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Literature for peptidase S01.192: complement component activated C1r

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, M Mutation, I Inhibitor, P Specificity, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Thomas,S., Schulz,A.M., Leong,J.M., Zeczycki,T.N. and Garcia,B.L.<br>The molecular determinants of classical pathway complement inhibition by OspEF-related proteins of Borrelia burgdorferi<br>J Biol Chem (2024) , 107236-107236. PubMed  Europe PubMed DOI
    2. 2023
  2. Wu,S., Chen,J., Teo,B.H.D., Wee,S.Y.K., Wong,M.H.M., Cui,J., Chen,J., Leong,K.P. and Lu,J.<br>The axis of complement C1 and nucleolus in antinuclear autoimmunity<br>Front Immunol (2023) 14, 1196544-1196544. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2021
  3. Garrigues,R.J., Powell-Pierce,A.D., Hammel,M., Skare,J.T. and Garcia,B.L.<br>A Structural Basis for Inhibition of the Complement Initiator Protease C1r by Lyme Disease Spirochetes<br>J Immunol (2021) 207, 2856-2867. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2020
  4. Holt,B.A. and Kwong,G.A.<br>Protease circuits for processing biological information<br>Nat Commun (2020) 11, 5021-5021. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Rushing,B.R., Rohlik,D.L., Roy,S., Skaff,D.A. and Garcia,B.L.<br>Targeting the Initiator Protease of the Classical Pathway of Complement Using Fragment-Based Drug Discovery<br>Molecules (2020) 25 PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2019
  6. Xavier,S., Sahu,R.K., Bontha,S.V., Mass,V., Taylor,R.P., Megyesi,J., Thielens,N.M. and Portilla,D.<br>Complement C1r serine protease contributes to kidney fibrosis<br>Am J Physiol Renal Physiol (2019) 317, F1293-F1293. PubMed  Europe PubMed DOI  K
    7. 2018
  7. Almitairi,J.O.M., Venkatraman Girija,U., Furze,C.M., Simpson-Gray,X., Badakshi,F., Marshall,J.E., Schwaeble,W.J., Mitchell,D.A., Moody,P.C.E. and Wallis,R.<br>Structure of the C1r-C1s interaction of the C1 complex of complement activation<br>Proc Natl Acad Sci U S A (2018) 115, 768-773. PubMed  Europe PubMed DOI  S
  8. Habib,A., Sawmiller,D., Hou,H., Kanithi,M., Tian,J., Zeng,J., Zi,D., He,Z.X., Sanberg,P.R. and Tan,J.<br>Human cord blood serum-derived APP alpha-secretase cleavage activity is mediated by C1 complement<br>Cell Transplant (2018) 27, 666-676. PubMed  Europe PubMed DOI
    9. 2017
  9. Lu,J. and Kishore,U.<br>C1 complex: an adaptable proteolytic module for complement and non-complement functions<br>Front Immunol (2017) 8, 592-592. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Nilojan,J., Bathige,S.D.N.K., Kugapreethan,R., Yang,H., Kim,M.J., Nam,B.H. and Lee,J.<br>Molecular features and the transcriptional and functional delineation of complement system activators C1r and C1s from Sebastes schlegelii<br>Dev Comp Immunol (2017) 81, 279-290. PubMed  Europe PubMed DOI
    11. 2013
  11. Wijeyewickrema,L.C., Yongqing,T., Tran,T.P., Thompson,P.E., Viljoen,J.E., Coetzer,T.H., Duncan,R.C., Kass,I., Buckle,A.M. and Pike,R.N.<br>Molecular determinants of the substrate specificity of the complement-initiating protease, C1r<br>J Biol Chem (2013) 288, 15571-15580. PubMed  Europe PubMed DOI  P
    12. 2012
  12. Forneris,F., Wu,J. and Gros,P.<br>The modular serine proteases of the complement cascade<br>Curr Opin Struct Biol (2012) 22, 333-341. PubMed  Europe PubMed DOI  V
  13. Gaboriaud,C., Thielens,N.M. and Arlaud,G.<br>Complement component C1r<br>[ISSN:978-0-12-407742-3] (2012) 3, 2849-2852. DOI
    14. 2010
  14. Brier,S., Pflieger,D., Le Mignon,M., Bally,I., Gaboriaud,C., Arlaud,G.J. and Daniel,R.<br>Mapping surface accessibility of the C1r/C1s tetramer by chemical modification and mass spectrometry provides new insights into assembly of the human C1 complex<br>J Biol Chem (2010) 285, 32251-32263. PubMed  Europe PubMed DOI
  15. Lang,A., Major,B., Szilagyi,K., Gaspari,Z., Gal,P., Zavodszky,P. and Perczel,A.<br>Interaction between separated consecutive complement control modules of human C1r: implications for dimerization of the full-length protease<br>FEBS Lett (2010) 584, 4565-4569. PubMed  Europe PubMed DOI
  16. Lang,A., Szilagyi,K., Major,B., Gal,P., Zavodszky,P. and Perczel,A.<br>Intermodule cooperativity in the structure and dynamics of consecutive complement control modules in human C1r: structural biology<br>FEBS J (2010) 277, 3986-3998. PubMed  Europe PubMed DOI
  17. Major,B., Kardos,J., Kekesi,K.A., Lorincz,Z., Zavodszky,P. and Gal,P.<br>Calcium-dependent conformational flexibility of a CUB domain controls activation of the complement serine protease C1r<br>J Biol Chem (2010) 285, 11863-11869. PubMed  Europe PubMed DOI
    18. 2009
  18. Bally,I., Rossi,V., Lunardi,T., Thielens,N.M., Gaboriaud,C. and Arlaud,G.J.<br>Identification of the C1q-binding sites of human C1r and C1s: a refined three-dimensional model of the C1 complex of complement<br>J Biol Chem (2009) 284, 19340-19348. PubMed  Europe PubMed DOI  PMC  EPMC  S
  19. Gal,P., Dobo,J., Zavodszky,P. and Sim,R.B.<br>Early complement proteases: C1r, C1s and MASPs. A structural insight into activation and functions<br>Mol Immunol (2009) 46, 2745-2752. PubMed  Europe PubMed DOI  V
  20. Phillips,A.E., Toth,J., Dodds,A.W., Girija,U.V., Furze,C.M., Pala,E., Sim,R.B., Reid,K.B., Schwaeble,W.J., Schmid,R., Keeble,A.H. and Wallis,R.<br>Analogous interactions in initiating complexes of the classical and lectin pathways of complement<br>J Immunol (2009) 182, 7708-7717. PubMed  Europe PubMed DOI  PMC  EPMC
    21. 2008
  21. Duncan,R.C., Wijeyewickrema,L.C. and Pike,R.N.<br>The initiating proteases of the complement system: controlling the cleavage<br>Biochimie (2008) 90, 387-395. PubMed  Europe PubMed DOI  V
  22. Kardos,J., Harmat,V., Pallo,A., Barabas,O., Szilagyi,K., Graf,L., Naray-Szabo,G., Goto,Y., Zavodszky,P. and Gal,P.<br>Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: structure of the active catalytic region of C1r<br>Mol Immunol (2008) 45, 1752-1760. PubMed  Europe PubMed DOI  S
    23. 2004
  23. Arlaud,G.J., Thielens,N.M. and Gaboriaud,C.<br>Complement component C1r<br>[ISSN:0-12-079610-4] (2004) 2, 1617-1620.  V
  24. [YEAR:1-7-2004]Gaboriaud,C., Thielens,N.M., Gregory,L.A., Rossi,V., Fontecilla-Camps,J.C. and Arlaud,G.J.<br>Structure and activation of the C1 complex of complement: unraveling the puzzle<br>Trends Immunol (1-7-2004) 25, 368-373. PubMed  Europe PubMed DOI
    25. 2003
  25. [YEAR:15-4-2003]Garnier,G., Circolo,A., Xu,Y. and Volanakis,J.E.<br>Complement C1r and C1s genes are duplicated in the mouse: differential expression generates alternative isomorphs in the liver and in the male reproductive system<br>Biochem J (15-4-2003) 371, 631-640. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Moralez,A., Busby,W.H., Jr. and Clemmons,D.<br>Control of insulin-like growth factor binding protein-5 protease synthesis and secretion by human fibroblasts and porcine aortic smooth muscle cells<br>Endocrinology (2003) 144, 2489-2495. PubMed  Europe PubMed DOI
  27. Nakagawa,M., Yuasa,I., Irizawa,Y. and Umetsu,K.<br>The human complement component C1R gene: the exon-intron structure and the molecular basis of allelic diversity<br>Ann Hum Genet (2003) 67, 207-215. PubMed  Europe PubMed DOI  M
    28. 2002
  28. Arlaud,G.J., Gaboriaud,C., Garnier,G., Circolo,A., Thielens,N.M., Budayova-Spano,M., Fontecilla-Camps,J.C. and Volanakis,J.E.<br>Structure, function and molecular genetics of human and murine C1r<br>Immunobiology (2002) 205, 365-382. PubMed  Europe PubMed DOI
  29. Arlaud,G.J., Gaboriaud,C., Thielens,N.M., Budayova-Spano,M., Rossi,V. and Fontecilla-Camps,J.C.<br>Structural biology of the C1 complex of complement unveils the mechanisms of its activation and proteolytic activity<br>Mol Immunol (2002) 39, 383-394. PubMed  Europe PubMed DOI
  30. Arlaud,G.J., Gaboriaud,C., Thielens,N.M. and Rossi,V.<br>Structural biology of C1<br>Biochem Soc Trans (2002) 30, 1001-1006. PubMed  Europe PubMed DOI
  31. Budayova-Spano,M., Grabarse,W., Thielens,N.M., Hillen,H., Lacroix,M., Schmidt,M., Fontecilla-Camps,J.C., Arlaud,G.J. and Gaboriaud,C.<br>Monomeric structures of the zymogen and active catalytic domain of complement protease C1r: further insights into the C1 activation mechanism<br>Structure (2002) 10, 1509-1519. PubMed  Europe PubMed DOI  S
  32. [YEAR:1-2-2002]Budayova-Spano,M., Lacroix,M., Thielens,N.M., Arlaud,G.J., Fontecilla-Camps,J.C. and Gaboriaud,C.<br>The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex<br>EMBO J (1-2-2002) 21, 231-239. PubMed  Europe PubMed DOI  PMC  EPMC  S
    33. 2001
  33. Byun,S.J., Bahk,Y.Y., Ryoo,Z.Y., Kim,K.E., Hwang,H.Y., Lee,J.W., Yi,J.Y. and Kim,T.Y.<br>Identification of cDNA encoding a serine protease homologous to human complement C1r precursor from grafted mouse skin<br>J Invest Dermatol (2001) 116, 374-379. PubMed  Europe PubMed DOI
  34. [YEAR:1-11-2001]Kardos,J., Gal,P., Szilagyi,L., Thielens,N.M., Szilagyi,K., Lorincz,Z., Kulcsar,P., Graf,L., Arlaud,G.J. and Zavodszky,P.<br>The role of the individual domains in the structure and function of the catalytic region of a modular serine protease, C1r<br>J Immunol (1-11-2001) 167, 5202-5208. PubMed  Europe PubMed
  35. [YEAR:28-9-2001]Lacroix,M., Ebel,C., Kardos,J., Dobo,J., Gal,P., Zavodszky,P., Arlaud,G.J. and Thielens,N.M.<br>Assembly and enzymatic properties of the catalytic domain of human complement protease C1r<br>J Biol Chem (28-9-2001) 276, 36233-36240. PubMed  Europe PubMed DOI
  36. Nakao,M., Osaka,K., Kato,Y., Fujiki,K. and Yano,T.<br>Molecular cloning of the complement C1r/C1s/MASP2-like serine proteases from the common carp (Cyprinus carpio)<br>Immunogenetics (2001) 52, 255-263. PubMed  Europe PubMed DOI
    37. 2000
  37. Sim,R.B. and Laich,A.<br>Serine proteases of the complement system<br>Biochem Soc Trans (2000) 28, 545-550. PubMed  Europe PubMed
    38. 1999
  38. [YEAR:22-3-1999]Plummer,J.S., Cai,C., Hays,S.J., Gilmore,J.L., Emmerling,M.R., Michael,W., Narasimhan,L.S., Watson,M.D., Wang,K., Nath,R., Evans,L.M. and Jaen,J.C.<br>Benzenesulfonamide derivatives of 2-substituted 4H-3,1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease<br>Bioorg Med Chem Lett (22-3-1999) 9, 815-820. PubMed  Europe PubMed DOI  I
  39. [YEAR:2-4-1999]Thielens,N.M., Enrie,K., Lacroix,M., Jaquinod,M., Hernandez,J.F., Esser,A.F. and Arlaud,G.J.<br>The N-terminal CUB-epidermal growth factor module pair of human complement protease C1r binds Ca2+ with high affinity and mediates Ca2+-dependent interaction with C1s<br>J Biol Chem (2-4-1999) 274, 9149-9159. PubMed  Europe PubMed DOI
  40. Thielens,N.M., Bersch,B., Hernandez,J.F. and Arlaud,G.J.<br>Structure and functions of the interaction domains of C1r and C1s: keystones of the architecture of the C1 complex<br>Immunopharmacology (1999) 42, 3-13. PubMed  Europe PubMed DOI
    41. 1998
  41. Arlaud,G.J., Volanakis,J.E., Thielens,N.M., Narayana,S.V., Rossi,V. and Xu,Y.<br>The atypical serine proteases of the complement system<br>Adv Immunol (1998) 69, 249-307. PubMed  Europe PubMed
  42. [YEAR:26-3-1998]Hays,S.J., Caprathe,B.W., Gilmore,J.L., Amin,N., Emmerling,M.R., Michael,W., Nadimpalli,R., Nath,R., Raser,K.J., Stafford,D., Watson,D., Wang,K. and Jaen,J.C.<br>2-amino-4H-3,1-benzoxazin-4-ones as inhibitors of C1r serine protease<br>J Med Chem (26-3-1998) 41, 1060-1067. PubMed  Europe PubMed DOI  I
    43. 1997
  43. Lacroix,M., Rossi,V., Gaboriaud,C., Chevallier,S., Jaquinod,M., Thielens,N.M., Gagnon,J. and Arlaud,G.J.<br>Structure and assembly of the catalytic region of human complement protease C1r: A three-dimensional model based on chemical cross-linking and homology modeling<br>Biochemistry (1997) 36, 6270-6282. PubMed  Europe PubMed DOI
    44. 1996
  44. Cseh,S., Gal,P., Sarvari,M., Dobo,J., Lorincz,Z., Schumaker,V.N. and Zavodszky,P.<br>Functional effects of domain deletions in a multidomain serine protease, C1r<br>Mol Immunol (1996) 33, 351-359. PubMed  Europe PubMed DOI
    45. 1994
  45. Nothen,M.M. and Dewald,G.<br>A common amino acid polymorphism in complement component C1R<br>Hum Mol Genet (1994) 3, 217-217. PubMed  Europe PubMed  M
  46. [YEAR:15-7-1994]Thielens,N.M., Illy,C., Bally,I.M. and Arlaud,G.J.<br>Activation of human complement serine-proteinase C1r is down-regulated by a Ca(2+)-dependent intramolecular control that is released in the C1 complex through a signal transmitted by C1q<br>Biochem J (15-7-1994) 301, 509-516. PubMed  Europe PubMed  PMC  EPMC
    47. 1993
  47. Arlaud,G.J. and Thielens,N.M.<br>Human complement serine proteases C1r and C1s and their proenzymes<br>Methods Enzymol (1993) 223, 61-82. PubMed  Europe PubMed DOI  V
    48. 1992
  48. Kam,C.M., Oglesby,T.J., Pangburn,M.K., Volanakis,J.E. and Powers,J.C.<br>Substituted isocoumarins as inhibitors of complement serine proteases<br>J Immunol (1992) 149, 163-168. PubMed  Europe PubMed  I
    49. 1991
  49. Bork,P.<br>Complement components C1r/C1s, bone morphogenic protein 1 and Xenopus laevis developmentally regulated protein UVS.2 share common repeats<br>FEBS Lett (1991) 282, 9-12. PubMed  Europe PubMed DOI
  50. Lane,P.D., Schumaker,V.N., Tseng,Y. and Poon,P.H.<br>Isolation of human complement subcomponents C1r and C1s in their unactivated, proenzyme forms<br>J Immunol Methods (1991) 141, 219-226. PubMed  Europe PubMed DOI  I
    51. 1989
  51. Gal,P., Sarvari,M., Szilagyi,K., Zavodszky,P. and Schumaker,V.N.<br>Expression of hemolytically active human complement component C1r proenzyme in insect cells using a baculovirus vector<br>Complement Inflamm (1989) 6, 433-441. PubMed  Europe PubMed  E
  52. Tosi,M., Duponchel,C., Meo,T. and Couture-Tosi,E.<br>Complement genes C1r and C1s feature an intronless serine protease domain closely related to haptoglobin<br>J Mol Biol (1989) 208, 709-714. PubMed  Europe PubMed
    53. 1988
  53. Kusumoto,H., Hirosawa,S., Salier,J.P., Hagen,F.S. and Kurachi,K.<br>Human genes for complement components c1r and c1s in a close tail-to- tail arrangement<br>Proc Natl Acad Sci U S A (1988) 85, 7307-7311. PubMed  Europe PubMed  PMC  EPMC
  54. Muller-Eberhard,H.J.<br>Molecular organization and function of the complement system<br>Annu Rev Biochem (1988) 57, 321-347. PubMed  Europe PubMed DOI
  55. Nguyen,V.C., Tosi,M., Gross,M.S., Cohen-Haguenauer,O., Jegou-Foubert,C., de Tand,M.F., Meo,T. and Frezal,J.<br>Assignment of the complement serine protease genes C1r and C1s to chromosome 12 region 12p13<br>Hum Genet (1988) 78, 363-368. PubMed  Europe PubMed
    56. 1987
  56. Garty,B.Z., Conley,M.E., Douglas,S.D. and Kolski,G.B.<br>Recurrent infections and staphylococcal liver abscess in a child with C1r deficiency<br>J Allergy Clin Immunol (1987) 80, 631-635. PubMed  Europe PubMed  M
    57. 1986
  57. Leytus,S.P., Kurachi,K., Sakariassen,K.S. and Davie,E.W.<br>Nucleotide sequence of the cDNA coding for human complement C1r<br>Biochemistry (1986) 25, 4855-4863. PubMed  Europe PubMed
    58. 1983
  58. [YEAR:12-4-1983]Arlaud,G.J. and Gagnon,J.<br>Complete amino acid sequence of the catalytic chain of human complement subcomponent C1-r<br>Biochemistry (12-4-1983) 22, 1758-1764. PubMed  Europe PubMed
  59. Nilsson,T. and Wiman,B.<br>Kinetics of the reaction between human C1-esterase inhibitor and C1r or C1s<br>Eur J Biochem (1983) 129, 663-667. PubMed  Europe PubMed
    60. 1982
  60. [YEAR:1-1-1982]Chesne,S., Villiers,C.L., Arlaud,G.J., Lacroix,M.B. and Colomb,M.G.<br>Fluid-phase interaction of C1 inhibitor (C1 Inh) and the subcomponents C1r and C1s of the first component of complement, C1<br>Biochem J (1-1-1982) 201, 61-70. PubMed  Europe PubMed  PMC  EPMC
  61. Hitomi,Y. and Fujii,S.<br>Inhibition of various immunological reactions in vivo by a new synthetic complement inhibitor<br>Int Arch Allergy Appl Immunol (1982) 69, 262-267. PubMed  Europe PubMed  I
    62. 1981
  62. Arlaud,G.J. and Gagnon,J.<br>Clr and Cls subcomponents of human complement: two serine proteinases lacking the 'histidine-loop' disulphide bridge<br>Biosci Rep (1981) 1, 779-784. PubMed  Europe PubMed
  63. Sim,R.B.<br>The human complement system serine proteases C1r and C1s and their proenzymes<br>Methods Enzymol (1981) 80, 26-42. PubMed  Europe PubMed DOI  V
    64. 1980
  64. Arlaud,G.J., Villiers,C.L., Chesne,S. and Colomb,M.G.<br>Purified proenzyme C1r. Some characteristics of its activation and subsequent proteolytic cleavage<br>Biochim Biophys Acta (1980) 616, 116-129. PubMed  Europe PubMed
    65. 1979
  65. [YEAR:25-1-1979]Arlaud,G.J., Reboul,A., Sim,R.B. and Colomb,M.G.<br>Interaction of C1-inhibitor with the C1r and C1s subcomponents in human C1<br>Biochim Biophys Acta (25-1-1979) 576, 151-162. PubMed  Europe PubMed
  66. [YEAR:1-1-1979]Sim,R.B., Reboul,A., Arlaud,G.J., Villiers,C.L. and Colomb,M.G.<br>Interaction of 125I-labelled complement subcomponents C-1r and C-1s with protease inhibitors in plasma<br>FEBS Lett (1-1-1979) 97, 111-115. PubMed  Europe PubMed DOI
    67. 1977
  67. Chapuis,R.M., Isliker,H. and Assimeh,S.N.<br>Studies on the precursor form of the first component of complement. 1. Isolation of the proenzyme forms of Clr and Cls<br>Immunochemistry (1977) 14, 313-317. PubMed  Europe PubMed DOI
  68. [YEAR:13-10-1977]Tamura,Y., Hirado,M., Okamura,K., Minato,Y. and Fujii,S.<br>Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C1r, and C1 esterase<br>Biochim Biophys Acta (13-10-1977) 484, 417-422. PubMed  Europe PubMed  I
    69. 1968
  69. Naff,G.B. and Ratnoff,O.S.<br>The enzymatic nature of C'1r. Conversion of C'1s to C'1 esterase and digestion of amino acid esters by C'1r<br>J Exp Med (1968) 128, 571-593. PubMed  Europe PubMed  PMC  EPMC
    70. 1964
  70. Haines,A.L. and Lepow,I.H.<br>Studies on human C'1-esterase. I. Purification and enzymatic properties<br>J Immunol (1964) 92, 456-467. PubMed  Europe PubMed
  71. Haines,A.L. and Lepow,I.H.<br>Studies on human C'1-esterase. II. Function of purified c'1-esterase in the human complement system<br>J Immunol (1964) 92, 468-478. PubMed  Europe PubMed
    72. 1963
  72. Lepow,I.H., Naff,G.B., Todd,E.W., Pensky,J. and Hinz,C.F.<br>Chromatographic resolution of the first component of human complement into three activities<br>J Exp Med (1963) 117, 983-1008. PubMed  Europe PubMed  PMC  EPMC

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