Substrates for peptidase M43.004: pappalysin-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
insulin-like growth factor binding protein 4 precursor	P22692	22-258	peptide-Met135+Lys-peptide	P	Gly	Gly	Lys	Met	Lys	Val	Asn	Gly	Qin et al., 2000	3430
insulin-like growth factor binding protein 5	P24593	21-272	peptide-Ser163+Lys-peptide	P	Leu	Thr	Gln	Ser	Lys	Phe	Val	Gly	Laursen et al., 2001	17158
insulin-like growth factor binding protein 5	P24593	21-272	peptide-Lys164+Phe-peptide	P	Thr	Gln	Ser	Lys	Phe	Val	Gly	Gly	Laursen et al., 2001
pappalysin-1	Q13219	81-1627	peptide-Phe466+Asn-peptide	P	Tyr	Glu	Arg	Phe	Asn	Phe	Asp	Gly	Boldt et al., 2001	17159