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Literature for peptidase M43.004: pappalysin-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: A Assay, T Target, M Mutation, R Splicing, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Conover,C.A.
    Cellular senescence and PAPP-A
    Growth Horm IGF Res80, 101637-101637. PubMed  Europe PubMed DOI  V
    2. 2024
  2. Dya,G.A., Lebedeva,O.S., Gushchevarov,D.A., Volovikov,E.A., Belikova,L.D., Kopylova,I.V., Postnikov,A.B., Artemieva,M.M., Medvedeva,N.A., Lagarkova,M.A., Katrukha,A.G. and Serebryanaya,D.V.
    Specific cleavage of IGFBP-4 by papp-a in nervous tissue
    Biochem Biophys Res Commun733, 150655-150655. PubMed  Europe PubMed DOI
  3. Harboe,M., Kjaer-Sorensen,K., Fuchtbauer,E.M., Fenton,R.A., Thomsen,J.S., Bruel,A. and Oxvig,C.
    The metalloproteinase PAPP-A is required for IGF-dependent chondrocyte differentiation and organization
    Sci Rep14, 20161-20161. PubMed  Europe PubMed DOI
  4. Poddar,A., Ahmady,F., Rao,S.R., Sharma,R., Kannourakis,G., Prithviraj,P. and Jayachandran,A.
    The role of pregnancy associated plasma protein-A in triple negative breast cancer: a promising target for achieving clinical benefits
    J Biomed Sci31, 23-23. PubMed  Europe PubMed DOI  V
    5. 2023
  5. Adasheva,D.A., Lebedeva,O.S., Goliusova,D.V., Postnikov,A.B., Teriakova,M.V., Kopylova,I.V., Lagarkova,M.A., Katrukha,A.G. and Serebryanaya,D.V.
    PAPP-A-Specific IGFBP-4 Proteolysis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
    Int J Mol Sci24, PubMed  Europe PubMed DOI
  6. Oxvig,C. and Conover,C.A.
    The Stanniocalcin-PAPP-A-IGFBP-IGF Axis
    J Clin Endocrinol Metab108, 1624-1633. PubMed  Europe PubMed DOI  V
    7. 2022
  7. Jepsen,M.R., Ostergaard,J.A., Conover,C.A., Wogensen,L., Birn,H., Krag,S.P., Fenton,R.A. and Oxvig,C.
    Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy
    Metabolism132, 155218-155218. PubMed  Europe PubMed DOI
  8. Judge,R.A., Sridar,J., Tunyasuvunakool,K., Jain,R., Wang,J.C.K., Ouch,C., Xu,J., Mafi,A., Nile,A.H., Remarcik,C., Smith,C.L., Ghosh,C., Xu,C., Stoll,V., Jumper,J., Singh,A.H., Eaton,D. and Hao,Q.
    Structure of the PAPP-A(BP5) complex reveals mechanism of substrate recognition
    Nat Commun13, 5500-5500. PubMed  Europe PubMed DOI
  9. Kobbero,S.D., Gajhede,M., Mirza,O.A., Kloverpris,S., Kjaer,T.R., Mikkelsen,J.H., Boesen,T. and Oxvig,C.
    Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism
    Nat Commun13, 6084-6084. PubMed  Europe PubMed DOI
  10. Zhang,J., Zhang,Y., Li,L., Nian,Y., Chen,Y., Shen,R. and Ma,X.
    Pregnancy-associated plasma protein-A (PAPPA) promotes breast cancer progression
    Bioengineered13, 291-307. PubMed  Europe PubMed DOI  K
    11. 2021
  11. Ming,G.F., Gao,B.H. and Chen,P.
    Identification of Conserved Pappalysin 1-Derived Circular RNA-Mediated Competing Endogenous RNA in Osteosarcoma
    Evol Bioinform Online17, 11769343211041379-11769343211041379. PubMed  Europe PubMed DOI
  12. Serebryanaya,D.V., Adasheva,D.A., Konev,A.A., Artemieva,M.M., Katrukha,I.A., Postnikov,A.B., Medvedeva,N.A. and Katrukha,A.G.
    IGFBP-4 Proteolysis by PAPP-A in a Primary Culture of Rat Neonatal Cardiomyocytes under Normal and Hypertrophic Conditions
    Biochemistry (Mosc)86, 1395-1406. PubMed  Europe PubMed DOI
  13. Wang,G., Zhao,H., Duan,X. and Ren,Z.
    CircRNA pappalysin 1 facilitates prostate cancer development through miR-515-5p/FKBP1A axis
    Andrologiae14227-e14227. PubMed  Europe PubMed DOI  K
    14. 2020
  14. Kashyap,S., Hein,K.Z., Chini,C.C., Lika,J., Warner,G.M., Bale,L.K., Torres,V.E., Harris,P.C., Oxvig,C., Conover,C.A. and Chini,E.N.
    Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis
    JCI Insight PubMed  Europe PubMed DOI
    15. 2019
  15. Alro Botkjaer,J., Rimmer Noer,P., Oxvig,C. and Yding Andersen,C.
    A common variant of the pregnancy-associated plasma protein-A (PAPPA) gene encodes a protein with reduced proteolytic activity towards IGF-binding proteins
    Sci Rep9, 13231-13231. PubMed  Europe PubMed DOI  M
  16. Heitzeneder,S., Sotillo,E., Shern,J.F., Sindiri,S., Xu,P., Jones,R., Pollak,M., Noer,P.R., Lorette,J., Fazli,L., Alag,A., Meltzer,P., Lau,C., Conover,C.A., Oxvig,C., Sorensen,P.H., Maris,J.M., Khan,J. and Mackall,C.L.
    Pregnancy-associated plasma protein-A (PAPP-A) in Ewing sarcoma: role in tumor growth and immune evasion
    J Natl Cancer Inst111, 970-982. PubMed  Europe PubMed DOI
  17. Slocum,E. and Germain,D.
    Collagen and PAPP-A in the etiology of postpartum breast cancer
    Horm Cancer10, 137-144. PubMed  Europe PubMed DOI
    18. 2018
  18. Guo,Y., Bao,Y., Guo,D. and Yang,W.
    Pregnancy-associated plasma protein A in cancer: expression, oncogenic functions and regulation
    Am J Cancer Res8, 955-963. PubMed  Europe PubMed  V
  19. Yu,X.H., He,L.H., Gao,J.H., Zhang,D.W., Zheng,X.L. and Tang,C.K.
    Pregnancy-associated plasma protein-A in atherosclerosis: molecular marker, mechanistic insight, and therapeutic target
    Atherosclerosis278, 250-258. PubMed  Europe PubMed DOI  T
    20. 2017
  20. Jayabal,P., Houghton,P.J. and Shiio,Y.
    EWS-FLI-1 creates a cell surface microenvironment conducive to IGF signaling by inducing pappalysin-1
    Genes Cancer8, 762-770. PubMed  Europe PubMed DOI  T
  21. Kirschner,A., Thiede,M., Grunewald,T.G.P., AlbaRubio,R., Richter,G.H.S., Kirchner,T., Busch,D.H., Burdach,S. and Thiel,U.
    Pappalysin-1 T cell receptor transgenic allo-restricted T cells kill Ewing sarcoma in vitro and in vivo
    Oncoimmunology6, DOI
    22. 2016
  22. Cirillo,P., Conte,S., Pellegrino,G., Ziviello,F., Barra,G., De Palma,R., Leonardi,A. and Trimarco,B.
    Pregnancy-associated plasma protein-A promotes TF procoagulant activity in human endothelial cells by Akt-NF-kappaB axis
    J Thromb Thrombolysis42, 225-232. PubMed  Europe PubMed DOI
  23. Monget,P. and Oxvig,C.
    PAPP-A and the IGF system
    Ann Endocrinol (Paris)77, 90-96. PubMed  Europe PubMed DOI
  24. Takabatake,Y., Oxvig,C., Nagi,C., Adelson,K., Jaffer,S., Schmidt,H., Keely,P.J., Eliceiri,K.W., Mandeli,J. and Germain,D.
    Lactation opposes pappalysin-1-driven pregnancy-associated breast cancer
    EMBO Mol Med8, 388-406. PubMed  Europe PubMed DOI
    25. 2015
  25. Jepsen,M.R., Kloverpris,S., Mikkelsen,J.H., Pedersen,J.H., Fuchtbauer,E.M., Laursen,L.S. and Oxvig,C.
    Stanniocalcin-2 inhibits mammalian growth by proteolytic inhibition of the insulin-like growth factor axis
    J Biol Chem290, 3430-3439. PubMed  Europe PubMed DOI
  26. Kloverpris,S., Mikkelsen,J.H., Pedersen,J.H., Jepsen,M.R., Laursen,L.S., Petersen,S.V. and Oxvig,C.
    Stanniocalcin-1 potently inhibits the proteolytic activity of the metalloproteinase pregnancy-associated plasma protein-A
    J Biol Chem290, 21915-21924. PubMed  Europe PubMed DOI
    27. 2014
  27. Mikkelsen,J.H., Resch,Z.T., Kalra,B., Savjani,G., Kumar,A., Conover,C.A. and Oxvig,C.
    Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity
    Oncotarget5, 1014-1025. PubMed  Europe PubMed  T
    28. 2013
  28. Gaidamauskas,E., Gyrup,C., Boldt,H.B., Schack,V.R., Overgaard,M.T., Laursen,L.S. and Oxvig,C.
    IGF dependent modulation of IGF binding protein (IGFBP) proteolysis by pregnancy-associated plasma protein-A (PAPP-A): Multiple PAPP-A-IGFBP interaction sites
    Biochim Biophys Acta1830, 2701-2709. PubMed  Europe PubMed DOI
  29. Kjaer-Sorensen,K., Engholm,D.H., Kamei,H., Morch,M.G., Kristensen,A.O., Zhou,J., Conover,C.A., Duan,C. and Oxvig,C.
    Pregnancy-associated plasma protein A (PAPP-A) modulates the early developmental rate in zebrafish independently of its proteolytic activity
    J Biol Chem288, 9982-9992. PubMed  Europe PubMed DOI
  30. Li,Y., Zhou,C., Zhou,X., Song,L. and Hui,R.
    PAPP-A in cardiac and non-cardiac conditions
    Clin Chim Acta417, 67-72. PubMed  Europe PubMed DOI  K  V
    31. 2012
  31. Oxvig,C.
    Pappalysin-1 (pregnancy-associated plasma protein-A)
    [ISSN:978-0-12-407744-7]3, 1212-1217. DOI
    32. 2011
  32. Boldt,H.B. and Conover,C.A.
    Overexpression of pregnancy-associated plasma protein-A in ovarian cancer cells promotes tumor growth in vivo
    Endocrinology152, 1470-1478. PubMed  Europe PubMed DOI
    33. 2010
  33. Conover,C.A., Bale,L.K., Grell,J.A., Mader,J.R. and Mason,M.A.
    Longevity is not influenced by prenatal programming of body size
    Aging Cell9, 647-649. PubMed  Europe PubMed DOI  K
  34. Conover,C.A., Mason,M.A., Bale,L.K., Harrington,S.C., Nyegaard,M., Oxvig,C. and Overgaard,M.T.
    Transgenic overexpression of pregnancy-associated plasma protein-A in murine arterial smooth muscle accelerates atherosclerotic lesion development
    Am J Physiol Heart Circ Physiol299, H284-H291. PubMed  Europe PubMed DOI
  35. Kirkegaard,I., Uldbjerg,N. and Oxvig,C.
    Biology of pregnancy-associated plasma protein-A in relation to prenatal diagnostics: an overview
    Acta Obstet Gynecol Scand89, 1118-1125. PubMed  Europe PubMed DOI
    36. 2009
  36. Consuegra-Sanchez,L., Fredericks,S. and Kaski,J.C.
    Pregnancy-associated plasma protein A: has this biomarker crossed the boundary from research to clinical practice?
    Drug News Perspect22, 341-348. PubMed  Europe PubMed DOI
    37. 2008
  37. Mikkelsen,J.H., Gyrup,C., Kristensen,P., Overgaard,M.T., Poulsen,C.B., Laursen,L.S. and Oxvig,C.
    Inhibition of the proteolytic activity of pregnancy-associated plasma protein-A by targeting substrate exosite binding
    J Biol Chem283, 16772-16780. PubMed  Europe PubMed DOI
  38. Ning,Y., Schuller,A.G., Conover,C.A. and Pintar,J.E.
    Insulin-like growth factor (IGF) binding protein-4 is both a positive and negative regulator of IGF activity in vivo
    Mol Endocrinol22, 1213-1225. PubMed  Europe PubMed DOI
    39. 2007
  39. Boldt,H.B. and Conover,C.A.
    Pregnancy-associated plasma protein-A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs
    Growth Horm IGF Res17, 10-18. PubMed  Europe PubMed DOI  V
  40. Chen,T., Hogan,S., Conley,G., Pazmany,C., Wu,Q.L., McNeil,G.L., Bassill,G., Macintyre,A.N., Martik,D., Nixon,A.E. and Sexton,D.J.
    Discovery and characterization of human antibody inhibitors of pregnancy-associated plasma protein-A
    Biol Chem388, 507-512. PubMed  Europe PubMed DOI  A
  41. Conover,C.A., Harrington,S.C., Bale,L.K. and Oxvig,C.
    Surface association of pregnancy-associated plasma protein-A accounts for its colocalization with activated macrophages
    Am J Physiol Heart Circ Physiol292, H994-H994. PubMed  Europe PubMed DOI
  42. Glerup,S., Kloverpris,S., Laursen,L.S., Dagnaes-Hansen,F., Thiel,S., Conover,C.A. and Oxvig,C.
    Cell surface detachment of pregnancy-associated plasma protein-A requires the formation of intermolecular proteinase-inhibitor disulfide bonds and glycosaminoglycan covalently bound to the inhibitor
    J Biol Chem282, 1769-1778. PubMed  Europe PubMed DOI
  43. Gyrup,C. and Oxvig,C.
    Quantitative Analysis of Insulin-like Growth Factor-Modulated Proteolysis of Insulin-like Growth Factor Binding Protein-4 and -5 by Pregnancy-Associated Plasma Protein-A
    Biochemistry46, 1972-1980. PubMed  Europe PubMed DOI
  44. Gyrup,C., Christiansen,M. and Oxvig,C.
    Quantification of proteolytically active pregnancy-associated plasma protein-A with an assay based on quenched fluorescence
    Clin Chem53, 947-954. PubMed  Europe PubMed DOI  A
  45. Harrington,S.C., Simari,R.D. and Conover,C.A.
    Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet
    Circ Res100, 1696-1702. PubMed  Europe PubMed DOI  K
  46. Laursen,L.S., Kjaer-Sorensen,K., Andersen,M.H. and Oxvig,C.
    Regulation of insulin-like growth factor (IGF) bioactivity by sequential proteolytic cleavage of IGF binding protein-4 and -5
    Mol Endocrinol21, 1246-1257. PubMed  Europe PubMed DOI
  47. Miller,B.S., Bronk,J.T., Nishiyama,T., Yamagiwa,H., Srivastava,A., Bolander,M.E. and Conover,C.A.
    Pregnancy associated plasma protein-A is necessary for expeditious fracture healing in mice
    J Endocrinol192, 505-513. PubMed  Europe PubMed DOI
  48. Weyer,K., Boldt,H.B., Poulsen,C.B., Kjaer-Sorensen,K., Gyrup,C. and Oxvig,C.
    A substrate specificity-determining unit of three Lin12-Notch repeat modules is formed in trans within the pappalysin-1 dimer and requires a sequence stretch C-terminal to the third module
    J Biol Chem282, 10988-10999. PubMed  Europe PubMed DOI
    49. 2006
  49. Boldt,H.B., Glerup,S., Overgaard,M.T., Sottrup-Jensen,L. and Oxvig,C.
    Definition, expression, and characterization of a protein domain in the N-terminus of pregnancy-associated plasma protein-A distantly related to the family of laminin G-like modules
    Protein Expr Purif48, 261-273. PubMed  Europe PubMed DOI
  50. [YEAR:31-8-2006]Qin,X., Wergedal,J.E., Rehage,M., Tran,K., Newton,J., Lam,P., Baylink,D.J. and Mohan,S.
    Pregnancy-associated plasma protein-A increases osteoblast proliferation in vitro and bone formation in vivo
    Endocrinology147, 5653-5661. PubMed  Europe PubMed DOI
  51. [YEAR:7-9-2006]Resch,Z.T., Simari,R.D. and Conover,C.A.
    Targeted disruption of the pregnancy-associated plasma protein-A gene is associated with diminished smooth muscle cell response to insulin-like growth factor-I and resistance to neointimal hyperplasia after vascular injury
    Endocrinology147, 5634-5640. PubMed  Europe PubMed DOI  K
    52. 2005
  52. Bale,L.K. and Conover,C.A.
    Disruption of insulin-like growth factor-II imprinting during embryonic development rescues the dwarf phenotype of mice null for pregnancy-associated plasma protein-A
    J Endocrinol186, 325-331. PubMed  Europe PubMed DOI  K
  53. [YEAR:26-5-2005]Jadlowiec,J., Dongell,D., Smith,J., Conover,C. and Campbell,P.
    Pregnancy-associated plasma protein-a is involved in matrix mineralization of human adult mesenchymal stem cells and angiogenesis in the chick chorioallontoic membrane
    Endocrinology146, 3765-3772. PubMed  Europe PubMed DOI
  54. [YEAR:22-8-2005]Kumar,A., Mohan,S., Newton,J., Rehage,M., Tran,K., Baylink,D.J. and Qin,X.
    Pregnancy-associated plasma protein-A regulates myoblast proliferation and differentiation through an insulin-like growth factor-dependent mechanism
    J Biol Chem280, 37782-37789. PubMed  Europe PubMed DOI
    55. 2004
  55. Boldt,H.B., Kjaer-Sorensen,K., Overgaard,M.T., Weyer,K., Poulsen,C.B., Sottrup-Jensen,L., Conover,C.A., Giudice,L.C. and Oxvig,C.
    The Lin12-notch repeats of pregnancy-associated plasma protein-A bind calcium and determine its proteolytic specificity
    J Biol Chem279, 38525-38531. PubMed  Europe PubMed DOI
  56. [YEAR:17-12-2004]Bunn,R.C., Green,L.D., Overgaard,M.T., Oxvig,C. and Fowlkes,J.L.
    IGFBP-4 degradation by pregnancy-associated plasma protein-A in MC3T3 osteoblasts
    Biochem Biophys Res Commun325, 698-706. PubMed  Europe PubMed DOI
  57. Conover,C.A., Bale,L.K., Overgaard,M.T., Johnstone,E.W., Laursen,U.H., Fuchtbauer,E.M., Oxvig,C. and van Deursen,J.
    Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development
    Development131, 1187-1194. PubMed  Europe PubMed DOI  K
  58. [YEAR:13-4-2004]Cosin-Sales,J., Christiansen,M., Kaminski,P., Oxvig,C., Overgaard,M.T., Cole,D., Holt,D.W. and Kaski,J.C.
    Pregnancy-associated plasma protein A and its endogenous inhibitor, the proform of eosinophil major basic protein (proMBP), are related to complex stenosis morphology in patients with stable angina pectoris
    Circulation109, 1724-1728. PubMed  Europe PubMed DOI
  59. Gerard,N., Delpuech,T., Oxvig,C., Overgaard,M.T. and Monget,P.
    Proteolytic degradation of IGF-binding protein (IGFBP)-2 in equine ovarian follicles: involvement of pregnancy-associated plasma protein-A (PAPP-A) and association with dominant but not subordinated follicles
    J Endocrinol182, 457-466. PubMed  Europe PubMed DOI
  60. [YEAR:10-7-2004]Kalli,K.R., Chen,B.K., Bale,L.K., Gernand,E., Overgaard,M.T., Oxvig,C., Cliby,W.A. and Conover,C.A.
    Pregnancy-associated plasma protein-A (PAPP-A) expression and insulin-like growth factor binding protein-4 protease activity in normal and malignant ovarian surface epithelial cells
    Int J Cancer110, 633-640. PubMed  Europe PubMed DOI
  61. [YEAR:27-2-2004]Overgaard,M.T., Glerup,S., Boldt,H.B., Rodacker,V., Olsen,I.M., Christiansen,M., Sottrup-Jensen,L., Giudice,L.C. and Oxvig,C.
    Inhibition of proteolysis by the proform of eosinophil major basic protein (proMBP) requires covalent binding to its target proteinase
    FEBS Lett560, 147-152. PubMed  Europe PubMed DOI
  62. Oxvig,C., Overgaard,M.T. and Sottrup-Jensen,L.
    Pappalysin-1(pregnancy-associated plasma protein A)
    [ISSN:0-12-079610-4]2, 754-757.  V
  63. [YEAR:15-3-2004]Sivanandam,A.S., Mohan,S., Kapur,S., Kita,H., Lau,K.H., Bagi,G., Baylink,D.J. and Qin,X.
    Covalent interaction between proform of eosinophil major basic protein (proMBP) and pregnancy-associated plasma protein-A (PAPP-A) is a cell-mediated event and required for proMBP inhibition of the catalytic activity of PAPP-A
    Arch Biochem Biophys423, 343-350. PubMed  Europe PubMed DOI
  64. [YEAR:10-4-2004]Tanaka,Y., Kobayashi,H., Suzuki,M., Hirashima,Y., Kanayama,N. and Terao,T.
    Genetic downregulation of pregnancy-associated plasma protein-A (PAPP-A) by bikunin reduces IGF-I-dependent Akt and ERK1/2 activation and subsequently reduces ovarian cancer cell growth, invasion and metastasis
    Int J Cancer109, 336-347. PubMed  Europe PubMed DOI
  65. Weyer,K., Overgaard,M.T., Laursen,L.S., Nielsen,C.G., Schmitz,A., Christiansen,M., Sottrup-Jensen,L., Giudice,L.C. and Oxvig,C.
    Cell surface adhesion of pregnancy-associated plasma protein-A is mediated by four clusters of basic residues located in its third and fourth CCP module
    Eur J Biochem271, 1525-1535. PubMed  Europe PubMed DOI
    66. 2003
  66. Monget,P., Mazerbourg,S., Delpuech,T., Maurel,M.C., Maniere,S., Zapf,J., Lalmanach,G., Oxvig,C. and Overgaard,M.T.
    Pregnancy-associated plasma protein-A is involved in insulin-like growth factor binding protein-2 (IGFBP-2) proteolytic degradation in bovine and porcine preovulatory follicles: identification of cleavage site and characterization of IGFBP-2 degradation
    Biol Reprod68, 77-86. PubMed  Europe PubMed DOI
  67. Ortiz,C.O., Chen,B.K., Bale,L.K., Overgaard,M.T., Oxvig,C. and Conover,C.A.
    Transforming growth factor-beta regulation of the insulin-like growth factor binding protein-4 protease system in cultured human osteoblasts
    J Bone Miner Res18, 1066-1072. PubMed  Europe PubMed DOI
  68. [YEAR:24-1-2003]Overgaard,M.T., Sorensen,E.S., Stachowiak,D., Boldt,H.B., Kristensen,L., Sottrup-Jensen,L. and Oxvig,C.
    Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment
    J Biol Chem278, 2106-2117. PubMed  Europe PubMed DOI
  69. Rivera,G.M. and Fortune,J.E.
    Selection of the dominant follicle and insulin-like growth factor (IGF)-binding proteins: evidence that pregnancy-associated plasma protein A contributes to proteolysis of IGF-binding protein 5 in bovine follicular fluid
    Endocrinology144, 437-446. PubMed  Europe PubMed DOI
    70. 2002
  70. Chen,B.K., Overgaard,M.T., Bale,L.K., Resch,Z.T., Christiansen,M., Oxvig,C. and Conover,C.A.
    Molecular regulation of the IGF-binding protein-4 protease system in human fibroblasts: Identification of a novel inducible inhibitor
    Endocrinology143, 1199-1205. PubMed  Europe PubMed DOI
  71. [YEAR:1-10-2002]Laursen,L.S., Overgaard,M.T., Nielsen,C.G., Boldt,H.B., Hopmann,K.H., Conover,C.A., Sottrup-Jensen,L., Giudice,L.C. and Oxvig,C.
    Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis
    Biochem J367, 31-40. PubMed  Europe PubMed DOI
  72. [YEAR:6-12-2002]Laursen,L.S., Overgaard,M.T., Weyer,K., Boldt,H.B., Ebbesen,P., Christiansen,M., Sottrup-Jensen,L., Giudice,L.C. and Oxvig,C.
    Cell surface targeting of pregnancy-associated plasma protein A proteolytic activity. Reversible adhesion is mediated by two neighboring short consensus repeats
    J Biol Chem277, 47225-47234. PubMed  Europe PubMed DOI
  73. Soe,R., Overgaard,M.T., Thomsen,A.R., Laursen,L.S., Olsen,I.M., Sottrup-Jensen,L., Haaning,J., Giudice,L.C., Conover,C.A. and Oxvig,C.
    Expression of recombinant murine pregnancy-associated plasma protein-A (PAPP-A) and a novel variant (PAPP-Ai) with differential proteolytic activity
    Eur J Biochem269, 2247-2256. PubMed  Europe PubMed DOI  R
    74. 2001
  74. [YEAR:4-10-2001]Bayes-Genis,A., Conover,C.A., Overgaard,M.T., Bailey,K.R., Christiansen,M., Holmes,D.R., Jr., Virmani,R., Oxvig,C. and Schwartz,R.S.
    Pregnancy-associated plasma protein A as a marker of acute coronary syndromes
    N Engl J Med345, 1022-1029. PubMed  Europe PubMed DOI
  75. [YEAR:1-9-2001]Boldt,H.B., Overgaard,M.T., Laursen,L.S., Weyer,K., Sottrup-Jensen,L. and Oxvig,C.
    Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin
    Biochem J358, 359-367. PubMed  Europe PubMed DOI
  76. Byun,D.W., Mohan,S., Yoo,M., Sexton,C., Baylink,D.J. and Qin,X.Z.
    Pregnancy-associated plasma protein-A accounts for the insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) proteolytic activity in human pregnancy serum and enhances the mitogenic activity of IGF by degrading IGFBP-4 in vitro
    J Clin Endocrinol Metab86, 847-854. PubMed  Europe PubMed DOI
  77. Conover,C.A., Faessen,G.F., Ilg,K.E., Chandrasekher,Y.A., Christiansen,M., Overgaard,M.T., Oxvig,C. and Giudice,L.C.
    Pregnancy-associated plasma protein-A is the insulin-like growth factor binding protein-4 protease secreted by human ovarian granulosa cells and is a marker of dominant follicle selection and the corpus luteum
    Endocrinology142, 2155-2158. PubMed  Europe PubMed DOI
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