Substrates for peptidase M24.038: aminopeptidase P (Plasmodium falciparum-type)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Ala-Pro-ACC			Ala+Pro-Acc	S	-	-	-	Ala	Pro	ACC	-	-	Drinkwater et al., 2016
Arg-Pro-ACC			Arg+Pro-Acc	S	-	-	-	Arg	Pro	ACC	-	-	Drinkwater et al., 2016
Asn-Pro-ACC			Asn+Pro-Acc	S	-	-	-	Asn	Pro	ACC	-	-	Drinkwater et al., 2016
bradykinin	P01042	381-389	Arg+Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg	N	-	-	-	Arg	Pro	Pro	Gly	Phe	Ragheb et al., 2009
Gln-Pro-ACC			Gln+Pro-Acc	S	-	-	-	Gln	Pro	ACC	-	-	Drinkwater et al., 2016
Glu-Pro-ACC			Glu+Pro-Acc	S	-	-	-	Glu	Pro	ACC	-	-	Drinkwater et al., 2016
Gly-Pro-ACC			Gly+Pro-Acc	S	-	-	-	Gly	Pro	ACC	-	-	Drinkwater et al., 2016
hemoglobin subunit alpha	P69905	44-48	Phe44+Pro-His-Phe-Asp	N	-	-	-	Phe	Pro	His	Phe	Asp	Ragheb et al., 2009
hemoglobin subunit beta	P68871	36-40	Tyr36+Pro-Trp-Thr-Gln	N	-	-	-	Tyr	Pro	Trp	Thr	Gln	Ragheb et al., 2009
His-Pro-ACC			His+Pro-Acc	S	-	-	-	His	Pro	ACC	-	-	Drinkwater et al., 2016
Ile-Pro-ACC			Ile+Pro-Acc	S	-	-	-	Ile	Pro	ACC	-	-	Drinkwater et al., 2016
Leu-Pro-ACC			Leu+Pro-Acc	S	-	-	-	Leu	Pro	ACC	-	-	Drinkwater et al., 2016
Lys-Pro-ACC			Lys+Pro-Acc	S	-	-	-	Lys	Pro	ACC	-	-	Drinkwater et al., 2016
Met-Pro-ACC			Met+Pro-Acc	S	-	-	-	Met	Pro	ACC	-	-	Drinkwater et al., 2016
Nle-Pro-ACC			Nle+Pro-Acc	S	-	-	-	Nle	Pro	ACC	-	-	Drinkwater et al., 2016
Phe-Pro-ACC			Phe+Pro-Acc	S	-	-	-	Phe	Pro	ACC	-	-	Drinkwater et al., 2016
Pro-Pro-ACC			Pro+Pro-Acc	S	-	-	-	Pro	Pro	ACC	-	-	Drinkwater et al., 2016
Ser-Pro-ACC			Ser+Pro-Acc	S	-	-	-	Ser	Pro	ACC	-	-	Drinkwater et al., 2016
Thr-Pro-ACC			Thr+Pro-Acc	S	-	-	-	Thr	Pro	ACC	-	-	Drinkwater et al., 2016
Trp-Pro-ACC			Trp+Pro-Acc	S	-	-	-	Trp	Pro	ACC	-	-	Drinkwater et al., 2016
Tyr-Pro-ACC			Tyr+Pro-Acc	S	-	-	-	Tyr	Pro	ACC	-	-	Drinkwater et al., 2016
Val-Pro-ACC			Val+Pro-Acc	S	-	-	-	Val	Pro	ACC	-	-	Drinkwater et al., 2016