Literature for peptidase M43.004: pappalysin-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: A Assay, T Target, M Mutation, R Splicing, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Campos,V.C., Aguiar Oliveira,M.H., Bidlingmaier,M., Yuen,K.C.J., Salvatori,R., Oliveira,C.R.P., Leal,A., Melo,E., Schilbach,K., Frystyk,J. and Schweizer,J.R.O.L. IGF-I bioavailability in congenital isolated growth hormone deficiency Eur J Endocrinol (2026) PubMed Europe PubMed DOI

2025

Conover,C.A. Cellular senescence and PAPP-A Growth Horm IGF Res (2025) 80, 101637-101637. PubMed Europe PubMed DOI V
Schloss,S.S., Marshall,Z.Q., Santistevan,N.J., Gjorcheska,S., Stenzel,A., Barske,L. and Nelson,J.C. Cadherin-16 regulates acoustic sensory gating in zebrafish through endocrine signaling PLoS Biol (2025) 23, e3003164-e3003164. PubMed Europe PubMed DOI

2024

Dya,G.A., Lebedeva,O.S., Gushchevarov,D.A., Volovikov,E.A., Belikova,L.D., Kopylova,I.V., Postnikov,A.B., Artemieva,M.M., Medvedeva,N.A., Lagarkova,M.A., Katrukha,A.G. and Serebryanaya,D.V. Specific cleavage of IGFBP-4 by papp-a in nervous tissue Biochem Biophys Res Commun (2024) 733, 150655-150655. PubMed Europe PubMed DOI
Harboe,M., Kjaer-Sorensen,K., Fuchtbauer,E.M., Fenton,R.A., Thomsen,J.S., Bruel,A. and Oxvig,C. The metalloproteinase PAPP-A is required for IGF-dependent chondrocyte differentiation and organization Sci Rep (2024) 14, 20161-20161. PubMed Europe PubMed DOI PMC EPMC
Poddar,A., Ahmady,F., Rao,S.R., Sharma,R., Kannourakis,G., Prithviraj,P. and Jayachandran,A. The role of pregnancy associated plasma protein-A in triple negative breast cancer: a promising target for achieving clinical benefits J Biomed Sci (2024) 31, 23-23. PubMed Europe PubMed DOI PMC EPMC V

2023

Adasheva,D.A., Lebedeva,O.S., Goliusova,D.V., Postnikov,A.B., Teriakova,M.V., Kopylova,I.V., Lagarkova,M.A., Katrukha,A.G. and Serebryanaya,D.V. PAPP-A-Specific IGFBP-4 Proteolysis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC
Hjortebjerg,R., Pedersen,D.A., Mengel-From,J., Jorgensen,L.H., Christensen,K. and Frystyk,J. Heritability and circulating concentrations of pregnancy-associated plasma protein-A and stanniocalcin-2 in elderly monozygotic and dizygotic twins Front Endocrinol (Lausanne) (2023) 14, 1193742-1193742. PubMed Europe PubMed DOI PMC EPMC
Oxvig,C. and Conover,C.A. The Stanniocalcin-PAPP-A-IGFBP-IGF Axis J Clin Endocrinol Metab (2023) 108, 1624-1633. PubMed Europe PubMed DOI V

2022

Jepsen,M.R., Ostergaard,J.A., Conover,C.A., Wogensen,L., Birn,H., Krag,S.P., Fenton,R.A. and Oxvig,C. Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy Metabolism (2022) 132, 155218-155218. PubMed Europe PubMed DOI
Judge,R.A., Sridar,J., Tunyasuvunakool,K., Jain,R., Wang,J.C.K., Ouch,C., Xu,J., Mafi,A., Nile,A.H., Remarcik,C., Smith,C.L., Ghosh,C., Xu,C., Stoll,V., Jumper,J., Singh,A.H., Eaton,D. and Hao,Q. Structure of the PAPP-A(BP5) complex reveals mechanism of substrate recognition Nat Commun (2022) 13, 5500-5500. PubMed Europe PubMed DOI PMC EPMC
Kobbero,S.D., Gajhede,M., Mirza,O.A., Kloverpris,S., Kjaer,T.R., Mikkelsen,J.H., Boesen,T. and Oxvig,C. Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism Nat Commun (2022) 13, 6084-6084. PubMed Europe PubMed DOI PMC EPMC
Zhang,J., Zhang,Y., Li,L., Nian,Y., Chen,Y., Shen,R. and Ma,X. Pregnancy-associated plasma protein-A (PAPPA) promotes breast cancer progression Bioengineered (2022) 13, 291-307. PubMed Europe PubMed DOI PMC EPMC K

2021

Li,S., Liu,C., Goldstein,A., Xin,Y., Ke,C. and Duan,C. Calcium State-Dependent Regulation of Epithelial Cell Quiescence by Stanniocalcin 1a Front Cell Dev Biol (2021) 9, 662915-662915. PubMed Europe PubMed DOI PMC EPMC
Ming,G.F., Gao,B.H. and Chen,P. Identification of Conserved Pappalysin 1-Derived Circular RNA-Mediated Competing Endogenous RNA in Osteosarcoma Evol Bioinform Online (2021) 17, 11769343211041379-11769343211041379. PubMed Europe PubMed DOI PMC EPMC
Serebryanaya,D.V., Adasheva,D.A., Konev,A.A., Artemieva,M.M., Katrukha,I.A., Postnikov,A.B., Medvedeva,N.A. and Katrukha,A.G. IGFBP-4 Proteolysis by PAPP-A in a Primary Culture of Rat Neonatal Cardiomyocytes under Normal and Hypertrophic Conditions Biochemistry (Mosc) (2021) 86, 1395-1406. PubMed Europe PubMed DOI
Wang,G., Zhao,H., Duan,X. and Ren,Z. CircRNA pappalysin 1 facilitates prostate cancer development through miR-515-5p/FKBP1A axis Andrologia (2021) , e14227-e14227. PubMed Europe PubMed DOI K

2020

Kashyap,S., Hein,K.Z., Chini,C.C., Lika,J., Warner,G.M., Bale,L.K., Torres,V.E., Harris,P.C., Oxvig,C., Conover,C.A. and Chini,E.N. Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis JCI Insight (2020) PubMed Europe PubMed DOI

2019

Alro Botkjaer,J., Rimmer Noer,P., Oxvig,C. and Yding Andersen,C. A common variant of the pregnancy-associated plasma protein-A (PAPPA) gene encodes a protein with reduced proteolytic activity towards IGF-binding proteins Sci Rep (2019) 9, 13231-13231. PubMed Europe PubMed DOI M
Heitzeneder,S., Sotillo,E., Shern,J.F., Sindiri,S., Xu,P., Jones,R., Pollak,M., Noer,P.R., Lorette,J., Fazli,L., Alag,A., Meltzer,P., Lau,C., Conover,C.A., Oxvig,C., Sorensen,P.H., Maris,J.M., Khan,J. and Mackall,C.L. Pregnancy-associated plasma protein-A (PAPP-A) in Ewing sarcoma: role in tumor growth and immune evasion J Natl Cancer Inst (2019) 111, 970-982. PubMed Europe PubMed DOI
Slocum,E. and Germain,D. Collagen and PAPP-A in the etiology of postpartum breast cancer Horm Cancer (2019) 10, 137-144. PubMed Europe PubMed DOI

2018

Guo,Y., Bao,Y., Guo,D. and Yang,W. Pregnancy-associated plasma protein A in cancer: expression, oncogenic functions and regulation Am J Cancer Res (2018) 8, 955-963. PubMed Europe PubMed PMC EPMC V
Yu,X.H., He,L.H., Gao,J.H., Zhang,D.W., Zheng,X.L. and Tang,C.K. Pregnancy-associated plasma protein-A in atherosclerosis: molecular marker, mechanistic insight, and therapeutic target Atherosclerosis (2018) 278, 250-258. PubMed Europe PubMed DOI T

2017

Jayabal,P., Houghton,P.J. and Shiio,Y. EWS-FLI-1 creates a cell surface microenvironment conducive to IGF signaling by inducing pappalysin-1 Genes Cancer (2017) 8, 762-770. PubMed Europe PubMed DOI PMC EPMC T
Kirschner,A., Thiede,M., Grunewald,T.G.P., AlbaRubio,R., Richter,G.H.S., Kirchner,T., Busch,D.H., Burdach,S. and Thiel,U. Pappalysin-1 T cell receptor transgenic allo-restricted T cells kill Ewing sarcoma in vitro and in vivo Oncoimmunology (2017) 6 DOI

2016

Cirillo,P., Conte,S., Pellegrino,G., Ziviello,F., Barra,G., De Palma,R., Leonardi,A. and Trimarco,B. Pregnancy-associated plasma protein-A promotes TF procoagulant activity in human endothelial cells by Akt-NF-kappaB axis J Thromb Thrombolysis (2016) 42, 225-232. PubMed Europe PubMed DOI
Monget,P. and Oxvig,C. PAPP-A and the IGF system Ann Endocrinol (Paris) (2016) 77, 90-96. PubMed Europe PubMed DOI
Takabatake,Y., Oxvig,C., Nagi,C., Adelson,K., Jaffer,S., Schmidt,H., Keely,P.J., Eliceiri,K.W., Mandeli,J. and Germain,D. Lactation opposes pappalysin-1-driven pregnancy-associated breast cancer EMBO Mol Med (2016) 8, 388-406. PubMed Europe PubMed DOI

2015

Jepsen,M.R., Kloverpris,S., Mikkelsen,J.H., Pedersen,J.H., Fuchtbauer,E.M., Laursen,L.S. and Oxvig,C. Stanniocalcin-2 inhibits mammalian growth by proteolytic inhibition of the insulin-like growth factor axis J Biol Chem (2015) 290, 3430-3439. PubMed Europe PubMed DOI
Kloverpris,S., Mikkelsen,J.H., Pedersen,J.H., Jepsen,M.R., Laursen,L.S., Petersen,S.V. and Oxvig,C. Stanniocalcin-1 potently inhibits the proteolytic activity of the metalloproteinase pregnancy-associated plasma protein-A J Biol Chem (2015) 290, 21915-21924. PubMed Europe PubMed DOI

2014

Mikkelsen,J.H., Resch,Z.T., Kalra,B., Savjani,G., Kumar,A., Conover,C.A. and Oxvig,C. Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity Oncotarget (2014) 5, 1014-1025. PubMed Europe PubMed T

2013

Gaidamauskas,E., Gyrup,C., Boldt,H.B., Schack,V.R., Overgaard,M.T., Laursen,L.S. and Oxvig,C. IGF dependent modulation of IGF binding protein (IGFBP) proteolysis by pregnancy-associated plasma protein-A (PAPP-A): Multiple PAPP-A-IGFBP interaction sites Biochim Biophys Acta (2013) 1830, 2701-2709. PubMed Europe PubMed DOI
Kjaer-Sorensen,K., Engholm,D.H., Kamei,H., Morch,M.G., Kristensen,A.O., Zhou,J., Conover,C.A., Duan,C. and Oxvig,C. Pregnancy-associated plasma protein A (PAPP-A) modulates the early developmental rate in zebrafish independently of its proteolytic activity J Biol Chem (2013) 288, 9982-9992. PubMed Europe PubMed DOI
Li,Y., Zhou,C., Zhou,X., Song,L. and Hui,R. PAPP-A in cardiac and non-cardiac conditions Clin Chim Acta (2013) 417, 67-72. PubMed Europe PubMed DOI K V

2012

Oxvig,C. Pappalysin-1 (pregnancy-associated plasma protein-A) [ISSN:978-0-12-407744-7] (2012) 3, 1212-1217. DOI

2011

Boldt,H.B. and Conover,C.A. Overexpression of pregnancy-associated plasma protein-A in ovarian cancer cells promotes tumor growth in vivo Endocrinology (2011) 152, 1470-1478. PubMed Europe PubMed DOI

2010

Conover,C.A., Mason,M.A., Bale,L.K., Harrington,S.C., Nyegaard,M., Oxvig,C. and Overgaard,M.T. Transgenic overexpression of pregnancy-associated plasma protein-A in murine arterial smooth muscle accelerates atherosclerotic lesion development Am J Physiol Heart Circ Physiol (2010) 299, H284-H291. PubMed Europe PubMed DOI
Conover,C.A., Bale,L.K., Grell,J.A., Mader,J.R. and Mason,M.A. Longevity is not influenced by prenatal programming of body size Aging Cell (2010) 9, 647-649. PubMed Europe PubMed DOI K
Kirkegaard,I., Uldbjerg,N. and Oxvig,C. Biology of pregnancy-associated plasma protein-A in relation to prenatal diagnostics: an overview Acta Obstet Gynecol Scand (2010) 89, 1118-1125. PubMed Europe PubMed DOI

2009

Consuegra-Sanchez,L., Fredericks,S. and Kaski,J.C. Pregnancy-associated plasma protein A: has this biomarker crossed the boundary from research to clinical practice? Drug News Perspect (2009) 22, 341-348. PubMed Europe PubMed DOI

2008

Mikkelsen,J.H., Gyrup,C., Kristensen,P., Overgaard,M.T., Poulsen,C.B., Laursen,L.S. and Oxvig,C. Inhibition of the proteolytic activity of pregnancy-associated plasma protein-A by targeting substrate exosite binding J Biol Chem (2008) 283, 16772-16780. PubMed Europe PubMed DOI
Ning,Y., Schuller,A.G., Conover,C.A. and Pintar,J.E. Insulin-like growth factor (IGF) binding protein-4 is both a positive and negative regulator of IGF activity in vivo Mol Endocrinol (2008) 22, 1213-1225. PubMed Europe PubMed DOI PMC EPMC

2007

Boldt,H.B. and Conover,C.A. Pregnancy-associated plasma protein-A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs Growth Horm IGF Res (2007) 17, 10-18. PubMed Europe PubMed DOI V
Chen,T., Hogan,S., Conley,G., Pazmany,C., Wu,Q.L., McNeil,G.L., Bassill,G., Macintyre,A.N., Martik,D., Nixon,A.E. and Sexton,D.J. Discovery and characterization of human antibody inhibitors of pregnancy-associated plasma protein-A Biol Chem (2007) 388, 507-512. PubMed Europe PubMed DOI A
Conover,C.A., Harrington,S.C., Bale,L.K. and Oxvig,C. Surface association of pregnancy-associated plasma protein-A accounts for its colocalization with activated macrophages Am J Physiol Heart Circ Physiol (2007) 292, H994-H994. PubMed Europe PubMed DOI
Glerup,S., Kloverpris,S., Laursen,L.S., Dagnaes-Hansen,F., Thiel,S., Conover,C.A. and Oxvig,C. Cell surface detachment of pregnancy-associated plasma protein-A requires the formation of intermolecular proteinase-inhibitor disulfide bonds and glycosaminoglycan covalently bound to the inhibitor J Biol Chem (2007) 282, 1769-1778. PubMed Europe PubMed DOI
Gyrup,C. and Oxvig,C. Quantitative Analysis of Insulin-like Growth Factor-Modulated Proteolysis of Insulin-like Growth Factor Binding Protein-4 and -5 by Pregnancy-Associated Plasma Protein-A Biochemistry (2007) 46, 1972-1980. PubMed Europe PubMed DOI
Gyrup,C., Christiansen,M. and Oxvig,C. Quantification of proteolytically active pregnancy-associated plasma protein-A with an assay based on quenched fluorescence Clin Chem (2007) 53, 947-954. PubMed Europe PubMed DOI A
Harrington,S.C., Simari,R.D. and Conover,C.A. Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet Circ Res (2007) 100, 1696-1702. PubMed Europe PubMed DOI K
Laursen,L.S., Kjaer-Sorensen,K., Andersen,M.H. and Oxvig,C. Regulation of insulin-like growth factor (IGF) bioactivity by sequential proteolytic cleavage of IGF binding protein-4 and -5 Mol Endocrinol (2007) 21, 1246-1257. PubMed Europe PubMed DOI
Miller,B.S., Bronk,J.T., Nishiyama,T., Yamagiwa,H., Srivastava,A., Bolander,M.E. and Conover,C.A. Pregnancy associated plasma protein-A is necessary for expeditious fracture healing in mice J Endocrinol (2007) 192, 505-513. PubMed Europe PubMed DOI
Weyer,K., Boldt,H.B., Poulsen,C.B., Kjaer-Sorensen,K., Gyrup,C. and Oxvig,C. A substrate specificity-determining unit of three Lin12-Notch repeat modules is formed in trans within the pappalysin-1 dimer and requires a sequence stretch C-terminal to the third module J Biol Chem (2007) 282, 10988-10999. PubMed Europe PubMed DOI

2006

Boldt,H.B., Glerup,S., Overgaard,M.T., Sottrup-Jensen,L. and Oxvig,C. Definition, expression, and characterization of a protein domain in the N-terminus of pregnancy-associated plasma protein-A distantly related to the family of laminin G-like modules Protein Expr Purif (2006) 48, 261-273. PubMed Europe PubMed DOI
[YEAR:31-8-2006]Qin,X., Wergedal,J.E., Rehage,M., Tran,K., Newton,J., Lam,P., Baylink,D.J. and Mohan,S. Pregnancy-associated plasma protein-A increases osteoblast proliferation in vitro and bone formation in vivo Endocrinology (31-8-2006) 147, 5653-5661. PubMed Europe PubMed DOI
[YEAR:7-9-2006]Resch,Z.T., Simari,R.D. and Conover,C.A. Targeted disruption of the pregnancy-associated plasma protein-A gene is associated with diminished smooth muscle cell response to insulin-like growth factor-I and resistance to neointimal hyperplasia after vascular injury Endocrinology (7-9-2006) 147, 5634-5640. PubMed Europe PubMed DOI K

2005

Bale,L.K. and Conover,C.A. Disruption of insulin-like growth factor-II imprinting during embryonic development rescues the dwarf phenotype of mice null for pregnancy-associated plasma protein-A J Endocrinol (2005) 186, 325-331. PubMed Europe PubMed DOI K
[YEAR:26-5-2005]Jadlowiec,J., Dongell,D., Smith,J., Conover,C. and Campbell,P. Pregnancy-associated plasma protein-a is involved in matrix mineralization of human adult mesenchymal stem cells and angiogenesis in the chick chorioallontoic membrane Endocrinology (26-5-2005) 146, 3765-3772. PubMed Europe PubMed DOI
[YEAR:22-8-2005]Kumar,A., Mohan,S., Newton,J., Rehage,M., Tran,K., Baylink,D.J. and Qin,X. Pregnancy-associated plasma protein-A regulates myoblast proliferation and differentiation through an insulin-like growth factor-dependent mechanism J Biol Chem (22-8-2005) 280, 37782-37789. PubMed Europe PubMed DOI

2004

Boldt,H.B., Kjaer-Sorensen,K., Overgaard,M.T., Weyer,K., Poulsen,C.B., Sottrup-Jensen,L., Conover,C.A., Giudice,L.C. and Oxvig,C. The Lin12-notch repeats of pregnancy-associated plasma protein-A bind calcium and determine its proteolytic specificity J Biol Chem (2004) 279, 38525-38531. PubMed Europe PubMed DOI
[YEAR:17-12-2004]Bunn,R.C., Green,L.D., Overgaard,M.T., Oxvig,C. and Fowlkes,J.L. IGFBP-4 degradation by pregnancy-associated plasma protein-A in MC3T3 osteoblasts Biochem Biophys Res Commun (17-12-2004) 325, 698-706. PubMed Europe PubMed DOI
Conover,C.A., Bale,L.K., Overgaard,M.T., Johnstone,E.W., Laursen,U.H., Fuchtbauer,E.M., Oxvig,C. and van Deursen,J. Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development Development (2004) 131, 1187-1194. PubMed Europe PubMed DOI K
[YEAR:13-4-2004]Cosin-Sales,J., Christiansen,M., Kaminski,P., Oxvig,C., Overgaard,M.T., Cole,D., Holt,D.W. and Kaski,J.C. Pregnancy-associated plasma protein A and its endogenous inhibitor, the proform of eosinophil major basic protein (proMBP), are related to complex stenosis morphology in patients with stable angina pectoris Circulation (13-4-2004) 109, 1724-1728. PubMed Europe PubMed DOI
Gerard,N., Delpuech,T., Oxvig,C., Overgaard,M.T. and Monget,P. Proteolytic degradation of IGF-binding protein (IGFBP)-2 in equine ovarian follicles: involvement of pregnancy-associated plasma protein-A (PAPP-A) and association with dominant but not subordinated follicles J Endocrinol (2004) 182, 457-466. PubMed Europe PubMed DOI
[YEAR:10-7-2004]Kalli,K.R., Chen,B.K., Bale,L.K., Gernand,E., Overgaard,M.T., Oxvig,C., Cliby,W.A. and Conover,C.A. Pregnancy-associated plasma protein-A (PAPP-A) expression and insulin-like growth factor binding protein-4 protease activity in normal and malignant ovarian surface epithelial cells Int J Cancer (10-7-2004) 110, 633-640. PubMed Europe PubMed DOI
[YEAR:27-2-2004]Overgaard,M.T., Glerup,S., Boldt,H.B., Rodacker,V., Olsen,I.M., Christiansen,M., Sottrup-Jensen,L., Giudice,L.C. and Oxvig,C. Inhibition of proteolysis by the proform of eosinophil major basic protein (proMBP) requires covalent binding to its target proteinase FEBS Lett (27-2-2004) 560, 147-152. PubMed Europe PubMed DOI
Oxvig,C., Overgaard,M.T. and Sottrup-Jensen,L. Pappalysin-1(pregnancy-associated plasma protein A) [ISSN:0-12-079610-4] (2004) 2, 754-757. V
[YEAR:15-3-2004]Sivanandam,A.S., Mohan,S., Kapur,S., Kita,H., Lau,K.H., Bagi,G., Baylink,D.J. and Qin,X. Covalent interaction between proform of eosinophil major basic protein (proMBP) and pregnancy-associated plasma protein-A (PAPP-A) is a cell-mediated event and required for proMBP inhibition of the catalytic activity of PAPP-A Arch Biochem Biophys (15-3-2004) 423, 343-350. PubMed Europe PubMed DOI
[YEAR:10-4-2004]Tanaka,Y., Kobayashi,H., Suzuki,M., Hirashima,Y., Kanayama,N. and Terao,T. Genetic downregulation of pregnancy-associated plasma protein-A (PAPP-A) by bikunin reduces IGF-I-dependent Akt and ERK1/2 activation and subsequently reduces ovarian cancer cell growth, invasion and metastasis Int J Cancer (10-4-2004) 109, 336-347. PubMed Europe PubMed DOI
Weyer,K., Overgaard,M.T., Laursen,L.S., Nielsen,C.G., Schmitz,A., Christiansen,M., Sottrup-Jensen,L., Giudice,L.C. and Oxvig,C. Cell surface adhesion of pregnancy-associated plasma protein-A is mediated by four clusters of basic residues located in its third and fourth CCP module Eur J Biochem (2004) 271, 1525-1535. PubMed Europe PubMed DOI

2003

Monget,P., Mazerbourg,S., Delpuech,T., Maurel,M.C., Maniere,S., Zapf,J., Lalmanach,G., Oxvig,C. and Overgaard,M.T. Pregnancy-associated plasma protein-A is involved in insulin-like growth factor binding protein-2 (IGFBP-2) proteolytic degradation in bovine and porcine preovulatory follicles: identification of cleavage site and characterization of IGFBP-2 degradation Biol Reprod (2003) 68, 77-86. PubMed Europe PubMed DOI
Ortiz,C.O., Chen,B.K., Bale,L.K., Overgaard,M.T., Oxvig,C. and Conover,C.A. Transforming growth factor-beta regulation of the insulin-like growth factor binding protein-4 protease system in cultured human osteoblasts J Bone Miner Res (2003) 18, 1066-1072. PubMed Europe PubMed DOI
[YEAR:24-1-2003]Overgaard,M.T., Sorensen,E.S., Stachowiak,D., Boldt,H.B., Kristensen,L., Sottrup-Jensen,L. and Oxvig,C. Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment J Biol Chem (24-1-2003) 278, 2106-2117. PubMed Europe PubMed DOI
Rivera,G.M. and Fortune,J.E. Selection of the dominant follicle and insulin-like growth factor (IGF)-binding proteins: evidence that pregnancy-associated plasma protein A contributes to proteolysis of IGF-binding protein 5 in bovine follicular fluid Endocrinology (2003) 144, 437-446. PubMed Europe PubMed DOI

2002

Chen,B.K., Overgaard,M.T., Bale,L.K., Resch,Z.T., Christiansen,M., Oxvig,C. and Conover,C.A. Molecular regulation of the IGF-binding protein-4 protease system in human fibroblasts: Identification of a novel inducible inhibitor Endocrinology (2002) 143, 1199-1205. PubMed Europe PubMed DOI
[YEAR:6-12-2002]Laursen,L.S., Overgaard,M.T., Weyer,K., Boldt,H.B., Ebbesen,P., Christiansen,M., Sottrup-Jensen,L., Giudice,L.C. and Oxvig,C. Cell surface targeting of pregnancy-associated plasma protein A proteolytic activity. Reversible adhesion is mediated by two neighboring short consensus repeats J Biol Chem (6-12-2002) 277, 47225-47234. PubMed Europe PubMed DOI
[YEAR:1-10-2002]Laursen,L.S., Overgaard,M.T., Nielsen,C.G., Boldt,H.B., Hopmann,K.H., Conover,C.A., Sottrup-Jensen,L., Giudice,L.C. and Oxvig,C. Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis Biochem J (1-10-2002) 367, 31-40. PubMed Europe PubMed DOI PMC EPMC
Soe,R., Overgaard,M.T., Thomsen,A.R., Laursen,L.S., Olsen,I.M., Sottrup-Jensen,L., Haaning,J., Giudice,L.C., Conover,C.A. and Oxvig,C. Expression of recombinant murine pregnancy-associated plasma protein-A (PAPP-A) and a novel variant (PAPP-Ai) with differential proteolytic activity Eur J Biochem (2002) 269, 2247-2256. PubMed Europe PubMed DOI R

2001

[YEAR:4-10-2001]Bayes-Genis,A., Conover,C.A., Overgaard,M.T., Bailey,K.R., Christiansen,M., Holmes,D.R., Jr., Virmani,R., Oxvig,C. and Schwartz,R.S. Pregnancy-associated plasma protein A as a marker of acute coronary syndromes N Engl J Med (4-10-2001) 345, 1022-1029. PubMed Europe PubMed DOI
[YEAR:1-9-2001]Boldt,H.B., Overgaard,M.T., Laursen,L.S., Weyer,K., Sottrup-Jensen,L. and Oxvig,C. Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin Biochem J (1-9-2001) 358, 359-367. PubMed Europe PubMed DOI PMC EPMC
Byun,D.W., Mohan,S., Yoo,M., Sexton,C., Baylink,D.J. and Qin,X.Z. Pregnancy-associated plasma protein-A accounts for the insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) proteolytic activity in human pregnancy serum and enhances the mitogenic activity of IGF by degrading IGFBP-4 in vitro J Clin Endocrinol Metab (2001) 86, 847-854. PubMed Europe PubMed DOI
Conover,C.A., Faessen,G.F., Ilg,K.E., Chandrasekher,Y.A., Christiansen,M., Overgaard,M.T., Oxvig,C. and Giudice,L.C. Pregnancy-associated plasma protein-A is the insulin-like growth factor binding protein-4 protease secreted by human ovarian granulosa cells and is a marker of dominant follicle selection and the corpus luteum Endocrinology (2001) 142, 2155-2158. PubMed Europe PubMed DOI
[YEAR:24-8-2001]Laursen,L.S., Overgaard,M.T., Soe,R., Boldt,H.B., Sottrup-Jensen,L., Giudice,L.C., Conover,C.A. and Oxvig,C. Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A FEBS Lett (24-8-2001) 504, 36-40. PubMed Europe PubMed DOI
Mazerbourg,S., Overgaard,M.T., Oxvig,C., Christiansen,M., Conover,C.A., Laurendeau,I., Vidaud,M., Tosser-Klopp,G., Zapf,J. and Monget,P. Pregnancy-associated plasma protein-A (PAPP-A) in ovine, bovine, porcine, and equine ovarian follicles: Involvement in IGF binding protein-4 proteolytic degradation and mRNA expression during follicular development Endocrinology (2001) 142, 5243-5253. PubMed Europe PubMed DOI

2000

Chelius,D., Conover,C.A., Baldwin,M.A. and Spencer,E.M. Characterization of the enzymatic specificity of the IGF-dependent insulin-like growth factor binding protein-4 (IGFBP-4) protease Growth Horm IGF Res (2000) 10, 360-366. PubMed Europe PubMed DOI
[YEAR:6-10-2000]Overgaard,M.T., Haaning,J., Boldt,H.B., Olsen,I.M., Laursen,L.S., Christiansen,M., Gleich,G.J., Sottrup-Jensen,L., Conover,C.A. and Oxvig,C. Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor J Biol Chem (6-10-2000) 275, 31128-31133. PubMed Europe PubMed DOI
[YEAR:15-7-2000]Qin,X., Byun,D., Lau,K.H., Baylink,D.J. and Mohan,S. Evidence that the interaction between insulin-like growth factor (IGF)-II and IGF binding protein (IGFBP)-4 is essential for the action of the IGF-II-dependent IGFBP-4 protease Arch Biochem Biophys (15-7-2000) 379, 209-216. PubMed Europe PubMed DOI

1999

Conover,C.A., Oxvig,C., Overgaard,M.T., Christiansen,M. and Giudice,L.C. Evidence that the insulin-like growth factor binding protein-4 protease in human ovarian follicular fluid is pregnancy associated plasma protein-A J Clin Endocrinol Metab (1999) 84, 4742-4745. PubMed Europe PubMed DOI
Lawrence,J.B., Bale,L.K., Haddad,T.C., Clarkson,J.T. and Conover,C.A. Characterization and partial purification of the insulin-like growth factor (IGF)-dependent IGF binding protein-4-specific protease from human fibroblast conditioned media Growth Horm IGF Res (1999) 9, 25-34. PubMed Europe PubMed DOI
[YEAR:16-3-1999]Lawrence,J.B., Oxvig,C., Overgaard,M.T., Sottrup-Jensen,L., Gleich,G.J., Hays,L.G., Yates,J.R., III and Conover,C.A. The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A Proc Natl Acad Sci U S A (16-3-1999) 96, 3149-3153. PubMed Europe PubMed DOI PMC EPMC
Overgaard,M.T., Oxvig,C., Christiansen,M., Lawrence,J.B., Conover,C.A., Gleich,G.J., Sottrup-Jensen,L. and Haaning,J. Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues Biol Reprod (1999) 61, 1083-1089. PubMed Europe PubMed DOI

1998

[YEAR:2-4-1998]Haddow,J.E., Palomaki,G.E., Knight,G.J., Williams,J., Miller,W.A. and Johnson,A. Screening of maternal serum for fetal Down's syndrome in the first trimester N Engl J Med (2-4-1998) 338, 955-961. PubMed Europe PubMed DOI

1997

Qin,Q.P., Christiansen,M., Oxvig,C., Pettersson,K., Sottrup-Jensen,L., Koch,C. and Norgaard-Pedersen,B. Double-monoclonal immunofluorometric assays for pregnancy-associated plasma protein A/proeosinophil major basic protein (PAPP-A/proMBP) complex in first-trimester maternal serum screening for Down syndrome Clin Chem (1997) 43, 2323-2332. PubMed Europe PubMed A

1996

Haaning,J., Oxvig,C., Overgaard,M.T., Ebbesen,P., Kristensen,T. and Sottrup-Jensen,L. Complete cDNA sequence of the preproform of human pregnancy-associated plasma protein-A. Evidence for expression in the brain and induction by cAMP Eur J Biochem (1996) 237, 159-163. PubMed Europe PubMed
Suzuki,Y., Takada,J., Isaka,K., Takayama,M. and Grudzinskas,J.G. [Isolation and purification of pregnancy-associated plasma protein A] Nippon Sanka Fujinka Gakkai Zasshi (1996) 48, 17-24. PubMed Europe PubMed

1995

[YEAR:9-6-1995]Oxvig,C., Haaning,J., Kristensen,L., Wagner,J.M., Rubin,I., Stigbrand,T., Gleich,G.J. and Sottrup-Jensen,L. Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma J Biol Chem (9-6-1995) 270, 13645-13651. PubMed Europe PubMed DOI

1994

Kristensen,T., Oxvig,C., Sand,O., Moller,N.P. and Sottrup-Jensen,L. Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA Biochemistry (1994) 33, 1592-1598. PubMed Europe PubMed
Oxvig,C., Haaning,J., Hojrup,P. and Sottrup-Jensen,L. Location and nature of carbohydrate groups in proform of human major basic protein isolated from pregnancy serum Biochem Mol Biol Int (1994) 33, 329-336. PubMed Europe PubMed
[YEAR:15-12-1994]Oxvig,C., Sand,O., Kristensen,T., Kristensen,L. and Sottrup-Jensen,L. Isolation and characterization of circulating complex between human pregnancy-associated plasma protein-A and proform of eosinophil major basic protein Biochim Biophys Acta (15-12-1994) 1201, 415-423. PubMed Europe PubMed DOI

1993

[YEAR:15-6-1993]Oxvig,C., Sand,O., Kristensen,T., Gleich,G.J. and Sottrup-Jensen,L. Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein J Biol Chem (15-6-1993) 268, 12243-12246. PubMed Europe PubMed

1983

Davey,M.W., Teisner,B., Sinosich,M. and Grudzinskas,J.G. Interaction between heparin and human pregnancy-associated plasma protein A (PAPP-A): a simple purification procedure Anal Biochem (1983) 131, 18-24. PubMed Europe PubMed

1981

[YEAR:15-4-1981]Folkersen,J., Grudzinskas,J.G., Hindersson,P., Teisner,B. and Westergaard,J.G. Pregnancy-associated plasma protein A: circulating levels during normal pregnancy Am J Obstet Gynecol (15-4-1981) 139, 910-914. PubMed Europe PubMed