$VAR1 = undef;
Summary for peptidase S01.192: complement component activated C1r
| Names | |
|---|---|
| MEROPS Name | complement component activated C1r |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.192 |
| Holotype | complement component activated C1r (Homo sapiens), Uniprot accession P00736 (peptidase unit: 478-716), MERNUM MER0000238 |
| History | Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London. |
| Activity | |||
|---|---|---|---|
| Catalytic type | Serine | ||
| Peplist | Included in the Peplist with identifier PL00300 | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.41 | ||
| Enzymology | BRENDA database | ||
| Proteolytic events | CutDB database (4 cleavages) | ||
| Activity status | human: active (Arlaud et al., 2004) mouse: active (Arlaud et al., 2002) | ||
| Physiology | Activates component C1s in complement activiation. | ||
| Pathways | KEGG | Complement and coagulation cascades | |
| KEGG | Pertussis | ||
| KEGG | Staphylococcus aureus infection | ||
| KEGG | Systemic lupus erythematosus | ||
| Other databases | TREEFAM | http://www.treefam.org/family/TF330373 | |
| Human genetics | ||||||
|---|---|---|---|---|---|---|
| Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
| C1R | 12p13 | ENSG00000159403 | 715 | C1R | 216950 | |
