Bally,I., Gaboriaud,C., Arlaud,G.J. and Daniel,R.
    Mapping surface accessibility of the C1r/C1s tetramer by chemical modification and mass spectrometry provides new insights into assembly of the human C1 complex
    J Biol Chem285, 32251-32263. PubMed  Europe PubMed DOI
  15. Lang,A., Szilagyi,K., Major,B., Gal,P., Zavodszky,P. and Perczel,A.
    Intermodule cooperativity in the structure and dynamics of consecutive complement control modules in human C1r: structural biology
    FEBS J277, 3986-3998. PubMed  Europe PubMed DOI
  16. Lang,A., Major,B., Szilagyi,K., Gaspari,Z., Gal,P., Zavodszky,P. and Perczel,A.
    Interaction between separated consecutive complement control modules of human C1r: implications for dimerization of the full-length protease
    FEBS Lett584, 4565-4569. PubMed  Europe PubMed DOI
  17. Major,B., Kardos,J., Kekesi,K.A., Lorincz,Z., Zavodszky,P. and Gal,P.
    Calcium-dependent conformational flexibility of a CUB domain controls activation of the complement serine protease C1r
    J Biol Chem285, 11863-11869. PubMed  Europe PubMed DOI
    18. 2009
  18. Bally,I., Rossi,V., Lunardi,T., Thielens,N.M., Gaboriaud,C. and Arlaud,G.J.
    Identification of the C1q-binding sites of human C1r and C1s: a refined three-dimensional model of the C1 complex of complement
    J Biol Chem284, 19340-19348. PubMed  Europe PubMed DOI  S
  19. Gal,P., Dobo,J., Zavodszky,P. and Sim,R.B.
    Early complement proteases: C1r, C1s and MASPs. A structural insight into activation and functions
    Mol Immunol46, 2745-2752. PubMed  Europe PubMed DOI  V
  20. Phillips,A.E., Toth,J., Dodds,A.W., Girija,U.V., Furze,C.M., Pala,E., Sim,R.B., Reid,K.B., Schwaeble,W.J., Schmid,R., Keeble,A.H. and Wallis,R.
    Analogous interactions in initiating complexes of the classical and lectin pathways of complement
    J Immunol182, 7708-7717. PubMed  Europe PubMed DOI
    21. 2008
  21. Duncan,R.C., Wijeyewickrema,L.C. and Pike,R.N.
    The initiating proteases of the complement system: controlling the cleavage
    Biochimie90, 387-395. PubMed  Europe PubMed DOI  V
  22. Kardos,J., Harmat,V., Pallo,A., Barabas,O., Szilagyi,K., Graf,L., Naray-Szabo,G., Goto,Y., Zavodszky,P. and Gal,P.
    Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: structure of the active catalytic region of C1r
    Mol Immunol45, 1752-1760. PubMed  Europe PubMed DOI  S
    23. 2004
  23. Arlaud,G.J., Thielens,N.M. and Gaboriaud,C.
    Complement component C1r
    [ISSN:0-12-079610-4]2, 1617-1620.  V
  24. [YEAR:1-7-2004]Gaboriaud,C., Thielens,N.M., Gregory,L.A., Rossi,V., Fontecilla-Camps,J.C. and Arlaud,G.J.
    Structure and activation of the C1 complex of complement: unraveling the puzzle
    Trends Immunol25, 368-373. PubMed  Europe PubMed DOI
    25. 2003
  25. [YEAR:15-4-2003]Garnier,G., Circolo,A., Xu,Y. and Volanakis,J.E.
    Complement C1r and C1s genes are duplicated in the mouse: differential expression generates alternative isomorphs in the liver and in the male reproductive system
    Biochem J371, 631-640. PubMed  Europe PubMed DOI
  26. Moralez,A., Busby,W.H., Jr. and Clemmons,D.
    Control of insulin-like growth factor binding protein-5 protease synthesis and secretion by human fibroblasts and porcine aortic smooth muscle cells
    Endocrinology144, 2489-2495. PubMed  Europe PubMed DOI
  27. Nakagawa,M., Yuasa,I., Irizawa,Y. and Umetsu,K.
    The human complement component C1R gene: the exon-intron structure and the molecular basis of allelic diversity
    Ann Hum Genet67, 207-215. PubMed  Europe PubMed DOI  M
    28. 2002
  28. Arlaud,G.J., Gaboriaud,C., Thielens,N.M., Budayova-Spano,M., Rossi,V. and Fontecilla-Camps,J.C.
    Structural biology of the C1 complex of complement unveils the mechanisms of its activation and proteolytic activity
    Mol Immunol39, 383-394. PubMed  Europe PubMed DOI
  29. Arlaud,G.J., Gaboriaud,C., Thielens,N.M. and Rossi,V.
    Structural biology of C1
    Biochem Soc Trans30, 1001-1006. PubMed  Europe PubMed DOI
  30. Arlaud,G.J., Gaboriaud,C., Garnier,G., Circolo,A., Thielens,N.M., Budayova-Spano,M., Fontecilla-Camps,J.C. and Volanakis,J.E.
    Structure, function and molecular genetics of human and murine C1r
    Immunobiology205, 365-382. PubMed  Europe PubMed DOI
  31. [YEAR:1-2-2002]Budayova-Spano,M., Lacroix,M., Thielens,N.M., Arlaud,G.J., Fontecilla-Camps,J.C. and Gaboriaud,C.
    The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex
    EMBO J21, 231-239. PubMed  Europe PubMed DOI  S
  32. Budayova-Spano,M., Grabarse,W., Thielens,N.M., Hillen,H., Lacroix,M., Schmidt,M., Fontecilla-Camps,J.C., Arlaud,G.J. and Gaboriaud,C.
    Monomeric structures of the zymogen and active catalytic domain of complement protease C1r: further insights into the C1 activation mechanism
    Structure10, 1509-1519. PubMed  Europe PubMed DOI  S
    33. 2001
  33. Byun,S.J., Bahk,Y.Y., Ryoo,Z.Y., Kim,K.E., Hwang,H.Y., Lee,J.W., Yi,J.Y. and Kim,T.Y.
    Identification of cDNA encoding a serine protease homologous to human complement C1r precursor from grafted mouse skin
    J Invest Dermatol116, 374-379. PubMed  Europe PubMed DOI
  34. [YEAR:1-11-2001]Kardos,J., Gal,P., Szilagyi,L., Thielens,N.M., Szilagyi,K., Lorincz,Z., Kulcsar,P., Graf,L., Arlaud,G.J. and Zavodszky,P.
    The role of the individual domains in the structure and function of the catalytic region of a modular serine protease, C1r
    J Immunol167, 5202-5208. PubMed  Europe PubMed
  35. [YEAR:28-9-2001]Lacroix,M., Ebel,C., Kardos,J., Dobo,J., Gal,P., Zavodszky,P., Arlaud,G.J. and Thielens,N.M.
    Assembly and enzymatic properties of the catalytic domain of human complement protease C1r
    J Biol Chem276, 36233-36240. PubMed  Europe PubMed DOI
  36. Nakao,M., Osaka,K., Kato,Y., Fujiki,K. and Yano,T.
    Molecular cloning of the complement C1r/C1s/MASP2-like serine proteases from the common carp (Cyprinus carpio)
    Immunogenetics52, 255-263. PubMed  Europe PubMed DOI
    37. 2000
  37. Sim,R.B. and Laich,A.
    Serine proteases of the complement system
    Biochem Soc Trans28, 545-550. PubMed  Europe PubMed
    38. 1999
  38. [YEAR:22-3-1999]Plummer,J.S., Cai,C., Hays,S.J., Gilmore,J.L., Emmerling,M.R., Michael,W., Narasimhan,L.S., Watson,M.D., Wang,K., Nath,R., Evans,L.M. and Jaen,J.C.
    Benzenesulfonamide derivatives of 2-substituted 4H-3,1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease
    Bioorg Med Chem Lett9, 815-820. PubMed  Europe PubMed DOI  I
  39. Thielens,N.M., Bersch,B., Hernandez,J.F. and Arlaud,G.J.
    Structure and functions of the interaction domains of C1r and C1s: keystones of the architecture of the C1 complex
    Immunopharmacology42, 3-13. PubMed  Europe PubMed DOI
  40. [YEAR:2-4-1999]Thielens,N.M., Enrie,K., Lacroix,M., Jaquinod,M., Hernandez,J.F., Esser,A.F. and Arlaud,G.J.
    The N-terminal CUB-epidermal growth factor module pair of human complement protease C1r binds Ca2+ with high affinity and mediates Ca2+-dependent interaction with C1s
    J Biol Chem274, 9149-9159. PubMed  Europe PubMed DOI
    41. 1998
  41. Arlaud,G.J., Volanakis,J.E., Thielens,N.M., Narayana,S.V., Rossi,V. and Xu,Y.
    The atypical serine proteases of the complement system
    Adv Immunol69, 249-307. PubMed  Europe PubMed
  42. [YEAR:26-3-1998]Hays,S.J., Caprathe,B.W., Gilmore,J.L., Amin,N., Emmerling,M.R., Michael,W., Nadimpalli,R., Nath,R., Raser,K.J., Stafford,D., Watson,D., Wang,K. and Jaen,J.C.
    2-amino-4H-3,1-benzoxazin-4-ones as inhibitors of C1r serine protease
    J Med Chem41, 1060-1067. PubMed  Europe PubMed DOI  I
    43. 1997
  43. Lacroix,M., Rossi,V., Gaboriaud,C., Chevallier,S., Jaquinod,M., Thielens,N.M., Gagnon,J. and Arlaud,G.J.
    Structure and assembly of the catalytic region of human complement protease C1r: A three-dimensional model based on chemical cross-linking and homology modeling
    Biochemistry36, 6270-6282. PubMed  Europe PubMed DOI
    44. 1996
  44. Cseh,S., Gal,P., Sarvari,M., Dobo,J., Lorincz,Z., Schumaker,V.N. and Zavodszky,P.
    Functional effects of domain deletions in a multidomain serine protease, C1r
    Mol Immunol33, 351-359. PubMed  Europe PubMed DOI
    45. 1994
  45. Nothen,M.M. and Dewald,G.
    A common amino acid polymorphism in complement component C1R
    Hum Mol Genet3, 217-217. PubMed  Europe PubMed  M
  46. [YEAR:15-7-1994]Thielens,N.M., Illy,C., Bally,I.M. and Arlaud,G.J.
    Activation of human complement serine-proteinase C1r is down-regulated by a Ca(2+)-dependent intramolecular control that is released in the C1 complex through a signal transmitted by C1q
    Biochem J301, 509-516. PubMed  Europe PubMed
    47. 1993
  47. Arlaud,G.J. and Thielens,N.M.
    Human complement serine proteases C1r and C1s and their proenzymes
    Methods Enzymol223, 61-82. PubMed  Europe PubMed DOI  V
    48. 1992
  48. Kam,C.M., Oglesby,T.J., Pangburn,M.K., Volanakis,J.E. and Powers,J.C.
    Substituted isocoumarins as inhibitors of complement serine proteases
    J Immunol149, 163-168. PubMed  Europe PubMed  I
    49. 1991
  49. Bork,P.
    Complement components C1r/C1s, bone morphogenic protein 1 and Xenopus laevis developmentally regulated protein UVS.2 share common repeats
    FEBS Lett282, 9-12. PubMed  Europe PubMed DOI
  50. Lane,P.D., Schumaker,V.N., Tseng,Y. and Poon,P.H.
    Isolation of human complement subcomponents C1r and C1s in their unactivated, proenzyme forms
    J Immunol Methods141, 219-226. PubMed  Europe PubMed DOI  I
    51. 1989
  51. Gal,P., Sarvari,M., Szilagyi,K., Zavodszky,P. and Schumaker,V.N.
    Expression of hemolytically active human complement component C1r proenzyme in insect cells using a baculovirus vector
    Complement Inflamm6, 433-441. PubMed  Europe PubMed  E
  52. Tosi,M., Duponchel,C., Meo,T. and Couture-Tosi,E.
    Complement genes C1r and C1s feature an intronless serine protease domain closely related to haptoglobin
    J Mol Biol208, 709-714. PubMed  Europe PubMed
    53. 1988
  53. Kusumoto,H., Hirosawa,S., Salier,J.P., Hagen,F.S. and Kurachi,K.
    Human genes for complement components c1r and c1s in a close tail-to- tail arrangement
    Proc Natl Acad Sci U S A85, 7307-7311. PubMed  Europe PubMed
  54. Muller-Eberhard,H.J.
    Molecular organization and function of the complement system
    Annu Rev Biochem57, 321-347. PubMed  Europe PubMed DOI
  55. Nguyen,V.C., Tosi,M., Gross,M.S., Cohen-Haguenauer,O., Jegou-Foubert,C., de Tand,M.F., Meo,T. and Frezal,J.
    Assignment of the complement serine protease genes C1r and C1s to chromosome 12 region 12p13
    Hum Genet78, 363-368. PubMed  Europe PubMed
    56. 1987
  56. Garty,B.Z., Conley,M.E., Douglas,S.D. and Kolski,G.B.
    Recurrent infections and staphylococcal liver abscess in a child with C1r deficiency
    J Allergy Clin Immunol80, 631-635. PubMed  Europe PubMed  M
    57. 1986
  57. Leytus,S.P., Kurachi,K., Sakariassen,K.S. and Davie,E.W.
    Nucleotide sequence of the cDNA coding for human complement C1r
    Biochemistry25, 4855-4863. PubMed  Europe PubMed
    58. 1983
  58. [YEAR:12-4-1983]Arlaud,G.J. and Gagnon,J.
    Complete amino acid sequence of the catalytic chain of human complement subcomponent C1-r
    Biochemistry22, 1758-1764. PubMed  Europe PubMed
  59. Nilsson,T. and Wiman,B.
    Kinetics of the reaction between human C1-esterase inhibitor and C1r or C1s
    Eur J Biochem129, 663-667. PubMed  Europe PubMed
    60. 1982
  60. [YEAR:1-1-1982]Chesne,S., Villiers,C.L., Arlaud,G.J., Lacroix,M.B. and Colomb,M.G.
    Fluid-phase interaction of C1 inhibitor (C1 Inh) and the subcomponents C1r and C1s of the first component of complement, C1
    Biochem J201, 61-70. PubMed  Europe PubMed
  61. Hitomi,Y. and Fujii,S.
    Inhibition of various immunological reactions in vivo by a new synthetic complement inhibitor
    Int Arch Allergy Appl Immunol69, 262-267. PubMed  Europe PubMed  I
    62. 1981
  62. Arlaud,G.J. and Gagnon,J.
    Clr and Cls subcomponents of human complement: two serine proteinases lacking the 'histidine-loop' disulphide bridge
    Biosci Rep1, 779-784. PubMed  Europe PubMed
  63. Sim,R.B.
    The human complement system serine proteases C1r and C1s and their proenzymes
    Methods Enzymol80, 26-42. PubMed  Europe PubMed DOI  V
    64. 1980
  64. Arlaud,G.J., Villiers,C.L., Chesne,S. and Colomb,M.G.
    Purified proenzyme C1r. Some characteristics of its activation and subsequent proteolytic cleavage
    Biochim Biophys Acta616, 116-129. PubMed  Europe PubMed
    65. 1979
  65. [YEAR:25-1-1979]Arlaud,G.J., Reboul,A., Sim,R.B. and Colomb,M.G.
    Interaction of C1-inhibitor with the C1r and C1s subcomponents in human C1
    Biochim Biophys Acta576, 151-162. PubMed  Europe PubMed
  66. [YEAR:1-1-1979]Sim,R.B., Reboul,A., Arlaud,G.J., Villiers,C.L. and Colomb,M.G.
    Interaction of 125I-labelled complement subcomponents C-1r and C-1s with protease inhibitors in plasma
    FEBS Lett97, 111-115. PubMed  Europe PubMed DOI
    67. 1977
  67. Chapuis,R.M., Isliker,H. and Assimeh,S.N.
    Studies on the precursor form of the first component of complement. 1. Isolation of the proenzyme forms of Clr and Cls
    Immunochemistry14, 313-317. PubMed  Europe PubMed DOI
  68. [YEAR:13-10-1977]Tamura,Y., Hirado,M., Okamura,K., Minato,Y. and Fujii,S.
    Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C1r, and C1 esterase
    Biochim Biophys Acta484, 417-422. PubMed  Europe PubMed  I
    69. 1968
  69. Naff,G.B. and Ratnoff,O.S.
    The enzymatic nature of C'1r. Conversion of C'1s to C'1 esterase and digestion of amino acid esters by C'1r
    J Exp Med128, 571-593. PubMed  Europe PubMed
    70. 1964
  70. Haines,A.L. and Lepow,I.H.
    Studies on human C'1-esterase. II. Function of purified c'1-esterase in the human complement system
    J Immunol92, 468-478. PubMed  Europe PubMed
  71. Haines,A.L. and Lepow,I.H.
    Studies on human C'1-esterase. I. Purification and enzymatic properties
    J Immunol92, 456-467. PubMed  Europe PubMed
    72. 1963
  72. Lepow,I.H., Naff,G.B., Todd,E.W., Pensky,J. and Hinz,C.F.
    Chromatographic resolution of the first component of human complement into three activities
    J Exp Med117, 983-1008. PubMed  Europe PubMed

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